The cheapest and fastest buses from Orlando, FL to Lake City, FL
- Cheapest price on Nov 14
- $42
- Average ticket price on Nov 14
- $42
- Fastest journey on Nov 14
- 3 h 45 m
- Average journey duration on Nov 14
- 4 h 22 m
- Buses on Nov 14
- 3
- Distance
- 221 km
The best way to find a cheap bus ticket from Orlando, FL to Lake City, FL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Orlando, FL to Lake City, FL will cost around $42 if you buy it on the day, but the cheapest tickets can be found for only $42.
On Sat, Nov 14, we found 3 buses from Orlando, FL to Lake City, FL, including 1 direct services.
On Sat, Nov 14 the direct buses cover the 221 km distance in an average of 4 h 22 m but if you time it right, some buses will get you there in just 3 h 45 m .
On Sat, Nov 14 the slowest buses will take 4 h 55 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

5:15 AM 3h45 Orlando, FL 9:00 AM Lake City, FL $42 1 One-way 0 transfers
4:45 AM 4h25 Orlando, FL 9:10 AM Lake City, FL $43 1 One-way 1 transfer
12:30 PM 4h55 Orlando, FL 5:25 PM Lake City, FL $43 1 One-way 1 transfer

5:15 AM 3h45 Orlando, FL 9:00 AM Lake City, FL $42 1 One-way 0 transfers
4:45 AM 4h25 Orlando, FL 9:10 AM Lake City, FL $43 1 One-way 1 transfer
12:30 PM 4h55 Orlando, FL 5:25 PM Lake City, FL $43 1 One-way 1 transfer
Journey information
Overview: Bus from Orlando, FL to Lake City, FL
Buses from Orlando, FL to Lake City, FL run on average 2 times per day, taking around 4h 1m. Cheap bus tickets for this journey start at $31 if you book in advance.
There are 1 buses per day. The earliest bus runs at 04:15, the last at 19:30. The fastest bus covers the 137 miles (221 km) distance in 3h 45m.
Distance 137 miles (221 km) |
Average bus duration 4h 1m |
Cheapest ticket price $31 |
Buses per day 2 |
Direct buses 1 |
Fastest bus 3h 45m |
First bus 4:15 AM |
Last bus 7:30 PM |
Cheapest Month Nov |
Cheapest Day Sat |
High Season Oct - Dec |
Low Season Jul - Sep |
Best time to book 49 days |
Frequently asked questions about your Orlando, FL to Lake City, FL trip
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Orlando, FL to Lake City, FL.
Orlando, FL to Lake City, FL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Flixbus USA | Departure Time 04:45AM | Arrival Time 09:10AM | Duration 4h25 | Departure days Sat | Cheapest price $43 |
Operator Greyhound USA | Departure Time 05:15AM | Arrival Time 09:00AM | Duration 3h45 | Departure days Fri, Sat | Cheapest price $39 |
Operator Greyhound | Departure Time 09:15AM | Arrival Time 01:00PM | Duration 3h45 | Departure days Mon, Tue, Wed, Thu, Sun | Cheapest price $38 |
Operator Greyhound | Departure Time 10:15AM | Arrival Time 02:00PM | Duration 3h45 | Departure days Wed | Cheapest price $38 |
Operator Flixbus USA | Departure Time 12:30PM | Arrival Time 05:25PM | Duration 4h55 | Departure days Fri, Sat | Cheapest price $43 |
Operator FlixBus | Departure Time 02:00PM | Arrival Time 05:20PM | Duration 3h20 | Departure days Mon | Cheapest price $28 |
Operator Greyhound | Departure Time 02:15PM | Arrival Time 09:25PM | Duration 7h10 | Departure days Tue | Cheapest price $70 |
Operator FlixBus | Departure Time 04:30PM | Arrival Time 09:25PM | Duration 4h55 | Departure days Wed | Cheapest price $71 |
Live departures
Orlando, FL to Lake City, FL bus times
The table below shows live departures for Orlando, FL to Lake City, FL buses for tomorrow, Saturday, November 14. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 4:45 AM Orlando, FL | 4h25 | 9:10 AM Lake City, FL | 1 transfer | |
![]() | 5:15 AM Orlando, FL | 3h45 | 9:00 AM Lake City, FL | 0 transfersDirect | |
![]() | 12:30 PM Orlando, FL | 4h55 | 5:25 PM Lake City, FL | 1 transfer | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Why should you book Orlando, FL to Lake City, FL buses with Omio?
Why book with Omio vs FlixBus?
- Compare with other providers: On Omio, you can not only buy tickets for FlixBus, but also compare tickets for the likes of Greyhound to find the best option for your trip from Orlando, FL to Lake City, FL.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
Why book with Omio over Wanderu or Trainline?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Greyhound to find the best option for your trip from Orlando, FL to Lake City, FL.
Bus providers: Greyhound, FlixBus from Orlando, FL to Lake City, FLYou can travel by bus between Orlando, FL to Lake City, FL with Greyhound, FlixBus for as low as $31. When you search for schedules and tickets, Omio will show you the best journey
FlixBus
Greyhound
Companies, tickets, and onboard amenities between Orlando, FL and Lake City, FL
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
- Greyhound
- Assistance
- Priority seating
- Wheelchair-accessible buses.
- FlixBus
- Assistance
- Priority boarding
- Wheelchair-accessible buses.
- Greyhound
- You can cancel your ticket for a refund or exchange up to 24 hours before departure, for a cancellation fee applied.
- FlixBus
- You can cancel your ticket up to 15 minutes before departure and receive a voucher for future travel. Refund requests for delays over 120 minutes are possible.
- Greyhound
- One carry-on bag up to 25 lbs (11 kg) and one checked bag up to 50 lbs (23 kg).
- FlixBus
- One carry-on bag up to 7kg (42x30x18 cm) and one checked bag up to 20kg (80x50x30 cm).
- Greyhound
- $15 per additional bag.
- FlixBus
- Additional luggage can be purchased for a fee.
- FlixBus
- Small pets in carriers allowed
- guide dogs travel for free.
FAQs: Bus from Orlando, FL to Lake City, FL
Find answers to the most common questions about traveling from Orlando, FL to Lake City, FL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Lake City, FL, this guide helps you travel smarter and with confidence.

popular bus stations
Popular bus stations from Orlando, FL to Lake City, FL
Most Orlando, FL to Lake City, FL buses use the Orlando, N John Young Pkwy (Greyhound Bus Station) to Lake City, S Marion Ave (Lake City Greyhound Station) station pair. Use this guide to compare Orlando, FL and Lake City, FL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Which Orlando, FL station do buses to Lake City, FL leave from?
Getting to Orlando, N John Young Pkwy (Greyhound Bus Station) from Orlando city centre
Orlando, N John Young Pkwy (Greyhound Bus Station) is 3 km from Orlando city centre. Public transport options include:
Orlando, N John Young Pkwy (Greyhound Bus Station) bus station facilities and services
Orlando, N John Young Pkwy (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Orlando, N John Young Pkwy (Greyhound Bus Station). ATMs are available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Tickets and information
Ticket office support is available at Orlando, N John Young Pkwy (Greyhound Bus Station).
Parking, taxis and toilets
Available at Orlando, N John Young Pkwy (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Orlando, N John Young Pkwy (Greyhound Bus Station): The station is accessible for individuals with disabilities.
Which Lake City, FL station do buses from Orlando, FL arrive at?
Getting to Lake City, S Marion Ave (Lake City Greyhound Station) from Lake City city centre
Lake City, S Marion Ave (Lake City Greyhound Station) bus station facilities and services
Lake City, S Marion Ave (Lake City Greyhound Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi and ATMs
Wi-Fi is available at Lake City, S Marion Ave (Lake City Greyhound Station). ATMs are available at Lake City, S Marion Ave (Lake City Greyhound Station).
Tickets and information
Ticket office support is available at Lake City, S Marion Ave (Lake City Greyhound Station).
Parking, taxis and toilets
Available at Lake City, S Marion Ave (Lake City Greyhound Station): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Lake City, S Marion Ave (Lake City Greyhound Station): Basic accessibility features are present.
Bus stations for Orlando, FL to Lake City, FL
Check bus stations information for Orlando, FL and Lake City, FL, including where buses depart and arrive on this route.
Most popular bus connections from Orlando, FL
More options for your journey from Orlando, FL to Lake City, FL
Here are some other resources that might have the information you need
