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Journey information
Overview: Train from Florence, SC to Lancaster, PA
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 446 miles (718 km) |
Average train duration 11h 29m |
Trains per day 2 |
First train 05:35 |
Last train 13:45 |
Key Takeaways
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Train companies: Amtrak from Florence, SC to Lancaster, PA trainsAmtrak trains will get you between Florence, SC and Lancaster, PA. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
12h 37m
Cheapest Price
$285 (€233)
Amtrak frequency
2 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone
FAQs: Trains from Florence, SC to Lancaster, PA
Find answers to the most common questions about traveling from Florence, SC to Lancaster, PA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lancaster, PA, this guide helps you travel smarter and with confidence.

Most visitors spend about 2 to 3 days in Lancaster, PA, which allows enough time to explore Amish Country, visit museums, and enjoy local attractions like farms and markets.
The distance by train from Florence, SC to Lancaster, PA is 446 miles (718 km).
In Lancaster, PA, you can enjoy a day of family fun at Dutch Wonderland amusement park or explore interactive exhibits at The Lancaster Science Factory. Relax at Long's Park with its walking trails and picnic areas, or experience the ice cream-making process at the Turkey Hill Experience. Visit the Wolf Sanctuary of PA for guided tours to see rescued wolves. For cultural insights, explore Lancaster Central Market, The Amish Farm and House, and Landis Valley Village & Farm Museum. History enthusiasts can tour the Rock Ford Plantation, while art lovers might enjoy the Demuth Museum, showcasing works by Charles Demuth.
The first train from Florence, SC to Lancaster, PA leaves at 5:35 AM.
The last train from Florence, SC to Lancaster, PA leaves at 1:45 PM.
The train station in Florence, SC that goes to Lancaster, PA is Florence Station, Florence, SC, which connects to Lancaster Station, Lancaster, PA.
There is no direct train service currently available from Florence, SC to Lancaster, PA.
The train journey from Florence, SC to Lancaster, PA offers a mix of urban and rural views, with highlights including stretches of Southern countryside, small towns, and glimpses of the Appalachian foothills as you travel northward. While not traditionally considered one of the most scenic routes, it provides a pleasant and varied landscape.
Unfortunately, there is no night train available from Florence, SC to Lancaster, PA.
There is no high speed train available from Florence, SC to Lancaster, PA.
Yes, you can take the train from Florence, SC to Lancaster, PA.
popular train stations
Popular train stations from Florence, SC to Lancaster, PA
Florence
Lancaster
The major train station for departures in Florence is Florence Station. Find all the information you need to know about services, amenities and connections at Florence Station for your trip from Florence to Lancaster.
Florence Station










Amenities at train station
information
Ticket Office Hours
- 6:00 AM - 11:00 PM Monday - Sunday
Number of platforms
2Parking
- Parking is available at the station.
Taxis
- Outside the main entrance.
Accessibility
- Elevators, ramps.
Hotel
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
Lost and Found Office
- Located in the main hall
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- The station has an enclosed waiting area.
Public transit options for Florence Station
- Bus: Greyhound services available nearby
The major train station for arrivals in Lancaster is Lancaster Station. Find all the information you need to know about services, amenities and connections at Lancaster Station for your journey to Lancaster from Florence.
Amenities at train station
information
Ticket Office Hours
- 6:00 AM - 10:00 PM Monday - Sunday
Distance to city center
1 kmNumber of platforms
2Parking
- Parking is available at the station.
Taxis
- Outside the main entrance.
Accessibility
- Elevators, ramps.
Hotel
- Lancaster Marriott at Penn Square
- The Hotel Lancaster
- Cork Factory Hotel
Lost and Found Office
- Located in the main hall
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- The station has an enclosed waiting area.
Public transit options for Lancaster Station
- Bus: Red Rose Transit Authority (RRTA) services available
Most popular train connections from Florence, SC
More options for your journey from Florence, SC to Lancaster, PA
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