- Must visit
Royal Museums of Fine Arts of Belgium
Major museum complex with Old Masters, Magritte works, and Belgian art; one of the city’s essential cultural visits.
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Travel Information
Compare bus and flight for Pisa International Airport to Brussels
Omio recommends booking the flight as it is the most popular option from Pisa International Airport to Brussels among Omio's users. If you are prioritising price take the bus with prices starting from $127. For those with little time consider booking a flight which can get you there in 2h 6m. The ticket price range depends on the travel mode: a bus costs an average of $127, and a flight costs an average of $23.
Distance: 569 miles (916 km)
Compare bus with
| Bus | Most popular Flight | Driving |
|---|---|---|
$130 Average price Cheapest | $159 Average price | $353 Average price (fuel + tolls) |
27h 15m Average total duration 26h 45m Onboard + 30m Additional time* | 5h 6m Average total duration Fastest 2h 6m Onboard + 3h 0m Additional time* | 11h 50m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Pisa International Airport to Brussels is a bus with an average price of $130 (€106).
This is compared to other travel options from Pisa International Airport to Brussels:
A bus is $29 (€23) less than a flight for this route with tickets for a flight from Pisa International Airport to Brussels costing on average $159 (€129).
The fastest way to travel from Pisa International Airport to Brussels is by flight with an average journey time of 2h 6m.
Other travel options to Brussels take longer:
Bus takes on average 26h 45m.
It's helpful to compare your options as there are 2 ways to travel between Pisa International Airport and Brussels including taking a bus and flight.
We recommend using the flight as it is the most popular way to get from Pisa International Airport to Brussels among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Pisa International Airport to Brussels Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 05:45AM | Arrival Time 08:30AM | Duration 26h45 | Departure days Fri, Sat, Sun | Cheapest price $127 |
Compare prices and tickets Pisa International Airport to Brussels by bus or flight
Compare bus and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Pisa International Airport to Brussels buses with Omio?
FlixBus operates all buses services from Pisa International Airport to Brussels.
Omio is an official ticket reseller for all your travel options from Pisa International Airport to Brussels.
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are bus and flight to ensure you get the best deal for traveling from Pisa International Airport to Brussels.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including bus and flight to find the ideal travel option from Pisa International Airport to Brussels.
Journey information
Overview: Bus from Pisa International Airport to Brussels
Italy
Belgium
Buses from Pisa International Airport to Brussels run on average 9 times per day, taking around 26h 45m. Cheap bus tickets for this journey start at $127 (€103) but you can travel from only $23 (€19) by flight.
The earliest bus runs at 05:45, the last at 05:45. The fastest bus covers the 569 miles (916 km) distance in 26h 45m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $23 (€19)
Distance 569 miles (916 km) |
Average bus duration 26h 45m |
Cheapest ticket price $127 (€103) |
Buses per day 9 |
Fastest bus 26h 45m |
First bus 5:45 AM |
Last bus 5:45 AM |
Cheapest Month May |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Sun |
Least Busy Day Thu |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Flight from $23 (€19)
Bus providers: FlixBus from Pisa International Airport to BrusselsYou can travel by bus between Pisa International Airport to Brussels with FlixBus for as low as $23 (€19). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
About
FlixBus is one of Europe’s leading low-cost bus companies, founded in Germany and now offering long-distance services across Europe and the United States. In addition to its extensive daytime network, FlixBus also operates overnight buses on select European routes. Standard amenities include free Wi-Fi, power outlets to charge devices, extra legroom, luggage space, and onboard toilets, with snacks and drinks available for purchase. FlixBus offers a single Standard ticket type for all routes, which includes one carry-on bag and one checked bag per passenger. Additional fees apply for extra luggage and for reserving specific seats, such as Extra Seats, Table Seats, or Panorama Seats. This combination of affordability, comfort, and wide coverage makes FlixBus a popular choice for budget-conscious travelers.
Luggage & cancellation policy
Average Duration
26h 45m
Cheapest Price
$127 (€103)
FlixBus frequency
9 a day
Luggage included
One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Additional luggage
Additional luggage can be purchased for a fee.
Cancellation Policy
You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Amenities on board the bus
Wifi
Food sold onboard
Seat reservation
Toilets
USB plugs
Accessibility
Assistance; Priority boarding; Wheelchair-accessible buses.
Bikes
Bikes are allowed for a fee; must be booked.
Pets
Small pets in carriers allowed; guide dogs travel for free.
Complete guide to Brussels
Things to do in Brussels
Discover the best of Brussels — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Brussels trip today.
- Must visit
Magritte Museum
Dedicated to René Magritte, with the world’s largest collection of his surrealist works in a central historic setting.
- Recommended
Musical Instruments Museum
Celebrated museum in an Art Nouveau building, known for its global instrument collection and audio-guided displays.
- Must visit
Mont des Arts
Popular cultural hill and viewpoint linking the upper and lower city, especially photogenic at sunset.
- Must visit
Galeries Royales Saint-Hubert
Historic covered arcade of elegant passages, shops, and architecture, often highlighted in social media imagery.
- Recommended
Place du Grand Sablon
Stylish square known for antiques, refined atmosphere, and easy access to nearby churches and museums.
- Gluten-free
Moules-Frites
Brussels classic of mussels steamed with white wine, celery, onions, or cream, served with crisp fries. It is one of the city’s most iconic comfort dishes.
Carbonnade Flamande
Traditional Belgian beef and onion stew slowly cooked with dark beer, often slightly sweet-sour and served with fries or bread. A staple in Brussels brasseries.
- Vegetarian
- Gluten-free
Stoemp
Rustic mashed potatoes mixed with vegetables such as carrots, leeks, or spinach, often served with sausage or meat. The base preparation is a classic local side dish.
Comme Chez Soi
One of Brussels’ most famous fine-dining restaurants, celebrated for refined Belgian and French cuisine in an elegant Art Nouveau setting.
Nüetnigenough
Respected restaurant specializing in carefully prepared Belgian cuisine and strong beer pairings, with a cozy, polished brasserie feel.
Fin de Siècle
Well-known old-school restaurant serving generous Belgian specialties such as carbonnade, stoemp, and sausage in a rustic, bustling atmosphere.
Euro
Moderate by Western European standards. Food and transport are manageable, but central hotels cost more.
Average meal costs
- Budget
- EUR 10-15 for fries, kebab, or a simple lunch.
- Mid-range
- EUR 20-35 per person at a casual restaurant.
- Fine dining
- EUR 70+ per person at upscale restaurants.
- Coffee
- EUR 3-5 for a cappuccino or latte.
Tipping culture
Service is usually included. Rounding up or leaving 5-10% for great restaurant service is appreciated, not required. Round up taxi fares; no tip is expected for bars or cafés.
STIB-MIVB
Get the appOfficial public transport app
Prices
- Single ticket
- 2.60 EUR
- Day pass
- 8.00 EUR
To the city center
Brussels South (Gare du Midi), Brussels -> Brussels Central Station, Brussels
- Distance
- 2 km
- Travel time
- 8 min
- Contactless card payment is accepted on STIB-MIVB buses, trams, and metro through tap-in validators.
- A STIB-MIVB ticket does not cover SNCB/NMBS trains unless explicitly stated, so check validity before boarding.
FAQs: Bus from Pisa International Airport to Brussels
Find answers to the most common questions about traveling from Pisa International Airport to Brussels by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brussels, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Pisa International Airport to Brussels can start from as little as $127 (€103) when you book in advance. The average bus ticket price for Pisa International Airport to Brussels is $130 (€106) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Pisa International Airport to Brussels is 26h 45m to travel the 569 miles (916 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Pisa International Airport to Brussels leaves at 5:45 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Pisa International Airport to Brussels leaves at 5:45 AM.
There are 9 buses a day from Pisa International Airport to Brussels which require at least one change with FlixBus. Schedules can vary on holidays or weekends with fewer buses.
When taking a bus from Pisa International Airport to Brussels, you can count on FlixBus for the best way to get you to Brussels. You can also check all possible bus companies who offer a service between Pisa International Airport and Brussels and compare the amenities they offer before buying a bus ticket.
A trip to Brussels from Pisa International Airport is worth doing but not as a day trip with a journey time of 26h 45m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Pisa International Airport to Brussels is May.
It's helpful to compare your options as there are 2 ways to travel between Pisa International Airport and Brussels including taking a bus and flight.
Yes, the following accessibility options are available when taking the bus from Pisa International Airport to Brussels:
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
Yes, there are bathrooms on board the bus from Pisa International Airport to Brussels for bus company FlixBus.
Some of the most interesting sights to explore in Brussels are:
- Grand Place, a UNESCO World Heritage site known for its opulent guildhalls and vibrant flower market
- Atomium, an iconic structure and museum offering panoramic views of the city
- Manneken Pis, a famous bronze statue symbolizing the irreverent spirit of Brussels
- Royal Palace of Brussels, the official palace of the Belgian king with impressive architecture and gardens
- Magritte Museum, dedicated to the works of surrealist artist René Magritte, featuring an extensive collection of his paintings and drawings.
The best things to do in Brussels include:
- Explore the vibrant Marolles district, known for its eclectic mix of antique shops and street art
- Enjoy a leisurely stroll through the picturesque Parc du Cinquantenaire, home to impressive arches and museums
- Sample Belgian chocolates at one of the city's renowned chocolatiers
- Discover the lively atmosphere of the Saint-Géry district, filled with trendy bars and cafes
- Attend a performance at the historic La Monnaie opera house, showcasing world-class productions.
Whether you can cancel your bus ticket from Pisa International Airport to Brussels depends on the bus companies:
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
Yes, bikes are allowed on board the bus with bus company FlixBus.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
Yes, there is food available to purchase on board the bus from Pisa International Airport to Brussels.
Yes, the following luggage options are included when booking a bus ticket from Pisa International Airport to Brussels:
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
Yes, the following additional luggage options are available when booking a bus ticket from Pisa International Airport to Brussels:
- FlixBus
- Additional luggage can be purchased for a fee.
Yes, you can bring your pet on the bus from Pisa International Airport to Brussels. The following conditions apply:
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
You can reserve your seat on the bus from Pisa International Airport to Brussels with the following bus company: FlixBus
Yes, there are USB plugs on board the bus from Pisa International Airport to Brussels with the following bus company: FlixBus.
Yes, there is Wifi on board the bus from Pisa International Airport to Brussels with the following bus company: FlixBus.
Since both Pisa International Airport and Brussels are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
We recommend using the flight as it is the most popular way to get from Pisa International Airport to Brussels among Omio's users.
Belgium uses the euro (EUR) as its currency. Travelers generally find card payments widely accepted in cities, restaurants, and shops, though carrying some cash is advisable for small purchases or in rural areas.
In Brussels, travelers should be cautious of pickpocketing, especially in crowded areas like Grand Place, public transport, and popular tourist sites. Common scams include distraction techniques and fake petitions. It's advisable to stay vigilant, avoid displaying expensive items, and use official taxi services to ensure safety.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Pisa International Airport to Brussels
Pisa
Brussels
Amenities at bus station
Wifi
Parking
Dining
ATM
Taxis
Accessibility
WC
Ticket Officeinformation
Ticket Office Hours
- 06:00-23:00
Distance to city center
2 km
Car connection
Avenue FonsnyWifi
- Free Wi-Fi
Dining
- Cafeteria Midi (in the station)
- Belgian Bites (in the station)
- Fritland Express (0.5 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Brussels, Brussels South (Gare du Midi)
- Bus: 27, 49, 50, 78 Metro: 2, 6 Train: IC, S, Thalys, Eurostar
Brussels, Gare Du Midi
information
Amenities at bus station
WifiParkingDiningATMTaxisAccessibilityWCTicket Officeinformation
Ticket Office Hours
- 06:00-23:59
Distance to city center
1 kmCar connection
Rue du ProgrèsWifi
- Free Wi-Fi
Dining
- Cafeteria Noord (in the station)
- Quick Brussels Noord (in the station)
- Le Pain Quotidien (0.5 km).
Taxis
- Available outside the main entrance.
Accessibility
- Elevators, ramps
WC
- Available in the station.
Public transit options for Brussels-Noord
- Bus: 14, 57, 58 Metro: 2, 6 Train: IC, S1, S2
Most popular bus connections from Pisa International Airport
More options for your journey from Pisa International Airport to Brussels
Here are some other resources that might have the information you need
Most popular buses to and from Brussels and Pisa International Airport
Most popular bus connections to Brussels
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