The cheapest and fastest buses from San Antonio, TX to Knoxville, TN
Cheapest price
$325
Average price
$325
Fastest journey
1 d 25 m
Average duration
1 d 25 m
Buses per day
1
Distance
1543 km
The best way to find a cheap bus ticket from San Antonio, TX to Knoxville, TN is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from San Antonio, TX to Knoxville, TN will cost around $325 if you buy it on the day, but the cheapest tickets can be found for only $325.
Of the 1 buses that leave San Antonio, TX for Knoxville, TN on Fri, May 15, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, May 15 the direct buses cover the 1543 km distance in an average of 1 d 25 m but if you time it right, some buses will get you there in just 1 d 25 m .
On Fri, May 15 the slowest buses will take 1 d 25 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:15 AM24h25San Antonio, TX3:40 AMKnoxville, TN$3251One-way0 transfers
3:15 AM24h25San Antonio, TX3:40 AMKnoxville, TN$3251One-way0 transfers
Travel Information
Compare bus and flight for San Antonio, TX to Knoxville, TN
Omio recommends booking the flight as it is the most popular option from San Antonio, TX to Knoxville, TN among Omio's users. If you are prioritising price take the bus with prices starting from $203. For those with little time consider booking a flight which can get you there in 4h 53m. The ticket price range depends on the travel mode: a bus costs an average of $203, and a flight costs an average of $318.
Distance: 958 miles (1543 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$264 Average price Cheapest | $323 Average price | $16 Average price (fuel + tolls) |
24h 35m Average total duration 24h 5m Onboard + 30m Additional time* | 7h 53m Average total duration Fastest 4h 53m Onboard + 3h 0m Additional time* | 16h 15m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from San Antonio, TX to Knoxville, TN:
A bus is $59 (€47) less than a flight for this route with tickets for a flight from San Antonio, TX to Knoxville, TN costing on average $323 (€259).
Other travel options to Knoxville, TN take longer:
Bus takes on average 24h 5m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
San Antonio, TX to Knoxville, TN Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 01:30PM | Arrival Time 09:50PM | Duration 31h20 | Departure days Wed | Cheapest price $255 |
Operator Greyhound | Departure Time 09:00PM | Arrival Time 10:40PM | Duration 24h40 | Departure days Wed | Cheapest price $257 |
Live departures
San Antonio, TX to Knoxville, TN bus times
The table below shows live departures for San Antonio, TX to Knoxville, TN buses for today, Wednesday, May 13. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
· +![]() | 9:00 PM San Antonio, N St Mary's St (Greyhound), TX | 24h40 | 10:40 PM Knoxville, Kirkwood Street, TN | 2 transfers | |
| Thursday, May 14 | |||||
![]() | 3:15 AM San Antonio, TX | 24h25 | 3:40 AM Knoxville, TN | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Antonio, TX to Knoxville, TN by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 14
May 15
May 16
May 17
May 18
May 19
May 20
Journey information
Overview: Bus from San Antonio, TX to Knoxville, TN
Buses from San Antonio, TX to Knoxville, TN run on average 3 times per day, taking around 24h 5m. Cheap bus tickets for this journey start at $203 (€162) if you book in advance.
The earliest bus runs at 13:30, the last at 21:15. The fastest bus covers the 958 miles (1543 km) distance in 23h 45m.
Distance 958 miles (1543 km) |
Average bus duration 24h 5m |
Cheapest ticket price $203 (€162) |
Buses per day 3 |
Fastest bus 23h 45m |
First bus 1:30 PM |
Last bus 9:15 PM |
Cheapest Month Jun |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
FAQs: Bus from San Antonio, TX to Knoxville, TN
Find answers to the most common questions about traveling from San Antonio, TX to Knoxville, TN by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Knoxville, TN, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from San Antonio, TX to Knoxville, TN
More options for your journey from San Antonio, TX to Knoxville, TN
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