- Must visit
Orlando Science Center
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Cheapest price on Oct 29
$77
Average ticket price on Oct 29
$77
Fastest journey on Oct 29
4 h 29 m
Average journey duration on Oct 29
4 h 29 m
Buses on Oct 29
1
Distance
221 km
The best way to find a cheap bus ticket from Lake City, FL to Orlando, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lake City, FL to Orlando, FL will cost around $77 if you buy it on the day, but the cheapest tickets can be found for only $77.
On Thu, Oct 29, we found 1 buses from Lake City, FL to Orlando, FL, including 1 direct services.
On Thu, Oct 29 the direct buses cover the 221 km distance in an average of 4 h 29 m but if you time it right, some buses will get you there in just 4 h 29 m .
On Thu, Oct 29 the slowest buses will take 4 h 29 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Lake City, FL to Orlando, FL run on average 2 times per day, taking around 3h 43m. Cheap bus tickets for this journey start at $45 if you book in advance.
There are 1 buses per day. The earliest bus runs at 05:15, the last at 23:40. The fastest bus covers the 137 miles (221 km) distance in 3h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Lake City, FL to Orlando, FL.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 12:30AM | Arrival Time 04:59AM | Duration 4h29 | Departure days Mon, Sat, Sun | Cheapest price $56 |
Operator Greyhound USA | Departure Time 02:00PM | Arrival Time 09:15PM | Duration 7h15 | Departure days Mon | Cheapest price $44 |
Operator Greyhound USA | Departure Time 07:30PM | Arrival Time 11:59PM | Duration 4h29 | Departure days Mon | Cheapest price $44 |
Operator FlixBus | Departure Time 11:30PM | Arrival Time 03:59AM | Duration 4h29 | Departure days Tue, Wed, Thu, Fri, Sun | Cheapest price $77 |
The table below shows live departures for Lake City, FL to Orlando, FL buses for today, Wednesday, October 28. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:30 PM Lake City, FL | 4h29 | 3:59 AM Orlando, FL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Buses from Lake City, FL to Orlando, FL with FlixBus. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Orlando, FL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Orlando, FL trip today.
Hands-on science center popular with families, offering interactive exhibits, live programming, and observatory experiences.
Major local history museum in a restored 1927 courthouse, covering Central Florida's past through engaging permanent and special exhibits.
Smithsonian-affiliated art museum with American, African, and ancient works, plus strong rotating exhibitions in Winter Park.
Orlando's signature urban park with lake views, swan boats, skyline scenes, and frequent festivals in the city center.
Upscale main street area famous for boutiques, brick streets, and a polished small-town atmosphere in nearby Winter Park.
Lively entertainment district with nightlife, murals, and historic architecture around downtown's Church Street corridor.
A Central Florida favorite of smoked or fried local catfish, often served with hushpuppies and grits. It reflects the region's freshwater fishing and Southern roots.
Fresh Atlantic or Gulf shrimp, commonly peel-and-eat, grilled, or fried. It is a staple across Florida and prized in Orlando seafood spots for its regional freshness.
Cuban coffee sweetened during brewing for a bold, syrupy shot. Popular in Central Florida's Latin communities, it is a daily ritual and local caffeine classic.
Popular Cuban cafe serving strong cafecito, Cuban sandwiches, and pastries in a busy, no-frills neighborhood setting.
Historic casual seafood house known for Florida gator tail, frog legs, and laid-back Old Florida charm near downtown Orlando.
Refined restaurant in Winter Park highlighting Florida seafood and seasonal Southern ingredients in an elegant but relaxed space.
Moderate for a major US tourist city. Theme parks and hotels raise trip costs, while casual dining and ride-hailing are widely available at typical US urban prices.
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis or ride-hailing, and small change or up to 10% at cafes if table service is provided.
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Orlando, FL.
Find answers to the most common questions about traveling from Lake City, FL to Orlando, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Orlando, FL, this guide helps you travel smarter and with confidence.

Most Lake City, FL to Orlando, FL buses use the Lake City, S Marion Ave (Lake City Greyhound Station) to Orlando, N John Young Pkwy (Greyhound Bus Station) station pair. Use this guide to compare Lake City, FL and Orlando, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lake City, S Marion Ave (Lake City Greyhound Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lake City, S Marion Ave (Lake City Greyhound Station). ATMs are available at Lake City, S Marion Ave (Lake City Greyhound Station).
Ticket office support is available at Lake City, S Marion Ave (Lake City Greyhound Station).
Available at Lake City, S Marion Ave (Lake City Greyhound Station): Parking, Taxis, WC.
Accessibility facilities are available at Lake City, S Marion Ave (Lake City Greyhound Station): Basic accessibility features are present.
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Check bus stations information for Lake City, FL and Orlando, FL, including where buses depart and arrive on this route.