- Must visit
Edison and Ford Winter Estates
Historic riverfront estate museum with Thomas Edison and Henry Ford homes, gardens, and a large inventions museum. One of Fort Myers' signature cultural attractions.
Omio recommends booking the bus as it is the most popular option from Florence, SC to Fort Myers, FL among Omio's users. If you are prioritising price take the bus with prices starting from $114. For those with little time consider booking a bus which can get you there in 18h 20m. The ticket price range depends on the travel mode: a bus costs an average of $114, and a bus costs an average of $114.
Distance: 537 miles (865 km)
Most popular Bus | Driving |
|---|---|
$114 Average price Cheapest | $122 Average price (fuel + tolls) |
18h 50m Average total duration Fastest 18h 20m Onboard + 30m Additional time* | 9h 11m Average total duration (door-to-door) |
Direct Options | Direct Options |
Other travel options to Fort Myers, FL take longer:
Bus takes on average 18h 20m.
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from Florence, SC to Fort Myers, FL and enjoy the approximately 537 miles (865 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 07:00, the last at 07:00.
Distance 537 miles (865 km) |
Average train duration 15h 31m |
Trains per day 2 |
First train 7:00 AM |
Last train 7:00 AM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 4 days |
Discover the best of Fort Myers — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Fort Myers trip today.
Historic riverfront estate museum with Thomas Edison and Henry Ford homes, gardens, and a large inventions museum. One of Fort Myers' signature cultural attractions.
Family-friendly science and local history museum with interactive exhibits, aquariums, and hands-on learning. Popular for visitors with children.
Downtown visual and performing arts venue hosting exhibitions, events, and community programming in a restored historic federal building.
The city's most popular walkable historic area, with brick streets, murals, shops, galleries, and nightlife. The top area to explore on foot.
Seasonal waterfront park famous for winter manatee viewing, boardwalks, and kayak access. Widely shared on social media during cooler months.
Popular nature preserve with a scenic boardwalk through wetlands, wildlife spotting, and strong appeal among photographers and nature lovers.
A Southwest Florida seasonal specialty, usually served chilled with mustard sauce. They are prized for sweet, firm meat and are strongly associated with Gulf Coast seafood culture.
A classic Florida coastal dish made with fresh local grouper, often grilled, blackened, or fried on a bun. It is a staple at waterfront restaurants around Fort Myers.
Fritters made with chopped conch in a seasoned batter, reflecting Caribbean and old Florida influences common in Southwest Florida seafood menus.
An established downtown fine-dining restaurant known for Southern-influenced cuisine, steaks, and seafood served in historic house-style rooms with a romantic atmosphere.
A popular Florida casual restaurant known for seafood, Yucatan-style flavors, and rum drinks in a lively, polished setting.
A casual, well-known seafood restaurant near the water, valued for fresh Gulf seafood and an old-Florida fish-house feel.
Moderate by U.S. standards. Casual dining is affordable, but beach areas, hotels, and seasonal travel can raise costs noticeably.
Tip 18-20% in restaurants; 20%+ for excellent service. Bartenders: USD 1-2 per drink. Taxis/rideshares: 10-15%. Hotel staff: USD 2-5. Not usually needed for fast food.
Find answers to the most common questions about traveling from Florence, SC to Fort Myers, FL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Fort Myers, FL, this guide helps you travel smarter and with confidence.

Most Florence, SC to Fort Myers, FL trains use the Florence Station to Fort Myers, McDowell Dr (Love's Travel Stop) station pair. Use this guide to compare Florence, SC and Fort Myers, FL train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
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