The cheapest and fastest trains from Rome Ostiense to Florence Santa Maria Novella
Cheapest price
$19
Average price
$26
Fastest journey
4 h 9 m
Average duration
4 h 36 m
Trains per day
5
Distance
235 km
The best way to find a cheap train ticket from Rome Ostiense to Florence Santa Maria Novella is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Rome Ostiense to Florence Santa Maria Novella will cost around $26 if you buy it on the day, but the cheapest tickets can be found for only $19.
Of the 5 trains that leave Rome Ostiense for Florence Santa Maria Novella on Tue, Dec 23, 5 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Tue, Dec 23 the direct trains cover the 235 km distance in an average of 4 h 36 m but if you time it right, some trains will get you there in just 4 h 9 m .
On Tue, Dec 23 the slowest trains will take 5 h 17 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.










Rome Ostiense - Florence Santa Maria NovellaCompare Frecciarossa, Regionale, Intercity



Travel Information
Compare train, bus, and flight for Rome Ostiense to Florence Santa Maria Novella
Omio recommends booking the train as it is the most popular option from Rome Ostiense to Florence Santa Maria Novella among Omio's users. If you are prioritising price take the bus with prices starting from €6. For those with little time consider booking a flight which can get you there in 55m. The ticket price range depends on the travel mode: a bus costs an average of €6, and a flight costs an average of €73.
Distance: 146 miles (235 km)
Compare train with
Most popular Train | Bus | Flight |
|---|---|---|
€23 Average price | €9 Average price Cheapest | €167 Average price |
3h 26m Average total duration 2h 56m Onboard + 30m Additional time* | 3h 56m Average total duration 3h 26m Onboard + 30m Additional time* | 3h 55m Average total duration Fastest 55m Onboard + 3h 0m Additional time* |
![]() Most popular train company | ![]() Most popular bus company | ![]() Most popular airline |
Direct Options | Direct Options | Direct Options |
Live departures
Rome Ostiense to Florence Santa Maria Novella train times
The table below shows live departures for Rome Ostiense to Florence Santa Maria Novella trains for today, Monday, December 22. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 12577+ FRECCIAROSSA 8506 | 7:22 AM Rome Ostiense | 2h05 | 9:27 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 20589 · Regionale Veloce 4100 | 7:31 AM Rome Ostiense | 6h17 | 1:48 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20593+ FRECCIAROSSA 9520 | 7:46 AM Rome Ostiense | 2h00 | 9:46 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 20595+ FRECCIAROSSA 1000 9308 | 8:01 AM Rome Ostiense | 2h00 | 10:01 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 12571+ FRECCIAROSSA 9414 | 8:07 AM Rome Ostiense | 2h04 | 10:11 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 20599+ FRECCIAROSSA 8508 | 8:31 AM Rome Ostiense | 1h56 | 10:27 AM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4125+ FRECCIAROSSA 9524 | 8:37 AM Rome Ostiense | 2h09 | 10:46 AM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4125+ Intercity 588+ Regionale 18222 | 8:37 AM Rome Ostiense | 4h15 | 12:52 PM Florence Santa Maria Novella | 2 transfers | |
Intercity 510+ Regionale Veloce 4034 | 9:07 AM Rome Ostiense | 3h54 | 1:01 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12523+ FRECCIAROSSA 1000 9416 | 9:07 AM Rome Ostiense | 2h04 | 11:11 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 20621+ FRECCIAROSSA 1000 8509 | 9:31 AM Rome Ostiense | 1h56 | 11:27 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 20621 · Regionale Veloce 4100 | 9:31 AM Rome Ostiense | 4h17 | 1:48 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12529+ FRECCIAROSSA 1000 9514 | 9:39 AM Rome Ostiense | 2h07 | 11:46 AM Florence Santa Maria Novella | 1 transfer | |
Regionale 12531+ FRECCIAROSSA 1000 8418 | 10:07 AM Rome Ostiense | 2h04 | 12:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20635 · Regionale 18720 · Regionale Veloce 4102 | 10:31 AM Rome Ostiense | 5h17 | 3:48 PM Florence Santa Maria Novella | 2 transfers | |
ETRUSCHI LINE 4129+ FRECCIAROSSA 9532 | 10:37 AM Rome Ostiense | 2h09 | 12:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20639+ Intercity 590+ Regionale 18226 | 11:01 AM Rome Ostiense | 3h51 | 2:52 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 12537+ FRECCIAROSSA 1000 9420 | 11:07 AM Rome Ostiense | 2h04 | 1:11 PM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4132 · Tuscany Line 4044 | 11:23 AM Rome Ostiense | 5h10 | 4:33 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20643 · Regionale Veloce 4104 | 11:31 AM Rome Ostiense | 6h17 | 5:48 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12539+ FRECCIAROSSA 9584 | 11:39 AM Rome Ostiense | 2h07 | 1:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12541+ FRECCIAROSSA 9422 | On time 12:07 PM Rome Ostiense | 2h04 | 2:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20653 · Regionale Veloce 4104 | 12:31 PM Rome Ostiense | 5h17 | 5:48 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12543+ FRECCIAROSSA 9540 | 12:39 PM Rome Ostiense | 2h07 | 2:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20659 · Regionale Veloce 4730 · Regionale Veloce 4104 | 1:01 PM Rome Ostiense | 4h47 | 5:48 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 12545+ FRECCIAROSSA 1000 9423 | 1:07 PM Rome Ostiense | 2h04 | 3:11 PM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4134 · Tuscany Line 4052 | 1:23 PM Rome Ostiense | 5h10 | 6:33 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20665+ FRECCIAROSSA 8520 | 1:31 PM Rome Ostiense | 1h56 | 3:27 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12547+ FRECCIAROSSA 9544 | 1:39 PM Rome Ostiense | 2h07 | 3:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20671+ Intercity 596+ Regionale 18236 | 2:01 PM Rome Ostiense | 4h51 | 6:52 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 12549+ FRECCIAROSSA 9426 | 2:07 PM Rome Ostiense | 2h04 | 4:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20677 · Regionale Veloce 4106 | 2:46 PM Rome Ostiense | 5h09 | 7:55 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20677+ FRECCIAROSSA 9588 | 2:46 PM Rome Ostiense | 2h00 | 4:46 PM Florence Santa Maria Novella | 1 transfer | |
Intercity 518+ TUSCANY LINE 4056 | 3:07 PM Rome Ostiense | 3h54 | 7:01 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12551+ FRECCIAROSSA 9428 | 3:07 PM Rome Ostiense | 2h04 | 5:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20683+ FRECCIAROSSA 8524 | 3:31 PM Rome Ostiense | 1h56 | 5:27 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12585+ FRECCIAROSSA 9552 | 3:40 PM Rome Ostiense | 2h06 | 5:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20687 · Regionale Veloce 4106 | 4:01 PM Rome Ostiense | 3h54 | 7:55 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12553+ FRECCIAROSSA 1000 9430 | 4:07 PM Rome Ostiense | 2h04 | 6:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20693+ FRECCIAROSSA 1000 8526 | 4:31 PM Rome Ostiense | 1h56 | 6:27 PM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4133+ Intercity 598 | 4:37 PM Rome Ostiense | 4h23 | 9:00 PM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4133+ FRECCIAROSSA 1000 9556 | 4:37 PM Rome Ostiense | 2h09 | 6:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20703+ FRECCIAROSSA 1000 9326 | 5:01 PM Rome Ostiense | 2h00 | 7:01 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20707 · Regionale Veloce 4158+ Intercity 598 | 5:16 PM Rome Ostiense | 3h44 | 9:00 PM Florence Santa Maria Novella | 2 transfers | |
Regionale 20711+ FRECCIAROSSA 1000 8528 | 5:31 PM Rome Ostiense | 1h56 | 7:27 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20711 · Regionale Veloce 4110 | 5:31 PM Rome Ostiense | 5h19 | 10:50 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 4511+ FRECCIAROSSA 1000 9560 | 5:39 PM Rome Ostiense | 2h07 | 7:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20717+ FRECCIAROSSA 9328 | 6:01 PM Rome Ostiense | 2h00 | 8:01 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12573+ FRECCIAROSSA 1000 9434 | 6:07 PM Rome Ostiense | 2h04 | 8:11 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20721+ FRECCIAROSSA 1000 9330 | 6:31 PM Rome Ostiense | 1h56 | 8:27 PM Florence Santa Maria Novella | 1 transfer | |
ETRUSCHI LINE 4135+ FRECCIAROSSA 9592 | 6:37 PM Rome Ostiense | 2h09 | 8:46 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 21371 · Regionale Veloce 4110 | 6:55 PM Rome Ostiense | 3h55 | 10:50 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 12561+ FRECCIAROSSA 1000 9568 | 7:37 PM Rome Ostiense | 2h21 | 9:58 PM Florence Santa Maria Novella | 1 transfer | |
Regionale 20735+ FRECCIAROSSA 1000 9674 | 8:16 PM Rome Ostiense | 2h04 | 10:20 PM Florence Santa Maria Novella | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Rome Ostiense to Florence Santa Maria Novella by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Why should you book Rome Ostiense to Florence Santa Maria Novella trains with Omio?
Italo as well as Frecciarossa, Regionale and Intercity Notte offer trains services from Rome Ostiense to Florence Santa Maria Novella. Omio is an official ticket reseller for all your travel options from Rome Ostiense to Florence Santa Maria Novella.
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Regionale and Intercity Notte to find the best option for your trip from Rome Ostiense to Florence Santa Maria Novella.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Rome Ostiense to Florence Santa Maria Novella.
Why book with Omio over Trainline and Rail Europe?
- Multiple travel company options: While Italo tickets can be bought on Italo's website or third party sellers, Omio allows you to compare with the likes of Frecciarossa, Regionale and Intercity Notte to help you choose the right option for your journey from Rome Ostiense to Florence Santa Maria Novella.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Rome Ostiense to Florence Santa Maria Novella.
Journey information
Overview: Train from Rome Ostiense to Florence Santa Maria Novella
Trains from Rome Ostiense to Florence Santa Maria Novella run on average 50 times per day, taking around 2h 56m. Cheap train tickets for this journey start at $17 (€14) but you can travel from only $7 (€6) by bus.
The earliest train runs at 04:23, the last at 17:37. The fastest train covers the 146 miles (235 km) distance in 3h 4m.
Distance 146 miles (235 km) |
Average train duration 2h 56m |
Cheapest ticket price $17 (€14) |
Trains per day 50 |
Fastest train 3h 4m |
First train 04:23 |
Last train 17:37 |
Train companies: Italo, Frecciarossa, Regionale, Intercity Notte, Intercity, Frecciargento from Rome Ostiense to Florence Santa Maria Novella trainsItalo, Frecciarossa, Regionale, Intercity Notte, Intercity, Frecciargento trains will get you between Rome Ostiense and Florence Santa Maria Novella from $7 (€6). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
Frecciarossa
Regionale
Intercity Notte
Intercity
Frecciargento
FAQs: Trains from Rome Ostiense to Florence Santa Maria Novella
Find answers to the most common questions about traveling from Rome Ostiense to Florence Santa Maria Novella by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Florence Santa Maria Novella, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Rome Ostiense to Florence Santa Maria Novella
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- Parking is available near the station with both short-term and long-term options.
- Ramen Bar Akira
- Eataly Roma
- Outside the main entrance.
- Elevators, ramps, restrooms.
- €1
- Hotel Abitart
- Hotel San Anselmo
- Hotel Villa San Pio
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platforms 1-5 for regional and intercity trains
- Hall 2: platforms 6-11 for metropolitan services
- Metro: Line B
- Bus: Several lines available
- Tram: Line 3
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
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