- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
The best way to find a cheap flight ticket from Chicago, IL to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Chicago, IL to Santa Ana, CA will cost around €310 if you buy it on the day, but the cheapest tickets can be found for only €176.
On Wed, Nov 04, we found 62 flights from Chicago, IL to Santa Ana, CA, including 6 direct services.
On Wed, Nov 04 the direct flights cover the 2787 km distance in an average of 4 h 38 m but if you time it right, some flights will get you there in just 4 h 34 m .
On Wed, Nov 04 the longest flights will take 4 h 41 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
AS583 · AS1307
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AA846 · AA2214
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AA3205 · AA2214
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AA1179
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AA2212
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Flights from Chicago, IL to Santa Ana, CA depart on average 58 times per day, taking around 6h 18m. Cheap flight tickets for this journey start at €181 but you can travel from only €150 by bus.
There are 7 flights per day. The earliest flight runs at 05:00, the last at 22:30. The fastest flight covers the 1731 miles (2787 km) distance in 4h 19m. February is the cheapest month to fly.
Distance 1731 miles (2787 km) |
Average flight duration 6h 18m |
Cheapest ticket price €181 |
Flights per day 58 |
Direct flights 7 |
Fastest flight 4h 19m |
First flight 5:00 AM |
Last flight 10:30 PM |
Cheapest Month Feb |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Jan - Mar |
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Chicago, IL to Santa Ana, CA.
The table below shows live departures for Chicago, IL to Santa Ana, CA flights for today, Tuesday, November 3. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
AA1885 · AA2490 | 12:02 PM O'Hare International Airport | 9h08 | 7:10 PM John Wayne Airport | 1 transfer | |
AA1885 · AA3223 | 12:02 PM O'Hare International Airport | 7h40 | 5:42 PM John Wayne Airport | 1 transfer | |
UA638 · UA5597 | 12:42 PM O'Hare International Airport | 8h02 | 6:44 PM John Wayne Airport | 1 transfer | |
UA2050 · UA1129 | 1:00 PM O'Hare International Airport | 6h33 | 5:33 PM John Wayne Airport | 1 transfer | |
AA3183 · AA2088 | 1:26 PM O'Hare International Airport | 7h28 | 6:54 PM John Wayne Airport | 1 transfer | |
UA1128 · UA282 | 1:30 PM O'Hare International Airport | 8h58 | 8:28 PM John Wayne Airport | 1 transfer | |
UA1811 · UA5597 | 1:30 PM O'Hare International Airport | 7h14 | 6:44 PM John Wayne Airport | 1 transfer | |
UA646 · UA1129 | 1:30 PM O'Hare International Airport | 6h03 | 5:33 PM John Wayne Airport | 1 transfer | |
AA531 · AA2490 | 1:44 PM O'Hare International Airport | 7h26 | 7:10 PM John Wayne Airport | 1 transfer | |
UA1658 · UA326 | 2:22 PM O'Hare International Airport | 9h28 | 9:50 PM John Wayne Airport | 1 transfer | |
UA1577 · UA589 | 2:30 PM O'Hare International Airport | 8h15 | 8:45 PM John Wayne Airport | 1 transfer | |
UA714 · UA326 | 4:07 PM O'Hare International Airport | 7h43 | 9:50 PM John Wayne Airport | 1 transfer | |
UA719 · UA1704 | 4:20 PM O'Hare International Airport | 6h59 | 9:19 PM John Wayne Airport | 1 transfer | |
UA1983 | 4:20 PM O'Hare International Airport | 4h41 | 7:01 PM John Wayne Airport | 0 transfersDirect | |
UA2458 · UA725 | 5:48 PM O'Hare International Airport | 6h12 | 10:00 PM John Wayne Airport | 1 transfer | |
AA1179 | 6:50 PM O'Hare International Airport | 4h34 | 9:24 PM John Wayne Airport | 0 transfersDirect | |
UA308 | 7:48 PM O'Hare International Airport | 4h40 | 10:28 PM John Wayne Airport | 0 transfersDirect | |
AA846 · AA2214 | 9:30 PM O'Hare International Airport | 13h34 | 9:04 AM John Wayne Airport | 1 transfer | |
| Wednesday, November 4 | |||||
AA1995 · AA2264 | 5:00 AM O'Hare International Airport | 9h35 | 12:35 PM John Wayne Airport | 1 transfer | |
AA2107 · AA543 | 5:00 AM O'Hare International Airport | 9h33 | 12:33 PM John Wayne Airport | 1 transfer | |
AA2107 · AA1925 | 5:00 AM O'Hare International Airport | 8h50 | 11:50 AM John Wayne Airport | 1 transfer | |
AA1995 · AA2253 | 5:00 AM O'Hare International Airport | 6h55 | 9:55 AM John Wayne Airport | 1 transfer | |
UA1982 · UA1383 | 5:30 AM O'Hare International Airport | 7h41 | 11:11 AM John Wayne Airport | 1 transfer | |
UA246 · UA643 | 6:00 AM O'Hare International Airport | 8h07 | 12:07 PM John Wayne Airport | 1 transfer | |
AA570 · AA2861 | 6:00 AM O'Hare International Airport | 10h03 | 2:03 PM John Wayne Airport | 1 transfer | |
AA570 · AA2264 | 6:00 AM O'Hare International Airport | 8h35 | 12:35 PM John Wayne Airport | 1 transfer | |
AA3172 · AA1925 | 6:50 AM O'Hare International Airport | 7h00 | 11:50 AM John Wayne Airport | 1 transfer | |
AA3172 · AA543 | 6:50 AM O'Hare International Airport | 7h43 | 12:33 PM John Wayne Airport | 1 transfer | |
UA2833 · UA2611 | 6:55 AM O'Hare International Airport | 8h56 | 1:51 PM John Wayne Airport | 1 transfer | |
AA2372 · AA2264 | 6:59 AM O'Hare International Airport | 7h36 | 12:35 PM John Wayne Airport | 1 transfer | |
AA2372 · AA2861 | 6:59 AM O'Hare International Airport | 9h04 | 2:03 PM John Wayne Airport | 1 transfer | |
AS587 · AS1307 | 7:00 AM O'Hare International Airport | 13h09 | 6:09 PM John Wayne Airport | 1 transfer | |
UA1217 · UA616 · UA2441 | 7:00 AM O'Hare International Airport | 9h14 | 2:14 PM John Wayne Airport | 2 transfers | |
AS587 · AS671 | 7:00 AM O'Hare International Airport | 16h10 | 9:10 PM John Wayne Airport | 1 transfer | |
AS587 · AS1357 | 7:00 AM O'Hare International Airport | 8h46 | 1:46 PM John Wayne Airport | 1 transfer | |
AS587 · AS773 | 7:00 AM O'Hare International Airport | 10h40 | 3:40 PM John Wayne Airport | 1 transfer | |
UA2795 · UA2619 · UA5440 | 7:15 AM O'Hare International Airport | 10h11 | 3:26 PM John Wayne Airport | 2 transfers | |
UA2483 · UA2611 | 7:29 AM O'Hare International Airport | 8h22 | 1:51 PM John Wayne Airport | 1 transfer | |
AA2285 | 8:05 AM O'Hare International Airport | 4h40 | 10:45 AM John Wayne Airport | 0 transfersDirect | |
AA2378 · AA2659 | 8:30 AM O'Hare International Airport | 9h17 | 3:47 PM John Wayne Airport | 1 transfer | |
AA2378 · AA2861 | 8:30 AM O'Hare International Airport | 7h33 | 2:03 PM John Wayne Airport | 1 transfer | |
UA318 · UA1812 · UA589 | 8:40 AM O'Hare International Airport | 14h05 | 8:45 PM John Wayne Airport | 2 transfers | |
UA1293 | 8:53 AM O'Hare International Airport | 4h47 | 11:40 AM John Wayne Airport | 0 transfersDirect | |
UA2610 · UA5440 | 8:55 AM O'Hare International Airport | 8h31 | 3:26 PM John Wayne Airport | 1 transfer | |
UA2610 · UA2441 | 8:55 AM O'Hare International Airport | 7h19 | 2:14 PM John Wayne Airport | 1 transfer | |
UA2811 · UA1799 · UA5597 | 9:00 AM O'Hare International Airport | 11h44 | 6:44 PM John Wayne Airport | 2 transfers | |
UA2238 · UA1847 | 9:00 AM O'Hare International Airport | 10h25 | 5:25 PM John Wayne Airport | 1 transfer | |
AS583 · AS1307 | 9:30 AM O'Hare International Airport | 10h39 | 6:09 PM John Wayne Airport | 1 transfer | |
AS583 · AS671 | 9:30 AM O'Hare International Airport | 13h40 | 9:10 PM John Wayne Airport | 1 transfer | |
AA312 · AA3223 | 9:59 AM O'Hare International Airport | 9h43 | 5:42 PM John Wayne Airport | 1 transfer | |
AA312 · AA2659 | 9:59 AM O'Hare International Airport | 7h48 | 3:47 PM John Wayne Airport | 1 transfer | |
AA793 · AA2094 | 10:10 AM O'Hare International Airport | 7h32 | 3:42 PM John Wayne Airport | 1 transfer | |
UA1803 · UA1799 · UA5597 | 10:38 AM O'Hare International Airport | 10h06 | 6:44 PM John Wayne Airport | 2 transfers | |
UA1803 · UA1799 · UA589 | 10:38 AM O'Hare International Airport | 12h07 | 8:45 PM John Wayne Airport | 2 transfers | |
UA1803 · UA2047 · UA589 | 10:38 AM O'Hare International Airport | 12h07 | 8:45 PM John Wayne Airport | 2 transfers | |
UA2857 · UA2300 | 10:55 AM O'Hare International Airport | 6h04 | 2:59 PM John Wayne Airport | 1 transfer | |
UA2164 · UA453 · UA589 | 11:08 AM O'Hare International Airport | 11h37 | 8:45 PM John Wayne Airport | 2 transfers | |
UA606 · UA1690 | 11:56 AM O'Hare International Airport | 10h18 | 8:14 PM John Wayne Airport | 1 transfer | |
AA2212 | 11:56 AM O'Hare International Airport | 4h37 | 2:33 PM John Wayne Airport | 0 transfersDirect | |
This is the last flight of the day. | |||||
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Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
Classic Orange County Mexican street snack of fresh fruit, cucumber, jicama and peanuts with lime, chili and chamoy. Common in Santa Ana's Latino neighborhoods.
Warm masa drink with cinnamon and piloncillo, traditionally sold by tamale vendors and panaderías. A comforting local favorite in Santa Ana's Mexican community.
Corn husks filled with masa and meats or chiles, then steamed. A staple for holidays and weekend breakfasts in Santa Ana's long-established Mexican families.
Refined restaurant focused on seasonal Californian cuisine with French influences. Stylish dining room suited for a more upscale meal.
Casual taquería known for Tijuana-style tacos, adobada and handmade tortillas. Busy, straightforward and highly regarded for flavorful meats.
Lively mariscos spot serving ceviches, aguachiles and seafood cocktails. Colorful, casual atmosphere with a strong local following.
Moderate for Southern California; hotels and dining are mid-priced, while local transit is affordable and many casual food options are available.
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or add 10-15% for taxis. Cafes often have tip jars or card prompts.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Santa Ana, CA.
Find answers to the most common questions about traveling from Chicago, IL to Santa Ana, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

Most Chicago, IL to Santa Ana, CA flights use the O'Hare International Airport to John Wayne Airport airport pair. Use this guide to compare Chicago, IL and Santa Ana, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
O'Hare International Airport is 3 km from Chicago city centre. Public transport options include:
O'Hare International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants are located in all terminals, offering a variety of cuisines including American and intertiol. Top options include Tortas Frontera and Publican Tavern.
Free Wi-Fi available throughout the airport. ATMs are located throughout all terminals.
Lost and found is available at the station.
Available at O'Hare International Airport: Parking, Taxis, WC.
Available at O'Hare International Airport: Car Rental.
Accessibility facilities are available at O'Hare International Airport: Elevators, ramps, toilets.
Nearby hotels include Hotels such as Hilton Chicago O'Hare are located on airport grounds, with others like the Hyatt Regency nearby..
John Wayne Airport is 3 km from Santa Ana city centre. Public transport options include:
John Wayne Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Located in terminals; options include fast food and sit-down restaurants like McDold's and Ruby's Diner
Free Wi-Fi available throughout the airport. ATMs are located in all terminals.
Lost and found is available at the station.
Available at John Wayne Airport: Parking, Taxis, WC.
Available at John Wayne Airport: Car Rental.
Accessibility facilities are available at John Wayne Airport: Elevators, ramps.
Nearby hotels include Hotels within walking distance, Hilton Irvine/Orange County Airport..
See which airports are used for flights between Chicago, IL and Santa Ana, CA, including airport details.
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