- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Omio recommends booking the bus as it is the most popular option from Porto Empedocle to Rome among Omio's users. If you are prioritising price take the bus with prices starting from €27. For those with little time consider booking a flight which can get you there in 1h 15m. The ticket price range depends on the travel mode: a bus costs an average of €27, and a flight costs an average of €56.
Distance: 322 miles (519 km)
Most popular Bus | Flight | Ferry | Driving |
|---|---|---|---|
€38 Average price Cheapest | €74 Average price | €56 Average price | €43 Average price (fuel + tolls) |
14h 25m Average total duration 13h 55m Onboard + 30m Additional time* | 4h 15m Average total duration Fastest 1h 15m Onboard + 3h 0m Additional time* | 15h 0m Average total duration 14h 0m Onboard + 1h 0m Additional time* | 10h 13m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Porto Empedocle to Rome:
A bus is €18 less than a ferry for this route with tickets for a ferry from Porto Empedocle to Rome costing on average €56.
A bus is €35 less than a flight for this route with tickets for a flight from Porto Empedocle to Rome costing on average €74.
Other travel options to Rome take longer:
Bus takes on average 13h 55m.
Ferry takes on average 14h 0m.
Tickets start at around €38 compared to roughly €43 in fuel and tolls — a saving of about €5. The journey takes 13h 55m versus 10h 13m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Direct services are operated by Autoservizi Salemi, Salemi.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Salemi | Departure Time 02:00PM | Arrival Time 04:15AM | Duration 14h15 | Departure days Mon, Wed, Thu, Fri, Sat | Cheapest price €60 |
The table below shows live departures for Porto Empedocle to Rome buses for today, Monday, August 24. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 2:00 PM Porto Empedocle | 14h15 | 4:15 AM Rome | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Porto Empedocle to Rome run on average 1 times per day, taking around 13h 55m. Cheap bus tickets for this journey start at €27 if you book in advance.
There are 1 buses per day. The earliest bus runs at 08:55, the last at 21:00. The fastest bus covers the 322 miles (519 km) distance in 14h 15m.
Distance 322 miles (519 km) |
Average bus duration 13h 55m |
Cheapest ticket price €27 |
Buses per day 1 |
Direct buses 1 |
Fastest bus 14h 15m |
First bus 8:55 AM |
Last bus 9:00 PM |
Cheapest Month May |
Cheapest Day Tue |
High Season Oct - Dec |
Low Season Jan - Mar |
Busiest Day Mon |
Least Busy Day Mon |
Best time to book 3 days |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Porto Empedocle to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Porto Empedocle to Rome buses use the Porto Empedocle, Via Variante Nord (Bar Fantasy) to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Porto Empedocle and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
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