- Must visit
Vatican Museums
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Cheapest price on Sep 20
$78
Average ticket price on Sep 20
$78
Fastest journey on Sep 20
15 h 45 m
Average journey duration on Sep 20
15 h 45 m
Buses on Sep 20
1
Distance
471 km
The best way to find a cheap bus ticket from Mazara del Vallo to Rome is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mazara del Vallo to Rome will cost around $78 if you buy it on the day, but the cheapest tickets can be found for only $78.
On Sun, Sep 20, we found 1 buses from Mazara del Vallo to Rome, including 1 direct services.
On Sun, Sep 20 the direct buses cover the 471 km distance in an average of 15 h 45 m but if you time it right, some buses will get you there in just 15 h 45 m .
On Sun, Sep 20 the slowest buses will take 15 h 45 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Omio recommends booking the flight as it is the most popular option from Mazara del Vallo to Rome among Omio's users. If you are prioritising price, take the ferry, with an average ticket price of $64 For those with little time, consider booking a flight, which has an average total journey time of 4h 11m. If you are seeking to minimise your carbon footprint, the bus is your best option, with estimated CO2 emissions of 0.5 - 1.2kg. Average ticket prices depend on the travel mode: a ferry costs an average of $64, while a flight costs an average of $375.
Distance: 292 miles (471 km)
| Bus | Most popular Flight | Ferry | Driving |
|---|---|---|---|
$112 Average price | $375 Average price | $64 Average price Cheapest | $61 Average price (fuel + tolls) |
17h 6m Average total duration 16h 36m Onboard + 30m Additional time* | 4h 11m Average total duration Fastest 2h 11m Onboard + 2h 0m Additional time* | 15h 5m Average total duration 14h 5m Onboard + 1h 0m Additional time* | 11h 18m Average total duration (door-to-door) |
0.5 - 1.2kg CO2 emissions Lowest | 1.4 - 2.8kg CO2 emissions | - CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular airline | ![]() Most popular ferry company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mazara del Vallo to Rome:
A ferry is $48 less than a bus for this route with tickets for a bus from Mazara del Vallo to Rome costing on average $112.
A ferry is $311 less than a flight for this route with tickets for a flight from Mazara del Vallo to Rome costing on average $375.
Other travel options to Rome take longer:
Ferry takes on average 14h 5m.
Bus takes on average 16h 36m.
Tickets start at around $112 compared to roughly $61 in fuel and tolls — a saving of about $-51.03. The journey takes 16h 36m versus 11h 18m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Salemi | Departure Time 12:30PM | Arrival Time 04:15AM | Duration 15h45 | Departure days Mon, Tue, Thu, Fri, Sat, Sun | Cheapest price $61 |
The table below shows live departures for Mazara del Vallo to Rome buses for today, Saturday, September 19. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:30 PM Mazara del Vallo | 15h45 | 4:15 AM Rome | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus, flight, and ferry prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Mazara del Vallo to Rome run on average 1 times per day, taking around 16h 36m. Cheap bus tickets for this journey start at $62 but you can travel from only $22 by flight.
There are 1 buses per day. The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 292 miles (471 km) distance in 15h 45m.
Distance 292 miles (471 km) |
Average bus duration 16h 36m |
Cheapest ticket price $62 |
Buses per day 1 |
Direct buses 1 |
Fastest bus 15h 45m |
First bus 1:20 AM |
Last bus 11:30 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Jul - Sep |
Low Season Apr - Jun |
Busiest Day Fri |
Least Busy Day Fri |
Best time to book 1 day |
Discover the best of Rome — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Rome trip today.
World-famous papal museums with the Sistine Chapel, Raphael Rooms, and major classical collections.
Outstanding ancient sculpture and mosaic museum housed in the Palazzo dei Conservatori and Palazzo Nuovo.
Celebrated villa museum with Bernini sculptures, Caravaggio paintings, and refined garden setting.
Elegant Baroque square with Bernini's fountains, lively atmosphere, and superb people-watching.
Historic square and gathering place at the Spanish Steps, ideal for classic city views and strolls.
Charming cobbled neighborhood filled with ivy-clad lanes, churches, nightlife, and local character.
Classic Roman pasta with guanciale, egg yolk, Pecorino Romano, and black pepper. A city icon known for rich flavor without cream.
Roman pasta with guanciale, tomato, and Pecorino Romano. A traditional Lazio staple tied to shepherd cooking and bold savory flavor.
Pasta with guanciale, Pecorino Romano, and black pepper. Considered one of Rome's oldest pasta dishes and prized for its simplicity.
Three-Michelin-star dining by Niko Romito at Bulgari Hotel Roma, offering refined Italian tasting menus in an elegant setting.
Historic trattoria in Testaccio known for classic Roman pasta and quinto quarto dishes in a lively, traditional setting.
Popular casual spot famed for Roman-style pizzas and fried starters. Bustling atmosphere and a long-standing local reputation.
Moderate for Europe: stays in central Rome are pricey, but transit is cheap and meals range from affordable pizza to costly tourist-area dining.
Service may be included via coperto or servizio. Round up or leave 5-10% at restaurants if service is good; round up in taxis; small change is fine at cafés.
Official public transport app
Via Marsala, Rome -> Piazza Barberini, Rome
Find answers to the most common questions about traveling from Mazara del Vallo to Rome by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Rome, this guide helps you travel smarter and with confidence.

Most Mazara del Vallo to Rome buses use the Mazara del Vallo, Distributore Q8 di Cipolla & Russo to Roma, Autostazione Tiburtina station pair. Use this guide to compare Mazara del Vallo and Rome bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Roma, Autostazione Tiburtina is 4 km from Rome city centre. Public transport options include:
Roma, Autostazione Tiburtina has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Cafes and vending machines available.
Wi-Fi is available at Roma, Autostazione Tiburtina. ATMs are aTM available near ticket office.
Ticket office support is available at Roma, Autostazione Tiburtina.
Available at Roma, Autostazione Tiburtina: Parking, Taxis, WC.
Accessibility facilities are available at Roma, Autostazione Tiburtina: Wheelchair accessible entrances and facilities.
Here are some other resources that might have the information you need