Travel Information
Compare train, bus, and flight for Grenoble to Brussels
Omio recommends booking the bus as it is the most popular option from Grenoble to Brussels among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $61 For those with little time, consider booking a flight, which has an average total journey time of 4h 45m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.6kg. Average ticket prices depend on the travel mode: a bus costs an average of $61, while a flight costs an average of $365.
Distance: 396 miles (638 km)
Compare bus with
Most popular Bus | Train | Flight | Driving |
|---|---|---|---|
$61 Average price Cheapest | $84 Average price | $365 Average price | $227 Average price (fuel + tolls) |
12h 37m Average total duration 12h 7m Onboard + 30m Additional time* | 5h 23m Average total duration 4h 53m Onboard + 30m Additional time* | 4h 45m Average total duration Fastest 2h 45m Onboard + 2h 0m Additional time* | 8h 3m Average total duration (door-to-door) |
0.6 - 1.6kg CO2 emissions | 0.2 - 0.6kg CO2 emissions Lowest | 1.9 - 3.8kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Grenoble to Brussels
Compare the available ways to get from Grenoble to Brussels, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Grenoble to Brussels:
A bus is $23 less than a train for this route with tickets for a train from Grenoble to Brussels costing on average $84.
A bus is $304 less than a flight for this route with tickets for a flight from Grenoble to Brussels costing on average $365.
Other travel options to Brussels take longer:
Train takes on average 5h 23m.
Bus takes on average 12h 37m.
Tickets start at around $61 compared to roughly $227 in fuel and tolls — a saving of about $166. The journey takes 12h 7m versus 8h 3m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
Travel optionsfrom Grenoble to Brussels
How to get from Grenoble to Brussels by train, bus or flight.
Our recommendation
The best way to travel from Grenoble to Brussels is by taking a bus because it’s the best combination of price and speed.
5132 · 165710:25 PM 13h35 Grenoble, Rue Emile Gueymard (Gare Routière) 12:00 PM Brussels, Brussels South (Gare du Midi) $60 1 One-way 1 transfer
Cheapest
5132 · 165710:25 PM 13h35 Grenoble, Rue Emile Gueymard (Gare Routière) 12:00 PM Brussels, Brussels South (Gare du Midi) $60 1 One-way 1 transfer
Fastest
SN27249:15 PM 1h15 Geneva International Airport 10:30 PM Brussels Airport $334 1 One-way 0 transfers
Other options
6922+
93894:45 PM 5h32 Gare de Grenoble 10:17 PM Brussels-Midi $114 1 One-way 1 transfer
6908+
94519:46 AM 6h01 Gare de Grenoble 3:47 PM Brussels-Midi $169 1 One-way 1 transfer
6908+
93519:46 AM 6h01 Gare de Grenoble 3:47 PM Brussels-Midi $169 1 One-way 1 transfer
5130 · 503359:00 AM 13h30 Grenoble, Rue Emile Gueymard (Gare Routière) 10:30 PM Brussels, Brussels South (Gare du Midi) $78 1 One-way 1 transfer
51984 · 510957:15 PM 12h45 Grenoble, Rue Emile Gueymard (Gare Routière) 8:00 AM Brussels, Brussels South (Gare du Midi) $101 1 One-way 1 transfer
FlixBus · FlixBus · FlixBus10:30 AM 14h05 Grenoble, Rue Emile Gueymard (Gare Routière) 12:35 AM Brussels, Brussels South (Gare du Midi) $108 1 One-way 2 transfers
KL1432 · KL17012:10 PM 17h25 Lyon Saint Exupery Airport 7:35 AM Brussels Airport $270 1 One-way 1 transfer
FlixBus+
KL1432 · KL17019:00 AM 22h35 Grenoble, Rue Emile Gueymard (Gare Routière) 7:35 AM Brussels Airport $288 1 One-way 2 transfers
FlixBus+
KL1432 · KL17016:00 AM 25h35 Grenoble, Rue Emile Gueymard (Gare Routière) 7:35 AM Brussels Airport $288 1 One-way 2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Grenoble to Brussels
Travel to Brussels easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Grenoble to Brussels.

This is compared to other travel options from Grenoble to Brussels:
A bus is $23 less than a train for this route with tickets for a train from Grenoble to Brussels costing on average $84.
A bus is $304 less than a flight for this route with tickets for a flight from Grenoble to Brussels costing on average $365.
Other travel options to Brussels take longer:
Train takes on average 5h 23m.
Bus takes on average 12h 37m.
- Around 41 flights per day.
- Around 27 trains per day.
- Around 8 buses per day.
However, we recommend checking specific travel dates for your route between Grenoble and Brussels as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Geneva International Airport and arrive in Brussels Airport.
- Trains mostly depart from Gare de Grenoble and arrive in Brussels-Midi.
- Buses mostly depart from Grenoble, Rue Emile Gueymard (Gare Routière) and arrive in Brussels, Brussels South (Gare du Midi).
- Travel with BlaBlaCar Bus, FlixBus to go to Brussels by bus.
- Travel with SNCF | TGV INOUI, Eurostar, SNCF | TGV Lyria to go to Brussels by train.
- Travel with Brussels Airlines, KLM, Vueling, Swiss, British Airways, Lufthansa, Air Baltic, Lot Polish Airlines, KLM Cityhopper, Helvetic Airways, Austrian Airlines, Air France, Qatar Airways, easyJet, Air Dolomiti, CitizenPlane, BA Euroflyer, Lufthansa Cityline, Lufthansa City Airlines, Edelweiss Air, Bulgaria Air, BA Cityflyer, Norwegian Air Shuttle to go to Brussels by flight.
- 7 direct flights per day with Brussels Airlines, Swiss, Air Baltic, easyJet, CitizenPlane.
Travelling from Grenoble to Brussels: related information
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