Travel Information
Compare train, flight, and bus for Domodossola to Rome
Omio recommends booking the train as it is the most popular option from Domodossola to Rome among Omio's users. If you are prioritising price, take the train, with an average ticket price of €46 For those with little time, consider booking a flight, which has an average total journey time of 3h 13m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.5kg. Average ticket prices depend on the travel mode: a train costs an average of €46, while a flight costs an average of €66.
Distance: 358 miles (577 km)
Compare train with
Most popular Train | Flight | Driving |
|---|---|---|
€46 Average price Cheapest | €66 Average price | €172 Average price (fuel + tolls) |
7h 7m Average total duration 6h 37m Onboard + 30m Additional time* | 3h 13m Average total duration Fastest 1h 13m Onboard + 2h 0m Additional time* | 7h 17m Average total duration (door-to-door) |
0.2 - 0.5kg CO2 emissions Lowest | 1.7 - 3.5kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Domodossola to Rome:
A train is €356 less than a flight for this route with tickets for a flight from Domodossola to Rome costing on average €390.
Other travel options to Rome take longer:
Train takes on average 6h 41m.
The journey is about 1h 6m faster (6h 11m by train vs 7h 17m by car) and roughly €138 cheaper once you factor in fuel and tolls (€34 vs €172). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
Travel optionsfrom Domodossola to Rome
How to get from Domodossola to Rome by train, bus or flight.
Our recommendation
The best way to travel from Domodossola to Rome is by taking a flight because it’s the best combination of price and speed.
12:50 PM1h15Domodossola2:05 PMRome€921One-way0 transfers
Cheapest
12:50 PM1h15Domodossola2:05 PMRome€921One-way0 transfers
Fastest
11:00 AM1h10Domodossola12:10 PMRome€1161One-way0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Domodossola to Rome
Travel to Rome easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Domodossola to Rome.

This is compared to other travel options from Domodossola to Rome:
A train is €15 less than a bus for this route with tickets for a bus from Domodossola to Rome costing on average €61.
A train is €20 less than a flight for this route with tickets for a flight from Domodossola to Rome costing on average €66.
Other travel options to Rome take longer:
Train takes on average 7h 7m.
Bus takes on average 15h 45m.
- Around 40 flights per day.
- Around 14 trains per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Domodossola and Rome as scheduled services by train, flight, and bus can vary by season or day of the week.
- Flights mostly depart from Milan Linate Airport and arrive in Rome Leonardo da Vinci Fiumicino Airport.
- Trains mostly depart from Domodossola station and arrive in Rome Termini.
- Travel with Autoservizi Comazzi srl to go to Rome by bus.
- Travel with ITA, Aeroitalia to go to Rome by flight.
- Travel with Italo, Frecciarossa, Intercity Notte, Intercity, Regionale, Trenord to go to Rome by train.
- 11 direct flights per day with Aeroitalia.
Travelling from Domodossola to Rome: related information
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