Travel Information
Compare bus and flight for Chicago, IL to Des Moines, IA
Omio recommends booking the bus as it is the most popular option from Chicago, IL to Des Moines, IA among Omio's users. If you are prioritising price take the bus with prices starting from €38. For those with little time consider booking a flight which can get you there in 1h 24m. The ticket price range depends on the travel mode: a bus costs an average of €38, and a flight costs an average of €183.
Distance: 307 miles (495 km)
Compare bus with
Most popular Bus | Flight |
|---|---|
€55 Average price Cheapest | €281 Average price |
8h 44m Average total duration 8h 14m Onboard + 30m Additional time* | 4h 24m Average total duration Fastest 1h 24m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
Compare prices and tickets Chicago, IL to Des Moines, IA by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Chicago, IL to Des Moines, IA
Take a train from Chicago, IL to Des Moines, IA and enjoy the approximately 307 miles (495 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
Distance 307 miles (495 km) |
FAQs: Trains from Chicago, IL to Des Moines, IA
Find answers to the most common questions about traveling from Chicago, IL to Des Moines, IA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Des Moines, IA, this guide helps you travel smarter and with confidence.

Most popular train connections from Chicago, IL
More options for your journey from Chicago, IL to Des Moines, IA
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