The cheapest and fastest buses from Orlando, FL to Knoxville, TN
Cheapest price
$260
Average price
$260
Fastest journey
1 d 14 h 40 m
Average duration
1 d 14 h 40 m
Buses per day
1
Distance
859 km
The best way to find a cheap bus ticket from Orlando, FL to Knoxville, TN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Knoxville, TN will cost around $260 if you buy it on the day, but the cheapest tickets can be found for only $260.
Of the 1 buses that leave Orlando, FL for Knoxville, TN on Tue, Mar 24, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Mar 24 the direct buses cover the 859 km distance in an average of 1 d 14 h 40 m but if you time it right, some buses will get you there in just 1 d 14 h 40 m .
On Tue, Mar 24 the slowest buses will take 1 d 14 h 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare bus and flight for Orlando, FL to Knoxville, TN
Omio recommends booking the flight as it is the most popular option from Orlando, FL to Knoxville, TN among Omio's users. If you are prioritising price take the flight with prices starting from $53. For those with little time consider booking a flight which can get you there in 1h 36m. The ticket price range depends on the travel mode: a flight costs an average of $53, and a bus costs an average of $107.
Distance: 533 miles (859 km)
Compare bus with
| Bus | Most popular Flight |
|---|---|
$161 Average price | $145 Average price Cheapest |
24h 55m Average total duration 24h 25m Onboard + 30m Additional time* | 4h 36m Average total duration Fastest 1h 36m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Compare prices and tickets Orlando, FL to Knoxville, TN by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 24
Mar 25
Mar 26
Mar 27
Mar 28
Mar 29
Mar 30
Why should you book Orlando, FL to Knoxville, TN buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Orlando, FL to Knoxville, TN.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Orlando, FL to Knoxville, TN.
Journey information
Overview: Bus from Orlando, FL to Knoxville, TN
Buses from Orlando, FL to Knoxville, TN run on average 3 times per day, taking around 24h 25m. Cheap bus tickets for this journey start at $107 (€87) but you can travel from only $53 (€43) by flight.
The earliest bus runs at 05:15, the last at 23:40. The fastest bus covers the 533 miles (859 km) distance in 15h 50m.
Distance 533 miles (859 km) |
Average bus duration 24h 25m |
Cheapest ticket price $107 (€87) |
Buses per day 3 |
Fastest bus 15h 50m |
First bus 05:15 |
Last bus 23:40 |
Bus providers: FlixBus from Orlando, FL to Knoxville, TNYou can travel by bus between Orlando, FL to Knoxville, TN with FlixBus for as low as $53 (€43). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Orlando, FL to Knoxville, TN
Find answers to the most common questions about traveling from Orlando, FL to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Orlando, FL to Knoxville, TN
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Knoxville, TN
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