Travel Information
Compare bus, train, and flight for Milan to Mainz
Omio recommends booking the bus as it is the most popular option from Milan to Mainz among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $102 For those with little time, consider booking a flight, which has an average total journey time of 5h 4m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.5 - 1.3kg. Average ticket prices depend on the travel mode: a bus costs an average of $102, while a flight costs an average of $457.
Distance: 315 miles (507 km)
Compare bus with
Most popular Bus | Flight | Train | Driving |
|---|---|---|---|
$102 Average price Cheapest | $457 Average price | $114 Average price | $200 Average price (fuel + tolls) |
16h 5m Average total duration 15h 35m Onboard + 30m Additional time* | 5h 4m Average total duration Fastest 3h 4m Onboard + 2h 0m Additional time* | 7h 57m Average total duration 7h 27m Onboard + 30m Additional time* | 7h 39m Average total duration (door-to-door) |
0.5 - 1.3kg CO2 emissions Lowest | 1.5 - 3.0kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Milan to Mainz
Compare the available ways to get from Milan to Mainz, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Milan to Mainz:
A bus is $12 less than a train for this route with tickets for a train from Milan to Mainz costing on average $114.
A bus is $355 less than a flight for this route with tickets for a flight from Milan to Mainz costing on average $457.
Other travel options to Mainz take longer:
Train takes on average 7h 57m.
Bus takes on average 16h 5m.
Tickets start at around $102 compared to roughly $200 in fuel and tolls — a saving of about $98. The journey takes 15h 35m versus 7h 39m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Milan to Mainz
How to get from Milan to Mainz by train, bus or flight.
Our recommendation
The best way to travel from Milan to Mainz is by taking a bus because it’s the best combination of price and speed.

2:45 PM 13h55 Milan 4:40 AM Mainz $46 1 One-way 0 transfers
Cheapest

2:45 PM 13h55 Milan 4:40 AM Mainz $46 1 One-way 0 transfers
Fastest

6:20 AM 11h25 Milan 5:45 PM Mainz $49 1 One-way 0 transfers
Other options

5:15 AM 12h15 Milan 5:30 PM Mainz $66 1 One-way 0 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
Compare bus, train, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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FAQs: Travel from Milan to Mainz
Travel to Mainz easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Milan to Mainz.

This is compared to other travel options from Milan to Mainz:
A bus is $12 less than a train for this route with tickets for a train from Milan to Mainz costing on average $114.
A bus is $355 less than a flight for this route with tickets for a flight from Milan to Mainz costing on average $457.
Other travel options to Mainz take longer:
Train takes on average 7h 57m.
Bus takes on average 16h 5m.
- Around 61 flights per day.
- Around 3 buses per day.
- Around 1 trains per day.
However, we recommend checking specific travel dates for your route between Milan and Mainz as scheduled services by bus, train, and flight can vary by season or day of the week.
- Trains mostly depart from Milan Centrale and arrive in Mainz Hbf.
- Flights mostly depart from Milan Malpensa Airport and arrive in Frankfurt am Main Airport.
- Buses mostly depart from Milano, Autostazione Lampugnano and arrive in Mainz, Binger Schlag (Kurzzeitparkplatz).
- Travel with FlixBus to go to Mainz by bus.
- Travel with Air Dolomiti, Air France, ITA, Lufthansa, Turkish Airlines, British Airways, Qatar Airways, Condor Flugdienst, Eurowings, AJet, Malta Air, easyJet, Lot Polish Airlines, Austrian Airlines, Helvetic Airways, Air Baltic, BA Cityflyer, Lufthansa Cityline, Smartwings, Swiss, Lufthansa City Airlines to go to Mainz by flight.
- Travel with Deutsche Bahn to go to Mainz by train.
- 1 direct buses per day with FlixBus.
- 23 direct flights per day with Air Dolomiti, ITA, Lufthansa, Condor Flugdienst, Eurowings, Malta Air, easyJet, Smartwings.
Travelling from Milan to Mainz: related information
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