- Must visit
Royal Museums of Fine Arts of Belgium
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Cheapest price
$93
Average price
$107
Fastest journey
1 d 5 h 10 m
Average duration
1 d 5 h 10 m
Buses per day
2
Distance
1643 km
The best way to find a cheap bus ticket from Santarém to Brussels is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Santarém to Brussels will cost around $107 if you buy it on the day, but the cheapest tickets can be found for only $93.
Of the 2 buses that leave Santarém for Brussels on Sun, May 31, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, May 31 the direct buses cover the 1643 km distance in an average of 1 d 5 h 10 m but if you time it right, some buses will get you there in just 1 d 5 h 10 m .
On Sun, May 31 the slowest buses will take 1 d 5 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the bus as it is the most popular option from Santarém to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $93. For those with little time consider booking a flight which can get you there in 3h 23m. The ticket price range depends on the travel mode: a bus costs an average of $93, and a flight costs an average of $85.
Distance: 1020 miles (1643 km)
Most popular Bus | Flight |
|---|---|
$141 Average price Cheapest | $263 Average price |
31h 15m Average total duration 30h 45m Onboard + 30m Additional time* | 6h 23m Average total duration Fastest 3h 23m Onboard + 3h 0m Additional time* |
![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options |
This is compared to other travel options from Santarém to Brussels:
A bus is $122 (€98) less than a flight for this route with tickets for a flight from Santarém to Brussels costing on average $263 (€212).
Other travel options to Brussels take longer:
Bus takes on average 30h 45m.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 06:00AM | Arrival Time 01:45PM | Duration 31h45 | Departure days Thu | Cheapest price $163 |
Operator FlixBus | Departure Time 07:00AM | Arrival Time 03:50PM | Duration 31h50 | Departure days Sat | Cheapest price $151 |
Operator BlaBlaCar Bus | Departure Time 07:00AM | Arrival Time 12:10PM | Duration 29h10 | Departure days Fri, Sun | Cheapest price $120 |
Operator BlaBlaCar Bus | Departure Time 08:00AM | Arrival Time 01:10PM | Duration 29h10 | Departure days Sun | Cheapest price $93 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 11:10PM | Duration 37h30 | Departure days Mon | Cheapest price $182 |
Operator FlixBus | Departure Time 10:40AM | Arrival Time 10:10PM | Duration 34h30 | Departure days Sat | Cheapest price $179 |
Operator FlixBus | Departure Time 07:45PM | Arrival Time 01:50PM | Duration 42h05 | Departure days Wed | Cheapest price $188 |
Operator FlixBus | Departure Time 08:45PM | Arrival Time 08:15AM | Duration 34h30 | Departure days Sat | Cheapest price $163 |
The table below shows live departures for Santarém to Brussels buses for today, Saturday, May 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus · FlixBus | 8:45 PM Santarem, Terminal Rodovario | 34h30 | 8:15 AM Brussels, Brussels South (Gare du Midi) | 2 transfers | |
| Sunday, May 31 | |||||
![]() | 7:00 AM Santarém | 29h10 | 12:10 PM Brussels | 0 transfersDirect | |
![]() | 8:00 AM Santarém | 29h10 | 1:10 PM Brussels | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Santarém to Brussels run on average 4 times per day, taking around 30h 45m. Cheap bus tickets for this journey start at $93 (€75) but you can travel from only $85 (€68) by flight.
There are 1 buses per day. The earliest bus runs at 00:45, the last at 22:55. The fastest bus covers the 1020 miles (1643 km) distance in 29h 10m.
Distance 1020 miles (1643 km) |
Average bus duration 30h 45m |
Cheapest ticket price $93 (€75) |
Buses per day 4 |
Direct buses 1 |
Fastest bus 29h 10m |
First bus 12:45 AM |
Last bus 10:55 PM |
Cheapest Month Jan |
Cheapest Day Sun |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Sun |
Least Busy Day Sun |
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
A major complex of art museums covering Flemish masters, Old Masters, and modern art. One of Brussels' essential cultural visits for its scale and national importance.
Dedicated to René Magritte, this museum holds the world's largest collection of his works. It is a standout stop for surrealism lovers and one of Brussels' most famous museums.
A contemporary art museum known for street art, digital culture, and youth-oriented exhibitions. It became especially popular with younger visitors and on social media.
A landscaped cultural hill linking the upper and lower city, known for its formal gardens and classic skyline view. It is one of Brussels' best walking and photography spots.
A beautiful 19th-century covered arcade with elegant glass roofing and historic atmosphere. It is one of the city's most photogenic and fashionable passages.
A grand urban park laid out around monumental buildings and the Cinquantenaire Arch. Ideal for a walk, photos, and combining with nearby museums.
Brussels’ classic pairing of mussels steamed with white wine, celery, and herbs, served with crisp fries. It is one of the city’s most iconic and widely loved meals.
A traditional Belgian beef and onion stew slowly cooked with dark beer, often slightly sweet-sour and served with fries or bread. It is a staple of local brasserie cuisine.
A comforting Brussels side dish of mashed potatoes mixed with seasonal vegetables such as carrots, leeks, or spinach, often served with sausage or meat.
Well-regarded Belgian restaurant serving regional classics, strong beer pairings, and seasonal ingredients in a cozy, old-Brussels dining room.
One of Brussels’ landmark fine-dining restaurants, celebrated for refined Belgian-influenced cuisine, polished service, and an elegant Art Nouveau setting.
Popular traditional restaurant near Sainte-Catherine known for generous Belgian comfort food, beer-based stews, and an unfussy, bustling atmosphere.
Moderate by Western European standards. Beer, waffles, and transit are reasonable; hotels and central dining cost more.
Service is usually included. Tipping is not required, but rounding up or leaving 5-10% for very good restaurant service is appreciated. Round up taxi fares.
Official public transport app
Brussels South (Gare du Midi) -> Brussels Central Station
Find answers to the most common questions about traveling from Santarém to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.

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