- Must visit
Greenville County Museum of Art
Major local art museum known for its Southern art collection and works by Andrew Wyeth and Jasper Johns.
2,000+ travel companies
2,000+ travel companies
Scan to get our free app
Use our app to get live travel updates and book mobile tickets for trains, buses, flights, and ferries.
App Store
4.942K ratings
Google Play
4.6136K reviews
The cheapest and fastest buses from Fort Myers, FL to Greenville, NC
Showing times and prices for Jul 07
Cheapest price
$198
Average price
$198
Fastest journey
1 d 14 h 25 m
Average duration
1 d 14 h 25 m
Buses per day
1
Distance
1086 km
Cheap tickets
The best way to find a cheap bus ticket from Fort Myers, FL to Greenville, NC is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Fort Myers, FL to Greenville, NC will cost around $198 if you buy it on the day, but the cheapest tickets can be found for only $198.
Fast buses
It's difficult to get from Fort Myers, FL to Greenville, NC without transferring at least 3 times.
FlixBus+
+FlixBus+6:30 PM38h25Fort Myers, Rosa Parks Transit Center8:55 AMGreenville, S Pitt St (Butterfield Transportation Center), NC$1981One-way3 transfers
- FlixBus++FlixBus+6:30 PM38h25Fort Myers, Rosa Parks Transit Center8:55 AMGreenville, S Pitt St (Butterfield Transportation Center), NC$1981One-way3 transfers
Travel Information
Compare bus for Fort Myers, FL to Greenville, NC
Omio recommends booking the bus as it is the most popular option from Fort Myers, FL to Greenville, NC among Omio's users. If you are prioritising price take the bus with prices starting from $160. For those with little time consider booking a bus which can get you there in 42h 10m. The ticket price range depends on the travel mode: a bus costs an average of $160, and a bus costs an average of $160.
Distance: 674 miles (1086 km)
Compare bus with
Most popular Bus | Driving |
|---|---|
$160 Average price Cheapest | $159 Average price (fuel + tolls) |
42h 40m Average total duration Fastest 42h 10m Onboard + 30m Additional time* | 11h 58m Average total duration (door-to-door) |
Direct Options | Direct Options |
The cheapest way to travel from Fort Myers, FL to Greenville, NC is a bus with an average price of $160 (€131).
The fastest way to travel from Fort Myers, FL to Greenville, NC is by bus with an average journey time of 42h 10m.
Yes, you can take a bus between Fort Myers, FL and Greenville, NC.
We recommend using the bus as it is the most popular way to get from Fort Myers, FL to Greenville, NC among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Fort Myers, FL to Greenville, NC Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 06:20PM | Arrival Time 12:30PM | Duration 42h10 | Departure days Wed | Cheapest price $160 |
Operator Greyhound | Departure Time 06:30PM | Arrival Time 08:55AM | Duration 38h25 | Departure days Tue | Cheapest price $198 |
Operator Greyhound | Departure Time 06:55PM | Arrival Time 08:55AM | Duration 38h00 | Departure days Thu, Fri, Sat | Cheapest price $149 |
Compare prices and tickets Fort Myers, FL to Greenville, NC by bus
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Tue
Jul 07
Jul 07
Wed
Jul 08
Jul 08
Thu
Jul 09
Jul 09
Fri
Jul 10
Jul 10
Sat
Jul 11
Jul 11
Sun
Jul 12
Jul 12
Mon
Jul 13
Jul 13
Why should you book Fort Myers, FL to Greenville, NC buses with Omio?
FlixBus operates all buses services from Fort Myers, FL to Greenville, NC.
Omio is an official ticket reseller for all your travel options from Fort Myers, FL to Greenville, NC.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Journey information
Overview: Bus from Fort Myers, FL to Greenville, NC
USAUSA
Buses from Fort Myers, FL to Greenville, NC run on average 2 times per day, taking around 42h 10m. Cheap bus tickets for this journey start at $160 (€131) if you book in advance.
The earliest bus runs at 11:57, the last at 18:20. The fastest bus covers the 674 miles (1086 km) distance in 42h 10m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 674 miles (1086 km) |
Average bus duration 42h 10m |
Cheapest ticket price $160 (€131) |
Buses per day 2 |
Fastest bus 42h 10m |
First bus 11:57 AM |
Last bus 6:20 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Jul - Sep |
Low Season Jul - Sep |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Bus providers: FlixBus from Fort Myers, FL to Greenville, NCYou can travel by bus between Fort Myers, FL to Greenville, NC with FlixBus for as low as $160 (€131). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
42h 10m
Cheapest Price
$160 (€131)
FlixBus frequency
1 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Greenville
Things to do in Greenville
Discover the best of Greenville — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Greenville trip today.
- Recommended
Upcountry History Museum
Regional history museum with family-friendly exhibits on the Upcountry of South Carolina and changing traveling shows.
- Recommended
Sigal Music Museum
Specialized museum displaying historic musical instruments from Europe, Asia, and America in a refined gallery setting.
- Must visit
Falls Park on the Reedy
Signature downtown park with waterfalls, gardens, lawns, and scenic walking paths at the heart of Greenville.
- Must visit
Main Street
Greenville’s lively central street lined with shops, public art, plazas, and a polished walkable downtown atmosphere.
- Must visit
Swamp Rabbit Trail
Popular multi-use greenway for walking and cycling, linking Greenville with riverfront and neighborhood scenery.
- Gluten-free
South Carolina Barbecue
Slow-smoked pork, often chopped or pulled, traditionally served with the state’s signature mustard-based barbecue sauce in the Upstate.
- Vegetarian
Fried Green Tomatoes
Sliced unripe tomatoes coated and fried until crisp, a classic Southern starter popular across Greenville and the Upstate.
- Gluten-free
Shrimp And Grits
Creamy stone-ground grits topped with shrimp, usually with bacon or rich pan sauce, reflecting Lowcountry influence on local menus.
The Anchorage
Well-regarded neighborhood restaurant with seasonal Southern-influenced cooking, craft cocktails, and a modern intimate setting.
Soby's
A long-running downtown restaurant known for refined Southern cuisine, shrimp and grits, and a polished but approachable atmosphere.
Jianna
Stylish Falls Park area restaurant known for house-made pasta, oysters, and scenic views, ideal for an upscale meal.
United States Dollar
Prices are moderate by U.S. standards. Dining and coffee are reasonable, while upscale restaurants cost more.
Average meal costs
- Budget
- USD 10-15 for fast food or casual lunch.
- Mid-range
- USD 20-35 per person at a standard restaurant.
- Fine dining
- USD 60+ per person before drinks and tip.
- Coffee
- USD 4-6 for a regular café drink.
Tipping culture
Tip 18-20% at full-service restaurants. Tip USD 1-2 per drink at bars, round up taxis, and tip hotel staff and delivery drivers.
FAQs: Bus from Fort Myers, FL to Greenville, NC
Find answers to the most common questions about traveling from Fort Myers, FL to Greenville, NC by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Greenville, NC, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Fort Myers, FL to Greenville, NC can start from as little as $160 (€131) when you book in advance. The average bus ticket price for Fort Myers, FL to Greenville, NC is $160 (€131) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Fort Myers, FL to Greenville, NC is 42h 10m to travel the 674 miles (1086 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Fort Myers, FL to Greenville, NC leaves at 11:57 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Fort Myers, FL to Greenville, NC leaves at 6:20 PM.
There are 2 buses a day from Fort Myers, FL to Greenville, NC which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Fort Myers, FL to Greenville, NC, you can count on FlixBus for the best way to get you to Greenville, NC. You can also check all possible bus companies who offer a service between Fort Myers, FL and Greenville, NC and compare the amenities they offer before buying a bus ticket.
A trip to Greenville, NC from Fort Myers, FL is worth doing but not as a day trip with a journey time of 42h 10m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Fort Myers, FL to Greenville, NC is September.
Yes, you can take a bus between Fort Myers, FL and Greenville, NC.
Yes, the following accessibility options are available when taking the bus from Fort Myers, FL to Greenville, NC:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Fort Myers, FL to Greenville, NC for bus company FlixBus.
Whether you can cancel your bus ticket from Fort Myers, FL to Greenville, NC depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Fort Myers, FL to Greenville, NC.
Yes, the following luggage options are included when booking a bus ticket from Fort Myers, FL to Greenville, NC:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Fort Myers, FL to Greenville, NC:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Fort Myers, FL to Greenville, NC. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Fort Myers, FL to Greenville, NC with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Fort Myers, FL to Greenville, NC with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Fort Myers, FL to Greenville, NC with the following bus company: FlixBus.
Since neither Fort Myers, FL nor Greenville, NC are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the bus as it is the most popular way to get from Fort Myers, FL to Greenville, NC among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Greenville, NC, travelers should be cautious of petty theft and vehicle break-ins, especially in crowded or tourist-heavy areas. Common scams include overcharging by unofficial taxi or ride-share services and unsolicited offers for tours or accommodations. It’s advisable to use licensed transportation, keep valuables secure, and remain aware of surroundings, particularly at night.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Fort Myers, FL to Greenville, NC
Most Fort Myers, FL to Greenville, NC buses use the Fort Myers, Rosa Parks Transit Center to Greenville, S Pitt St (Butterfield Transportation Center) station pair. Use this guide to compare Fort Myers, FL and Greenville, NC bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Fort Myers
Arrival bus stations in Greenville
Fort Myers, Rosa Parks Transit Center
City-centre transport
Getting to Fort Myers, Rosa Parks Transit Center from Fort Myers city centre
Bus10 · 7m · $4 · every ~1 min
Greenville, S Pitt St (Butterfield Transportation Center)
More options for your journey from Fort Myers, FL to Greenville, NC
Here are some other resources that might have the information you need
Most popular buses to and from Greenville, NC and Fort Myers, FL
Most popular bus connections to Greenville, NC
The Omio App Makes Travel Planning Easy
We’ll get you where you want to go. From live train updates to mobile tickets, our innovative app is the ideal way to plan and keep track of your travel.
