- Must visit
Pinacoteca di Brera
One of Milan’s premier art museums, known for masterpieces by Raphael, Caravaggio, and Mantegna in the historic Brera district.
Cheapest price
$55
Average price
$107
Fastest journey
3 h 32 m
Average duration
3 h 45 m
Trains per day
14
Distance
481 km
The best way to find a cheap train ticket from Rome Ostiense to Milan Centrale is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome Ostiense to Milan Centrale will cost around $107 if you buy it on the day, but the cheapest tickets can be found for only $55.
Of the 14 trains that leave Rome Ostiense for Milan Centrale on Sun, Jun 21, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Jun 21 the direct trains cover the 481 km distance in an average of 3 h 45 m but if you time it right, some trains will get you there in just 3 h 32 m .
On Sun, Jun 21 the slowest trains will take 3 h 52 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
Regionale Veloce 4134 · Regionale 2296
Intercity 1588
Intercity 596
Intercity 590
InterCityNotte 796+
Intercity 652
Regionale 4507+
FRECCIAROSSA 9620
Regionale 12545+
FRECCIAROSSA 9640
Regionale 12505+
FRECCIAROSSA 9612
Regionale 12551+
FRECCIAROSSA 9650
Regionale 12511+
FRECCIAROSSA 9618Omio recommends booking the train as it is the most popular option from Rome Ostiense to Milan Centrale among Omio's users. If you are prioritising price take the bus with prices starting from $9. For those with little time consider booking a flight which can get you there in 1h 18m. The ticket price range depends on the travel mode: a bus costs an average of $9, and a flight costs an average of $62.
Distance: 298 miles (481 km)
Most popular Train | Bus | Flight | Driving |
|---|---|---|---|
$56 Average price | $18 Average price Cheapest | $132 Average price | $174 Average price (fuel + tolls) |
6h 10m Average total duration 5h 40m Onboard + 30m Additional time* | 8h 29m Average total duration 7h 59m Onboard + 30m Additional time* | 4h 18m Average total duration Fastest 1h 18m Onboard + 3h 0m Additional time* | 6h 25m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Rome Ostiense to Milan Centrale:
A bus is $39 (€32) less than a train for this route with tickets for a train from Rome Ostiense to Milan Centrale costing on average $56 (€46).
A bus is $115 (€94) less than a flight for this route with tickets for a flight from Rome Ostiense to Milan Centrale costing on average $132 (€108).
Other travel options to Milan Centrale take longer:
Train takes on average 5h 40m.
Bus takes on average 7h 59m.
The journey is about 45m faster (5h 40m by train vs 6h 25m by car) and roughly $118 (€96) cheaper once you factor in fuel and tolls ($56 (€46) vs $174 (€142)). You'll also arrive in the city centre rather than hunting for parking, and you can work, read, or watch the landscape go by instead of concentrating on the road.
Direct services run with Intercity.
Driving is still worth considering if you want to stop along the way or need a car once you arrive.
The table below shows live departures for Rome Ostiense to Milan Centrale trains for tomorrow, Sunday, June 21. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
InterCityNotte 796+ Intercity 652 | 12:15 AM Rome Ostiense | 8h10 | 8:25 AM Milan Centrale | 1 transfer | |
Regionale 12505+ FRECCIAROSSA 9612 | 7:08 AM Rome Ostiense | 3h50 | 10:58 AM Milan Centrale | 1 transfer | |
Regionale 12511+ FRECCIAROSSA 9618 | 8:06 AM Rome Ostiense | 3h52 | 11:58 AM Milan Centrale | 1 transfer | |
Regionale 4507+ FRECCIAROSSA 9620 | 8:52 AM Rome Ostiense | 3h32 | 12:24 PM Milan Centrale | 1 transfer | |
Regionale 12517+ FRECCIAROSSA 9414 · FRECCIAROSSA 9806 | 9:07 AM Rome Ostiense | 4h18 | 1:25 PM Milan Centrale | 2 transfers | |
Intercity 590 | 11:37 AM Rome Ostiense | 9h38 | 9:15 PM Milan Centrale | 0 transfersDirect | |
Regionale 12545+ FRECCIAROSSA 9640 | 1:52 PM Rome Ostiense | 3h38 | 5:30 PM Milan Centrale | 1 transfer | |
Regionale Veloce 4134 · Regionale 2296 | 2:08 PM Rome Ostiense | 9h14 | 11:22 PM Milan Centrale | 1 transfer | |
Intercity 596 | 3:11 PM Rome Ostiense | 8h06 | 11:17 PM Milan Centrale | 0 transfersDirect | |
Regionale 12551+ FRECCIAROSSA 9650 | 4:07 PM Rome Ostiense | 3h51 | 7:58 PM Milan Centrale | 1 transfer | |
Intercity 1588 | 4:37 PM Rome Ostiense | 7h38 | 12:15 AM Milan Centrale | 0 transfersDirect | |
Regionale 12555+ FRECCIAROSSA 9660 | 5:36 PM Rome Ostiense | 3h54 | 9:30 PM Milan Centrale | 1 transfer | |
Regionale 12557+ FRECCIAROSSA 9668 | 7:07 PM Rome Ostiense | 3h53 | 11:00 PM Milan Centrale | 1 transfer | |
InterCityNotte 798 · InterCityNotte 752 | 11:51 PM Rome Ostiense | 7h24 | 7:15 AM Milan Centrale | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Rome Ostiense to Milan Centrale run on average 30 times per day, taking around 5h 40m. Cheap train tickets for this journey start at $23 (€19) but you can travel from only $9 (€7) by bus.
There are 1 trains per day. The earliest train runs at 09:23, the last at 22:52. The fastest train covers the 298 miles (481 km) distance in 7h 18m.
Distance 298 miles (481 km) |
Average train duration 5h 40m |
Cheapest ticket price $23 (€19) |
Trains per day 30 |
Direct trains 1 |
Fastest train 7h 18m |
First train 9:23 AM |
Last train 10:52 PM |
Cheapest Month May |
Cheapest Day Sat |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Sat |
Least Busy Day Wed |
Discover the best of Milano Centrale — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Milano Centrale trip today.
One of Milan’s premier art museums, known for masterpieces by Raphael, Caravaggio, and Mantegna in the historic Brera district.
Italy’s largest science museum, featuring Leonardo-inspired displays, transport collections, and interactive exhibits in a former monastery.
A major museum of 20th-century Italian art facing Piazza del Duomo, especially noted for Futurist works and its central location.
Milan’s central square and the city’s main gathering point, ideal for first-time visitors and iconic city views.
A charming historic district known for elegant streets, art atmosphere, boutiques, and a classic Milanese walking experience.
Milan’s canal district, very popular for waterside walks, photos, and lively urban atmosphere, especially in the evening.
Milan’s signature saffron risotto, rich with butter and cheese, celebrated for its golden color and elegant, comforting flavor.
A classic Milanese breaded veal cutlet, traditionally cooked in butter and prized as one of the city’s most iconic dishes.
Braised veal shank, often served with risotto alla Milanese, valued for its tender meat and rich marrow-filled sauce.
Long-standing fine dining destination and one of Milan’s best-known vegetarian restaurants, refined and creative in style.
Well-known Milanese restaurant with a modern approach to Lombard classics such as risotto and mondeghili in a stylish setting.
Historic traditional trattoria known for classic Milanese dishes, old-world atmosphere, and a strong local reputation.
Prices are above the Italian average, especially near the station. Casual meals are manageable, but hotels and sit-down dining cost more.
Service is often included or covered by a coperto. Tipping is not mandatory; round up or leave EUR 1-5 for good service. Taxis can be rounded up.
Official public transport app
Milano Centrale, Milan -> Duomo di Milano, Milan
Find answers to the most common questions about traveling from Rome Ostiense to Milan Centrale by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Milan Centrale, this guide helps you travel smarter and with confidence.

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