The cheapest and fastest buses from Lyon to Brno
Cheapest price
$90
Average price
$94
Fastest journey
21 h 5 m
Average duration
22 h 40 m
Buses per day
2
Distance
962 km
The best way to find a cheap bus ticket from Lyon to Brno is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lyon to Brno will cost around $94 if you buy it on the day, but the cheapest tickets can be found for only $90.
Of the 2 buses that leave Lyon for Brno on Sat, Mar 21, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Mar 21 the direct buses cover the 962 km distance in an average of 22 h 40 m but if you time it right, some buses will get you there in just 21 h 5 m .
On Sat, Mar 21 the slowest buses will take 1 d 15 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Travel Information
Compare train and bus for Lyon to Brno
Omio recommends booking the bus as it is the most popular option from Lyon to Brno among Omio's users. If you are prioritising price take the bus with prices starting from $65. For those with little time consider booking a train which can get you there in 18h 54m. The ticket price range depends on the travel mode: a bus costs an average of $65, and a train costs an average of $376.
Distance: 597 miles (962 km)
Compare bus with
Most popular Bus | Train |
|---|---|
$92 Average price Cheapest | $389 Average price |
19h 28m Average total duration 18h 58m Onboard + 30m Additional time* | 19h 24m Average total duration Fastest 18h 54m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Lyon to Brno bus times
The table below shows live departures for Lyon to Brno buses for today, Friday, March 20. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:15 PM Lyon | 19h05 | 12:20 PM Brno | 0 transfersDirect | |
![]() | 9:00 PM Lyon | 24h15 | 9:15 PM Brno | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Lyon to Brno by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 21
Mar 22
Mar 23
Mar 24
Mar 25
Mar 26
Mar 27
Why should you book Lyon to Brno buses with Omio?
Why book with Omio vs FlixBus?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare FlixBus with all available travel options, which are train and bus to ensure you get the best deal for traveling from Lyon to Brno.
Why book with Omio over Wanderu or Trainline?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Lyon to Brno.
Journey information
Overview: Bus from Lyon to Brno
Buses from Lyon to Brno run on average 6 times per day, taking around 18h 58m. Cheap bus tickets for this journey start at $65 (€53) if you book in advance.
The earliest bus runs at 01:20, the last at 23:30. The fastest bus covers the 597 miles (962 km) distance in 19h 5m.
Distance 597 miles (962 km) |
Average bus duration 18h 58m |
Cheapest ticket price $65 (€53) |
Buses per day 6 |
Fastest bus 19h 5m |
First bus 01:20 |
Last bus 23:30 |
Bus providers: FlixBus from Lyon to BrnoYou can travel by bus between Lyon to Brno with FlixBus for as low as $65 (€53). When you search for schedules and tickets, Omio will show you the best journey
FlixBus
FAQs: Bus from Lyon to Brno
Find answers to the most common questions about traveling from Lyon to Brno by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Brno, this guide helps you travel smarter and with confidence.

- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Špilberk Castle, a historic fortress offering panoramic views of the city and housing a museum
- Cathedral of St. Peter and Paul, a striking Gothic cathedral known for its twin spires and rich history
- Villa Tugendhat, a UNESCO World Heritage site showcasing modernist architecture by Mies van der Rohe
- Brno Underground, a network of historical tunnels and cellars beneath the city center
- Moravian Museum, the second-largest museum in the Czech Republic, featuring diverse exhibits on natural history and culture.
- Moravian Karst, a natural reserve with stunning caves and hiking trails located just outside the city
- Brno Technical Museum, an interactive museum featuring exhibits on the history of technology and industry in the region
- Mendel Museum, dedicated to the life and work of Gregor Mendel, the father of genetics
- Lužánky Park, the oldest public park in Brno, perfect for a leisurely stroll or a picnic
- Brno Zoo, offering a fun and educational experience with a variety of animal species.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
popular bus stations
Popular bus stations from Lyon to Brno
- 06:00-23:00
- Free Wi-Fi
- Café de la Gare (in the station)
- Le Bistrot de Lyon (0.5 km)
- Brasserie Georges (0.6 km).
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: C19, C20, 31, 46, 49, 55, 60, S1 Metro: A Tram: T1, T2
- 00:00-23:59
- Free Wi-Fi
- Available outside the main entrance.
- Elevators, ramps
- Available in the station.
- Bus: 40, 61, 67 Tram: 1, 2, 4, 8, 9, 10, 12 Train: S2, S3, S6
Most popular bus connections from Lyon
More options for your journey from Lyon to Brno
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