- Must visit
Museum of Fine Arts, Houston
One of America’s top fine arts museums, spanning antiquity to modern works. A must for major collections, architecture, and rotating exhibitions.
Cheapest price
$245
Average price
$245
Fastest journey
18 h 56 m
Average duration
18 h 56 m
Buses per day
1
Distance
1226 km
The best way to find a cheap bus ticket from Lake City, FL to Houston, TX is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Lake City, FL to Houston, TX will cost around $245 if you buy it on the day, but the cheapest tickets can be found for only $245.
It's difficult to get from Lake City, FL to Houston, TX without transferring at least 2 times.


Omio recommends booking the bus as it is the most popular option from Lake City, FL to Houston, TX among Omio's users.
Distance: 761 miles (1226 km)
Most popular Bus | Driving |
|---|---|
$170 Average price (fuel + tolls) | |
11h 36m Average total duration (door-to-door) | |
Direct Options | Direct Options |
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound USA | Departure Time 05:30PM | Arrival Time 12:24PM | Duration 18h54 | Departure days Mon, Tue, Wed, Thu, Fri, Sun | Cheapest price $245 |
The table below shows live departures for Lake City, FL to Houston, TX buses for today, Tuesday, August 25. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 5:30 PM Lake City, FL | 18h56 | 12:26 PM Houston, TX | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Take a bus from Lake City, FL to Houston, TX and enjoy the approximately 761 miles (1226 km) long journey. Find schedules and pricing options for a convenient and affordable trip.
The earliest bus runs at 17:30, the last at 17:30.
Distance 761 miles (1226 km) |
First bus 5:30 PM |
Last bus 5:30 PM |
Cheapest Month Sep |
Cheapest Day Mon |
High Season Oct - Dec |
Low Season Jul - Sep |
Discover the best of Houston, TX — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Houston, TX trip today.
One of America’s top fine arts museums, spanning antiquity to modern works. A must for major collections, architecture, and rotating exhibitions.
Premier space museum with spacecraft, simulators, and NASA history. Essential for understanding Houston’s link to human spaceflight.
Large natural science museum known for dinosaurs, gems, and immersive displays. A family favorite with broad appeal and strong exhibits.
Houston’s signature urban park with skyline views, events, lawns, and public art. A central gathering place for visitors and locals.
Museum District green space with trails, gardens, and major attractions nearby. Ideal for a scenic walk between Houston’s top institutions.
Former rail corridor turned urban trail with art, landscaping, and skyline glimpses. A modern favorite for walking and casual exploration.
Slow-smoked beef brisket with a peppery bark. Central Texas barbecue is a Houston staple thanks to the city’s strong smokehouse culture.
Spiced beef or chicken fajitas served sizzling with onions and peppers. Houston helped popularize Tex-Mex restaurant fajitas nationwide.
Warm flour tortillas filled with breakfast staples like egg, potato, bacon, or chorizo. A daily Houston favorite shaped by Texas Mexican food culture.
Refined Gulf Coast fine dining with polished service and seasonal seafood. One of Houston’s most acclaimed upscale restaurants.
Highly regarded barbecue spot serving brisket, ribs, and sausage in a simple, old-school setting loved by locals and visitors.
Beloved casual Vietnamese restaurant famous for garlic noodles, shaken beef, and fusion dishes that reflect Houston’s diverse food scene.
Moderate for U.S. cities: hotels vary widely, dining is reasonable, and car-based transit can add costs for visitors.
Tip 18-20% at restaurants, $1-2 per drink at bars, and 10-15% for taxis. Cafes often have tip jars or card prompts.
Official public transport app
University of Houston / UH South -> Central Station Main, Houston, TX
Find answers to the most common questions about traveling from Lake City, FL to Houston, TX by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Houston, TX, this guide helps you travel smarter and with confidence.

Most Lake City, FL to Houston, TX buses use the Lake City, S Marion Ave (Lake City Greyhound Station) to Houston, Harrisburg Blvd (Greyhound Bus Station) station pair, with some services arriving at Houston, Gray St Parking (Bus Station). Use this guide to compare Lake City, FL and Houston, TX bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Lake City, S Marion Ave (Lake City Greyhound Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Lake City, S Marion Ave (Lake City Greyhound Station). ATMs are available at Lake City, S Marion Ave (Lake City Greyhound Station).
Ticket office support is available at Lake City, S Marion Ave (Lake City Greyhound Station).
Available at Lake City, S Marion Ave (Lake City Greyhound Station): Parking, Taxis, WC.
Accessibility facilities are available at Lake City, S Marion Ave (Lake City Greyhound Station): Basic accessibility features are present.
Houston, Harrisburg Blvd (Greyhound Bus Station) is 6 km from Houston city centre. Public transport options include:
Houston, Harrisburg Blvd (Greyhound Bus Station) has practical services for this route, including Wifi, Parking, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Wi-Fi is available at Houston, Harrisburg Blvd (Greyhound Bus Station). ATMs are aTM available in the waiting area.
Ticket office support is available at Houston, Harrisburg Blvd (Greyhound Bus Station).
Available at Houston, Harrisburg Blvd (Greyhound Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Houston, Harrisburg Blvd (Greyhound Bus Station): Wheelchair accessible entrances and facilities.
Houston, Gray St Parking (Bus Station) is 1 km from Houston city centre. Public transport options include:
Houston, Gray St Parking (Bus Station) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food options include: Restaurants are available nearby.
Wi-Fi is available at Houston, Gray St Parking (Bus Station). ATMs are available at Houston, Gray St Parking (Bus Station).
Ticket office support is available at Houston, Gray St Parking (Bus Station).
Available at Houston, Gray St Parking (Bus Station): Parking, Taxis, WC.
Accessibility facilities are available at Houston, Gray St Parking (Bus Station): The station is accessible for disabled passengers.
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