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Travel Information
Compare train, bus, and flight for Detroit, MI to St. Louis, MO
Omio recommends booking the train as it is the most popular option from Detroit, MI to St. Louis, MO among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $95 For those with little time, consider booking a flight, which has an average total journey time of 6h 26m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.2 - 0.7kg. Average ticket prices depend on the travel mode: a bus costs an average of $95, while a flight costs an average of $639.
Distance: 454 miles (731 km)
Compare train with
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$214 Average price | $95 Average price Cheapest | $639 Average price | $104 Average price (fuel + tolls) |
10h 59m Average total duration 10h 29m Onboard + 30m Additional time* | 12h 48m Average total duration 12h 18m Onboard + 30m Additional time* | 6h 26m Average total duration Fastest 4h 26m Onboard + 2h 0m Additional time* | 7h 46m Average total duration (door-to-door) |
0.2 - 0.7kg CO2 emissions Lowest | 0.7 - 1.8kg CO2 emissions | 2.2 - 4.4kg CO2 emissions | - CO2 emissions |
 Most popular train company |  Most popular bus company |  Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Detroit, MI to St. Louis, MO
Compare the available ways to get from Detroit, MI to St. Louis, MO, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Detroit, MI to St. Louis, MO:
A bus is $120 (€101) less than a train for this route with tickets for a train from Detroit, MI to St. Louis, MO costing on average $214 (€181).
A bus is $545 (€460) less than a flight for this route with tickets for a flight from Detroit, MI to St. Louis, MO costing on average $639 (€539).
Other travel options to St. Louis, MO take longer:
Train takes on average 10h 59m.
Bus takes on average 12h 48m.
Tickets start at around $214 (€181) compared to roughly $104 (€88) in fuel and tolls — a saving of about -$110 (-€92). The journey takes 10h 29m versus 7h 46m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Detroit, MI to St. Louis, MO
How to get from Detroit, MI to St. Louis, MO by train, bus or flight.
Our recommendation
The best way to travel from Detroit, MI to St. Louis, MO is by taking a bus because it’s the best combination of price and speed.
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7:55 PM 13h00 Detroit, Greyhound Terminal 7:55 AM St. Louis, S 15th St (Civic center) $84 1 One-way 1 transfer
Cheapest
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7:55 PM 13h00 Detroit, Greyhound Terminal 7:55 AM St. Louis, S 15th St (Civic center) $84 1 One-way 1 transfer
Fastest
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7:55 PM 13h00 Detroit, Greyhound Terminal 7:55 AM St. Louis, S 15th St (Civic center) $84 1 One-way 1 transfer
Other options
- +
FlixBus4:20 PM 15h00 Detroit, Greyhound Terminal 6:20 AM St. Louis, S 15th St (Civic center) $84 1 One-way 1 transfer - +FlixBus
11:15 PM 17h25 Detroit, Greyhound Terminal 3:40 PM St. Louis, S 15th St (Civic center) $84 1 One-way 1 transfer - · ·
8:20 AM 15h55 Detroit, Greyhound Terminal 11:15 PM St. Louis, S 15th St (Civic center) $84 1 One-way 2 transfers
Find all the dates and times for this journey by train, bus, flight, and ferry .
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FAQs: Travel from Detroit, MI to St. Louis, MO
Travel to St. Louis, MO easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Detroit, MI to St. Louis, MO.
This is compared to other travel options from Detroit, MI to St. Louis, MO:
A bus is $120 (€101) less than a train for this route with tickets for a train from Detroit, MI to St. Louis, MO costing on average $214 (€181).
A bus is $545 (€460) less than a flight for this route with tickets for a flight from Detroit, MI to St. Louis, MO costing on average $639 (€539).
Other travel options to St. Louis, MO take longer:
Train takes on average 10h 59m.
Bus takes on average 12h 48m.
- Around 48 flights per day.
- Around 4 buses per day.
- Around 2 trains per day.
However, we recommend checking specific travel dates for your route between Detroit, MI and St. Louis, MO as scheduled services by train, bus, and flight can vary by season or day of the week.
- Flights mostly depart from Detroit Wayne County Airport and arrive in St. Louis Lambert International Airport.
- Trains mostly depart from Detroit Amtrak, Detroit, MI and arrive in St. Louis Station, St. Louis, MO.
- Buses mostly depart from Detroit, Greyhound Terminal and arrive in St. Louis, S 15th St (Civic center).
- Travel with Greyhound, FlixBus to go to St. Louis, MO by bus.
- Travel with Amtrak to go to St. Louis, MO by train.
- Travel with United, American Airlines, skywest airlines, Republic Airlines, psa airlines to go to St. Louis, MO by flight.
Travelling from Detroit, MI to St. Louis, MO: related information
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