- Must visit
Orlando Science Center
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Cheapest price on Sep 14
$46
Average ticket price on Sep 14
$46
Fastest journey on Sep 14
4 h 29 m
Average journey duration on Sep 14
5 h 52 m
Buses on Sep 14
2
Distance
221 km
The best way to find a cheap bus ticket from Lake City, FL to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lake City, FL to Orlando, FL will cost around $46 if you buy it on the day, but the cheapest tickets can be found for only $46.
It's difficult to get from Lake City, FL to Orlando, FL without transferring at least once.




Omio recommends booking the bus as it is the most popular option from Lake City, FL to Orlando, FL among Omio's users. If you are prioritising price, take the bus, with an average ticket price of $85 For those with little time, consider booking a bus, which has an average total journey time of 4h 13m. Average ticket prices depend on the travel mode: a bus costs an average of $85, while a bus costs an average of $85.
Distance: 137 miles (221 km)
Most popular Bus | Driving |
|---|---|
$85 Average price Cheapest | $40 Average price (fuel + tolls) |
4h 13m Average total duration Fastest 3h 43m Onboard + 30m Additional time* | 2h 19m Average total duration (door-to-door) |
![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options |
This is compared to other travel options from Lake City, FL to Orlando, FL:
A bus is $816 (€660) less than a flight for this route with tickets for a flight from Lake City, FL to Orlando, FL costing on average $900 (€728).
Other travel options to Orlando, FL take longer:
Bus takes on average 3h 43m.
Tickets start at around $85 (€69) compared to roughly $40 (€32) in fuel and tolls — a saving of about $-44.73 (€-36.17). The journey takes 3h 43m versus 2h 19m by car, so you'll arrive a bit later, but you can use the time productively rather than spending it behind the wheel. No parking to sort, no fuel stops, and most coaches have Wi-Fi and power outlets.
Driving is worth considering if you're on a tight schedule, travelling as a group (where fuel costs split several ways), or want the flexibility to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:30AM | Arrival Time 04:59AM | Duration 4h29 | Departure days Sat | Cheapest price $69 |
Operator FlixBus | Departure Time 01:45PM | Arrival Time 06:45PM | Duration 5h00 | Departure days Sat, Sun | Cheapest price $98 |
Operator Greyhound USA | Departure Time 02:00PM | Arrival Time 09:15PM | Duration 7h15 | Departure days Mon | Cheapest price $46 |
Operator Greyhound USA | Departure Time 07:30PM | Arrival Time 11:59PM | Duration 4h29 | Departure days Mon | Cheapest price $46 |
Operator FlixBus | Departure Time 07:30PM | Arrival Time 11:59PM | Duration 4h29 | Departure days Sat, Sun | Cheapest price $87 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 03:59AM | Duration 4h29 | Departure days Tue, Wed, Thu, Fri | Cheapest price $80 |
The table below shows live departures for Lake City, FL to Orlando, FL buses for today, Sunday, September 13. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
+ FlixBus | 7:30 PM Lake City, S Marion Ave (Lake City Greyhound Station), FL | 4h29 | 11:59 PM Orlando, N John Young Pkwy (Greyhound Bus Station) | 1 transfer | |
| Monday, September 14 | |||||
![]() | 2:00 PM Lake City, FL | 7h15 | 9:15 PM Orlando, FL | 1 transfer | |
![]() | 7:30 PM Lake City, FL | 4h29 | 11:59 PM Orlando, FL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Lake City, FL to Orlando, FL run on average 2 times per day, taking around 3h 43m. Cheap bus tickets for this journey start at $47 (€38) if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:15, the last at 23:40. The fastest bus covers the 137 miles (221 km) distance in 3h 15m.
Distance 137 miles (221 km) |
Average bus duration 3h 43m |
Cheapest ticket price $47 (€38) |
Buses per day 2 |
Direct buses 1 |
Fastest bus 3h 15m |
First bus 5:15 AM |
Last bus 11:40 PM |
Cheapest Month Feb |
Cheapest Day Tue |
High Season Jan - Mar |
Low Season Jul - Sep |
Discover the best of Orlando, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando, FL trip today.
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Major local history museum in a restored 1927 courthouse, covering Central Florida's past through engaging permanent and special exhibits.
Smithsonian-affiliated art museum with American, African, and ancient works, plus strong rotating exhibitions in Winter Park.
Orlando's signature urban park with lake views, swan boats, skyline scenes, and frequent festivals in the city center.
Upscale main street area famous for boutiques, brick streets, and a polished small-town atmosphere in nearby Winter Park.
Lively entertainment district with nightlife, murals, and historic architecture around downtown's Church Street corridor.
A Central Florida favorite of smoked or fried local catfish, often served with hushpuppies and grits. It reflects the region's freshwater fishing and Southern roots.
Fresh Atlantic or Gulf shrimp, commonly peel-and-eat, grilled, or fried. It is a staple across Florida and prized in Orlando seafood spots for its regional freshness.
Cuban coffee sweetened during brewing for a bold, syrupy shot. Popular in Central Florida's Latin communities, it is a daily ritual and local caffeine classic.
Popular Cuban cafe serving strong cafecito, Cuban sandwiches, and pastries in a busy, no-frills neighborhood setting.
Historic casual seafood house known for Florida gator tail, frog legs, and laid-back Old Florida charm near downtown Orlando.
Refined restaurant in Winter Park highlighting Florida seafood and seasonal Southern ingredients in an elegant but relaxed space.
Moderate for a major US tourist city. Theme parks and hotels raise trip costs, while casual dining and ride-hailing are widely available at typical US urban prices.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis or ride-hailing, and small change or up to 10% at cafes if table service is provided.
Find answers to the most common questions about traveling from Lake City, FL to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

Most Lake City, FL to Orlando, FL buses use the Lake City, S Marion Ave (Lake City Greyhound Station) to Orlando, N John Young Pkwy (Greyhound Bus Station) station pair. Use this guide to compare Lake City, FL and Orlando, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lake City, S Marion Ave (Lake City Greyhound Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lake City, S Marion Ave (Lake City Greyhound Station). ATMs are available at Lake City, S Marion Ave (Lake City Greyhound Station).
Ticket office support is available at Lake City, S Marion Ave (Lake City Greyhound Station).
Available at Lake City, S Marion Ave (Lake City Greyhound Station): Parking, Taxis, WC.
Accessibility facilities are available at Lake City, S Marion Ave (Lake City Greyhound Station): Basic accessibility features are present.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
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