- Must visit
Greenville County Museum of Art
Major art museum in downtown Greenville with Southern art, traveling exhibitions, and a strong permanent collection.
Buses from Tampa, FL to Greenville, NC run on average 4 times per day, taking around 20h 57m. Cheap bus tickets for this journey start at €84 if you book in advance.
The earliest bus runs at 06:50, the last at 22:35. The fastest bus covers the 607 miles (978 km) distance in 15h 45m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Tampa, FL to Greenville, NC.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 06:50AM | Arrival Time 12:30PM | Duration 29h40 | Departure days Thu, Sun | Cheapest price €127 |
Operator FlixBus | Departure Time 06:50AM | Arrival Time 08:55AM | Duration 26h05 | Departure days Fri | Cheapest price €96 |
Operator Greyhound | Departure Time 11:10AM | Arrival Time 12:30PM | Duration 25h20 | Departure days Fri | Cheapest price €106 |
Operator FlixBus | Departure Time 11:50AM | Arrival Time 04:30PM | Duration 28h40 | Departure days Sat | Cheapest price €143 |
Operator Greyhound | Departure Time 10:25PM | Arrival Time 08:55AM | Duration 34h30 | Departure days Fri | Cheapest price €94 |
Operator Greyhound | Departure Time 10:35PM | Arrival Time 08:55AM | Duration 34h20 | Departure days Fri | Cheapest price €94 |
Buses from Tampa, FL to Greenville, NC with Greyhound and FlixBus. Overnight buses available on this route with Greyhound and FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Greenville, NC — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville, NC trip today.
Major art museum in downtown Greenville with Southern art, traveling exhibitions, and a strong permanent collection.
Children's museum with hands-on science, art, and play exhibits designed for families and young learners.
Railway museum featuring historic cabooses and locomotives, with seasonal excursions on the Greenville and Western line.
Signature downtown park with waterfalls, gardens, lawns, and river walks centered around the Reedy River.
Tree-lined pedestrian-friendly main street with shops, public art, and easy access to downtown attractions.
Long multi-use greenway for walking and cycling that links parks, public art, and several Greenville districts.
South Carolina barbecue, often pork shoulder with a mustard-based sauce. The Upstate is known for this tangy regional style.
A Lowcountry classic of shrimp simmered in rich gravy and served over creamy grits. Popular across South Carolina, including Greenville.
Stone-ground grits cooked until creamy, often with butter and cheese. A Southern staple frequently served at breakfast in Greenville.
Upscale American restaurant known for wood-fired cooking, seasonal ingredients, and a polished downtown setting.
Stylish Southern restaurant for brunch and dinner, popular for shrimp and grits, fried chicken, and creative cocktails.
Well-known local brewery and pub offering house beers, burgers, and hearty comfort food in a relaxed atmosphere.
Moderate for U.S. travelers; hotels and dining are usually cheaper than major U.S. cities, while car-based transport can add costs.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or screen prompts; small tips are appreciated.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Greenville, NC.
Find answers to the most common questions about traveling from Tampa, FL to Greenville, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, NC, this guide helps you travel smarter and with confidence.

Most Tampa, FL to Greenville, NC buses use the Tampa, Marion Transit Center to Greenville, S Pitt St (Butterfield Transportation Center) station pair. Use this guide to compare Tampa, FL and Greenville, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Tampa, Marion Transit Center has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, Marion Transit Center. ATMs are available at Tampa, Marion Transit Center.
Ticket office support is available at Tampa, Marion Transit Center.
Available at Tampa, Marion Transit Center: Parking, Taxis, WC.
Accessibility facilities are available at Tampa, Marion Transit Center: Wheelchair accessible with ramps.
Tampa, USF Holly Drive (Central Plant) is 13 km from Tampa city centre. Public transport options include:
Tampa, USF Holly Drive (Central Plant) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Tampa, USF Holly Drive (Central Plant). ATMs are available at Tampa, USF Holly Drive (Central Plant).
Ticket office support is available at Tampa, USF Holly Drive (Central Plant).
Available at Tampa, USF Holly Drive (Central Plant): Parking, Taxis, WC.
Accessibility facilities are available at Tampa, USF Holly Drive (Central Plant): Wheelchair accessible facilities.
Greenville, S Pitt St (Butterfield Transportation Center) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Free wifi available in waiting areas. ATMs are available at Greenville, S Pitt St (Butterfield Transportation Center).
Ticket office support is available at Greenville, S Pitt St (Butterfield Transportation Center).
Available at Greenville, S Pitt St (Butterfield Transportation Center): Parking, Taxis, WC.
Accessibility facilities are available at Greenville, S Pitt St (Butterfield Transportation Center): Wheelchair accessible entrances and seating areas.
Check bus stations information for Tampa, FL and Greenville, NC, including where buses depart and arrive on this route.