- Must visit
Buffalo AKG Art Museum
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
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Cheapest price
$174
Average price
$192
Fastest journey
20h 40m
Average duration
22h 5m
Buses per day
5
Distance
867 km
Omio recommends booking the train as it is the most popular option from Charlotte, NC to Buffalo, NY among Omio's users. If you are prioritising price take the bus with prices starting from $102. For those with little time consider booking a flight which can get you there in 2h 54m. In case you are seeking to minimise your carbon footprint the train is your best bet as it emits only 0.3 - 0.8kg. The ticket price range depends on the travel mode: a bus costs an average of $102, and a flight costs an average of $300.
Distance: 539 miles (868 km)
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$187 Average price Cheapest | $294 Average price | $433 Average price | $143 Average price (fuel + tolls) |
22h 14m Average total duration 21h 44m Onboard + 30m Additional time* | 22h 36m Average total duration 22h 6m Onboard + 30m Additional time* | 5h 54m Average total duration Fastest 2h 54m Onboard + 3h 0m Additional time* | 9h 50m Average total duration (door-to-door) |
0.9 - 2.2kg CO2 emissions | 0.3 - 0.8kg CO2 emissions Lowest | 2.6 - 5.2kg CO2 emissions | - CO2 emissions |
![]() Most popular bus company | ![]() Most popular train company | ![]() Most popular airline | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Charlotte, NC to Buffalo, NY:
A bus is $107 (€88) less than a train for this route with tickets for a train from Charlotte, NC to Buffalo, NY costing on average $294 (€241).
A bus is $246 (€202) less than a flight for this route with tickets for a flight from Charlotte, NC to Buffalo, NY costing on average $433 (€355).
Other travel options to Buffalo, NY take longer:
Bus takes on average 21h 44m.
Train takes on average 22h 6m.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator Greyhound | Departure Time 02:35AM | Arrival Time 05:00AM | Duration 26h25 | Departure days Everyday | Cheapest price $135 |
Operator Greyhound | Departure Time 06:55AM | Arrival Time 04:45PM | Duration 33h50 | Departure days Wed | Cheapest price $163 |
Operator Greyhound | Departure Time 09:20AM | Arrival Time 08:25AM | Duration 23h05 | Departure days Everyday | Cheapest price $138 |
Operator Greyhound | Departure Time 06:05PM | Arrival Time 04:40PM | Duration 22h35 | Departure days Everyday | Cheapest price $139 |
Operator Greyhound | Departure Time 09:50PM | Arrival Time 06:50PM | Duration 21h00 | Departure days Everyday | Cheapest price $147 |
Operator FlixBus | Departure Time 11:35PM | Arrival Time 05:00AM | Duration 29h25 | Departure days Everyday | Cheapest price $171 |
The table below shows live departures for Charlotte, NC to Buffalo, NY buses for today, Wednesday, July 15. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
+ FlixBus | 6:05 PM Charlotte, W 4th St (Greyhound Bus Station) | 22h55 | 5:00 PM Buffalo, NFTA Metro Center | 1 transfer | |
+ FlixBus | 6:05 PM Charlotte, W 4th St (Greyhound Bus Station) | 22h35 | 4:40 PM Cheektowaga, BNIA Drway & BNIA Terminal | 1 transfer | |
· + FlixBus | 9:50 PM Charlotte, W 4th St (Greyhound Bus Station) | 21h00 | 6:50 PM Buffalo, NFTA Metro Center | 2 transfers | |
· + FlixBus | 9:50 PM Charlotte, W 4th St (Greyhound Bus Station) | 20h40 | 6:30 PM Cheektowaga, BNIA Drway & BNIA Terminal | 2 transfers | |
FlixBus · FlixBus+ · | 11:35 PM Charlotte, W 4th St (Greyhound Bus Station) | 23h15 | 10:50 PM Buffalo, NFTA Metro Center | 3 transfers | |
+ FlixBus · FlixBus | 2:35 AM Charlotte, W 4th St (Greyhound Bus Station) | 26h25 | 5:00 AM Buffalo, NFTA Metro Center | 2 transfers | |
· + FlixBus | 2:35 AM Charlotte, W 4th St (Greyhound Bus Station) | 26h05 | 4:40 AM Cheektowaga, BNIA Drway & BNIA Terminal | 2 transfers | |
· + FlixBus | 9:20 AM Charlotte, W 4th St (Greyhound Bus Station) | 23h25 | 8:45 AM Buffalo, NFTA Metro Center | 2 transfers | |
· + FlixBus | 9:20 AM Charlotte, W 4th St (Greyhound Bus Station) | 23h05 | 8:25 AM Cheektowaga, BNIA Drway & BNIA Terminal | 2 transfers | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Buses from Charlotte, NC to Buffalo, NY run on average 15 times per day, taking around 21h 44m. Cheap bus tickets for this journey start at $102 (€84) if you book in advance.
The earliest bus runs at 00:55, the last at 23:55. The fastest bus covers the 539 miles (868 km) distance in 21h 5m.
Distance 539 miles (868 km) |
Average bus duration 21h 44m |
Cheapest ticket price $102 (€84) |
Buses per day 15 |
Fastest bus 21h 5m |
First bus 12:55 AM |
Last bus 11:55 PM |
Cheapest Month Sep |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Sat |
Best time to book 14 days |
Discover the best of Buffalo, NY — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Buffalo, NY trip today.
Major regional art museum with modern, contemporary, and historic works, plus a growing campus and frequent exhibitions.
Former presidential inaugural site with exhibits on Theodore Roosevelt, the Pan-American Exposition, and Buffalo politics.
Community museum preserving Buffalo’s African American heritage through local history, culture, and rotating exhibitions.
Waterfront district with canal history, public art, seasonal events, skating, and frequent family-friendly activities downtown.
Lively walkable neighborhood known for boutiques, galleries, architecture, and one of Buffalo’s most popular main streets.
Long urban trail and greenway connecting waterfront areas, parks, and neighborhoods for walking, biking, and sightseeing.
Crisp fried chicken wings coated in spicy butter-hot sauce. Created in Buffalo, they are the city’s signature bar food and a must-try local classic.
Thin-sliced roast beef on a kummelweck roll topped with coarse salt and caraway, usually dipped in jus. It is a longtime Western New York sandwich staple.
Slow-cooked bean soup with ham, tomatoes, and vegetables. It is strongly associated with Buffalo’s old taverns and Friday lunch traditions.
Refined fine-dining restaurant known for seasonal New American tasting menus, polished service, and an elegant special-occasion atmosphere.
Traditional German restaurant celebrated for beef on weck, sausages, and old-world charm. A Buffalo dining landmark with a cozy historic feel.
Long-standing wing institution known for crispy, saucy chicken wings in a classic neighborhood bar setting with a devoted local following.
Moderate for U.S. city travel; hotels are often cheaper than NYC, while dining and local transit stay fairly manageable for visitors.
Tip 18-20% at restaurants, more for great service. Taxis usually 10-15%. For cafes, round up or add $1 per drink.
Find answers to the most common questions about traveling from Charlotte, NC to Buffalo, NY by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Buffalo, NY, this guide helps you travel smarter and with confidence.

Most Charlotte, NC to Buffalo, NY buses use the Charlotte, W 4th St (Greyhound Bus Station) to Buffalo, NFTA Metro Center station pair, with some services arriving at Cheektowaga, BNIA Drway & BNIA Terminal. Use this guide to compare Charlotte, NC and Buffalo, NY bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Here are some other resources that might have the information you need