Travel Information
Compare bus, train, and flight for Wiesbaden to Prague
Omio recommends booking the train as it is the most popular option from Wiesbaden to Prague among Omio's users. If you are prioritising price, take the bus, with an average ticket price of zł 314 For those with little time, consider booking a flight, which has an average total journey time of 4h 46m. If you are seeking to minimise your carbon footprint, the train is your best option, with estimated CO2 emissions of 0.1 - 0.4kg. Average ticket prices depend on the travel mode: a bus costs an average of zł 314, while a flight costs an average of zł 1,680.
Distance: 273 miles (440 km)
Compare train with
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
zł 571 Average price | zł 1,680 Average price | zł 314 Average price Cheapest | zł 412 Average price (fuel + tolls) |
8h 8m Average total duration 7h 38m Onboard + 30m Additional time* | 4h 46m Average total duration Fastest 2h 46m Onboard + 2h 0m Additional time* | 14h 16m Average total duration 13h 46m Onboard + 30m Additional time* | 5h 41m Average total duration (door-to-door) |
0.1 - 0.4kg CO2 emissions Lowest | 1.3 - 2.6kg CO2 emissions | 0.4 - 1.1kg CO2 emissions | - CO2 emissions |
![]() Most popular train company | ![]() Most popular airline | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
Compare ways to travel from Wiesbaden to Prague
Compare the available ways to get from Wiesbaden to Prague, with the key details around price, speed, convenience, and direct service.
This is compared to other travel options from Wiesbaden to Prague:
A bus is zł 257 less than a train for this route with tickets for a train from Wiesbaden to Prague costing on average zł 571.
A bus is zł 1,367 less than a flight for this route with tickets for a flight from Wiesbaden to Prague costing on average zł 1,680.
Other travel options to Prague take longer:
Train takes on average 8h 8m.
Bus takes on average 14h 16m.
Tickets start at around zł 571 compared to roughly zł 412 in fuel and tolls — a saving of about -zł 159. The journey takes 7h 38m versus 5h 41m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Travel optionsfrom Wiesbaden to Prague
How to get from Wiesbaden to Prague by train, bus or flight.
Our recommendation
The best way to travel from Wiesbaden to Prague is by taking a bus because it’s the best combination of price and speed.
(Amsterdam -> Prague)10:30 PM 6h18 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 4:48 AM Praha, ÚAN Florenc zł 188 1 One-way 0 transfers
Cheapest
(Amsterdam -> Prague)10:30 PM 6h18 Frankfurt, Stuttgarter Straße (Fermomnibusbahnhof) 4:48 AM Praha, ÚAN Florenc zł 188 1 One-way 0 transfers
Fastest
DE44099:55 AM 1h00 Frankfurt am Main Airport 10:55 AM Prague Vaclav Havel Airport zł 813 1 One-way 0 transfers
Other options
VIA 25007 · ICE 1557 · rj 3838:32 AM 8h53 Wiesbaden Hbf 5:25 PM Prague hlavní nádraží zł 531 1 One-way 2 transfers
ICE 1557 · rj 3838:26 AM 8h59 Wiesbaden Hbf 5:25 PM Prague hlavní nádraží zł 531 1 One-way 1 transfer
ICE 1557 · RJ 3838:26 AM 8h59 Wiesbaden Hbf 5:25 PM Prague hlavní nádraží zł 629 1 One-way 1 transfer
(Amsterdam -> Prague)10:00 PM 6h48 Frankfurt am Main, Flughafen Frankfurt (Terminal 1 - Busparkplatz P36) 4:48 AM Praha, ÚAN Florenc zł 188 1 One-way 0 transfers
FlixBus · FlixBus4:35 AM 15h25 Wiesbaden, Busbahnhof 8:00 PM Praha, M. Horákové (Hradčanská) zł 305 1 One-way 1 transfer
FlixBus · FlixBus1:10 PM 14h05 Wiesbaden, Busbahnhof 3:15 AM Prague, Central Train Station zł 308 1 One-way 1 transfer
DE44118:10 PM 1h00 Frankfurt am Main Airport 9:10 PM Prague Vaclav Havel Airport zł 813 1 One-way 0 transfers
LO382 · LO52110:35 AM 6h40 Frankfurt am Main Airport 5:15 PM Prague Vaclav Havel Airport zł 1,095 1 One-way 1 transfer
LO382 · LO52510:35 AM 8h20 Frankfurt am Main Airport 6:55 PM Prague Vaclav Havel Airport zł 1,095 1 One-way 1 transfer
Find all the dates and times for this journey by train, bus, flight, and ferry .
Compare prices and tickets Prices for trains, buses and flights
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FAQs: Travel from Wiesbaden to Prague
Travel to Prague easily. Whether you want fast, cheap or something entirely different, our travel experts have collected everything you need to know so you can find the best option from Wiesbaden to Prague.

This is compared to other travel options from Wiesbaden to Prague:
A bus is zł 257 less than a train for this route with tickets for a train from Wiesbaden to Prague costing on average zł 571.
A bus is zł 1,367 less than a flight for this route with tickets for a flight from Wiesbaden to Prague costing on average zł 1,680.
Other travel options to Prague take longer:
Train takes on average 8h 8m.
Bus takes on average 14h 16m.
- Around 59 flights per day.
- Around 8 trains per day.
- Around 5 buses per day.
However, we recommend checking specific travel dates for your route between Wiesbaden and Prague as scheduled services by bus, train, and flight can vary by season or day of the week.
- Flights mostly depart from Frankfurt am Main Airport and arrive in Prague Vaclav Havel Airport.
- Trains mostly depart from Wiesbaden Hbf and arrive in Prague hlavní nádraží.
- Buses mostly depart from Wiesbaden, Busbahnhof and arrive in Praha, ÚAN Florenc.
- Travel with Lufthansa, KLM, Lot Polish Airlines, Turkish Airlines, Condor Flugdienst, Eurowings, British Airways, Austrian Airlines, Swiss, Air Baltic, KLM Cityhopper, Qatar Airways, Lufthansa City Airlines, Air Dolomiti, Lufthansa Cityline, Brussels Airlines, Helvetic Airways, Smartwings, Edelweiss Air to go to Prague by flight.
- Travel with FlixBus to go to Prague by bus.
- Travel with České dráhy, Deutsche Bahn, alex-Länderbahn und Vogtlandbahn-GmbH, Leo Express to go to Prague by train.
- 8 direct flights per day with Lufthansa, Condor Flugdienst, Air Dolomiti, Smartwings.
- 0 direct trains per day with Leo Express.
Travelling from Wiesbaden to Prague: related information
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