How to travel from Detroit, MI to St. Louis, MO

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The distance from Detroit, MI to St. Louis, MO is approximately 453 miles (731 km).

Looking to extend your trip from Detroit, MI to St. Louis, MO? Many Omio customers who go from Detroit, MI to St. Louis, MO usually extend their vacation to explore other popular destinations like Chicago, London or Paris. If you're looking to explore Chicago, London or Paris from St. Louis, MO, let Omio find you the best connections available at an affordable price.

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