- Must visit
Brewery Museum
Modern interactive brewery museum in a 15th-century malt house, explaining beer-making history and daily life in old Plzeň.
The best way to find a cheap bus ticket from Frankfurt am Main to Plzeň is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Frankfurt am Main to Plzeň will cost around DKK 216 if you buy it on the day, but the cheapest tickets can be found for only DKK 209.
On Tue, Nov 03, we found 2 buses from Frankfurt am Main to Plzeň, including 2 direct services.
On Tue, Nov 03 the direct buses cover the 338 km distance in an average of 7 h but if you time it right, some buses will get you there in just 7 h .
On Tue, Nov 03 the slowest buses will take 7 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.

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Buses from Frankfurt am Main to Plzeň run on average 6 times per day, taking around 6h 45m. Cheap bus tickets for this journey start at DKK 148 but you can travel from only DKK 56 by train.
There are 2 buses per day. The earliest bus runs at 00:20, the last at 23:55. The fastest bus covers the 210 miles (338 km) distance in 5h 15m.
Plan this route
Use these quick route answers to check fares, travel time, departure options, and direct services before booking from Frankfurt am Main to Plzeň.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:20AM | Arrival Time 01:50PM | Duration 9h30 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price DKK 291 |
Operator FlixBus | Departure Time 04:50AM | Arrival Time 01:50PM | Duration 9h00 | Departure days Thu, Fri, Sat, Sun | Cheapest price DKK 251 |
Operator FlixBus | Departure Time 06:05AM | Arrival Time 01:50PM | Duration 7h45 | Departure days Mon | Cheapest price DKK 422 |
Operator FlixBus | Departure Time 08:40AM | Arrival Time 03:40PM | Duration 7h00 | Departure days Tue, Wed | Cheapest price DKK 209 |
Operator FlixBus | Departure Time 09:40AM | Arrival Time 04:40PM | Duration 7h00 | Departure days Tue, Wed | Cheapest price DKK 218 |
Operator FlixBus | Departure Time 10:40AM | Arrival Time 05:40PM | Duration 7h00 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price DKK 223 |
Operator FlixBus | Departure Time 11:15AM | Arrival Time 05:40PM | Duration 6h25 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price DKK 191 |
Operator FlixBus | Departure Time 08:15PM | Arrival Time 08:00AM | Duration 11h45 | Departure days Mon, Wed, Thu, Fri, Sat, Sun | Cheapest price DKK 251 |
Operator FlixBus | Departure Time 08:35PM | Arrival Time 06:00AM | Duration 9h25 | Departure days Mon, Fri, Sat, Sun | Cheapest price DKK 287 |
Operator FlixBus | Departure Time 10:00PM | Arrival Time 06:00AM | Duration 8h00 | Departure days Fri, Sat, Sun | Cheapest price DKK 251 |
Operator RegioJet a.s. | Departure Time 10:30PM | Arrival Time 03:25AM | Duration 4h55 | Departure days Mon, Thu, Fri, Sat, Sun | Cheapest price DKK 239 |
The table below shows live departures for Frankfurt am Main to Plzeň buses for today, Monday, November 2. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
FlixBus · FlixBus | 8:15 PM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 9h15 | 5:30 AM Plzeň, Centrální Autobusové Nádraží | 1 transfer | |
FlixBus · FlixBus | 8:35 PM Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) | 9h25 | 6:00 AM Plzeň, Centrální Autobusové Nádraží | 1 transfer | |
(Amsterdam -> Prague) | 10:30 PM Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) | 4h55 | 3:25 AM Plzeň, Centrální Autobusové Nádraží | 0 transfersDirect | |
| Tuesday, November 3 | |||||
![]() | 8:40 AM Frankfurt am Main | 7h00 | 3:40 PM Plzeň | 0 transfersDirect | |
![]() | 9:40 AM Frankfurt am Main | 7h00 | 4:40 PM Plzeň | 0 transfersDirect | |
Find all the dates and times for this journey
Buses from Frankfurt am Main to Plzeň with FlixBus. Overnight buses available on this route with FlixBus. Use the details below to compare onboard facilities.
Review the details behind your booking, from operators and ticket rules to luggage, onboard amenities, accessibility, and route-specific travel policies.
Discover the best of Plzeň — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Plzeň trip today.
Modern interactive brewery museum in a 15th-century malt house, explaining beer-making history and daily life in old Plzeň.
Major regional museum with archaeology, applied arts, weapons and civic history, housed in a remarkable historic building.
Popular puppetry museum in the old town presenting Czech marionette traditions, stagecraft and family-friendly exhibits.
Plzeň’s main square, lined with major monuments and colorful facades. The essential starting point for exploring the historic center.
Historic pedestrian street linking the station area with the center, valued for architecture, shops and an everyday city atmosphere.
Large urban park with mature trees, paths and open lawns. A favorite local place for walks close to the old town.
Bottom-fermented pale lager first brewed in Plzeň in 1842. Its soft water, Saaz hops, and triple decoction made the city world-famous.
Crisp fried cheese, usually Edam, served with tartar sauce and potatoes. A classic Czech pub meal commonly eaten in Plzeň.
Beef goulash slow-cooked with onions and paprika, often served with bread dumplings. A staple in Czech beer halls across Plzeň.
Refined fine dining with seasonal tasting menus, polished service, and a modern setting inside Hotel Rous.
Historic brewery restaurant beside Pilsner Urquell. Best for unfiltered tank beer and classic Czech dishes in a lively traditional setting.
Traditional Plzeň beer hall known for Pilsner Urquell, hearty Czech meals, and a classic local pub atmosphere.
Moderate for Czech city travel: hotels, dining, and transit are usually cheaper than Prague, but tourist areas and brewery venues can cost more.
Tip about 5-10% in restaurants if service is good, often by rounding up. Round up small taxi fares. In cafes, small change or rounding up is common.
Official public transport app
Plzeň, Centrální Autobusové Nádraží -> Náměstí Republiky, Plzeň
Get destination-focused answers for the end of your trip, including what to do, when to go, practical entry details, and tips for making the most of your time in Plzeň.
Find answers to the most common questions about traveling from Frankfurt am Main to Plzeň by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Plzeň, this guide helps you travel smarter and with confidence.

Most Frankfurt am Main to Plzeň buses use the Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) to Plzeň, Centrální Autobusové Nádraží station pair. Use this guide to compare Frankfurt am Main and Plzeň bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) is 10 km from Frankfurt am Main city centre. Public transport options include:
Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, and Ticket Office.
Food options include: McDonald's (in the station), Hausmann's (in the station).
Free Wi-Fi. ATMs are located throughout the terminal, offering various banking services.
Ticket office support is available at Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36).
Available at Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36): Parking, Taxis, WC.
Accessibility facilities are available at Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36): Elevators, ramps, assistance.