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Journey information
Overview: Bus from Santa Ana, CA to Mesa, AZ
Take a bus from Santa Ana, CA to Mesa, AZ and enjoy the approximately 348 miles (561 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 02:25, the last at 22:50.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 348 miles (561 km) |
First bus 02:25 |
Last bus 22:50 |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
FAQs: Bus from Santa Ana, CA to Mesa, AZ
Find answers to the most common questions about traveling from Santa Ana, CA to Mesa, AZ by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Mesa, AZ, this guide helps you travel smarter and with confidence.

The earliest bus from Santa Ana, CA to Mesa, AZ leaves at 2:25 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Santa Ana, CA to Mesa, AZ leaves at 10:50 PM.
Yes, you can take a between Santa Ana, CA and Mesa, AZ.
No, there are no bathrooms on board the bus from Santa Ana, CA to Mesa, AZ.
No, the bus from Santa Ana, CA to Mesa, AZ has no accessibility options.
No, bikes are not allowed on board the bus from Santa Ana, CA to Mesa, AZ.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Santa Ana, CA to Mesa, AZ.
No, luggage for the bus from Santa Ana, CA to Mesa, AZ needs to be booked in addition.
No, there are no additional luggage options for the bus from Santa Ana, CA to Mesa, AZ.
Unfortunately, pets are not allowed on the bus from Santa Ana, CA to Mesa, AZ.
No, there are no USB plugs on board the bus from Santa Ana, CA to Mesa, AZ.
No, there is no WiFi on board the bus from Santa Ana, CA to Mesa, AZ.
popular bus stations
Popular bus stations from Santa Ana, CA to Mesa, AZ
Santa Ana
Mesa
The major bus station for departures in Santa Ana is Santa Ana, E Santa Ana Blvd (Train Station). Find all the information you need to know about services, amenities and connections at Santa Ana, E Santa Ana Blvd (Train Station) for your trip from Santa Ana to Mesa.
Santa Ana, E Santa Ana Blvd (Train Station)
information
The major bus station for arrivals in Mesa is Mesa, South Country Club Drive (Greyhound Bus Station). Find all the information you need to know about services, amenities and connections at Mesa, South Country Club Drive (Greyhound Bus Station) for your trip to Mesa from Santa Ana.
Mesa, South Country Club Drive (Greyhound Bus Station)
information
Most popular bus connections from Santa Ana, CA
More options for your journey from Santa Ana, CA to Mesa, AZ
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