Journey information
Overview: Bus from Santa Ana, CA to Palo Alto, CA
Buses from Santa Ana, CA to Palo Alto, CA run on average 6 times per day, taking around 8h 46m. Cheap bus tickets for this journey start at €46 if you book in advance.
There are 4 buses per day. The earliest bus runs at 00:05, the last at 14:48. The fastest bus covers the 350 miles (564 km) distance in 7h 50m.
Distance 350 miles (564 km) |
Average bus duration 8h 46m |
Cheapest ticket price €46 |
Buses per day 6 |
Direct buses 4 |
Fastest bus 7h 50m |
First bus 12:05 AM |
Last bus 2:48 PM |
Cheapest Month Jul |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Frequently asked questions about your Santa Ana, CA to Palo Alto, CA trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Santa Ana, CA to Palo Alto, CA.
Why should you book Santa Ana, CA to Palo Alto, CA buses with Omio?
Why book with Omio vs Greyhound?
- Compare with other providers: On Omio, you can not only buy tickets for Greyhound, but also compare tickets for the likes of FlixBus to find the best option for your trip from Santa Ana, CA to Palo Alto, CA.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Greyhound with all available travel options, which are bus and train to ensure you get the best deal for traveling from Santa Ana, CA to Palo Alto, CA.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of FlixBus to find the best option for your trip from Santa Ana, CA to Palo Alto, CA.
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Santa Ana, CA to Palo Alto, CA.
Bus providers: Greyhound, FlixBus from Santa Ana, CA to Palo Alto, CAYou can travel by bus between Santa Ana, CA to Palo Alto, CA with Greyhound, FlixBus for as low as €46. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
Companies, tickets, and onboard amenities between Santa Ana, CA and Palo Alto, CA
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
FAQs: Bus from Santa Ana, CA to Palo Alto, CA
Find answers to the most common questions about traveling from Santa Ana, CA to Palo Alto, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Palo Alto, CA, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Santa Ana, CA to Palo Alto, CA
Most Santa Ana, CA to Palo Alto, CA buses use the Santa Ana, E Santa Ana Blvd (Train Station) to station pair. Use this guide to compare Santa Ana, CA and Palo Alto, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Santa Ana, CA station do buses to Palo Alto, CA leave from?
Getting to Santa Ana, E Santa Ana Blvd (Train Station) from Santa Ana city centre
Santa Ana, E Santa Ana Blvd (Train Station) is 1 km from Santa Ana city centre. Public transport options include:
Santa Ana, E Santa Ana Blvd (Train Station) bus station facilities and services
Santa Ana, E Santa Ana Blvd (Train Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Santa Ana, E Santa Ana Blvd (Train Station). ATMs are available at Santa Ana, E Santa Ana Blvd (Train Station).
Tickets and information
Ticket office support is available at Santa Ana, E Santa Ana Blvd (Train Station).
Parking, taxis and toilets
Available at Santa Ana, E Santa Ana Blvd (Train Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Santa Ana, E Santa Ana Blvd (Train Station): Bus access is available.
Most popular bus connections from Santa Ana, CA
More options for your journey from Santa Ana, CA to Palo Alto, CA
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