- Must visit
Uffizi Galleries
Florence’s premier art museum, famed for Botticelli, Leonardo, and Michelangelo. One of Italy’s essential Renaissance collections and a top priority for first-time visitors.
Omio recommends booking the train as it is the most popular option from Sanford, FL to Florence, SC among Omio's users. If you are prioritising price take the bus with prices starting from $95. For those with little time consider booking a train which can get you there in 11h 51m. The ticket price range depends on the travel mode: a bus costs an average of $95, and a train costs an average of $119.
Distance: 383 miles (617 km)
Most popular Train | Bus |
|---|---|
$121 Average price | $95 Average price Cheapest |
12h 21m Average total duration Fastest 11h 51m Onboard + 30m Additional time* | 18h 7m Average total duration 17h 37m Onboard + 30m Additional time* |
Direct Options | Direct Options |
This is compared to other travel options from Sanford, FL to Florence, SC:
A bus is $26 (€22) less than a train for this route with tickets for a train from Sanford, FL to Florence, SC costing on average $121 (€100).
Other travel options to Florence, SC take longer:
Bus takes on average 17h 37m.
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Sanford, FL to Florence, SC run on average 5 times per day, taking around 11h 51m. Cheap train tickets for this journey start at $119 (€98) but you can travel from only $95 (€78) by bus.
There are 2 trains per day. The earliest train runs at 03:18, the last at 19:49. The fastest train covers the 383 miles (617 km) distance in 8h 42m.
Distance 383 miles (617 km) |
Average train duration 11h 51m |
Cheapest ticket price $119 (€98) |
Trains per day 5 |
Direct trains 2 |
Fastest train 8h 42m |
First train 3:18 AM |
Last train 7:49 PM |
Cheapest Month Aug |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Jan - Mar |
Discover the best of Florence — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Florence trip today.
Florence’s premier art museum, famed for Botticelli, Leonardo, and Michelangelo. One of Italy’s essential Renaissance collections and a top priority for first-time visitors.
Best known for Michelangelo’s David, this compact museum is one of Florence’s most iconic cultural stops and often requires advance booking.
A vast palace museum complex with royal apartments, galleries, and decorative arts. Ideal for visitors wanting art and Medici history in one place.
The monumental heart of Florence, surrounded by the cathedral, baptistery, and bell tower. Constantly lively and central to most visits.
Florence’s grand civic square, filled with historic atmosphere, sculpture, and major landmarks including Palazzo Vecchio.
The city’s most famous viewpoint, especially popular at sunset and on social media for sweeping panoramas over Florence.
Slow-smoked pork, usually chopped or pulled and served with a tangy sauce. It is a staple across the Pee Dee region and one of the most recognizable local comfort foods.
Cornmeal-coated catfish fried until crisp, often served with hush puppies and slaw. It reflects the river and Southern fish-fry traditions common in the area.
Creamy grits topped with seasoned shrimp, a Lowcountry and coastal Carolinas classic also widely enjoyed in Florence. It blends Southern farmhouse cooking with seafood traditions.
An established upscale restaurant in Florence known for steaks, seafood, and polished Southern-American dining in an elegant setting.
A popular casual barbecue spot known for smoked meats, Southern sides, and a lively downtown atmosphere.
A long-running local favorite serving Southern and American comfort food in a distinctive, character-filled setting.
Prices are moderate by U.S. standards. Casual dining is affordable, while upscale restaurants and hotels cost more.
Tip 18-20% in restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff USD 1-5 depending on service.
Find answers to the most common questions about traveling from Sanford, FL to Florence, SC by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence, SC, this guide helps you travel smarter and with confidence.

Most Sanford, FL to Florence, SC trains use the DeLand Station to Florence Station station pair. Use this guide to compare Sanford, FL and Florence, SC train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
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