- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
The best way to find a cheap bus ticket from Milazzo to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Milazzo to Rome will cost around €29 if you buy it on the day, but the cheapest tickets can be found for only €18.
On Sat, Oct 31, we found 7 buses from Milazzo to Rome, including 7 direct services.
On Sat, Oct 31 the direct buses cover the 471 km distance in an average of 9 h 42 m but if you time it right, some buses will get you there in just 9 h 20 m .
On Sat, Oct 31 the slowest buses will take 10 h 10 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Milazzo to Rome run on average 3 times per day, taking around 10h 6m. Cheap bus tickets for this journey start at €14 if you book in advance.
There are 2 buses per day. The earliest bus runs at 00:45, the last at 23:50. The fastest bus covers the 292 miles (471 km) distance in 8h 55m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Milazzo to Rome.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 09:55AM | Arrival Time 08:30PM | Duration 10h35 | Departure days Mon, Tue, Thu | Cheapest price €34 |
Operator FlixBus | Departure Time 03:10PM | Arrival Time 04:35AM | Duration 13h25 | Departure days Sat | Cheapest price €41 |
Operator BlaBlaCar | Departure Time 05:20PM | Arrival Time 01:40AM | Duration 8h20 | Departure days Fri | Cheapest price €51 |
Operator Salemi | Departure Time 06:25PM | Arrival Time 04:15AM | Duration 9h50 | Departure days Mon, Tue, Thu, Sat | Cheapest price €60 |
Operator FlixBus | Departure Time 07:15PM | Arrival Time 12:20PM | Duration 17h05 | Departure days Mon, Tue | Cheapest price €47 |
Operator FlixBus | Departure Time 07:30PM | Arrival Time 04:50AM | Duration 9h20 | Departure days Sat | Cheapest price €18 |
Operator Salemi | Departure Time 08:25PM | Arrival Time 06:15AM | Duration 9h50 | Departure days Sun | Cheapest price €60 |
Operator Salemi | Departure Time 08:30PM | Arrival Time 06:15AM | Duration 9h45 | Departure days Wed, Fri, Sun | Cheapest price €39 |
Operator FlixBus | Departure Time 08:30PM | Arrival Time 06:05AM | Duration 9h35 | Departure days Mon, Thu, Sat | Cheapest price €20 |
Operator Itabus | Departure Time 08:35PM | Arrival Time 06:45AM | Duration 10h10 | Departure days Tue, Thu, Sat | Cheapest price €19 |
Operator FlixBus | Departure Time 08:40PM | Arrival Time 06:15AM | Duration 9h35 | Departure days Sat | Cheapest price €25 |
Operator FlixBus | Departure Time 09:50PM | Arrival Time 07:10AM | Duration 9h20 | Departure days Thu | Cheapest price €16 |
Operator Itabus | Departure Time 09:50PM | Arrival Time 12:20PM | Duration 14h30 | Departure days Sat | Cheapest price €18 |
Operator Itabus | Departure Time 10:50PM | Arrival Time 01:20PM | Duration 14h30 | Departure days Mon | Cheapest price €30 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 09:30AM | Duration 10h00 | Departure days Mon | Cheapest price €15 |
The table below shows live departures for Milazzo to Rome buses for today, Friday, October 30. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
S202 | 8:30 PM Milazzo | 9h45 | 6:15 AM Roma, Autostazione Tiburtina | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Milazzo to Rome with Salemi, FlixBus, and Itabus. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Rome.
Find answers to the most common questions about traveling from Milazzo to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Milazzo to Rome buses use the to Roma, Autostazione Tiburtina station pair, with some services arriving at Roma, Autostazione (Metro Anagnina). Use this guide to compare Milazzo and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus) is 3 km from Rome city centre. Public transport options include:
Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: Ristorante Italiano (in the station), Fast Food Express (in the station), Caffè del Terminal (in the station).
Free Wi-Fi. ATMs are located near the arrivals area.
Ticket office support is available at Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus).
Available at Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus): Parking, Taxis, WC.
Accessibility facilities are available at Fiumicino, Aeroporto Leonardo de Vinci (T3 Arrivi - Stazione degli autobus): Elevators, ramps.