- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price on Sep 19
lei145
Average ticket price on Sep 19
lei283
Fastest journey on Sep 19
5 h 19 m
Average journey duration on Sep 19
9 h 25 m
Trains on Sep 19
8
Distance
577 km
The best way to find a cheap train ticket from Domodossola to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Domodossola to Rome will cost around lei283 if you buy it on the day, but the cheapest tickets can be found for only lei145.
On Sat, Sep 19, we found 8 trains from Domodossola to Rome, including 8 direct services.
On Sat, Sep 19 the direct trains cover the 577 km distance in an average of 9 h 25 m but if you time it right, some trains will get you there in just 5 h 19 m .
On Sat, Sep 19 the slowest trains will take 10 h 51 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Omio recommends booking the train as it is the most popular option from Domodossola to Rome among Omio's users. If you are prioritising price, take the train, with an average ticket price of lei189 For those with little time, consider booking a flight, which has an average total journey time of 4h 57m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a train costs an average of lei189, while a flight costs an average of lei2186.
Distance: 358 miles (577 km)
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
lei189 Average price Cheapest | lei2186 Average price | lei964 Average price (fuel + tolls) | |
6h 41m Average total duration 6h 11m Onboard + 30m Additional time* | 4h 57m Average total duration Fastest 2h 57m Onboard + 2h 0m Additional time* | 7h 17m Average total duration (door-to-door) | |
0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.5kg CO2 emissions | - CO2 emissions | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Domodossola to Rome:
A train is lei1997 less than a flight for this route with tickets for a flight from Domodossola to Rome costing on average lei2186.
Other travel options to Rome take longer:
Train takes on average 6h 11m.
The journey is about 1h 6m faster (6h 11m by train vs 7h 17m by car) and roughly lei775 cheaper once you factor in fuel and tolls (lei189 vs lei964). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
The table below shows live departures for Domodossola to Rome trains for today, Friday, September 18. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Autobus TRENORD 4415A · Regionale TRENORD 2415+ FRECCIAROSSA 9615 | 5:53 AM Domodossola station | 6h22 | 12:15 PM Rome Termini | 2 transfers | |
Regionale 11415 · Regionale Veloce 2015+ FRECCIAROSSA 9617 | 6:17 AM Domodossola station | 6h27 | 12:44 PM Rome Termini | 2 transfers | |
Regionale 11417 · Regionale Veloce 2016+ Intercity 511 | 6:48 AM Domodossola station | 11h15 | 6:03 PM Rome Termini | 2 transfers | |
Autobus TRENORD 4417A · Regionale TRENORD 2417+ FRECCIAROSSA 9619 | 7:03 AM Domodossola station | 6h08 | 1:11 PM Rome Termini | 2 transfers | |
Autobus TRENORD 4419A · Regionale TRENORD 2419+ FRECCIAROSSA 9623 | 8:03 AM Domodossola station | 6h07 | 2:10 PM Rome Termini | 2 transfers | |
Autobus EC041+ FRECCIAROSSA 9625 | 8:30 AM Domodossola station | 6h13 | 2:43 PM Rome Termini | 1 transfer | |
Autobus EC061+ Intercity 597 | 9:30 AM Domodossola station | 11h37 | 9:07 PM Rome Tiburtina | 1 transfer | |
Autobus EC061+ FRECCIAROSSA 9535 | 9:30 AM Domodossola station | 6h19 | 3:49 PM Rome Termini | 1 transfer | |
Autobus TRENORD 2427A · Regionale TRENORD 2427+ FRECCIAROSSA 9641 | 12:10 PM Domodossola station | 6h08 | 6:18 PM Rome Termini | 2 transfers | |
Regionale 11427 · Regionale Veloce 2029+ FRECCIAROSSA 9645 | 12:45 PM Domodossola station | 6h30 | 7:15 PM Rome Termini | 2 transfers | |
Autobus TRENORD 4431A · Regionale TRENORD 2431+ FRECCIAROSSA 9649 | 2:03 PM Domodossola station | 6h12 | 8:15 PM Rome Termini | 2 transfers | |
Autobus TRENORD 4433A · Regionale TRENORD 2433+ FRECCIAROSSA 9653 | 3:03 PM Domodossola station | 6h07 | 9:10 PM Rome Termini | 2 transfers | |
Autobus EC065+ FRECCIAROSSA 9657 | 3:30 PM Domodossola station | 6h10 | 9:40 PM Rome Termini | 1 transfer | |
Autobus TRENORD 4435A · Regionale TRENORD 2435+ FRECCIAROSSA 9661 | 4:03 PM Domodossola station | 6h07 | 10:10 PM Rome Termini | 2 transfers | |
Autobus EC045+ FRECCIAROSSA 9663 | 4:30 PM Domodossola station | 6h09 | 10:39 PM Rome Termini | 1 transfer | |
Autobus TRENORD 4437A · Regionale TRENORD 2437+ FRECCIAROSSA 9681 | 5:03 PM Domodossola station | 6h22 | 11:25 PM Rome Termini | 2 transfers | |
Regionale 11437 · Regionale Veloce 2038+ InterCityNotte 799 | 5:47 PM Domodossola station | 11h56 | 5:43 AM Rome Ostiense | 2 transfers | |
Regionale 11439+ InterCityNotte 797 | 6:48 PM Domodossola station | 11h31 | 6:19 AM Rome Ostiense | 1 transfer | |
| Saturday, September 19 | |||||
![]() | 2:55 AM Domodossola | 10h17 | 1:12 PM Rome | 0 transfersDirect | |
![]() | 3:03 AM Domodossola | 11h06 | 2:09 PM Rome | 0 transfersDirect | |
Find all the dates and times for this journey
Compare train, flight, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Domodossola to Rome run on average 25 times per day, taking around 6h 11m. Cheap train tickets for this journey start at lei58 if you book in advance.
The earliest train runs at 00:01, the last at 23:55. The fastest train covers the 358 miles (577 km) distance in 4h 29m.
Distance 358 miles (577 km) |
Average train duration 6h 11m |
Cheapest ticket price lei58 |
Trains per day 25 |
Fastest train 4h 29m |
First train 12:01 AM |
Last train 11:55 PM |
Cheapest Month Oct |
Cheapest Day Wed |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Sun |
Least Busy Day Wed |
Best time to book 5 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Roma Termini -> Piazza Di Spagna, Rome
Find answers to the most common questions about traveling from Domodossola to Rome by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Domodossola to Rome trains use the Domodossola to Roma Termini station pair, with some services arriving at Roma Tiburtina. Use this guide to compare Domodossola and Rome train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Domodossola has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ristorante La Meridiana, Osteria Vecchio Borgo
Free. ATMs are available in the train station.
Ticket office support is available at Domodossola. Information desks are located in the main hall.
Luggage storage is available at Domodossola. Lost and found is available at the station.
Available at Domodossola: Parking, Taxis, WC.
Available at Domodossola: Bike Parking, Car Rental.
Accessibility facilities are available at Domodossola: Elevators, ramps.
Nearby hotels include Hotel Corona, Hotel Ristorante Eurossola, Hotel Domodossola.
Roma Termini is 1 km from Rome city centre. Public transport options include:
Roma Termini has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Acafe, Moka Café, Roadhouse Grill, McDonald's, Gusto, Chef Express, Coop Minimarket, Mercato Centrale
Free WiFi in the station. ATMs are there are ATMs in various locations around the station.
The ticket office is open Mon - Sun: 06:30 - 22:00. Information desks are located near Platform 24.
Luggage storage is provided by KiPoint and located on Platform 24. Open every day from 06:00 to 23:00.
Available at Roma Termini: Parking, Taxis, WC.
Available at Roma Termini: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Termini: The Sala Blu, Trenitalia's office of assistance for disabled travelers, is located next to Platform 1.
Nearby hotels include Archi di Roma Guest House, Gemma di Roma, The Liberty Boutique Hotel.
Roma Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma Tiburtina has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, Car Rental, and Information Desk.
Food options include: Rock n’ Coffee Roma, Arabian Kebab, Ingredienti, McDonald’s, Numb's Bakery Café
Free, limited Wi-Fi available in the station for 15 minutes. ATMs are located on the ground floor level.
The ticket office is open Mon - Sun: 06:35 - 20:20. Information desks are located inside the main terminal. .
Luggage storage is luggage lockers are located in the station lobby.
Available at Roma Tiburtina: Parking, Taxis, WC.
Available at Roma Tiburtina: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Tiburtina: Accessible facilities include elevators and escalators.
Nearby hotels include B&B Rome Tiburtina, B&B Alba Domus Roma, Hotel delle Province.
Roma Ostiense is 2 km from Rome city centre. Public transport options include:
Roma Ostiense has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ramen Bar Akira, Eataly Roma
Free. ATMs are available in the train station.
Ticket office support is available at Roma Ostiense. Information desks are located in the main hall.
Luggage storage is available at Roma Ostiense. Lost and found is available at the station.
Available at Roma Ostiense: Parking, Taxis, WC.
Available at Roma Ostiense: Bike Parking, Car Rental.
Accessibility facilities are available at Roma Ostiense: Elevators, ramps, restrooms.
Nearby hotels include Hotel Abitart, Hotel San Anselmo, Hotel Villa San Pio.
Here are some other resources that might have the information you need