- Must visit
USS Midway Museum
Museum aboard the historic aircraft carrier USS Midway with restored aircraft, flight deck exhibits, and audio tours on San Diego Bay.
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Travel Information
Compare bus, train, and flight for South San Francisco, CA to San Diego, CA
Omio recommends booking the train as it is the most popular option from South San Francisco, CA to San Diego, CA among Omio's users. If you are prioritising price take the bus with prices starting from $72. For those with little time consider booking a flight which can get you there in 2h 32m. The ticket price range depends on the travel mode: a bus costs an average of $72, and a flight costs an average of $83.
Distance: 451 miles (727 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$72 Average price Cheapest | $91 Average price | $258 Average price | $101 Average price (fuel + tolls) |
15h 40m Average total duration 15h 10m Onboard + 30m Additional time* | 14h 53m Average total duration 14h 23m Onboard + 30m Additional time* | 5h 32m Average total duration Fastest 2h 32m Onboard + 3h 0m Additional time* | 7h 37m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from South San Francisco, CA to San Diego, CA is a bus with an average price of $72 (€59).
This is compared to other travel options from South San Francisco, CA to San Diego, CA:
A bus is $18 (€15) less than a train for this route with tickets for a train from South San Francisco, CA to San Diego, CA costing on average $91 (€74).
A bus is $185 (€151) less than a flight for this route with tickets for a flight from South San Francisco, CA to San Diego, CA costing on average $258 (€211).
The fastest way to travel from South San Francisco, CA to San Diego, CA is by flight with an average journey time of 2h 32m.
Other travel options to San Diego, CA take longer:
Train takes on average 14h 23m.
Bus takes on average 15h 10m.
It's helpful to compare your options as there are 3 ways to travel between South San Francisco, CA and San Diego, CA including taking a bus, train, and flight.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
South San Francisco, CA to San Diego, CA Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Amtrak | Departure Time 06:35AM | Arrival Time 09:07PM | Duration 14h32 | Departure days Thu | Cheapest price $74 |
Operator Amtrak | Departure Time 02:45PM | Arrival Time 06:07AM | Duration 15h22 | Departure days Thu | Cheapest price $72 |
Operator Amtrak | Departure Time 03:45PM | Arrival Time 07:07AM | Duration 15h22 | Departure days Mon, Sun | Cheapest price $72 |
Live departures
South San Francisco, CA to San Diego, CA bus times
The table below shows live departures for South San Francisco, CA to San Diego, CA buses for today, Thursday, June 18. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 2:45 PM South San Francisco, CA | 15h22 | 6:07 AM San Diego, CA | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets South San Francisco, CA to San Diego, CA by bus, train, or flight
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from South San Francisco, CA to San Diego, CA
USAUSA
Buses from South San Francisco, CA to San Diego, CA run on average 15 times per day, taking around 15h 10m. Cheap bus tickets for this journey start at $72 (€59) if you book in advance.
There are 2 buses per day. The earliest bus runs at 04:01, the last at 23:25. The fastest bus covers the 451 miles (727 km) distance in 14h 32m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 451 miles (727 km) |
Average bus duration 15h 10m |
Cheapest ticket price $72 (€59) |
Buses per day 15 |
Direct buses 2 |
Fastest bus 14h 32m |
First bus 4:01 AM |
Last bus 11:25 PM |
Cheapest Month Mar |
Cheapest Day Sun |
High Season Jan - Mar |
Low Season Apr - Jun |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Complete guide to San Diego
Things to do in San Diego
Discover the best of San Diego — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect San Diego trip today.
- Recommended
San Diego Museum of Art
Balboa Park art museum known for Spanish old masters, South Asian works, and rotating exhibitions in a landmark building.
- Recommended
Museum of Contemporary Art San Diego
Leading contemporary art museum with major postwar and current works, especially strong in Southern California and Pacific Rim artists.
- Must visit
Balboa Park
Vast cultural park with gardens, museums, Spanish Colonial Revival architecture, walking paths, and some of San Diego's best photo spots.
- Must visit
La Jolla Cove
Scenic cove known for sea lions, clear water, coastal cliffs, and highly shareable sunset and ocean-view walks.
- Must visit
Coronado Beach
Wide sandy beach beside the Hotel del Coronado, popular for walking, photography, and classic Southern California scenery.
- Gluten-free
Fish Tacos
Beer-battered or grilled local fish in tortillas, usually topped with cabbage, crema, and salsa. A signature coastal San Diego staple with strong Baja influence.
California Burrito
A San Diego original burrito filled with carne asada, fries, cheese, and salsa. It is one of the city’s most iconic late-night and casual foods.
- Gluten-free
Carne Asada Fries
French fries topped with carne asada, cheese, guacamole, sour cream, and salsa. This indulgent dish is strongly associated with San Diego taco shop culture.
Mitch's Seafood
Popular waterfront seafood restaurant serving fresh local catch, fish tacos, and sandwiches in a relaxed harbor setting near the fishing fleet.
Las Cuatro Milpas
Historic, no-frills Mexican restaurant famous for house-made tortillas, rolled tacos, and comforting traditional plates. A beloved local institution with a classic atmosphere.
Hodad's
Iconic casual spot in Ocean Beach known for oversized burgers, fries, and a lively beach-town vibe. A long-standing San Diego favorite.
United States Dollar
Prices are high by U.S. standards, especially for hotels, dining, and parking near the coast and downtown.
Average meal costs
- Budget
- USD 10-18 for tacos, fast food, or casual takeout.
- Mid-range
- USD 20-40 per person at a standard sit-down restaurant.
- Fine dining
- USD 75+ per person before drinks and tax.
- Coffee
- USD 4-7 for a latte or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 20%+ for great service. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and valet.
FAQs: Bus from South San Francisco, CA to San Diego, CA
Find answers to the most common questions about traveling from South San Francisco, CA to San Diego, CA by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at San Diego, CA, this guide helps you travel smarter and with confidence.
Cheap bus tickets from South San Francisco, CA to San Diego, CA can start from as little as $72 (€59) when you book in advance. The average bus ticket price for South San Francisco, CA to San Diego, CA is $72 (€59) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from South San Francisco, CA to San Diego, CA is 14h 32m to travel the 451 miles (727 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from South San Francisco, CA to San Diego, CA leaves at 4:01 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from South San Francisco, CA to San Diego, CA leaves at 11:25 PM.
A trip to San Diego, CA from South San Francisco, CA is worth doing but not as a day trip with a journey time of 14h 32m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from South San Francisco, CA to San Diego, CA is March.
It's helpful to compare your options as there are 3 ways to travel between South San Francisco, CA and San Diego, CA including taking a bus, train, and flight.
No, there are no bathrooms on board the bus from South San Francisco, CA to San Diego, CA.
No, the bus from South San Francisco, CA to San Diego, CA has no accessibility options.
Some of the most interesting sights to explore in San Diego, CA are:
- Balboa Park, a sprawling urban park with museums, gardens, and the San Diego Zoo
- USS Midway Museum, a historic naval aircraft carrier museum offering interactive exhibits and tours
- La Jolla Cove, a picturesque coastal area known for its stunning views and marine life
- Gaslamp Quarter, a lively historic district with Victorian architecture, dining, and entertainment options
- Coronado Beach, a beautiful sandy beach known for its gentle waves and iconic hotel.
The best things to do in San Diego, CA include:
- Explore the vibrant art scene at the Museum of Contemporary Art San Diego
- enjoy a harbor cruise for stunning views of the skyline and naval ships
- hike the scenic trails at Torrey Pines State Natural Reserve
- visit the Birch Aquarium to learn about marine life and ocean conservation
- experience the thrill of a whale watching tour off the coast.
No, bikes are not allowed on board the bus from South San Francisco, CA to San Diego, CA.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from South San Francisco, CA to San Diego, CA.
No, luggage for the bus from South San Francisco, CA to San Diego, CA needs to be booked in addition.
No, there are no additional luggage options for the bus from South San Francisco, CA to San Diego, CA.
Unfortunately, pets are not allowed on the bus from South San Francisco, CA to San Diego, CA.
No, there are no USB plugs on board the bus from South San Francisco, CA to San Diego, CA.
No, there is no WiFi on board the bus from South San Francisco, CA to San Diego, CA.
Since neither South San Francisco, CA nor San Diego, CA are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In San Diego, CA, travelers should be cautious of pickpocketing and petty theft, especially in crowded areas like beaches, public transportation, and popular tourist spots such as the Gaslamp Quarter and Old Town. Common scams include overpriced parking fees and unauthorized ticket sellers near attractions. Staying aware of surroundings, securing belongings, and using official transportation services help reduce risks. Additionally, travelers should avoid isolated areas at night and be mindful of local traffic laws when using scooters or bikes.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from South San Francisco, CA to San Diego, CA
South San Francisco
San Diego
San Diego, Congress Street (Old Town Park)
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San Diego, San Ysidro Transit Center
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San Diego, West Harbor Drive (The Headquarters at Seaport District)
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More options for your journey from South San Francisco, CA to San Diego, CA
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Most popular buses to and from San Diego, CA and South San Francisco, CA
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