- Must visit
Antonino Salinas Regional Archaeological Museum
Palermo’s top museum displays Sicilian archaeology, including the famous Punic Stone and Selinunte finds, in a former convent complex.
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The cheapest and fastest buses from Siena to Palermo
Showing times, prices and bookable tickets for Sep 19
Cheapest price on Sep 19
$33
Average ticket price on Sep 19
$44
Fastest journey on Sep 19
20 h 55 m
Average journey duration on Sep 19
22 h
Buses on Sep 19
2
Distance
603 km
Cheap tickets
The best way to find a cheap bus ticket from Siena to Palermo is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Siena to Palermo will cost around $44 if you buy it on the day, but the cheapest tickets can be found for only $33.
Fast buses
On Sat, Sep 19, we found 2 buses from Siena to Palermo, including 2 direct services.
On Sat, Sep 19 the direct buses cover the 603 km distance in an average of 22 h but if you time it right, some buses will get you there in just 20 h 55 m .
On Sat, Sep 19 the slowest buses will take 23 h 4 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
1:51 PM23h04Siena12:55 PMPalermo$331One-way0 transfers- 8:25 PM20h55Siena5:20 PMPalermo$541One-way0 transfers
- 8:25 PM20h55Siena5:20 PMPalermo$541One-way0 transfers
- 1:51 PM23h04Siena12:55 PMPalermo$331One-way0 transfers
Travel Information
Compare train, bus, flight, and ferry for Siena to Palermo
Omio recommends booking the bus as it is the most popular option from Siena to Palermo among Omio's users. If you are prioritising price, take the train, with an average ticket price of $26 For those with little time, consider booking a flight, which has an average total journey time of 3h 19m. Average ticket prices depend on the travel mode: a train costs an average of $26, while a flight costs an average of $182.
Distance: 374 miles (603 km)
Compare bus with
Most popular Bus | Flight | Ferry | Train | Driving |
|---|---|---|---|---|
$110 Average price | $182 Average price | $63 Average price | $26 Average price Cheapest | $82 Average price (fuel + tolls) |
17h 5m Average total duration 16h 35m Onboard + 30m Additional time* | 3h 19m Average total duration Fastest 1h 19m Onboard + 2h 0m Additional time* | 20h 35m Average total duration 19h 35m Onboard + 1h 0m Additional time* | 16h 29m Average total duration 15h 59m Onboard + 30m Additional time* | 11h 30m Average total duration (door-to-door) |
Most popular bus company |  Most popular airline |  Most popular ferry company |  Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Siena to Palermo is a train with an average price of $26.
This is compared to other travel options from Siena to Palermo:
A train is $37 less than a ferry for this route with tickets for a ferry from Siena to Palermo costing on average $63.
A train is $85 less than a bus for this route with tickets for a bus from Siena to Palermo costing on average $110.
A train is $156 less than a flight for this route with tickets for a flight from Siena to Palermo costing on average $182.
The fastest way to travel from Siena to Palermo is by flight with an average journey time of 1h 19m.
Other travel options to Palermo take longer:
Train takes on average 15h 59m.
Bus takes on average 16h 35m.
Ferry takes on average 19h 35m.
It's helpful to compare your options as there are 4 ways to travel between Siena and Palermo including taking a train, bus, flight, and ferry.
We recommend using the bus as it is the most popular way to get from Siena to Palermo among Omio's users.
Take the bus. It's the cheapest way to make this trip, and the price gap is usually bigger than people expect.
Tickets start at around $110 compared to roughly $82 in fuel and tolls — a saving of about $-27.90. The journey takes 16h 35m versus 11h 30m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Siena to Palermo Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:51PM | Arrival Time 12:55PM | Duration 23h04 | Departure days Tue, Sat | Cheapest price $33 |
Operator FlixBus | Departure Time 05:00PM | Arrival Time 09:00AM | Duration 16h00 | Departure days Mon, Tue, Wed, Thu | Cheapest price $77 |
Operator FlixBus | Departure Time 06:00PM | Arrival Time 10:00AM | Duration 16h00 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $47 |
Operator FlixBus | Departure Time 07:00PM | Arrival Time 11:00AM | Duration 16h00 | Departure days Mon, Tue, Fri | Cheapest price $68 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 01:15PM | Duration 17h15 | Departure days Tue | Cheapest price $145 |
Operator FlixBus | Departure Time 08:25PM | Arrival Time 05:20PM | Duration 20h55 | Departure days Mon, Wed, Thu, Sat, Sun | Cheapest price $49 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 03:15PM | Duration 18h15 | Departure days Fri | Cheapest price $67 |
Operator FlixBus | Departure Time 10:25PM | Arrival Time 07:20PM | Duration 20h55 | Departure days Fri | Cheapest price $88 |
Live departures
Siena to Palermo bus times
The table below shows live departures for Siena to Palermo buses for today, Friday, September 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| FlixBus | 7:00 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 16h00 | 11:00 AM Palermo, Via Tommaso Fazello (Terminal Bus) | 0 transfersDirect | |
| FlixBus · FlixBus | 9:00 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 18h15 | 3:15 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
| FlixBus · FlixBus | 10:25 PM Siena, Stazione FS (Piazzale Carlo Rosselli) | 20h55 | 7:20 PM Palermo, Via Tommaso Fazello (Terminal Bus) | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Siena to Palermo by train, bus, flight, or ferry
Compare train, bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Siena to Palermo buses with Omio?
FlixBus as well as Itabus offer buses services from Siena to Palermo.
Omio is an official ticket reseller for all your travel options from Siena to Palermo.
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Itabus to find the best option for your trip from Siena to Palermo.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train, bus, flight and ferry to ensure you get the best deal for traveling from Siena to Palermo.
Why book with Omio over Wanderu, Trainline or Checkmybus?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Itabus to find the best option for your trip from Siena to Palermo.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus, flight and ferry to find the ideal travel option from Siena to Palermo.
Journey information
Overview: Bus from Siena to Palermo
ItalyItaly
Buses from Siena to Palermo run on average 4 times per day, taking around 16h 35m. Cheap bus tickets for this journey start at $42 but you can travel from only $12 by train.
There are 1 buses per day. The earliest bus runs at 00:52, the last at 22:25. The fastest bus covers the 374 miles (603 km) distance in 15h 35m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $12
Distance 374 miles (603 km) |
Average bus duration 16h 35m |
Cheapest ticket price $42 |
Buses per day 4 |
Direct buses 1 |
Fastest bus 15h 35m |
First bus 12:52 AM |
Last bus 10:25 PM |
Cheapest Month Feb |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Mon |
Best time to book 14 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $12
Bus providers: FlixBus, Itabus from Siena to PalermoYou can travel by bus between Siena to Palermo with FlixBus, Itabus for as low as $29. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average FlixBus Duration
15h 35m
Cheapest FlixBus Price
$42
FlixBus frequency
4 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Itabus
About
Itabus is a leading bus company in Italy, providing reliable and comfortable transportation services to its customers. Itabus operates a fleet of modern buses, ranging from luxury coaches to standard buses, all equipped with air conditioning, comfortable seating, and onboard entertainment.
Luggage & cancellation policy
Average Itabus Duration
16h 45m
Cheapest Itabus Price
$44
Itabus frequency
1 a day
Luggage included
One carry-on bag up to 10kg and one checked bag up to 20kg.
Additional luggage
5€ per additional bag.
Cancellation Policy
You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Dedicated seating areas; Accessible restrooms.
Bikes
Bikes are allowed.
Pets
Small pets allowed in carriers; larger pets must be leashed and muzzled.
Complete guide to Palermo
Things to do in Palermo
Discover the best of Palermo — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Palermo trip today.
- Recommended
Palazzo Mirto
Historic rooms and vivid majolica floors showcase aristocratic Palermo. Visit for decorative arts, period interiors and city history.
- Recommended
Steri Museum
Housed in the grand Steri Palace, this museum presents the Sicilian Inquisition’s story through cells, graffiti and historical documents.
- Must visit
Via Vittorio Emanuele
Palermo’s elegant main boulevard links major monuments, shops and theaters. Ideal for first walks and observing the city’s layered architecture.
- Must visit
Via Maqueda
This historic street cuts across the old center and hosts markets, churches and daily life. A lively route for exploring local Palermo.
- Recommended
Albergheria
A bustling old quarter famous for layered street life, churches and market culture. Best explored on foot for atmosphere and urban history.
Arancina
Crisp fried rice ball stuffed with ragù, peas and caciocavallo. A Sicilian street food icon widely loved in Palermo.
Pane con la Milza
Soft sesame-topped bun filled with spleen and lung, often with caciocavallo or ricotta. A classic Palermo street food with deep local roots.
Pasta con le Sarde
Pasta with sardines, wild fennel, pine nuts and raisins. Its sweet-savory flavor reflects Palermo's Arab-Norman culinary heritage.
I Pupi
Refined Michelin-starred restaurant known for creative Sicilian tasting menus in an elegant, intimate setting.
Osteria Ballarò
Historic seafood restaurant near the port, praised for fresh catch, raw dishes and classic Palermo fish recipes.
Nni Franco U Vastiddaru
Legendary no-frills street-food stop celebrated for pane con la milza and authentic local sandwiches loved by residents.
Euro (€)
Moderate for Italy. Street food and local meals are affordable, while hotels in peak season cost more. Public transport is cheap, keeping overall tourist costs reasonable.
Average meal costs
- Budget
- €8-12 for street food or a simple meal.
- Mid-range
- €20-35 per person for a restaurant meal.
- Fine dining
- €60+ per person for upscale dining.
- Coffee
- €1.50-3 for coffee or cappuccino.
Tipping culture
Service is often included or modest. Round up or leave 5-10% for great restaurant service. Taxis are usually rounded up. Small change is fine in cafes.
FAQs: Bus from Siena to Palermo
Find answers to the most common questions about traveling from Siena to Palermo by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palermo, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Siena to Palermo can start from as little as $42 when you book in advance. The average bus ticket price for Siena to Palermo is $110 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Siena to Palermo is 15h 35m to travel the 374 miles (603 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Siena to Palermo leaves at 12:52 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Siena to Palermo leaves at 10:25 PM.
Yes, there are 1 direct buses a day from Siena to Palermo with FlixBus. Schedules can vary on holidays or weekends with fewer direct buses.
When taking a bus from Siena to Palermo, you can count on FlixBus, Itabus for the best way to get you to Palermo. You can also check all possible bus companies who offer a service between Siena and Palermo and compare the amenities they offer before buying a bus ticket.
When departing from Siena , you have various bus station options to start your journey from including Siena, Stazione FS (Piazzale Carlo Rosselli), Siena, Siena/Viale Pietro Toselli . When arriving in Palermo , you can end your journey in bus stations like Palermo, Via Tommaso Fazello (Terminal Bus) .Passengers board the bus most frequently from Siena, Stazione FS (Piazzale Carlo Rosselli), which is located around 0 miles (1 km) away from the city centre, and they get off the bus at Palermo, Via Tommaso Fazello (Terminal Bus), located 1 away from the city centre.
A trip to Palermo from Siena is worth doing but not as a day trip with a journey time of 15h 35m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Siena to Palermo is February.
It's helpful to compare your options as there are 4 ways to travel between Siena and Palermo including taking a train, bus, flight, and ferry.
Yes, the following accessibility options are available when taking the bus from Siena to Palermo:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Itabus
- Assistance
- Dedicated seating areas
- Accessible restrooms.
Yes, there are bathrooms on board the bus from Siena to Palermo for bus company FlixBus, Itabus.
Some of the most interesting sights to explore in Palermo are:
- Palermo Cathedral, a stunning architectural blend of Norman, Moorish, and Baroque styles
- Teatro Massimo, Italy's largest opera house known for its grand performances and impressive acoustics
- Palazzo dei Normanni, a historic palace featuring the exquisite Palatine Chapel with its Byzantine mosaics
- Quattro Canti, a Baroque square at the intersection of Palermo's two main streets, known for its symmetrical fountains and statues
- Orto Botanico di Palermo, a lush botanical garden showcasing diverse plant species.
The best things to do in Palermo include:
- Capuchin Catacombs, an eerie yet fascinating underground cemetery with mummified remains
- Ballarò Market, a bustling street market offering a taste of local Sicilian produce and culture
- Explore the vibrant street art in the Vucciria district
- Take a cooking class to learn how to make traditional Sicilian dishes
- Enjoy a leisurely stroll along the picturesque Foro Italico promenade.
Whether you can cancel your bus ticket from Siena to Palermo depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Itabus
- You can cancel your ticket up to 24 hours before departure for a partial refund. Changes allowed for a fee.
Yes, bikes are allowed on board the bus with bus company FlixBus, Itabus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Siena to Palermo.
Yes, the following luggage options are included when booking a bus ticket from Siena to Palermo:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Itabus
- One carry-on bag up to 10kg and one checked bag up to 20kg.
Yes, the following additional luggage options are available when booking a bus ticket from Siena to Palermo:
- FlixBus
- Additional luggage can be purchased for a fee.
- Itabus
- 5€ per additional bag.
Yes, you can bring your pet on the bus from Siena to Palermo. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
- Itabus
- Small pets allowed in carriers
- larger pets must be leashed and muzzled.
You can reserve your seat on the bus from Siena to Palermo with the following bus company: FlixBus, Itabus
Yes, there are USB plugs on board the bus from Siena to Palermo with the following bus company: FlixBus, Itabus.
Yes, there is Wifi on board the bus from Siena to Palermo with the following bus company: FlixBus, Itabus.
Since both Siena and Palermo are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the bus as it is the most popular way to get from Siena to Palermo among Omio's users.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
In Palermo, travelers should be cautious of petty theft, especially pickpocketing in crowded areas like markets and public transport. Scams include overcharging by taxi drivers and vendors, as well as unofficial guides offering overpriced tours. It's advisable to use authorized services and stay vigilant in busy tourist spots.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Siena to Palermo
Most Siena to Palermo buses use the Siena, Stazione FS (Piazzale Carlo Rosselli) to Palermo, Via Tommaso Fazello (Terminal Bus) station pair. Use this guide to compare Siena and Palermo bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Siena
Arrival bus stations in Palermo
Which Siena station do buses to Palermo leave from?
Buses from Siena to Palermo leave from Siena, Stazione FS (Piazzale Carlo Rosselli). The station is 0 miles (1 km) from Siena city centre at Siena - Ferrovia, 53100 Siena SI, Italy.
Siena, Stazione FS (Piazzale Carlo Rosselli)Siena - Ferrovia, 53100 Siena SI, Italy
City-centre transport
Getting to Siena, Stazione FS (Piazzale Carlo Rosselli) from Siena city centre
Siena, Stazione FS (Piazzale Carlo Rosselli) is 1 km from Siena city centre. Public transport options include:
BusS10, 0S3, 544 · 7m · $1 · every ~6 min
Siena, Stazione FS (Piazzale Carlo Rosselli) bus station facilities and services
Siena, Stazione FS (Piazzale Carlo Rosselli) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Cafeteria and vending machines available.
Wi-Fi and ATMs
Wi-Fi is available at Siena, Stazione FS (Piazzale Carlo Rosselli). ATMs are available at Siena, Stazione FS (Piazzale Carlo Rosselli).
Tickets and information
Ticket office support is available at Siena, Stazione FS (Piazzale Carlo Rosselli).
Parking, taxis and toilets
Available at Siena, Stazione FS (Piazzale Carlo Rosselli): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Siena, Stazione FS (Piazzale Carlo Rosselli): Wheelchair ramps are provided.
Siena, Siena/Viale Pietro ToselliViale Pietro Toselli, 53100 Siena SI, Italy
City-centre transport
Getting to Siena, Siena/Viale Pietro Toselli from Siena city centre
Siena, Siena/Viale Pietro Toselli is 1 km from Siena city centre. Public transport options include:
BusS52 · 14m · $1 · every ~5 min
Siena, Siena/Viale Pietro Toselli bus station facilities and services
Siena, Siena/Viale Pietro Toselli has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Nearby cafes and fast food available.
Wi-Fi and ATMs
Wi-Fi is available at Siena, Siena/Viale Pietro Toselli. ATMs are available at Siena, Siena/Viale Pietro Toselli.
Tickets and information
Ticket office support is available at Siena, Siena/Viale Pietro Toselli.
Parking, taxis and toilets
Available at Siena, Siena/Viale Pietro Toselli: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Siena, Siena/Viale Pietro Toselli: Ramps and accessible paths available.
Most popular bus connections from Siena
More options for your journey from Siena to Palermo
Here are some other resources that might have the information you need
Most popular buses to and from Palermo and Siena
Most popular bus connections to Palermo
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