- Must visit
Saint Louis Art Museum
Major fine arts museum in Forest Park with collections spanning ancient to modern works. A top cultural stop known for strong European, American, and global holdings.
Flights from Detroit, MI to St. Louis, MO depart on average 36 times per day, taking around 4h 52m. Cheap flight tickets for this journey start at $125 (€101) but you can travel from only $71 (€57) by bus.
The earliest flight runs at 05:00, the last at 22:25. The fastest flight covers the 454 miles (731 km) distance in 3h 29m. August is the cheapest month to fly.
Distance 454 miles (731 km) |
Average flight duration 4h 52m |
Cheapest ticket price $125 (€101) |
Flights per day 36 |
Fastest flight 3h 29m |
First flight 5:00 AM |
Last flight 10:25 PM |
Cheapest Month Aug |
Cheapest Day Mon |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 21 days |
Cheapest price
$125
Average price
$347
Fastest journey
3 h 55 m
Average duration
5 h 5 m
Flights per day
7
Distance
731 km
The best way to find a cheap flight ticket from Detroit, MI to St. Louis, MO is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Detroit, MI to St. Louis, MO will cost around $347 if you buy it on the day, but the cheapest tickets can be found for only $125.
Of the 7 flights that leave Detroit, MI for St. Louis, MO onWed, Jun 17, 7 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jun 17 the direct flights cover the 731 km distance in an average of 5 h 5 m but if you time it right, some flights will get you there in just 3 h 55 m .
On Wed, Jun 17 the longest flights will take 6 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Omio recommends booking the train as it is the most popular option from Detroit, MI to St. Louis, MO among Omio's users. If you are prioritising price take the bus with prices starting from $71. For those with little time consider booking a flight which can get you there in 4h 52m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.2 - 0.7kg. The ticket price range depends on the travel mode: a bus costs an average of $71, and a flight costs an average of $125.
Distance: 454 miles (731 km)
| Flight | Most popular Train | Bus | Driving |
|---|---|---|---|
$376 Average price | $143 Average price | $142 Average price Cheapest | $106 Average price (fuel + tolls) |
7h 52m Average total duration Fastest 4h 52m Onboard + 3h 0m Additional time* | 11h 4m Average total duration 10h 34m Onboard + 30m Additional time* | 13h 46m Average total duration 13h 16m Onboard + 30m Additional time* | 7h 46m Average total duration (door-to-door) |
2.2 - 4.4kg CO2 emissions | 0.2 - 0.7kg CO2 emissions Lowest | 0.7 - 1.8kg CO2 emissions | - CO2 emissions |
![]() Most popular airline | ![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Detroit, MI to St. Louis, MO:
A bus is $2 (€1) less than a train for this route with tickets for a train from Detroit, MI to St. Louis, MO costing on average $143 (€116).
A bus is $234 (€190) less than a flight for this route with tickets for a flight from Detroit, MI to St. Louis, MO costing on average $376 (€305).
Other travel options to St. Louis, MO take longer:
Train takes on average 10h 34m.
Bus takes on average 13h 16m.
The table below shows live departures for Detroit, MI to St. Louis, MO flights for today, Tuesday, June 16. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
AA1108+ AA5655 | 5:37 AM Detroit Wayne County Airport | 8h12 | 12:49 PM St. Louis Lambert International Airport | 1 transfer | |
AA2720+ AA5170 | 6:00 AM Detroit Wayne County Airport | 5h37 | 10:37 AM St. Louis Lambert International Airport | 1 transfer | |
UA1114 · UA6160 | 6:15 AM Detroit Wayne County Airport | 12h27 | 5:42 PM St. Louis Lambert International Airport | 1 transfer | |
AA6465 · AA6352 | 6:45 AM Detroit Wayne County Airport | 7h27 | 1:12 PM St. Louis Lambert International Airport | 1 transfer | |
AA6465+ AA4537 | 6:45 AM Detroit Wayne County Airport | 10h48 | 4:33 PM St. Louis Lambert International Airport | 1 transfer | |
AA6465+ AA3815 | 6:45 AM Detroit Wayne County Airport | 8h17 | 2:02 PM St. Louis Lambert International Airport | 1 transfer | |
UA3652 · UA1525 · UA2000 | 7:00 AM Detroit Wayne County Airport | 9h46 | 3:46 PM St. Louis Lambert International Airport | 2 transfers | |
UA3652 · UA1525 · UA4581 | 7:00 AM Detroit Wayne County Airport | 8h23 | 2:23 PM St. Louis Lambert International Airport | 2 transfers | |
UA3652 · UA3630 | 7:00 AM Detroit Wayne County Airport | 5h41 | 11:41 AM St. Louis Lambert International Airport | 1 transfer | |
UA3652 · UA1875 · UA2000 | 7:00 AM Detroit Wayne County Airport | 9h46 | 3:46 PM St. Louis Lambert International Airport | 2 transfers | |
AA5244 · AA5582 | 7:00 AM Detroit Wayne County Airport | 10h30 | 4:30 PM St. Louis Lambert International Airport | 1 transfer | |
UA1355 | 7:05 AM Detroit Wayne County Airport | 6h06 | 12:11 PM St. Louis Lambert International Airport | 0 transfersDirect | |
UA1355 · UA4613 | 7:05 AM Detroit Wayne County Airport | 4h34 | 10:39 AM St. Louis Lambert International Airport | 1 transfer | |
AA482+ AA6384 | 7:47 AM Detroit Wayne County Airport | 7h44 | 2:31 PM St. Louis Lambert International Airport | 1 transfer | |
AA482+ AA5655 | 7:47 AM Detroit Wayne County Airport | 6h02 | 12:49 PM St. Louis Lambert International Airport | 1 transfer | |
UA2302 · UA1422 | 8:00 AM Detroit Wayne County Airport | 14h10 | 9:10 PM St. Louis Lambert International Airport | 1 transfer | |
UA2302 · UA214 | 8:00 AM Detroit Wayne County Airport | 16h57 | 11:57 PM St. Louis Lambert International Airport | 1 transfer | |
UA2302 · UA1639 | 8:00 AM Detroit Wayne County Airport | 9h33 | 4:33 PM St. Louis Lambert International Airport | 1 transfer | |
UA426 · UA1355 | 8:50 AM Detroit Wayne County Airport | 4h21 | 12:11 PM St. Louis Lambert International Airport | 1 transfer | |
UA3409 · UA3719 | 9:07 AM Detroit Wayne County Airport | 8h00 | 4:07 PM St. Louis Lambert International Airport | 1 transfer | |
UA3409 · UA2053 · UA4552 | 9:07 AM Detroit Wayne County Airport | 9h21 | 5:28 PM St. Louis Lambert International Airport | 2 transfers | |
AA5582 · AA5516 | 10:03 AM Detroit Wayne County Airport | 7h27 | 4:30 PM St. Louis Lambert International Airport | 1 transfer | |
UA3500 · UA4527 | 10:13 AM Detroit Wayne County Airport | 10h13 | 7:26 PM St. Louis Lambert International Airport | 1 transfer | |
UA3500 · UA2649 · UA4416 | 10:13 AM Detroit Wayne County Airport | 10h00 | 7:13 PM St. Louis Lambert International Airport | 2 transfers | |
UA3500 · UA2331 · UA4552 | 10:13 AM Detroit Wayne County Airport | 8h15 | 5:28 PM St. Louis Lambert International Airport | 2 transfers | |
UA3500 · UA2331 · UA4518 | 10:13 AM Detroit Wayne County Airport | 9h00 | 6:13 PM St. Louis Lambert International Airport | 2 transfers | |
AA6352+ AA4103 | 10:33 AM Detroit Wayne County Airport | 3h39 | 1:12 PM St. Louis Lambert International Airport | 1 transfer | |
AA4103+ AA4537 | 10:33 AM Detroit Wayne County Airport | 7h00 | 4:33 PM St. Louis Lambert International Airport | 1 transfer | |
AA3815 · AA4103 | 10:33 AM Detroit Wayne County Airport | 4h29 | 2:02 PM St. Louis Lambert International Airport | 1 transfer | |
AA1004+ AA4103 | 10:33 AM Detroit Wayne County Airport | 14h43 | 12:16 AM St. Louis Lambert International Airport | 1 transfer | |
UA6251 · UA6160 | 10:55 AM Detroit Wayne County Airport | 7h47 | 5:42 PM St. Louis Lambert International Airport | 1 transfer | |
UA6251 · UA6187 | 10:55 AM Detroit Wayne County Airport | 12h50 | 10:45 PM St. Louis Lambert International Airport | 1 transfer | |
UA1746 · UA4581 | 11:00 AM Detroit Wayne County Airport | 4h23 | 2:23 PM St. Louis Lambert International Airport | 1 transfer | |
AA1792 · AA2712 | 11:50 AM Detroit Wayne County Airport | 5h43 | 4:33 PM St. Louis Lambert International Airport | 1 transfer | |
AA2714+ AA5530 | 12:59 PM Detroit Wayne County Airport | 4h59 | 4:58 PM St. Louis Lambert International Airport | 1 transfer | |
AA4537+ AA3498 | 1:02 PM Detroit Wayne County Airport | 4h31 | 4:33 PM St. Louis Lambert International Airport | 1 transfer | |
AA1004+ AA3498 | 1:02 PM Detroit Wayne County Airport | 12h14 | 12:16 AM St. Louis Lambert International Airport | 1 transfer | |
AA1781 · AA2686 | 1:43 PM Detroit Wayne County Airport | 6h17 | 7:00 PM St. Louis Lambert International Airport | 1 transfer | |
AA1781 · AA2731 | 1:43 PM Detroit Wayne County Airport | 4h36 | 5:19 PM St. Louis Lambert International Airport | 1 transfer | |
UA5381 · UA4518 | 2:10 PM Detroit Wayne County Airport | 5h03 | 6:13 PM St. Louis Lambert International Airport | 1 transfer | |
UA6190 · UA2497 · UA2144 | 2:35 PM Detroit Wayne County Airport | 7h55 | 9:30 PM St. Louis Lambert International Airport | 2 transfers | |
UA6190 · UA4527 | 2:35 PM Detroit Wayne County Airport | 5h51 | 7:26 PM St. Louis Lambert International Airport | 1 transfer | |
UA3611 · UA1527 | 3:15 PM Detroit Wayne County Airport | 9h21 | 11:36 PM St. Louis Lambert International Airport | 1 transfer | |
UA302 · UA1422 | 3:32 PM Detroit Wayne County Airport | 6h38 | 9:10 PM St. Louis Lambert International Airport | 1 transfer | |
UA302 · UA214 | 3:32 PM Detroit Wayne County Airport | 9h25 | 11:57 PM St. Louis Lambert International Airport | 1 transfer | |
AA1793 · AA1010 | 4:10 PM Detroit Wayne County Airport | 6h27 | 9:37 PM St. Louis Lambert International Airport | 1 transfer | |
UA3565 · UA1527 | 4:48 PM Detroit Wayne County Airport | 7h48 | 11:36 PM St. Louis Lambert International Airport | 1 transfer | |
AA5309 · AA5172 | 5:11 PM Detroit Wayne County Airport | 5h18 | 9:29 PM St. Louis Lambert International Airport | 1 transfer | |
AA1004+ AA3980 | 5:29 PM Detroit Wayne County Airport | 7h47 | 12:16 AM St. Louis Lambert International Airport | 1 transfer | |
UA5264 · UA2144 | 6:20 PM Detroit Wayne County Airport | 4h10 | 9:30 PM St. Louis Lambert International Airport | 1 transfer | |
UA4032 · UA6214 | 6:40 PM Detroit Wayne County Airport | 16h27 | 10:07 AM St. Louis Lambert International Airport | 1 transfer | |
UA3644 · UA1527 | 7:00 PM Detroit Wayne County Airport | 5h36 | 11:36 PM St. Louis Lambert International Airport | 1 transfer | |
UA6362 · UA4388 | 7:45 PM Detroit Wayne County Airport | 15h42 | 10:27 AM St. Louis Lambert International Airport | 1 transfer | |
AA1794 · AA459 | 7:58 PM Detroit Wayne County Airport | 4h46 | 11:44 PM St. Louis Lambert International Airport | 1 transfer | |
AA1004+ AA3500 | 8:58 PM Detroit Wayne County Airport | 4h18 | 12:16 AM St. Louis Lambert International Airport | 1 transfer | |
AA3500 · AA4104 | 8:58 PM Detroit Wayne County Airport | 12h33 | 8:31 AM St. Louis Lambert International Airport | 1 transfer | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Discover the best of St. Louis — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect St. Louis trip today.
Major fine arts museum in Forest Park with collections spanning ancient to modern works. A top cultural stop known for strong European, American, and global holdings.
Highly original museum and artist-built environment with architectural salvage, tunnels, slides, and installations. One of the city’s most distinctive and widely shared attractions.
History museum in Forest Park covering St. Louis, Missouri, and regional stories through permanent and rotating exhibitions. Well suited for visitors wanting local context.
One of the largest urban parks in the United States, home to major institutions, lakes, trails, and broad green spaces. Essential for first-time visitors.
Riverfront grounds around the Arch with lawns, paths, and strong skyline views, useful for walking and iconic photos.
Lively entertainment and walking district known for music venues, public art, shops, and the St. Louis Walk of Fame.
A local pizza style with a very thin, cracker-like crust, cut into squares and traditionally topped with Provel cheese. It is one of the city’s signature foods.
Breaded and fried meat- or cheese-filled ravioli, usually served with marinara sauce. This St. Louis Italian-American specialty is strongly associated with The Hill neighborhood.
A rich, dense cake with a buttery base and sweet cream cheese-like topping. It is one of the most famous desserts identified with St. Louis.
A long-established Italian restaurant on The Hill, known for classic red-sauce dishes, toasted ravioli, and an old-school fine dining feel.
An iconic St. Louis custard stand famous for thick concretes and nostalgic roadside charm. A must for trying the city’s best-known frozen treat.
A respected contemporary American restaurant known for refined cooking, strong wine service, and a polished neighborhood setting.
Generally moderate by U.S. standards. Hotels and attractions are often reasonable, while dining costs vary by neighborhood and venue.
Tip 18-20% at restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and delivery drivers.
Find answers to the most common questions about traveling from Detroit, MI to St. Louis, MO by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at St. Louis, MO, this guide helps you travel smarter and with confidence.

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