Travel Information
Compare train for Florence, SC to Lancaster, PA
Omio recommends booking the train as it is the most popular option from Florence, SC to Lancaster, PA among Omio's users. If you are prioritising price take the train with prices starting from $173. For those with little time consider booking a train which can get you there in 11h 28m. The ticket price range depends on the travel mode: a train costs an average of $173, and a train costs an average of $173.
Distance: 446 miles (718 km)
Compare train with
Most popular Train |
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$194 Average price Cheapest |
11h 58m Average total duration Fastest 11h 28m Onboard + 30m Additional time* |
![]() Most popular train company |
Direct Options |
Compare prices and tickets Florence, SC to Lancaster, PA by train
Compare train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Florence, SC to Lancaster, PA
Trains from Florence, SC to Lancaster, PA run on average 2 times per day, taking around 11h 28m. Cheap train tickets for this journey start at $173 (€138) if you book in advance.
The earliest train runs at 05:35, the last at 13:45. The fastest train covers the 446 miles (718 km) distance in 12h 36m.
Distance 446 miles (718 km) |
Average train duration 11h 28m |
Cheapest ticket price $173 (€138) |
Trains per day 2 |
Fastest train 12h 36m |
First train 5:35 AM |
Last train 1:45 PM |
Cheapest Month Jan |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Oct - Dec |
Train companies: Amtrak from Florence, SC to Lancaster, PA trainsAmtrak trains will get you between Florence, SC and Lancaster, PA from $173 (€138). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Florence, SC to Lancaster, PA
Find answers to the most common questions about traveling from Florence, SC to Lancaster, PA by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Lancaster, PA, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence, SC to Lancaster, PA
- 6:00 AM - 11:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Aloft Florence
- Hyatt Place Florence Downtown
- Hotel Florence, Tapestry Collection by Hilton
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Greyhound services available nearby
- 6:00 AM - 10:00 PM Monday - Sunday
- Parking is available at the station.
- Outside the main entrance.
- Elevators, ramps.
- Lancaster Marriott at Penn Square
- The Hotel Lancaster
- Cork Factory Hotel
- Located in the main hall
- Located in the main hall
- Free
- The station has an enclosed waiting area.
- Bus: Red Rose Transit Authority (RRTA) services available
Most popular train connections from Florence, SC
More options for your journey from Florence, SC to Lancaster, PA
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