- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price on Sep 20
$73
Average ticket price on Sep 20
$73
Fastest journey on Sep 20
9 h 25 m
Average journey duration on Sep 20
9 h 25 m
Buses on Sep 20
1
Distance
380 km
The best way to find a cheap bus ticket from Santa Margherita Ligure to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santa Margherita Ligure to Rome will cost around $73 if you buy it on the day, but the cheapest tickets can be found for only $73.
It's difficult to get from Santa Margherita Ligure to Rome without transferring at least once.
061 · 055
061 · 055Omio recommends booking the train as it is the most popular option from Santa Margherita Ligure to Rome among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $59 For those with little time, consider booking a flight, which has an average total journey time of 4h 48m. Average ticket prices depend on the travel mode: a bus costs an average of $59, while a flight costs an average of $526.
Distance: 236 miles (380 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$59 Average price Cheapest | $68 Average price | $526 Average price | $132 Average price (fuel + tolls) |
10h 24m Average total duration 9h 54m Onboard + 30m Additional time* | 6h 1m Average total duration 5h 31m Onboard + 30m Additional time* | 4h 48m Average total duration Fastest 2h 48m Onboard + 2h 0m Additional time* | 5h 4m Average total duration (door-to-door) |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Santa Margherita Ligure to Rome:
A bus is $9 less than a train for this route with tickets for a train from Santa Margherita Ligure to Rome costing on average $68.
A bus is $467 less than a flight for this route with tickets for a flight from Santa Margherita Ligure to Rome costing on average $526.
Other travel options to Rome take longer:
Train takes on average 5h 31m.
Bus takes on average 9h 54m.
Tickets start at around $59 compared to roughly $132 in fuel and tolls — a saving of about $73. The journey takes 9h 54m versus 5h 4m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:15AM | Arrival Time 07:00AM | Duration 6h45 | Departure days Mon, Sat | Cheapest price $43 |
Operator BlaBlaCar | Departure Time 10:00AM | Arrival Time 02:40PM | Duration 4h40 | Departure days Tue | Cheapest price $40 |
Operator BlaBlaCar | Departure Time 10:30AM | Arrival Time 04:00PM | Duration 5h30 | Departure days Sun | Cheapest price $47 |
Operator Marino Autolinee | Departure Time 05:05PM | Arrival Time 02:30AM | Duration 9h25 | Departure days Thu | Cheapest price $78 |
Operator Marino Autolinee | Departure Time 06:05PM | Arrival Time 03:30AM | Duration 9h25 | Departure days Thu | Cheapest price $62 |
Operator Marino Autolinee | Departure Time 07:05PM | Arrival Time 04:30AM | Duration 9h25 | Departure days Mon, Tue, Wed, Fri, Sat, Sun | Cheapest price $55 |
Operator FlixBus | Departure Time 08:10PM | Arrival Time 02:35AM | Duration 6h25 | Departure days Mon, Sat | Cheapest price $39 |
Operator FlixBus | Departure Time 09:35PM | Arrival Time 05:55AM | Duration 8h20 | Departure days Mon, Sat | Cheapest price $22 |
The table below shows live departures for Santa Margherita Ligure to Rome buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
061 · 055 | 7:05 PM Genoa, Piazza della Vittoria | 9h25 | 4:30 AM Roma, Autostazione Tiburtina | 1 transfer | |
FlixBus | 8:10 PM Sestri Levante, Piazza Italia | 6h25 | 2:35 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
FlixBus | 9:35 PM Genoa, Piazza della Vittoria | 8h20 | 5:55 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santa Margherita Ligure to Rome run on average 4 times per day, taking around 9h 54m. Cheap bus tickets for this journey start at $18 but you can travel from only $6 by train.
There are 2 buses per day. The earliest bus runs at 00:02, the last at 23:55. The fastest bus covers the 236 miles (380 km) distance in 6h 0m.
Distance 236 miles (380 km) |
Average bus duration 9h 54m |
Cheapest ticket price $18 |
Buses per day 4 |
Direct buses 2 |
Fastest bus 6h 0m |
First bus 12:02 AM |
Last bus 11:55 PM |
Cheapest Month Feb |
Cheapest Day Mon |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Wed |
Best time to book 1 day |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Santa Margherita Ligure to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Santa Margherita Ligure to Rome buses use the Genoa, Piazza della Vittoria to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Santa Margherita Ligure and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Here are some other resources that might have the information you need