- Must visit
San Diego Museum of Art
Major Balboa Park museum with works from Spanish old masters to modern art, plus strong regional and international exhibitions.
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The cheapest and fastest buses from South San Francisco, CA to San Diego, CA
Showing times, prices and bookable tickets for Sep 17
Cheapest price on Sep 17
CHF59
Average ticket price on Sep 17
CHF59
Fastest journey on Sep 17
15 h 22 m
Average journey duration on Sep 17
15 h 22 m
Buses on Sep 17
1
Distance
727 km
Cheap tickets
The best way to find a cheap bus ticket from South San Francisco, CA to San Diego, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from South San Francisco, CA to San Diego, CA will cost around CHF59 if you buy it on the day, but the cheapest tickets can be found for only CHF59.
Fast buses
On Thu, Sep 17, we found 1 buses from South San Francisco, CA to San Diego, CA, including 1 direct services.
On Thu, Sep 17 the direct buses cover the 727 km distance in an average of 15 h 22 m but if you time it right, some buses will get you there in just 15 h 22 m .
On Thu, Sep 17 the slowest buses will take 15 h 22 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:45 PM15h22South San Francisco, CA6:07 AMSan Diego, CACHF591One-way0 transfers
- 2:45 PM15h22South San Francisco, CA6:07 AMSan Diego, CACHF591One-way0 transfers
Travel Information
Compare bus, train, and flight for South San Francisco, CA to San Diego, CA
Omio recommends booking the flight as it is the most popular option from South San Francisco, CA to San Diego, CA among Omio's users.
Distance: 451 miles (727 km)
Compare bus with
| Bus | Most popular Flight | Train | Driving |
|---|---|---|---|
CHF84 Average price (fuel + tolls) | |||
7h 37m Average total duration (door-to-door) | |||
Direct Options | Direct Options | Direct Options | Direct Options |
South San Francisco, CA to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:35AM | Arrival Time 09:07PM | Duration 14h32 | Departure days Thu | Cheapest price CHF61 |
Operator Amtrak | Departure Time 02:45PM | Arrival Time 06:07AM | Duration 15h22 | Departure days Thu | Cheapest price CHF59 |
Operator Amtrak | Departure Time 03:45PM | Arrival Time 07:07AM | Duration 15h22 | Departure days Mon, Sun | Cheapest price CHF59 |
Live departures
South San Francisco, CA to San Diego, CA bus times
The table below shows live departures for South San Francisco, CA to San Diego, CA buses for tomorrow, Thursday, September 17. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:45 PM South San Francisco, CA | 15h22 | 6:07 AM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets South San Francisco, CA to San Diego, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from South San Francisco, CA to San Diego, CA
USAUSA
Take a bus from South San Francisco, CA to San Diego, CA and enjoy the approximately 451 miles (727 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 04:01, the last at 23:25.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 451 miles (727 km) |
First bus 4:01 AM |
Last bus 11:25 PM |
Cheapest Month Mar |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to San Diego, CA
Things to do in San Diego, CA
Discover the best of San Diego, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego, CA trip today.
- Must visit
Museum of Contemporary Art San Diego
Acclaimed contemporary art museum in La Jolla featuring oceanfront settings, modern works, and rotating global exhibitions.
- Must visit
USS Midway Museum
Museum aboard a historic aircraft carrier with restored aircraft, naval exhibits, and immersive views of life at sea.
- Must visit
Balboa Park
Balboa Park is San Diego's grand cultural park, packed with gardens, architecture, museums, and walkable plazas worth lingering in.
- Must visit
Gaslamp Quarter
Historic Gaslamp Quarter offers Victorian-era streets, nightlife energy, and preserved downtown architecture for an atmospheric walk.
- Must visit
La Jolla Cove
Dramatic seaside cliffs and walking paths in La Jolla, famous for waves, sea lions, and sweeping Pacific views.
Fish Taco
A San Diego staple: grilled fish in a soft tortilla with cabbage, crema, and salsa. Popularized by Baja influence and coastal seafood culture.
California Burrito
French fries, carne asada, cheese, guacamole, and crema wrapped in a flour tortilla. A late-night local favorite born in San Diego taquerias.
- Gluten-free
Sea Urchin (Uni)
Fresh local sea urchin served raw, prized for its rich, buttery taste. It reflects San Diego's access to Pacific seafood and sushi culture.
Sushi Ota
Celebrated sushi restaurant specializing in omakase and pristine seafood, including uni. Intimate, polished, and highly respected by locals.
Mitch's Seafood
Iconic casual seafood counter known for fish tacos, smoked fish, and harbor views. A classic stop for San Diego's Baja-inspired seafood style.
Juniper and Ivy
Refined fine-dining restaurant showcasing local seafood and seasonal California ingredients. Elegant room with one of the city's strongest reputations.
US Dollar ($)
San Diego is pricey for US travel, with higher hotel rates, dining, and parking than many cities, though casual food and buses stay manageable.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $25-45 per person for a mid-range meal.
- Fine dining
- $75+ per person for upscale dining.
- Coffee
- $4-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 for coffee drinks or small cafe orders.
FAQs: Bus from South San Francisco, CA to San Diego, CA
Find answers to the most common questions about traveling from South San Francisco, CA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
popular bus stations
Popular bus stations from South San Francisco, CA to San Diego, CA
Most South San Francisco, CA to San Diego, CA buses use the San Francisco, Townsend Street / 5th Street to San Diego, Congress Street (Old Town Park) station pair, with some services arriving at San Diego, West Harbor Drive (The Headquarters at Seaport District). Use this guide to compare South San Francisco, CA and San Diego, CA bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in South San Francisco
Arrival bus stations in San Diego
Which San Diego, CA station do buses from South San Francisco, CA arrive at?
Buses from South San Francisco, CA to San Diego, CA most often arrive at San Diego, San Ysidro Transit Center. Some services arrive at San Diego, Congress Street (Old Town Park), so check your ticket before travel to confirm your San Diego, CA arrival station.
San Diego, San Ysidro Transit CenterSan Ysidro Station, San Diego, CA 92173, USA
City-centre transport
Getting to San Diego, San Ysidro Transit Center from San Diego city centre
San Diego, San Ysidro Transit Center is 22 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 25m · CHF2
910 · 41m · CHF5
TramBlue · 41m · CHF14 · every ~14 min
Blue · 43m · CHF14 · every ~14 min
San Diego, San Ysidro Transit Center bus station facilities and services
San Diego, San Ysidro Transit Center has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several fast food eateries located nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, San Ysidro Transit Center. ATMs are available near the entrance.
Tickets and information
Ticket office support is available at San Diego, San Ysidro Transit Center.
Parking, taxis and toilets
Available at San Diego, San Ysidro Transit Center: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, San Ysidro Transit Center: Wheelchair accessible with ramps.
San Diego, Congress Street (Old Town Park)Congress St, San Diego, CA 92110, USA
City-centre transport
Getting to San Diego, Congress Street (Old Town Park) from San Diego city centre
San Diego, Congress Street (Old Town Park) is 5 km from San Diego city centre. Public transport options include:
BusFlixBus 2017 · 20m · CHF1
83 · 26m · CHF5
TramGreen, Blue, Event · 16m · every ~18 min
Blue · 21m · every ~9 min
San Diego, Congress Street (Old Town Park) bus station facilities and services
San Diego, Congress Street (Old Town Park) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options nearby.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, Congress Street (Old Town Park). ATMs are available at San Diego, Congress Street (Old Town Park).
Tickets and information
Ticket office support is available at San Diego, Congress Street (Old Town Park).
Parking, taxis and toilets
Available at San Diego, Congress Street (Old Town Park): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, Congress Street (Old Town Park): Wheelchair accessible routes available.
San Diego, West Harbor Drive (The Headquarters at Seaport District)W Harbor Dr, San Diego, CA, USA
City-centre transport
Getting to San Diego, West Harbor Drive (The Headquarters at Seaport District) from San Diego city centre
San Diego, West Harbor Drive (The Headquarters at Seaport District) is 1 km from San Diego city centre. Public transport options include:
TRUE
San Diego, West Harbor Drive (The Headquarters at Seaport District) bus station facilities and services
San Diego, West Harbor Drive (The Headquarters at Seaport District) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Several dining options are in the area.
Wi-Fi and ATMs
Wi-Fi is available at San Diego, West Harbor Drive (The Headquarters at Seaport District). ATMs are available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Tickets and information
Ticket office support is available at San Diego, West Harbor Drive (The Headquarters at Seaport District).
Parking, taxis and toilets
Available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Diego, West Harbor Drive (The Headquarters at Seaport District): Accessible for persons with disabilities.
More options for your journey from South San Francisco, CA to San Diego, CA
Here are some other resources that might have the information you need
Most popular buses to and from San Diego, CA and South San Francisco, CA
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