- Must visit
Vatican Museums
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.
Cheapest price
$73
Average price
$73
Fastest journey
14 h 15 m
Average duration
14 h 15 m
Buses per day
1
Distance
519 km
The best way to find a cheap bus ticket from Porto Empedocle to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Porto Empedocle to Rome will cost around $73 if you buy it on the day, but the cheapest tickets can be found for only $73.
Of the 1 buses that leave Porto Empedocle for Rome on Fri, Jul 10, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, Jul 10 the direct buses cover the 519 km distance in an average of 14 h 15 m but if you time it right, some buses will get you there in just 14 h 15 m .
On Fri, Jul 10 the slowest buses will take 14 h 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the bus as it is the most popular option from Porto Empedocle to Rome among Omio's users. If you are prioritising price take the ferry with prices starting from $66. For those with little time consider booking a flight which can get you there in 1h 15m. The ticket price range depends on the travel mode: a ferry costs an average of $66, and a flight costs an average of $56.
Distance: 322 miles (519 km)
Most popular Bus | Flight | Ferry | Driving |
|---|---|---|---|
$72 Average price | $125 Average price | $68 Average price Cheapest | $52 Average price (fuel + tolls) |
14h 30m Average total duration 14h 0m Onboard + 30m Additional time* | 4h 15m Average total duration Fastest 1h 15m Onboard + 3h 0m Additional time* | 14h 58m Average total duration 13h 58m Onboard + 1h 0m Additional time* | 10h 13m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Porto Empedocle to Rome:
A ferry is $4 (€3) less than a bus for this route with tickets for a bus from Porto Empedocle to Rome costing on average $72 (€59).
A ferry is $57 (€47) less than a flight for this route with tickets for a flight from Porto Empedocle to Rome costing on average $125 (€102).
Other travel options to Rome take longer:
Ferry takes on average 13h 58m.
Bus takes on average 14h 0m.
You'll arrive about -4h -47m sooner (14h 0m by bus vs 10h 13m by car) and save roughly $-19.69 (€-16.16) compared to fuel and tolls ($72 (€59) vs $52 (€43)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Autoservizi Salemi.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Salemi | Departure Time 02:00PM | Arrival Time 04:15AM | Duration 14h15 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price $73 |
The table below shows live departures for Porto Empedocle to Rome buses for tomorrow, Friday, July 10. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 PM Porto Empedocle | 14h15 | 4:15 AM Rome | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Porto Empedocle to Rome run on average 1 times per day, taking around 14h 0m. Cheap bus tickets for this journey start at $62 (€50) but you can travel from only $56 (€46) by flight.
There are 1 buses per day. The earliest bus runs at 08:55, the last at 21:00. The fastest bus covers the 322 miles (519 km) distance in 14h 15m.
Distance 322 miles (519 km) |
Average bus duration 14h 0m |
Cheapest ticket price $62 (€50) |
Buses per day 1 |
Direct buses 1 |
Fastest bus 14h 15m |
First bus 8:55 AM |
Last bus 9:00 PM |
Cheapest Month May |
Cheapest Day Fri |
High Season Apr - Jun |
Low Season Jan - Mar |
Best time to book 3 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
One of the world's great museum complexes, home to vast papal collections and the Sistine Chapel. A priority visit for art, history, and Renaissance masterpieces.
A superb villa museum with Bernini sculptures and major paintings by Caravaggio, Raphael, and Titian. Timed entry is essential due to limited capacity.
The city's historic civic museums on Capitoline Hill, known for classical sculpture, ancient Roman art, and excellent views over the Forum.
A lively Baroque square with monumental fountains, elegant facades, and one of the most recognizable urban spaces in Rome.
A famous stairway and gathering point linking Piazza di Spagna with Trinita dei Monti, especially popular for photos and central city strolls.
A beloved neighborhood of narrow lanes, ivy-covered buildings, and lively Roman atmosphere, ideal for wandering day or night.
A classic Roman pasta with pecorino Romano, black pepper, and pasta water. It is one of the city’s most iconic dishes for its simplicity and bold flavor.
Traditional Roman pasta made with guanciale, egg yolk, pecorino Romano, and black pepper. It is a defining dish of Rome and is famously made without cream.
A beloved pasta sauce of tomato, guanciale, pecorino Romano, and chili. Though linked to Amatrice, it is deeply rooted in Roman trattoria cooking.
Rome’s best-known luxury fine-dining restaurant, famous for panoramic views, elegant service, and sophisticated Italian cuisine.
A historic restaurant near the Pantheon serving refined Roman classics with strong local identity. Well known for seasonal specialties and pasta.
A celebrated central Rome dining room known for Roman pasta, cured meats, and an exceptional wine list. Lively, polished, and very popular.
Moderate for Western Europe. Sights and central hotels cost more, but food, coffee, and transit can be good value.
Service is often included or modest. Locals may round up or leave EUR 1-2 at cafes; 5-10% is appreciated at restaurants for good service, not obligatory. Round up taxis.
Official public transport app
Rome, Via Marsala / Viale Enrico De Nicola, Rome -> Rome Termini
Find answers to the most common questions about traveling from Porto Empedocle to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Porto Empedocle to Rome buses use the Porto Empedocle, Via Variante Nord (Bar Fantasy) to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Porto Empedocle and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need