- Must visit
National Museum
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Cheapest price
€52
Average price
€67
Fastest journey
18 h 10 m
Average duration
21 h 36 m
Buses per day
4
Distance
848 km
The best way to find a cheap bus ticket from Lyon Saint Exupery Airport to Prague is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon Saint Exupery Airport to Prague will cost around €67 if you buy it on the day, but the cheapest tickets can be found for only €52.
Of the 4 buses that leave Lyon Saint Exupery Airport for Prague on Wed, Aug 05, 4 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 848 km distance in an average of 21 h 36 m but if you time it right, some buses will get you there in just 18 h 10 m .
On Wed, Aug 05 the slowest buses will take 1 d 40 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.








Buses from Lyon Saint Exupery Airport to Prague run on average 9 times per day, taking around 16h 3m. Cheap bus tickets for this journey start at €52 but you can travel from only €46 by flight.
There are 4 buses per day. The earliest bus runs at 01:25, the last at 21:00. The fastest bus covers the 526 miles (848 km) distance in 15h 5m.
Distance 526 miles (848 km) |
Average bus duration 16h 3m |
Cheapest ticket price €52 |
Buses per day 9 |
Direct buses 4 |
Fastest bus 15h 5m |
First bus 1:25 AM |
Last bus 9:00 PM |
Cheapest Month Oct |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Jul - Sep |
Busiest Day Sun |
Least Busy Day Sun |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 01:25AM | Arrival Time 01:50AM | Duration 24h25 | Departure days Wed | Cheapest price €84 |
Operator FlixBus | Departure Time 03:10AM | Arrival Time 11:55PM | Duration 20h45 | Departure days Sat | Cheapest price €86 |
Operator FlixBus | Departure Time 03:20AM | Arrival Time 10:25PM | Duration 19h05 | Departure days Mon, Tue, Fri | Cheapest price €58 |
Operator FlixBus | Departure Time 03:30AM | Arrival Time 10:15PM | Duration 18h45 | Departure days Sat | Cheapest price €89 |
Operator FlixBus | Departure Time 04:20AM | Arrival Time 11:25PM | Duration 19h05 | Departure days Mon | Cheapest price €54 |
Operator FlixBus | Departure Time 05:20AM | Arrival Time 12:45AM | Duration 19h25 | Departure days Sat | Cheapest price €68 |
Operator FlixBus | Departure Time 08:30AM | Arrival Time 07:30AM | Duration 23h00 | Departure days Sat | Cheapest price €110 |
Operator FlixBus | Departure Time 11:05AM | Arrival Time 11:45AM | Duration 24h40 | Departure days Wed | Cheapest price €52 |
Operator FlixBus | Departure Time 12:05PM | Arrival Time 08:30AM | Duration 20h25 | Departure days Sat | Cheapest price €70 |
Operator FlixBus | Departure Time 12:30PM | Arrival Time 10:35AM | Duration 22h05 | Departure days Sat | Cheapest price €134 |
Operator FlixBus | Departure Time 01:05PM | Arrival Time 07:10AM | Duration 18h05 | Departure days Sat | Cheapest price €93 |
Operator FlixBus | Departure Time 01:10PM | Arrival Time 08:20AM | Duration 19h10 | Departure days Wed | Cheapest price €71 |
Operator RegioJet a.s. | Departure Time 02:35PM | Arrival Time 06:30AM | Duration 15h55 | Departure days Sat | Cheapest price €80 |
Operator FlixBus | Departure Time 03:00PM | Arrival Time 07:20AM | Duration 16h20 | Departure days Thu | Cheapest price €91 |
Operator FlixBus | Departure Time 04:05PM | Arrival Time 07:55AM | Duration 15h50 | Departure days Mon, Fri, Sun | Cheapest price €58 |
Operator FlixBus | Departure Time 05:00PM | Arrival Time 11:20AM | Duration 18h20 | Departure days Sat | Cheapest price €107 |
Operator FlixBus | Departure Time 05:15PM | Arrival Time 08:20AM | Duration 15h05 | Departure days Mon | Cheapest price €66 |
Operator FlixBus | Departure Time 05:30PM | Arrival Time 02:35PM | Duration 21h05 | Departure days Sat | Cheapest price €110 |
Operator FlixBus | Departure Time 05:55PM | Arrival Time 04:10PM | Duration 22h15 | Departure days Sat | Cheapest price €120 |
Operator FlixBus | Departure Time 06:05PM | Arrival Time 11:20AM | Duration 17h15 | Departure days Sat | Cheapest price €109 |
Operator FlixBus | Departure Time 08:00PM | Arrival Time 02:10PM | Duration 18h10 | Departure days Wed | Cheapest price €61 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 01:35PM | Duration 17h05 | Departure days Tue | Cheapest price €64 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 03:10PM | Duration 18h10 | Departure days Fri | Cheapest price €64 |
Operator FlixBus | Departure Time 09:30PM | Arrival Time 02:45PM | Duration 17h15 | Departure days Sat | Cheapest price €92 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 03:25PM | Duration 17h25 | Departure days Sat | Cheapest price €98 |
The table below shows live departures for Lyon Saint Exupery Airport to Prague buses for today, Tuesday, August 4. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:30 PM Lyon Saint Exupery Airport | 17h05 | 1:35 PM Prague | 0 transfersDirect | |
| Wednesday, August 5 | |||||
![]() | 1:25 AM Lyon Saint Exupery Airport | 24h25 | 1:50 AM Prague | 0 transfersDirect | |
![]() | 11:05 AM Lyon Saint Exupery Airport | 24h40 | 11:45 AM Prague | 0 transfersDirect | |
![]() | 1:10 PM Lyon Saint Exupery Airport | 19h10 | 8:20 AM Prague | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Prague — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Prague trip today.
Major museum of Czech history and natural sciences in a monumental Neo-Renaissance building overlooking Wenceslas Square.
Well-curated Jewish history museum across several historic sites. Important for understanding Prague's Jewish heritage and resilience.
Leading Czech art museum with medieval to modern works in a grand historic palace. Essential for fine art and decorative arts lovers.
Historic square at Prague's core, surrounded by Gothic and Baroque landmarks. A must for first-time visitors and classic city views.
Lively boulevard of Czech modern history, lined with shops and major buildings. Worth visiting for atmosphere and historic significance.
Romantic quarter of palaces, lanes, and church domes beneath Prague Castle. Ideal for wandering, photography, and quieter historic charm.
Slow-braised beef in a creamy root-vegetable sauce, usually served with bread dumplings. A classic Czech Sunday dish strongly linked to Bohemian home cooking.
Crisp roasted pork knuckle, often served with mustard, horseradish, and pickles. A hearty pub staple popular with Czech beer culture.
Roast pork with sauerkraut and dumplings. This iconic Czech combination is a cornerstone of traditional pub and family meals.
Traditional Czech restaurant and brewery by Prague Castle, praised for roast meats, dumplings, and polished historic interiors.
Upscale restaurant focused on Czech ingredients and game, with sophisticated service in an Art Nouveau municipal house setting.
Elegant Michelin-starred restaurant known for modern Czech tasting menus in a refined setting near the Vltava.
Moderate for Europe: transit is cheap, casual meals are reasonable, and hotels in the center can raise daily costs in peak season.
Service is often not included. Tip about 5-10% in restaurants, round up for cafes, and round up or add about 10% for taxis if service is good.
Official public transport app
Prague Central Train Station -> Wenceslas Square
Find answers to the most common questions about traveling from Lyon Saint Exupery Airport to Prague by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Prague, this guide helps you travel smarter and with confidence.

Most Lyon Saint Exupery Airport to Prague buses use the Lyon, Gare Routière de Perrache to Praha, ÚAN Florenc station pair, with some services arriving at Praha, Hlavní Nádraží. Use this guide to compare Lyon Saint Exupery Airport and Prague bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Praha, ÚAN Florenc is 1 km from Prague city centre. Public transport options include:
Praha, ÚAN Florenc has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Cafeteria Florenc (in the station), Bistro Florenc (0.2 km), Restaurace U Rozvařilů (0.5 km).
Free Wi-Fi. ATMs are located inside the station, offering multiple currency options.
Ticket office support is available at Praha, ÚAN Florenc.
Available at Praha, ÚAN Florenc: Parking, Taxis, WC.
Accessibility facilities are available at Praha, ÚAN Florenc: Elevators, ramps.
Praha, Hlavní Nádraží is 1 km from Prague city centre. Public transport options include:
Praha, Hlavní Nádraží has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Czech Bistro (in the station), Fast Food Express (in the station), Bohemian Café (0.2 km).
Free Wi-Fi. ATMs are located near the main entrance and ticketing area.
Ticket office support is available at Praha, Hlavní Nádraží.
Available at Praha, Hlavní Nádraží: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Hlavní Nádraží: Elevators, ramps.
Praha, Na Knížecí is 2 km from Prague city centre. Public transport options include:
Praha, Na Knížecí has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, and WC.
Food options include: Café Na Knížecí (in the station), Bistro Praha (0.2 km), Restaurace U Knížete (0.5 km).
Free Wi-Fi. ATMs are located near the entrance.
Available at Praha, Na Knížecí: Parking, Taxis, WC.
Accessibility facilities are available at Praha, Na Knížecí: Elevators, ramps.
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