- Must visit
Palazzo Abatellis - Regional Gallery of Sicily
Major art museum in a Gothic-Catalan palace, known for Sicilian medieval and Renaissance masterpieces including works by Antonello da Messina.
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The cheapest and fastest buses from Siena to Palermo
Showing times and prices for Jun 21
Cheapest price
$47
Average price
$64
Fastest journey
16 h
Average duration
18 h 28 m
Buses per day
2
Distance
603 km
Cheap tickets
The best way to find a cheap bus ticket from Siena to Palermo is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Siena to Palermo will cost around $64 if you buy it on the day, but the cheapest tickets can be found for only $47.
Fast buses
Of the 2 buses that leave Siena for Palermo on Sun, Jun 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct buses cover the 603 km distance in an average of 18 h 28 m but if you time it right, some buses will get you there in just 16 h .
On Sun, Jun 21 the slowest buses will take 20 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
6:00 PM16h00Siena10:00 AMPalermo$471One-way0 transfers- 8:25 PM20h55Siena5:20 PMPalermo$811One-way0 transfers
- 6:00 PM16h00Siena10:00 AMPalermo$471One-way0 transfers
- 8:25 PM20h55Siena5:20 PMPalermo$811One-way0 transfers
Travel Information
Compare train, bus, flight, and ferry for Siena to Palermo
Omio recommends booking the bus as it is the most popular option from Siena to Palermo among Omio's users. If you are prioritising price take the flight with prices starting from $21. For those with little time consider booking a flight which can get you there in 1h 22m. The ticket price range depends on the travel mode: a flight costs an average of $21, and a train costs an average of $95.
Distance: 374 miles (603 km)
Compare bus with
Most popular Bus | Flight | Ferry | Train | Driving |
|---|---|---|---|---|
$68 Average price | $48 Average price Cheapest | $60 Average price | $160 Average price | $82 Average price (fuel + tolls) |
16h 47m Average total duration 16h 17m Onboard + 30m Additional time* | 4h 22m Average total duration Fastest 1h 22m Onboard + 3h 0m Additional time* | 20h 30m Average total duration 19h 30m Onboard + 1h 0m Additional time* | 16h 37m Average total duration 16h 7m Onboard + 30m Additional time* | 11h 30m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline |  Most popular ferry company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Siena to Palermo is a flight with an average price of $48 (€39).
This is compared to other travel options from Siena to Palermo:
A flight is $12 (€10) less than a ferry for this route with tickets for a ferry from Siena to Palermo costing on average $60 (€49).
A flight is $19 (€16) less than a bus for this route with tickets for a bus from Siena to Palermo costing on average $68 (€55).
A flight is $112 (€91) less than a train for this route with tickets for a train from Siena to Palermo costing on average $160 (€131).
The fastest way to travel from Siena to Palermo is by flight with an average journey time of 1h 22m.
Other travel options to Palermo take longer:
Train takes on average 16h 7m.
Bus takes on average 16h 17m.
Ferry takes on average 19h 30m.
It's helpful to compare your options as there are 4 ways to travel between Siena and Palermo including taking a train, bus, flight, and ferry.
We recommend using the bus as it is the most popular way to get from Siena to Palermo among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $68 (€55) compared to roughly $82 (€67) in fuel and tolls — a saving of about $14 (€12). The journey takes 16h 17m versus 11h 30m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by FlixBus.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Siena to Palermo Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:51PM | Arrival Time 12:55PM | Duration 23h04 | Departure days Fri | Cheapest price $59 |
Operator FlixBus | Departure Time 05:00PM | Arrival Time 09:00AM | Duration 16h00 | Departure days Mon, Fri | Cheapest price $101 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 01:15PM | Duration 19h15 | Departure days Mon, Fri, Sun | Cheapest price $31 |
Operator FlixBus | Departure Time 07:00PM | Arrival Time 01:15PM | Duration 18h15 | Departure days Mon, Tue, Wed, Thu, Sat | Cheapest price $65 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 05:20PM | Duration 20h55 | Departure days Mon, Fri, Sun | Cheapest price $60 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 03:15PM | Duration 18h15 | Departure days Tue, Sat | Cheapest price $90 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 07:20PM | Duration 20h55 | Departure days Tue, Wed, Thu, Sat | Cheapest price $77 |
Live departures
Siena to Palermo bus times
The table below shows live departures for Siena to Palermo buses for today, Saturday, June 20. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus | 7:00 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 16h00 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 0 transfersDirect | |
| FlixBus · FlixBus | 9:00 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 18h15 | 3:15 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
| FlixBus · FlixBus | 10:25 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 20h55 | 7:20 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Palermo by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Siena to Palermo buses with Omio?
FlixBus as well as Itabus offer buses services from Siena to Palermo.
Omio is an official ticket reseller for all your travel options from Siena to Palermo.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus to find the best option for your trip from Siena to Palermo.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Siena to Palermo.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus to find the best option for your trip from Siena to Palermo.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus, flight and ferry to find the ideal travel option from Siena to Palermo.
Journey information
Overview: Bus from Siena to Palermo
ItalyItaly
Buses from Siena to Palermo run on average 4 times per day, taking around 16h 17m. Cheap bus tickets for this journey start at $31 (€26) but you can travel from only $21 (€17) by flight.
There are 1 buses per day. The earliest bus runs at 00:52, the last at 22:25. The fastest bus covers the 374 miles (603 km) distance in 16h 0m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $21 (€17)
Distance 374 miles (603 km) |
Average bus duration 16h 17m |
Cheapest ticket price $31 (€26) |
Buses per day 4 |
Direct buses 1 |
Fastest bus 16h 0m |
First bus 12:52 AM |
Last bus 10:25 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Wed |
Best time to book 70 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $21 (€17)
Bus providers: FlixBus, Itabus from Siena to PalermoYou can travel by bus between Siena to Palermo with FlixBus, Itabus for as low as $21 (€17). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
16h 0m
Cheapest Price
$31 (€26)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Itabus
About
Itabus is a leading bus company in Italy, providing reliable and comfortable transportation services to its customers. Itabus operates a fleet of modern buses, ranging from luxury coaches to standard buses, all equipped with air conditioning, comfortable seating, and onboard entertainment.
Luggage & cancellation policy
Average Duration
20h 35m
Cheapest Price
$134 (€110)
Itabus frequency
1 a day
Luggage included
One carry-on bag up to 10kg and one checked bag up to 20kg.
Additional luggage
5€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Dedicated seating areas; Accessible restrooms.
Bikes
Bikes are allowed.
Pets
Small pets allowed in carriers; larger pets must be leashed and muzzled.
Complete guide to Palermo
Things to do in Palermo
Discover the best of Palermo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Palermo trip today.
- Must visit
Museo Archeologico Regionale Antonino Salinas
One of Sicily's most important archaeological museums, with Punic, Greek and Roman collections and notable sculpture fragments.
- Recommended
Palazzo Mirto
Historic noble residence preserved with original furnishings, offering a vivid look at aristocratic life in Palermo.
- Must visit
Ballaro Market Area
Energetic historic district centered on Palermo's most famous street market, full of everyday local life and vivid street scenes.
- Must visit
Piazza Pretoria
Striking central square framed by historic buildings and the famous fountain, a key stop in the old town.
- Must visit
Via Maqueda
One of Palermo's main historic streets, largely pedestrianized and lined with landmarks, shops and lively urban scenes.
Arancine
Fried rice balls stuffed with ragù, mozzarella, or butter and ham. Palermo is famous for its round arancine and strong street-food tradition.
Pane con la Milza
A classic Palermo street sandwich made with veal spleen and lung, often topped with caciocavallo or ricotta. It is one of the city's most iconic local bites.
- Vegetarian
- Vegan
Panelle
Chickpea fritters, usually served in a sesame bread roll. They are a beloved Palermo snack and a staple of the city's historic friggitorie.
Osteria Ballarò
Well-regarded restaurant near the historic center serving refined Sicilian cuisine with local ingredients in an elegant but relaxed atmosphere.
Bisso Bistrot
Popular central spot for approachable Sicilian cooking, including pasta and regional classics, with a casual and lively atmosphere.
Corona Trattoria
Established seafood-focused trattoria appreciated for traditional Palermo and Sicilian dishes in a classic local dining room.
Euro
Moderate by Italian standards: street food is cheap, while central hotels and tourist restaurants cost more.
Average meal costs
- Budget
- EUR 6-12 for street food or a simple lunch.
- Mid-range
- EUR 20-35 per person at a casual restaurant.
- Fine dining
- EUR 60+ per person at upscale restaurants.
- Coffee
- EUR 1.20-2.50 for espresso or cappuccino.
Tipping culture
Service is often included or minimal. Rounding up or leaving EUR 1-2 at cafes is common; about 5-10% for very good restaurant service. Taxis are usually rounded up.
FAQs: Bus from Siena to Palermo
Find answers to the most common questions about traveling from Siena to Palermo by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palermo, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Siena to Palermo can start from as little as $31 (€26) when you book in advance. The average bus ticket price for Siena to Palermo is $68 (€55) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Siena to Palermo is 16h 0m to travel the 374 miles (603 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Siena to Palermo leaves at 12:52 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Siena to Palermo leaves at 10:25 PM.
Yes, there are 1 direct buses a day from Siena to Palermo with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Siena to Palermo, you can count on FlixBus, Itabus for the best way to get you to Palermo. You can also check all possible bus companies who offer a service between Siena and Palermo and compare the amenities they offer before buying a bus ticket.
A trip to Palermo from Siena is worth doing but not as a day trip with a journey time of 16h 0m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Siena to Palermo is February.
It's helpful to compare your options as there are 4 ways to travel between Siena and Palermo including taking a train, bus, flight, and ferry.
Yes, the following accessibility options are available when taking the bus from Siena to Palermo:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
Yes, there are bathrooms on board the bus from Siena to Palermo for bus company FlixBus, Itabus.
Some of the most interesting sights to explore in Palermo are:
- Palermo Cathedral, a stunning architectural blend of Norman, Moorish, and Baroque styles
- Teatro Massimo, Italy's largest opera house known for its grand performances and impressive acoustics
- Palazzo dei Normanni, a historic palace featuring the exquisite Palatine Chapel with its Byzantine mosaics
- Quattro Canti, a Baroque square at the intersection of Palermo's two main streets, known for its symmetrical fountains and statues
- Orto Botanico di Palermo, a lush botanical garden showcasing diverse plant species.
The best things to do in Palermo include:
- Capuchin Catacombs, an eerie yet fascinating underground cemetery with mummified remains
- Ballarò Market, a bustling street market offering a taste of local Sicilian produce and culture
- Explore the vibrant street art in the Vucciria district
- Take a cooking class to learn how to make traditional Sicilian dishes
- Enjoy a leisurely stroll along the picturesque Foro Italico promenade.
Whether you can cancel your bus ticket from Siena to Palermo depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Yes, bikes are allowed on board the bus with bus company FlixBus, Itabus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Siena to Palermo.
Yes, the following luggage options are included when booking a bus ticket from Siena to Palermo:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
Yes, the following additional luggage options are available when booking a bus ticket from Siena to Palermo:
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
Yes, you can bring your pet on the bus from Siena to Palermo. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
You can reserve your seat on the bus from Siena to Palermo with the following bus company: FlixBus, Itabus
Yes, there are USB plugs on board the bus from Siena to Palermo with the following bus company: FlixBus, Itabus.
Yes, there is Wifi on board the bus from Siena to Palermo with the following bus company: FlixBus, Itabus.
Since both Siena and Palermo are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the bus as it is the most popular way to get from Siena to Palermo among Omio's users.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
In Palermo, travelers should be cautious of petty theft, especially pickpocketing in crowded areas like markets and public transport. Scams include overcharging by taxi drivers and vendors, as well as unofficial guides offering overpriced tours. It's advisable to use authorized services and stay vigilant in busy tourist spots.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Siena to Palermo
Siena
Palermo
Siena, Stazione FS (Piazzale Carlo Rosselli)
information
Siena, Siena/Viale Pietro Toselli
information
Siena, P.za Gramsc
information
Most popular bus connections from Siena
More options for your journey from Siena to Palermo
Here are some other resources that might have the information you need
Most popular buses to and from Palermo and Siena
Most popular bus connections to Palermo
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