- Must visit
Vatican Museums
World-famous museum complex with the Sistine Chapel, Raphael Rooms, and major classical and Renaissance collections. Timed entry is strongly recommended due to very high demand.
Cheapest price
$78
Average price
$78
Fastest journey
15 h 45 m
Average duration
15 h 45 m
Buses per day
1
Distance
471 km
The best way to find a cheap bus ticket from Mazara del Vallo to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mazara del Vallo to Rome will cost around $78 if you buy it on the day, but the cheapest tickets can be found for only $78.
Of the 1 buses that leave Mazara del Vallo for Rome on Sat, Jun 20, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Jun 20 the direct buses cover the 471 km distance in an average of 15 h 45 m but if you time it right, some buses will get you there in just 15 h 45 m .
On Sat, Jun 20 the slowest buses will take 15 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the bus as it is the most popular option from Mazara del Vallo to Rome among Omio's users. If you are prioritising price take the bus with prices starting from $61. For those with little time consider booking a flight which can get you there in 1h 13m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.5 - 1.2kg. The ticket price range depends on the travel mode: a bus costs an average of $61, and a flight costs an average of $21.
Distance: 292 miles (471 km)
Most popular Bus | Flight | Ferry | Driving |
|---|---|---|---|
$74 Average price Cheapest | $87 Average price | $79 Average price | $61 Average price (fuel + tolls) |
16h 10m Average total duration 15h 40m Onboard + 30m Additional time* | 4h 13m Average total duration Fastest 1h 13m Onboard + 3h 0m Additional time* | 15h 0m Average total duration 14h 0m Onboard + 1h 0m Additional time* | 11h 18m Average total duration (door-to-door) |
0.5 - 1.2kg CO2 emissions Lowest | 1.4 - 2.8kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mazara del Vallo to Rome:
A bus is $4 (€3) less than a ferry for this route with tickets for a ferry from Mazara del Vallo to Rome costing on average $79 (€65).
A bus is $12 (€10) less than a flight for this route with tickets for a flight from Mazara del Vallo to Rome costing on average $87 (€71).
Other travel options to Rome take longer:
Ferry takes on average 14h 0m.
Bus takes on average 15h 40m.
You'll arrive about -5h -22m sooner (15h 40m by bus vs 11h 18m by car) and save roughly $-13.59 (€-11.15) compared to fuel and tolls ($74 (€61) vs $61 (€50)). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by Autoservizi Salemi.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Salemi | Departure Time 12:30PM | Arrival Time 04:15AM | Duration 15h45 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $61 |
The table below shows live departures for Mazara del Vallo to Rome buses for today, Friday, June 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:30 PM Mazara del Vallo | 15h45 | 4:15 AM Rome | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare flight, ferry, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Mazara del Vallo to Rome run on average 1 times per day, taking around 15h 40m. Cheap bus tickets for this journey start at $61 (€50) but you can travel from only $21 (€17) by flight.
There are 1 buses per day. The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 292 miles (471 km) distance in 15h 45m.
Distance 292 miles (471 km) |
Average bus duration 15h 40m |
Cheapest ticket price $61 (€50) |
Buses per day 1 |
Direct buses 1 |
Fastest bus 15h 45m |
First bus 1:20 AM |
Last bus 11:30 PM |
Cheapest Month Jun |
Cheapest Day Thu |
High Season Jul - Sep |
Low Season Oct - Dec |
Busiest Day Sun |
Least Busy Day Sun |
Best time to book 1 day |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous museum complex with the Sistine Chapel, Raphael Rooms, and major classical and Renaissance collections. Timed entry is strongly recommended due to very high demand.
One of Rome’s finest art museums, known for Bernini sculptures and paintings by Caravaggio and Raphael. Advance reservation is typically required because entry is strictly timed.
The city’s historic civic museums on Capitoline Hill, featuring Roman bronzes, imperial sculpture, and art with views over the Forum.
Elegant Baroque square built on an ancient stadium, lined with fountains, palaces, and lively street life. A classic area for strolling and people-watching.
Atmospheric neighborhood of narrow lanes, ivy-covered buildings, and busy evening streets. Popular with visitors but still one of Rome’s most characteristic areas.
Famous monumental staircase linking Piazza di Spagna and Trinità dei Monti. A highly photographed landmark and social-media favorite.
A classic Roman pasta with pecorino Romano and black pepper. It is one of the city’s most iconic dishes and a benchmark of Roman cooking.
Traditional Roman pasta made with guanciale, egg yolk, pecorino Romano, and black pepper. It is famous for its rich sauce without cream.
A beloved pasta sauce of tomato, guanciale, and pecorino Romano, closely tied to Rome’s culinary identity and served with bucatini or rigatoni.
Rome’s most famous fine-dining restaurant, offering elegant tasting menus, panoramic views, and one of the city’s most prestigious dining experiences.
A historic trattoria near the Pantheon, famous for traditional Roman dishes such as gricia, amatriciana, and seasonal specialties.
A celebrated central Rome venue known for classic Roman pasta, exceptional cured meats, and a refined but lively atmosphere.
Rome is moderate by Western Europe standards: sights are affordable, but central hotels and tourist-area dining cost more.
Service is usually included or modest. Tipping is not required, but rounding up or leaving EUR 1-2 at cafes and 5-10% at restaurants for good service is appreciated.
Official public transport app
Rome, Via Marsala / Viale Enrico De Nicola -> Roma Termini
Find answers to the most common questions about traveling from Mazara del Vallo to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Mazara del Vallo to Rome buses use the Mazara del Vallo, Distributore Q8 di Cipolla & Russo to Roma, Autostazione Tiburtina station pair. Use this guide to compare Mazara del Vallo and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need