Travel Information
Compare flight and train for San Isidro to Madrid
Omio recommends booking the train as it is the most popular option from San Isidro to Madrid among Omio's users. If you are prioritising price take the train with prices starting from €9. For those with little time consider booking a flight which can get you there in 1h 20m. The ticket price range depends on the travel mode: a train costs an average of €9, and a flight costs an average of €21.
Distance: 218 miles (351 km)
Compare train with
Most popular Train | Flight |
|---|---|
€17 Average price Cheapest | €55 Average price |
3h 51m Average total duration 3h 21m Onboard + 30m Additional time* | 4h 20m Average total duration Fastest 1h 20m Onboard + 3h 0m Additional time* |
![]() Most popular train company | ![]() Most popular airline |
Direct Options | Direct Options |
Live departures
San Isidro to Madrid train times
The table below shows live departures for San Isidro to Madrid trains for today, Wednesday, December 31. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 11:02 AM San Isidro | 2h21 | 1:23 PM Madrid | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets San Isidro to Madrid by flight or train
Compare flight and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jan 01
Jan 02
Jan 03
Jan 04
Jan 05
Jan 06
Jan 07
Why should you book San Isidro to Madrid trains with Omio?
AVE as well as iryo and Renfe AVLO offer trains services from San Isidro to Madrid. Omio is an official ticket reseller for all your travel options from San Isidro to Madrid.
Why book with Omio vs AVE?
- Compare with other providers: On Omio, you can not only buy tickets for AVE, but also compare tickets for the likes of iryo and Renfe AVLO to find the best option for your trip from San Isidro to Madrid.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare AVE with all available travel options, which are flight and train to ensure you get the best deal for traveling from San Isidro to Madrid.
Why book with Omio over Trainline and Rail Europe?
- Multiple travel company options: While AVE tickets can be bought on AVE's website or third party sellers, Omio allows you to compare with the likes of iryo and Renfe AVLO to help you choose the right option for your journey from San Isidro to Madrid.
- Multiple modes of transport: Omio allows you to compare travel options including flight and train to find the ideal travel option from San Isidro to Madrid.
Journey information
Overview: Train from San Isidro to Madrid
Trains from San Isidro to Madrid run on average 3 times per day, taking around 3h 21m. Cheap train tickets for this journey start at $11 (€9) if you book in advance.
There are 3 trains per day. The earliest train runs at 06:15, the last at 21:02. The fastest train covers the 218 miles (351 km) distance in 2h 21m.
Distance 218 miles (351 km) |
Average train duration 3h 21m |
Cheapest ticket price $11 (€9) |
Trains per day 3 |
Direct trains 3 |
Fastest train 2h 21m |
First train 06:15 |
Last train 21:02 |
Train companies: AVE, iryo, Renfe AVLO from San Isidro to Madrid trainsAVE, iryo, Renfe AVLO trains will get you between San Isidro and Madrid from $11 (€9). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
AVE
iryo
Renfe AVLO
FAQs: Trains from San Isidro to Madrid
Find answers to the most common questions about traveling from San Isidro to Madrid by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Madrid, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from San Isidro to Madrid
Most popular train connections from San Isidro
More options for your journey from San Isidro to Madrid
Here are some other resources that might have the information you need



