Journey information
Overview: Columbus, OH to Greenville, SC flight
Flights from Columbus, OH to Greenville, SC depart on average 37 times per day, taking around 5h 32m. Cheap flight tickets for this journey start at $201 (€163) but you can travel from only $121 (€98) by bus.
The earliest flight runs at 05:00, the last at 20:17. The fastest flight covers the 354 miles (571 km) distance in 5h 32m. June is the cheapest month to fly.
Distance 354 miles (571 km) |
Average flight duration 5h 32m |
Cheapest ticket price $201 (€163) |
Flights per day 37 |
Fastest flight 5h 32m |
First flight 05:00 |
Last flight 20:17 |
Cheapest month Jun |
Cheapest day Fri |
High season Oct - Dec |
Low season Jan - Mar |
The cheapest and fastest flights from Columbus, OH to Greenville, SC
Cheapest price
$201
Average price
$201
Fastest journey
5 h 32 m
Average duration
5 h 32 m
Flights per day
1
Distance
571 km
The best way to find a cheap flight ticket from Columbus, OH to Greenville, SC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Columbus, OH to Greenville, SC will cost around $201 if you buy it on the day, but the cheapest tickets can be found for only $201.
Of the 1 flights that leave Columbus, OH for Greenville, SC onMon, Mar 23, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Mar 23 the direct flights cover the 571 km distance in an average of 5 h 32 m but if you time it right, some flights will get you there in just 5 h 32 m .
On Mon, Mar 23 the longest flights will take 5 h 32 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Columbus, OH to Greenville, SC
Omio recommends booking the bus as it is the most popular option from Columbus, OH to Greenville, SC among Omio's users. If you are prioritising price take the bus with prices starting from $121. For those with little time consider booking a flight which can get you there in 5h 32m. The ticket price range depends on the travel mode: a bus costs an average of $121, and a flight costs an average of $201.
Distance: 354 miles (571 km)
Compare flight with
| Flight | Most popular Bus |
|---|---|
$201 Average price | $121 Average price Cheapest |
8h 32m Average total duration Fastest 5h 32m Onboard + 3h 0m Additional time* | 13h 35m Average total duration 13h 5m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Columbus, OH to Greenville, SC flight times
The table below shows live departures for Columbus, OH to Greenville, SC flights for tomorrow, Sunday, March 22. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:48 PM Columbus, OH | 5h32 | 6:20 PM Greenville, SC | 0 transfersDirect | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Columbus, OH to Greenville, SC by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Mar 29
FAQs: Columbus, OH to Greenville, SC Flight
Find answers to the most common questions about traveling from Columbus, OH to Greenville, SC by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Greenville, SC, this guide helps you travel smarter and with confidence.

- Greenville Jazz Festival, a vibrant celebration of jazz music featuring local and national artists performing in various venues
- Artisphere, an annual arts festival showcasing visual arts, live performances, and culinary delights from regional artists
- Fall for Greenville, a food and music festival highlighting the best local cuisine and entertainment in a family-friendly atmosphere.
- Memorial Day, the unofficial start of summer with vibrant local events and parades
- Independence Day, spectacular fireworks and festive celebrations throughout the city
- Labor Day, a perfect time for outdoor activities and community gatherings as summer winds down.
popular airports
Popular airports from Columbus, OH to Greenville, SC
- Free Wi-Fi available throughout the airport.
- Shops in terminals, including duty-free and local brands.
- Parking available near the terminal, approximately 0.18€ (5 TRY) per hour.
- Various locations, including American, Italian, and fast food
- Available outside the terminal.
- Elevators, ramps
- Available throughout the airport.
- Hotels nearby, such as Hilton Garden Inn and Hampton Inn.
- No showers available.
- Several lounges, including airline-specific and independent.
- Available throughout the airport.
- Car rental services available on-site, including major brands like Hertz and Avis
- COTA AirConnect Bus, John Glenn Intertiol Airport stop, 15-20 minutes
Most popular flights from Columbus, OH
More options for your journey from Columbus, OH to Greenville, SC
Here are some other resources that might have the information you need
