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If you want to witness the spectacular Palio horse race or just see the beautiful Renaissance heart of Siena, traveling in Italy from Rome is easy and won't take over 4 hours in most cases. Anyone traveling from Rome to Siena has a choice of buses and trains, but both forms of transport vary slightly - so find a bus or train with a schedule that meets your needs. There are also car pooling services such as Bla Bla Car, which may be the fastest way to reach Siena.
Return trips from Siena to Rome are also available.
Buses from Rome to Siena are a great option for traveling between these two cities, with a wide range of bus departures every day. Services are provided by a number of companies, including Baltour, Flixbus, Megabus and Simet, and the journey will take between 2 hours 30 minutes and 3 hours 30 minutes. The earliest bus of the day leaves Tiburtina Bus Station at 5:45 a.m., and there are then regular departures until a 1:40 a.m. service, which gets you into Siena at 5:10 a.m. - leaving the whole day free to see the city.
Trains from Rome to Siena offered by Trenitalia are a comfortable way to get travel between these two cities. Traveling by rail can take just over 3 hours, but some journeys last for almost 5 hours - so make sure you board the best service for your schedule. All train routes from Rome to Siena require a change, usually in Grosseto or Chiusi - which adds to the journey time and makes traveling by rail comparable with bus travel. All trains depart from Termini station, which is easily accessible by both of Rome's Metro lines.