- Must visit
Wheatland
Former home of President James Buchanan with guided tours, period rooms, and political history on landscaped grounds west of downtown.
Omio recommends booking the train as it is the most popular option from Florence, SC to Lancaster, PA among Omio's users. If you are prioritising price take the train with prices starting from kr1101. For those with little time consider booking a train which can get you there in 11h 36m. The ticket price range depends on the travel mode: a train costs an average of kr1101, and a train costs an average of kr1101.
Distance: 446 miles (718 km)
Most popular Train | Driving |
|---|---|
kr1210 Average price Cheapest | kr665 Average price (fuel + tolls) |
12h 6m Average total duration Fastest 11h 36m Onboard + 30m Additional time* | 8h 10m Average total duration (door-to-door) |
![]() Most popular train company | Your own car or car rental |
Direct Options | Direct Options |
Tickets start at around kr1210 compared to roughly kr665 in fuel and tolls — a saving of about kr-545.74. The journey takes 11h 36m versus 8h 10m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Florence, SC to Lancaster, PA run on average 2 times per day, taking around 11h 36m. Cheap train tickets for this journey start at kr1101 if you book in advance.
The earliest train runs at 05:35, the last at 13:45. The fastest train covers the 446 miles (718 km) distance in 13h 37m.
Distance 446 miles (718 km) |
Average train duration 11h 36m |
Cheapest ticket price kr1101 |
Trains per day 2 |
Fastest train 13h 37m |
First train 5:35 AM |
Last train 1:45 PM |
Cheapest Month Feb |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Oct - Dec |
Discover the best of Lancaster, PA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Lancaster, PA trip today.
Former home of President James Buchanan with guided tours, period rooms, and political history on landscaped grounds west of downtown.
Hands-on museum and gallery hub in a restored factory complex, featuring regional art, science exhibits, and family-friendly learning.
Leading regional art museum with American art, Pennsylvania Impressionists, and rotating exhibitions in a refined downtown setting.
The city’s historic commercial heart, lined with preserved architecture, boutiques, galleries, and theaters; ideal for first-time exploration.
Beloved public market district and surrounding blocks, busy with local life, architecture, and easy walking access to downtown highlights.
Popular arts corridor known for murals, galleries, small shops, and a lively walkable atmosphere just north of the core.
A Pennsylvania Dutch pot pie is a rich chicken stew with hand-rolled square noodles, not a baked pie, and is a cherished regional comfort food.
Slow-cooked chicken and sweet corn in creamy broth, often with hard-boiled egg. It is a classic Lancaster County Sunday and church supper dish.
Scrapple is a fried loaf of pork scraps and cornmeal, served at breakfast. It is a long-standing Pennsylvania Dutch and Amish country staple.
Historic market with many local vendors for Pennsylvania Dutch baked goods, breakfast, sandwiches, and regional snacks in a lively casual setting.
Upscale American restaurant in a restored tobacco warehouse, known for seasonal local ingredients, polished service, and a refined but approachable atmosphere.
Long-running Lancaster favorite serving classic Pennsylvania Dutch fare, hearty breakfasts, pies, and local comfort food in a traditional setting.
Moderate for U.S. travel. Hotels and dining are usually cheaper than major East Coast cities, while car use and limited transit can raise visitor costs.
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. Cafes often have tip jars; $1 per drink is common.
Find answers to the most common questions about traveling from Florence, SC to Lancaster, PA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lancaster, PA, this guide helps you travel smarter and with confidence.

Most Florence, SC to Lancaster, PA trains use the Florence Station to Lancaster Station station pair. Use this guide to compare Florence, SC and Lancaster, PA train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Florence Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Information Desk, and Luggage Carts.
Food and drink options are available at Florence Station.
Ticket office support is available at Florence Station. Information desks are located in the main hall.
Luggage storage is available at Florence Station. Lost and found is available at the station.
Available at Florence Station: Parking, Taxis, WC.
Accessibility facilities are available at Florence Station: Elevators, ramps.
Nearby hotels include Aloft Florence, Hyatt Place Florence Downtown, Hotel Florence, Tapestry Collection by Hilton.
Lancaster Station is 1 km from Lancaster city centre. Public transport options include:
Lancaster Station has practical services for this route, including Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Rental, Information Desk, and Luggage Carts.
Food and drink options are available at Lancaster Station.
Ticket office support is available at Lancaster Station. Information desks are located in the main hall.
Luggage storage is available at Lancaster Station. Lost and found is available at the station.
Available at Lancaster Station: Parking, Taxis, WC.
Available at Lancaster Station: Bike Rental.
Accessibility facilities are available at Lancaster Station: Elevators, ramps.
Nearby hotels include Lancaster Marriott at Penn Square, The Hotel Lancaster, Cork Factory Hotel.
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