- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price on Oct 12
$75
Average ticket price on Oct 12
$75
Fastest journey on Oct 12
16 h 5 m
Average journey duration on Oct 12
16 h 5 m
Buses on Oct 12
1
Distance
579 km
The best way to find a cheap bus ticket from Comiso to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Comiso to Rome will cost around $75 if you buy it on the day, but the cheapest tickets can be found for only $75.
It's difficult to get from Comiso to Rome without transferring at least once.
FlixBus · FlixBus
FlixBus · FlixBusBuses from Comiso to Rome run on average 2 times per day, taking around 14h 38m. Cheap bus tickets for this journey start at $49 but you can travel from only $20 by flight.
The earliest bus runs at 05:14, the last at 23:30. The fastest bus covers the 359 miles (579 km) distance in 14h 15m.
Distance 359 miles (579 km) |
Average bus duration 14h 38m |
Cheapest ticket price $49 |
Buses per day 2 |
Fastest bus 14h 15m |
First bus 5:14 AM |
Last bus 11:30 PM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Thu |
Least Busy Day Wed |
Best time to book 14 days |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:30PM | Arrival Time 10:30AM | Duration 22h00 | Departure days Wed | Cheapest price $60 |
Operator FlixBus | Departure Time 12:45PM | Arrival Time 09:40AM | Duration 20h55 | Departure days Wed | Cheapest price $87 |
Operator FlixBus | Departure Time 01:30PM | Arrival Time 07:10AM | Duration 17h40 | Departure days Wed | Cheapest price $116 |
Operator FlixBus | Departure Time 01:45PM | Arrival Time 07:10AM | Duration 17h25 | Departure days Wed | Cheapest price $129 |
Operator FlixBus | Departure Time 02:45PM | Arrival Time 11:50AM | Duration 21h05 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $57 |
The table below shows live departures for Comiso to Rome buses for today, Sunday, October 11. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 2:45 PM Comiso, Via Ghandi (Fermata Sais Comiso) | 16h05 | 6:50 AM Roma, Autostazione Tiburtina | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Comiso to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Comiso to Rome buses use the Comiso, Via Ghandi (Fermata Sais Comiso) to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Comiso and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Here are some other resources that might have the information you need