- Recommended
East Tennessee History Center
Engaging museum on regional history with permanent and rotating exhibits covering people, places, and events from East Tennessee's past.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from San Antonio, TX to Knoxville, TN
Showing times, prices and bookable tickets for Oct 03
Cheapest price on Oct 03
$195
Average ticket price on Oct 03
$195
Fastest journey on Oct 03
23 h 45 m
Average journey duration on Oct 03
23 h 45 m
Buses on Oct 03
1
Distance
1543 km
Cheap tickets
The best way to find a cheap bus ticket from San Antonio, TX to Knoxville, TN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Antonio, TX to Knoxville, TN will cost around $195 if you buy it on the day, but the cheapest tickets can be found for only $195.
Fast buses
On Sat, Oct 03, we found 1 buses from San Antonio, TX to Knoxville, TN, including 1 direct services.
On Sat, Oct 03 the direct buses cover the 1543 km distance in an average of 23 h 45 m but if you time it right, some buses will get you there in just 23 h 45 m .
On Sat, Oct 03 the slowest buses will take 23 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:55 AM23h45San Antonio, TX2:40 AMKnoxville, TN$1951One-way0 transfers
- 2:55 AM23h45San Antonio, TX2:40 AMKnoxville, TN$1951One-way0 transfers
Journey information
Overview: Bus from San Antonio, TX to Knoxville, TN
USAUSA
Buses from San Antonio, TX to Knoxville, TN run on average 3 times per day, taking around 25h 27m. Cheap bus tickets for this journey start at $180 (€150) if you book in advance.
The earliest bus runs at 13:30, the last at 21:15. The fastest bus covers the 958 miles (1543 km) distance in 21h 35m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 958 miles (1543 km) |
Average bus duration 25h 27m |
Cheapest ticket price $180 (€150) |
Buses per day 3 |
Fastest bus 21h 35m |
First bus 1:30 PM |
Last bus 9:15 PM |
Cheapest Month Apr |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
San Antonio, TX to Knoxville, TN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:55AM | Arrival Time 02:40AM | Duration 23h45 | Departure days Sat | Cheapest price $195 |
Operator Greyhound | Departure Time 03:15AM | Arrival Time 03:40AM | Duration 24h25 | Departure days Fri | Cheapest price $314 |
Operator Greyhound | Departure Time 01:30PM | Arrival Time 09:50PM | Duration 31h20 | Departure days Wed | Cheapest price $143 |
Operator Greyhound | Departure Time 09:00PM | Arrival Time 10:30PM | Duration 24h30 | Departure days Wed | Cheapest price $171 |
Live departures
San Antonio, TX to Knoxville, TN bus times
The table below shows live departures for San Antonio, TX to Knoxville, TN buses for tomorrow, Friday, October 2. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 2:55 AM San Antonio, TX | 23h45 | 2:40 AM Knoxville, TN | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book San Antonio, TX to Knoxville, TN buses with Omio?
Greyhound operates all buses services from San Antonio, TX to Knoxville, TN.
Omio is an official ticket reseller for all your travel options from San Antonio, TX to Knoxville, TN.
Why book with Omio vs Greyhound?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Bus providers: Greyhound from San Antonio, TX to Knoxville, TNYou can travel by bus between San Antonio, TX to Knoxville, TN with Greyhound for as low as $180 (€150). When you search for schedules and tickets, Omio will show you the best journey
Greyhound
About
Greyhound Lines, Inc. is a prominent American intercity bus transportation provider, established in 1914. It operates the largest intercity bus network in the United States, also extending services to Canada and Mexico. Greyhound is known for offering affordable and reliable long-distance travel, connecting major cities and rural communities across North America. The company's buses are equipped with amenities such as free Wi-Fi, power outlets, and extra legroom to enhance passenger comfort. Greyhound is a subsidiary of Flix SE, which also owns FlixBus, and together they offer an extensive network of over 1,600 destinations.
Luggage & cancellation policy
Average Greyhound Duration
21h 35m
Cheapest Greyhound Price
$180 (€150)
Greyhound frequency
3 a day
Luggage included
One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Additional luggage
$15 per additional bag.
Cancellation Policy
You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority seating; Wheelchair-accessible buses.
Bikes
Bikes are allowed.
Complete guide to Knoxville, TN
Things to do in Knoxville, TN
Discover the best of Knoxville, TN — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Knoxville, TN trip today.
- Recommended
McClung Museum of Natural History and Culture
University museum featuring changing exhibitions of American and international art in a modern gallery setting near campus.
- Recommended
Mabry-Hazen House
Historic house museum preserving the home of artist Adelia Armstrong Lutz, with decorative arts, local history, and period rooms.
- Must visit
Market Square
Lively pedestrian-friendly square lined with shops, events, and public seating. It is a central gathering place and a great base for exploring downtown.
- Must visit
World's Fair Park
Urban park from the 1982 World's Fair with lawns, walking paths, performance spaces, and easy access to the Sunsphere and museums.
- Recommended
Old City
Historic warehouse district with brick streets, galleries, murals, and nightlife. It blends railroad-era character with a creative local feel.
Pulled Pork Barbecue
Smoky pulled pork barbecue is a regional staple in East Tennessee, usually hickory-smoked and served with slaw and sauce at local cookouts and barbecue joints.
Fried Catfish
Fried catfish is a longtime Tennessee favorite, coated in cornmeal and served with hush puppies or sides, especially popular in casual Southern eateries.
Biscuits And Sausage Gravy
Biscuits with sausage gravy are a classic Southern breakfast in Knoxville, featuring flaky biscuits topped with rich peppery gravy made with pork drippings and milk.
Litton's Market Restaurant
Long-running neighborhood restaurant known for hearty Southern comfort food, pies, and a warm, traditional dining room.
Stock & Barrel
Upscale Southern restaurant in Market Square known for shrimp and grits, steaks, and a polished downtown atmosphere.
Sweet P's Barbeque And Soul House
Casual old-school barbecue spot serving hickory-smoked pork, ribs, and classic East Tennessee sides in a relaxed setting.
$ US dollar
Moderate for U.S. city breaks: hotels and dining are reasonable, while car travel is common and public transit is limited for tourists.
Average meal costs
- Budget
- $10-15 for fast food or a casual lunch.
- Mid-range
- $18-35 per person for a restaurant meal.
- Fine dining
- $50+ per person for upscale dining.
- Coffee
- $3-5 for a coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, 10-15% for taxis, and $1-2 per drink or coffee is appreciated at cafes.
FAQs: Bus from San Antonio, TX to Knoxville, TN
Find answers to the most common questions about traveling from San Antonio, TX to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.
Cheap bus tickets from San Antonio, TX to Knoxville, TN can start from as little as $180 (€150) when you book in advance. The average bus ticket price for San Antonio, TX to Knoxville, TN is $186 (€155) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from San Antonio, TX to Knoxville, TN is 21h 35m to travel the 958 miles (1543 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from San Antonio, TX to Knoxville, TN leaves at 1:30 PM. Plan your trip with the Journey Planner from Omio.
The latest bus from San Antonio, TX to Knoxville, TN leaves at 9:15 PM.
There are 3 buses a day from San Antonio, TX to Knoxville, TN which require at least one change with Greyhound. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from San Antonio, TX to Knoxville, TN, you can count on Greyhound for the best way to get you to Knoxville, TN. You can also check all possible bus companies who offer a service between San Antonio, TX and Knoxville, TN and compare the amenities they offer before buying a bus ticket.
When departing from San Antonio, TX , you have various bus station options to start your journey from including San Antonio, N St Mary's St (Greyhound), TX, San Antonio, Avenue A / Pearl Pkwy, TX . When arriving in Knoxville, TN , you can end your journey in bus stations like Knoxville, Kirkwood Street, TN .Passengers board the bus most frequently from San Antonio, N St Mary's St (Greyhound), TX, which is located around away from the city centre, and they get off the bus at Knoxville, Kirkwood Street, TN, located 5 away from the city centre.
Yes, you can take a between San Antonio, TX and Knoxville, TN.
Yes, there are bathrooms on board the bus from San Antonio, TX to Knoxville, TN for bus company Greyhound.
Yes, the following accessibility options are available when taking the bus from San Antonio, TX to Knoxville, TN:
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
Whether you can cancel your bus ticket from San Antonio, TX to Knoxville, TN depends on the bus companies:
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
Yes, bikes are allowed on board the bus with bus company Greyhound.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from San Antonio, TX to Knoxville, TN.
Yes, the following luggage options are included when booking a bus ticket from San Antonio, TX to Knoxville, TN:
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
Yes, the following additional luggage options are available when booking a bus ticket from San Antonio, TX to Knoxville, TN:
- Greyhound
- $15 per additional bag.
Unfortunately, pets are not allowed on the bus from San Antonio, TX to Knoxville, TN.
You can reserve your seat on the bus from San Antonio, TX to Knoxville, TN with the following bus company: Greyhound
Yes, there are USB plugs on board the bus from San Antonio, TX to Knoxville, TN with the following bus company: Greyhound.
Yes, there is Wifi on board the bus from San Antonio, TX to Knoxville, TN with the following bus company: Greyhound.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Knoxville, TN, travelers should be cautious of pickpocketing and vehicle break-ins, especially in crowded areas and parking lots. Avoid accepting unsolicited offers for transportation or tours, as unlicensed operators may overcharge or provide unsafe services. It's also advisable to stay in well-lit areas at night and be aware of local traffic patterns when using ride-share or public transportation to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from San Antonio, TX to Knoxville, TN
Most San Antonio, TX to Knoxville, TN buses use the San Antonio, N St Mary's St (Greyhound) to Knoxville, Kirkwood Street station pair. Use this guide to compare San Antonio, TX and Knoxville, TN bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in San Antonio
Arrival bus stations in Knoxville
Which San Antonio, TX station do buses to Knoxville, TN leave from?
Buses from San Antonio, TX to Knoxville, TN leave from San Antonio, N St Mary's St (Greyhound). The station is 0 miles (1 km) from San Antonio, TX city centre at 500 N St Mary's St, San Antonio, TX 78205, USA.
San Antonio, N St Mary's St (Greyhound)500 N St Mary's St, San Antonio, TX 78205, USA
City-centre transport
Getting to San Antonio, N St Mary's St (Greyhound) from San Antonio city centre
TRUE
San Antonio, N St Mary's St (Greyhound) bus station facilities and services
San Antonio, N St Mary's St (Greyhound) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at San Antonio, N St Mary's St (Greyhound). ATMs are available at San Antonio, N St Mary's St (Greyhound).
Tickets and information
Ticket office support is available at San Antonio, N St Mary's St (Greyhound).
Parking, taxis and toilets
Available at San Antonio, N St Mary's St (Greyhound): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Antonio, N St Mary's St (Greyhound): Limited accessibility features.
San Antonio, Avenue A / Pearl PkwyAvenue A & Pearl Pkwy, San Antonio, TX 78215, USA
City-centre transport
Getting to San Antonio, Avenue A / Pearl Pkwy from San Antonio city centre
San Antonio, Avenue A / Pearl Pkwy is 2 km from San Antonio city centre. Public transport options include:
BusFlixBus 2230 · 11m · $1
10, 14, 214, 9 · 12m · $2 · every ~17 min
San Antonio, Avenue A / Pearl Pkwy bus station facilities and services
San Antonio, Avenue A / Pearl Pkwy has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Nearby Pearl Brewery offers dining options.
Wi-Fi and ATMs
Wi-Fi is available at San Antonio, Avenue A / Pearl Pkwy. ATMs are available at San Antonio, Avenue A / Pearl Pkwy.
Tickets and information
Ticket office support is available at San Antonio, Avenue A / Pearl Pkwy.
Parking, taxis and toilets
Available at San Antonio, Avenue A / Pearl Pkwy: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at San Antonio, Avenue A / Pearl Pkwy: Accessible to wheelchair users.
Which Knoxville, TN station do buses from San Antonio, TX arrive at?
Buses from San Antonio, TX to Knoxville, TN arrive at Knoxville, Kirkwood Street. Knoxville, Kirkwood Street is 3 miles (6 km) from Knoxville, TN city centre.
Knoxville, Kirkwood StreetKirkwood St, Knoxville, TN 37914, USA
City-centre transport
Getting to Knoxville, Kirkwood Street from Knoxville city centre
Knoxville, Kirkwood Street is 5 km from Knoxville city centre. Public transport options include:
Bus31, 33 · 20m · $2 · every ~6 min
Knoxville, Kirkwood Street bus station facilities and services
Knoxville, Kirkwood Street has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Knoxville, Kirkwood Street. ATMs are available at Knoxville, Kirkwood Street.
Tickets and information
Ticket office support is available at Knoxville, Kirkwood Street.
Parking, taxis and toilets
Available at Knoxville, Kirkwood Street: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Knoxville, Kirkwood Street: Wheelchair accessible buses available.
Most popular bus connections from San Antonio, TX
More options for your journey from San Antonio, TX to Knoxville, TN
Here are some other resources that might have the information you need
Most popular buses to and from Knoxville, TN and San Antonio, TX
Most popular bus connections to Knoxville, TN
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
