Journey information
Overview: San Diego, CA to South San Francisco, CA flight
Flights from San Diego, CA to South San Francisco, CA depart on average 86 times per day, taking around 3h 24m. Cheap flight tickets for this journey start at $115 (€94) but you can travel from only $67 (€55) by bus.
There are 16 flights per day. The earliest flight runs at 00:30, the last at 23:58. The fastest flight covers the 451 miles (727 km) distance in 1h 44m. February is the cheapest month to fly.
Distance 451 miles (727 km) |
Average flight duration 3h 24m |
Cheapest ticket price $115 (€94) |
Flights per day 86 |
Direct flights 16 |
Fastest flight 1h 44m |
First flight 12:30 AM |
Last flight 11:58 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jul - Sep |
Travel Information
Compare bus, train, and flight for San Diego, CA to South San Francisco, CA
Omio recommends booking the flight as it is the most popular option from San Diego, CA to South San Francisco, CA among Omio's users. If you are prioritising price take the bus with prices starting from $67. For those with little time consider booking a flight which can get you there in 3h 24m. The ticket price range depends on the travel mode: a bus costs an average of $67, and a flight costs an average of $115.
Distance: 451 miles (727 km)
Compare flight with
Most popular Flight | Train | Bus | Driving |
|---|---|---|---|
$191 Average price | $88 Average price | $77 Average price Cheapest | $100 Average price (fuel + tolls) |
6h 24m Average total duration Fastest 3h 24m Onboard + 3h 0m Additional time* | 14h 33m Average total duration 14h 3m Onboard + 30m Additional time* | 14h 9m Average total duration 13h 39m Onboard + 30m Additional time* | 8h 3m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from San Diego, CA to South San Francisco, CA:
A bus is $11 (€9) less than a train for this route with tickets for a train from San Diego, CA to South San Francisco, CA costing on average $88 (€73).
A bus is $113 (€93) less than a flight for this route with tickets for a flight from San Diego, CA to South San Francisco, CA costing on average $191 (€157).
Other travel options to South San Francisco, CA take longer:
Bus takes on average 13h 39m.
Train takes on average 14h 3m.
Compare prices and tickets San Diego, CA to South San Francisco, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: San Diego, CA to South San Francisco, CA Flight
Find answers to the most common questions about traveling from San Diego, CA to South San Francisco, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at South San Francisco, CA, this guide helps you travel smarter and with confidence.

popular airports
Popular airports from San Diego, CA to South San Francisco, CA
Most San Diego, CA to South San Francisco, CA flights use the San Diego International Airport to San Francisco International Airport airport pair. Use this guide to compare San Diego, CA and South San Francisco, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Which San Diego, CA airport do flights to South San Francisco, CA leave from?
Getting to San Diego International Airport from San Diego city centre
San Diego International Airport is 4 km from San Diego city centre. Public transport options include:
San Diego International Airport airport facilities and services
San Diego International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food and drink
Food options include: Restaurants in terminals 1 and 2, including fast food and sit-down options like The Counter and Phil's BBQ
Wi-Fi and ATMs
Free Wi-Fi available throughout the airport. ATMs are located in all terminals.
Luggage and lost property
Lost and found is available at the station.
Parking, taxis and toilets
Available at San Diego International Airport: Parking, Taxis, WC.
Bike and car services
Available at San Diego International Airport: Car Rental.
Accessibility
Accessibility facilities are available at San Diego International Airport: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotels nearby, Sheraton San Diego Hotel & Mari within walking distance..
Getting to McClellan-Palomar Airport from San Diego city centre
McClellan-Palomar Airport airport facilities and services
McClellan-Palomar Airport has practical services for this route, including Accessibility.
Accessibility
Accessibility facilities are available at McClellan-Palomar Airport: The place has an entrance that is wheelchair-accessible.
More options for your journey from San Diego, CA to South San Francisco, CA
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