- Must visit
Bowers Museum
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
The best way to find a cheap flight ticket from Louisville, KY to Santa Ana, CA is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Louisville, KY to Santa Ana, CA will cost around $388 if you buy it on the day, but the cheapest tickets can be found for only $194.
It's difficult to get from Louisville, KY to Santa Ana, CA without transferring at least once.
UA6266 · UA2611
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UA405 · UA616 · UA2441
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UA3498 · UA1116 · UA2441
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UA6228 · UA589
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AA4768+
AA2212
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AA2253+
AA3459
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AA3223+
AA3791
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AA4768+
AA2212
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AA4622+
AA2285
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UA3518 · UA308
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Flights from Louisville, KY to Santa Ana, CA depart on average 51 times per day, taking around 6h 40m. Cheap flight tickets for this journey start at $196 but you can travel from only $127 by bus.
The earliest flight runs at 19:36, the last at 19:36. The fastest flight covers the 1812 miles (2917 km) distance in 5h 23m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Louisville, KY to Santa Ana, CA.
The table below shows live departures for Louisville, KY to Santa Ana, CA flights for today, Tuesday, November 3. You can also manually refresh the results below to see updated flight journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
UA6228 · UA2611 | 9:10 AM Louisville International Airport | 7h41 | 1:51 PM John Wayne Airport | 1 transfer | |
UA6228 · UA589 | 9:10 AM Louisville International Airport | 14h35 | 8:45 PM John Wayne Airport | 1 transfer | |
UA3674 · UA2857 · UA2300 | 9:17 AM Louisville International Airport | 8h42 | 2:59 PM John Wayne Airport | 2 transfers | |
UA4059 · UA1587 · UA1129 | 9:55 AM Louisville International Airport | 10h38 | 5:33 PM John Wayne Airport | 2 transfers | |
AA2212+ AA4768 | 10:08 AM Louisville International Airport | 7h25 | 2:33 PM John Wayne Airport | 1 transfer | |
UA3520 · UA2050 · UA1129 | 10:37 AM Louisville International Airport | 9h56 | 5:33 PM John Wayne Airport | 2 transfers | |
UA3520 · UA638 · UA5597 | 10:37 AM Louisville International Airport | 11h07 | 6:44 PM John Wayne Airport | 2 transfers | |
UA3520 · UA1811 · UA5597 | 10:37 AM Louisville International Airport | 11h07 | 6:44 PM John Wayne Airport | 2 transfers | |
UA3520 · UA646 · UA1129 | 10:37 AM Louisville International Airport | 9h56 | 5:33 PM John Wayne Airport | 2 transfers | |
AA2659+ AA3457 | 10:53 AM Louisville International Airport | 7h54 | 3:47 PM John Wayne Airport | 1 transfer | |
AA871 · AA2088+ AA3457 | 10:53 AM Louisville International Airport | 11h01 | 6:54 PM John Wayne Airport | 2 transfers | |
AA2257 · AA2088+ AA3457 | 10:53 AM Louisville International Airport | 11h01 | 6:54 PM John Wayne Airport | 2 transfers | |
AA3223+ AA3457 | 10:53 AM Louisville International Airport | 9h49 | 5:42 PM John Wayne Airport | 1 transfer | |
UA3449 · UA1847 | 11:17 AM Louisville International Airport | 9h08 | 5:25 PM John Wayne Airport | 1 transfer | |
UA3449 · UA1690 | 11:17 AM Louisville International Airport | 11h57 | 8:14 PM John Wayne Airport | 1 transfer | |
AA2962 · AA2088+ AA5634 | 11:57 AM Louisville International Airport | 9h57 | 6:54 PM John Wayne Airport | 2 transfers | |
AA1179+ AA5316 | 1:14 PM Louisville International Airport | 11h10 | 9:24 PM John Wayne Airport | 1 transfer | |
AA1044 · AA3223 | 1:24 PM Louisville International Airport | 7h18 | 5:42 PM John Wayne Airport | 1 transfer | |
AA1044 · AA2490 | 1:24 PM Louisville International Airport | 8h46 | 7:10 PM John Wayne Airport | 1 transfer | |
UA3452 · UA1690 | 1:45 PM Louisville International Airport | 9h29 | 8:14 PM John Wayne Airport | 1 transfer | |
UA5471 · UA1983 | 2:10 PM Louisville International Airport | 7h51 | 7:01 PM John Wayne Airport | 1 transfer | |
UA4067 · UA282 | 2:11 PM Louisville International Airport | 9h17 | 8:28 PM John Wayne Airport | 1 transfer | |
UA4067 · UA599 · UA725 | 2:11 PM Louisville International Airport | 10h49 | 10:00 PM John Wayne Airport | 2 transfers | |
UA1510 · UA1704 | 3:24 PM Louisville International Airport | 8h55 | 9:19 PM John Wayne Airport | 1 transfer | |
UA1510 · UA725 | 3:24 PM Louisville International Airport | 9h36 | 10:00 PM John Wayne Airport | 1 transfer | |
UA1510 · UA5237 | 3:24 PM Louisville International Airport | 20h22 | 8:46 AM John Wayne Airport | 1 transfer | |
UA6310 · UA326 | 3:45 PM Louisville International Airport | 9h05 | 9:50 PM John Wayne Airport | 1 transfer | |
AA2854 · AA1140 | 4:35 PM Louisville International Airport | 8h57 | 10:32 PM John Wayne Airport | 1 transfer | |
AA1140+ AA5585 | 5:42 PM Louisville International Airport | 7h50 | 10:32 PM John Wayne Airport | 1 transfer | |
UA3518 · UA308 | 5:57 PM Louisville International Airport | 7h31 | 10:28 PM John Wayne Airport | 1 transfer | |
UA3498 · UA1116 · UA2441 | 5:10 AM Louisville International Airport | 12h04 | 2:14 PM John Wayne Airport | 2 transfers | |
UA3498 · UA2610 · UA2441 | 5:10 AM Louisville International Airport | 12h04 | 2:14 PM John Wayne Airport | 2 transfers | |
UA3498 · UA1293 | 5:10 AM Louisville International Airport | 9h30 | 11:40 AM John Wayne Airport | 1 transfer | |
UA3594 · UA1847 | 6:00 AM Louisville International Airport | 14h25 | 5:25 PM John Wayne Airport | 1 transfer | |
AA2253+ AA3459 | 6:01 AM Louisville International Airport | 6h54 | 9:55 AM John Wayne Airport | 1 transfer | |
AA902 · AA2094+ AA3459 | 6:01 AM Louisville International Airport | 12h41 | 3:42 PM John Wayne Airport | 2 transfers | |
AA2264+ AA3459 | 6:01 AM Louisville International Airport | 9h34 | 12:35 PM John Wayne Airport | 1 transfer | |
AA2488 · AA543+ AA3459 | 6:01 AM Louisville International Airport | 9h32 | 12:33 PM John Wayne Airport | 2 transfers | |
AA2861+ AA3459 | 6:01 AM Louisville International Airport | 11h02 | 2:03 PM John Wayne Airport | 1 transfer | |
AA1496 · AA1925+ AA3459 | 6:01 AM Louisville International Airport | 8h49 | 11:50 AM John Wayne Airport | 2 transfers | |
AA1496 · AA543+ AA3459 | 6:01 AM Louisville International Airport | 9h32 | 12:33 PM John Wayne Airport | 2 transfers | |
AA2212+ AA4622 | 6:21 AM Louisville International Airport | 11h12 | 2:33 PM John Wayne Airport | 1 transfer | |
AA793 · AA2094+ AA4622 | 6:21 AM Louisville International Airport | 12h21 | 3:42 PM John Wayne Airport | 2 transfers | |
AA2285+ AA4622 | 6:21 AM Louisville International Airport | 7h24 | 10:45 AM John Wayne Airport | 1 transfer | |
UA3635 · UA318 · UA2300 | 7:00 AM Louisville International Airport | 10h59 | 2:59 PM John Wayne Airport | 2 transfers | |
UA3635 · UA2610 · UA2441 | 7:00 AM Louisville International Airport | 10h14 | 2:14 PM John Wayne Airport | 2 transfers | |
UA3635 · UA1293 | 7:00 AM Louisville International Airport | 7h40 | 11:40 AM John Wayne Airport | 1 transfer | |
UA6266 · UA2611 | 7:00 AM Louisville International Airport | 9h51 | 1:51 PM John Wayne Airport | 1 transfer | |
UA3635 · UA2610 · UA5440 | 7:00 AM Louisville International Airport | 11h26 | 3:26 PM John Wayne Airport | 2 transfers | |
AA3100 · AA902 · AA2094 | 7:10 AM Louisville International Airport | 11h32 | 3:42 PM John Wayne Airport | 2 transfers | |
AA3100 · AA2488 · AA543 | 7:10 AM Louisville International Airport | 8h23 | 12:33 PM John Wayne Airport | 2 transfers | |
AA3100 · AA2861 | 7:10 AM Louisville International Airport | 9h53 | 2:03 PM John Wayne Airport | 1 transfer | |
AA3100 · AA808 · AA2094 | 7:10 AM Louisville International Airport | 11h32 | 3:42 PM John Wayne Airport | 2 transfers | |
AA3100 · AA2264 | 7:10 AM Louisville International Airport | 8h25 | 12:35 PM John Wayne Airport | 1 transfer | |
UA405 · UA616 · UA2441 | 8:00 AM Louisville International Airport | 9h14 | 2:14 PM John Wayne Airport | 2 transfers | |
UA405 · UA2300 | 8:00 AM Louisville International Airport | 9h59 | 2:59 PM John Wayne Airport | 1 transfer | |
UA405 · UA1320 | 8:00 AM Louisville International Airport | 8h14 | 1:14 PM John Wayne Airport | 1 transfer | |
This is the last flight of the day. | |||||
Find all the dates and times for this journey
Flights from Louisville, KY to Santa Ana, CA with United and American Airlines. Flights with a stop available on this route with United and American Airlines. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Santa Ana, CA — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Santa Ana, CA trip today.
Major Orange County museum campus with art exhibitions, family programs, and rotating contemporary and historical shows.
Hands-on science museum with interactive exhibits, a Discovery Cube, and family-friendly learning in downtown Santa Ana.
Small local museum preserving Orange County aviation and aerospace history with artifacts, photos, and volunteer-led interpretation.
Walkable downtown district with historic buildings, murals, shops, galleries, and regular arts and community events.
Lively pedestrian-friendly arts corridor known for galleries, murals, boutiques, and monthly art-focused street activity.
Historic neighborhood of preserved early 20th-century homes, ideal for architecture walks and seasonal house tours.
Classic Orange County Mexican street snack of fresh fruit, cucumber, jicama and peanuts with lime, chili and chamoy. Common in Santa Ana's Latino neighborhoods.
Warm masa drink with cinnamon and piloncillo, traditionally sold by tamale vendors and panaderías. A comforting local favorite in Santa Ana's Mexican community.
Corn husks filled with masa and meats or chiles, then steamed. A staple for holidays and weekend breakfasts in Santa Ana's long-established Mexican families.
Refined restaurant focused on seasonal Californian cuisine with French influences. Stylish dining room suited for a more upscale meal.
Casual taquería known for Tijuana-style tacos, adobada and handmade tortillas. Busy, straightforward and highly regarded for flavorful meats.
Lively mariscos spot serving ceviches, aguachiles and seafood cocktails. Colorful, casual atmosphere with a strong local following.
Moderate for Southern California; hotels and dining are mid-priced, while local transit is affordable and many casual food options are available.
Tip 15-20% at restaurants, $1-2 per drink at bars, and round up or add 10-15% for taxis. Cafes often have tip jars or card prompts.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Santa Ana, CA.
Find answers to the most common questions about traveling from Louisville, KY to Santa Ana, CA by flight. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest flight, the cheapest option, or tips for making the most of your visit at Santa Ana, CA, this guide helps you travel smarter and with confidence.

Most Louisville, KY to Santa Ana, CA flights use the Louisville International Airport to John Wayne Airport airport pair. Use this guide to compare Louisville, KY and Santa Ana, CA airports on this route, check city-centre transport, alongside checking practicalities like airport facilities and services.
Louisville International Airport is 7 km from Louisville city centre. Public transport options include:
Louisville International Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Restaurants available, primarily in the main terminal, includes fast food and sit-down options like Starbucks and Chili's
Free Wi-Fi available throughout the airport. ATMs are located in the main terminal.
Lost and found is available at the station.
Available at Louisville International Airport: Parking, Taxis, WC.
Available at Louisville International Airport: Car Rental.
Accessibility facilities are available at Louisville International Airport: Ramps, assistance.
Nearby hotels include Hotels nearby, within walking distance, such as Hilton Garden Inn..
John Wayne Airport is 3 km from Santa Ana city centre. Public transport options include:
John Wayne Airport has practical services for this route, including Wifi, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, and Car Rental.
Food options include: Located in terminals; options include fast food and sit-down restaurants like McDold's and Ruby's Diner
Free Wi-Fi available throughout the airport. ATMs are located in all terminals.
Lost and found is available at the station.
Available at John Wayne Airport: Parking, Taxis, WC.
Available at John Wayne Airport: Car Rental.
Accessibility facilities are available at John Wayne Airport: Elevators, ramps.
Nearby hotels include Hotels within walking distance, Hilton Irvine/Orange County Airport..
See which airports are used for flights between Louisville, KY and Santa Ana, CA, including airport details.