- Must visit
Edison and Ford Winter Estates Museum
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
Omio recommends booking the bus as it is the most popular option from Florence, SC to Fort Myers, FL among Omio's users. If you are prioritising price take the bus with prices starting from $114. For those with little time consider booking a bus which can get you there in 18h 20m. The ticket price range depends on the travel mode: a bus costs an average of $114, and a bus costs an average of $114.
Distance: 537 miles (865 km)
Most popular Bus | Driving |
|---|---|
$114 Average price Cheapest | $122 Average price (fuel + tolls) |
18h 50m Average total duration Fastest 18h 20m Onboard + 30m Additional time* | 9h 11m Average total duration (door-to-door) |
Direct Options | Direct Options |
Other travel options to Fort Myers, FL take longer:
Bus takes on average 18h 20m.
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a train from Florence, SC to Fort Myers, FL and enjoy the approximately 537 miles (865 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest train runs at 07:00, the last at 07:00.
Distance 537 miles (865 km) |
Average train duration 15h 31m |
Trains per day 2 |
First train 7:00 AM |
Last train 7:00 AM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 4 days |
Discover the best of Fort Myers, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Fort Myers, FL trip today.
Major local museum at the Edison and Ford estates with inventions, automobiles, and exhibits on two influential American innovators.
Excellent regional history museum covering Southwest Florida's people, places, and development through engaging permanent exhibitions.
Interactive science museum with aquariums, live animals, and hands-on exhibits that make it especially strong for families and curious adults.
Walkable historic downtown filled with shops, galleries, event spaces, and river views, making it the city's main strolling district.
Large urban nature preserve with boardwalks, trails, and birding, offering a wild contrast to the built-up city center.
Palm-lined downtown street known for preserved architecture, boutiques, murals, and an easy introduction to the city's historic core.
Fresh Gulf shrimp, often peeled and eaten chilled or quickly sautéed. A Southwest Florida staple thanks to nearby shrimping waters and seafood culture.
A Florida classic of flaky local fish, usually grouper, served blackened, grilled, or fried in a sandwich. Popular along Fort Myers waterfronts.
Cracked Florida stone crab claws served chilled with mustard sauce. A prized seasonal seafood known across coastal South Florida and the Gulf.
Established fine dining restaurant serving refined seafood and steaks in an elegant historic downtown setting.
Casual waterfront seafood spot known for fresh local shrimp, grouper, and island atmosphere near the marina.
Beloved local Cuban cafe offering pressed sandwiches, coffee, pastries, and traditional Latin comfort food in a casual setting.
Moderate for Florida beach travel. Hotels and dining run mid-range, while car travel and parking add costs. Cheaper than Miami, but pricier than many inland US cities.
Tip 18-20% at restaurants, 15-20% for taxis or rideshares, and $1-2 per drink or coffee in cafes and bars.
Find answers to the most common questions about traveling from Florence, SC to Fort Myers, FL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Fort Myers, FL, this guide helps you travel smarter and with confidence.

Most Florence, SC to Fort Myers, FL trains use the Florence Station to Fort Myers, McDowell Dr (Love's Travel Stop) station pair. Use this guide to compare Florence, SC and Fort Myers, FL train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
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