The cheapest and fastest trains from Mestre to Siena
Cheapest price
$58
Average price
$58
Fastest journey
4 h 18 m
Average duration
4 h 18 m
Trains per day
1
Distance
252 km
The best way to find a cheap train ticket from Mestre to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Siena will cost around $58 if you buy it on the day, but the cheapest tickets can be found for only $58.
Of the 1 trains that leave Mestre for Siena on Fri, May 08, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Fri, May 08 the direct trains cover the 252 km distance in an average of 4 h 18 m but if you time it right, some trains will get you there in just 4 h 18 m .
On Fri, May 08 the slowest trains will take 4 h 18 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
4:20 AM4h18Mestre8:38 AMSiena$581One-way0 transfers
4:20 AM4h18Mestre8:38 AMSiena$581One-way0 transfers
Travel Information
Compare train and bus for Mestre to Siena
Omio recommends booking the bus as it is the most popular option from Mestre to Siena among Omio's users. If you are prioritising price take the bus with prices starting from $13. For those with little time consider booking a train which can get you there in 4h 4m. The ticket price range depends on the travel mode: a bus costs an average of $13, and a train costs an average of $37.
Distance: 156 miles (252 km)
Compare train with
| Train | Most popular Bus | Driving |
|---|---|---|
$51 Average price | $22 Average price Cheapest | $92 Average price (fuel + tolls) |
4h 34m Average total duration Fastest 4h 4m Onboard + 30m Additional time* | 4h 49m Average total duration 4h 19m Onboard + 30m Additional time* | 3h 8m Average total duration (door-to-door) |
![]() Most popular train company | ![]() Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Mestre to Siena:
A bus is $29 (€23) less than a train for this route with tickets for a train from Mestre to Siena costing on average $51 (€41).
Other travel options to Siena take longer:
Bus takes on average 4h 19m.
Tickets start at around $51 (€41) compared to roughly $92 (€74) in fuel and tolls — a saving of about $41 (€33). The journey takes 4h 4m versus 3h 8m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Mestre to Siena train times
The table below shows live departures for Mestre to Siena trains for today, Thursday, May 7. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 7:36 AM Mestre | 7h01 | 2:37 PM Siena | 0 transfersDirect | |
![]() | 11:26 AM Mestre | 6h14 | 5:40 PM Siena | 0 transfersDirect | |
![]() | 1:28 PM Mestre | 6h12 | 7:40 PM Siena | 0 transfersDirect | |
| Friday, May 8 | |||||
![]() | 4:20 AM Mestre | 4h18 | 8:38 AM Siena | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mestre to Siena by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
May 08
May 09
May 10
May 11
May 12
May 13
May 14
Why should you book Mestre to Siena trains with Omio?
Why book with Omio vs Frecciarossa?
- Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo or Regionale to find the best option for your trip from Mestre to Siena.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are train and bus to ensure you get the best deal for traveling from Mestre to Siena.
Why book with Omio over Raileurope?
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Mestre to Siena.
Journey information
Overview: Train from Mestre to Siena
Trains from Mestre to Siena run on average 11 times per day, taking around 4h 4m. Cheap train tickets for this journey start at $37 (€30) but you can travel from only $13 (€10) by bus.
There are 1 trains per day. The earliest train runs at 05:00, the last at 21:26. The fastest train covers the 156 miles (252 km) distance in 4h 18m.
Distance 156 miles (252 km) |
Average train duration 4h 4m |
Cheapest ticket price $37 (€30) |
Trains per day 11 |
Direct trains 1 |
Fastest train 4h 18m |
First train 5:00 AM |
Last train 9:26 PM |
Cheapest Month Sep |
Cheapest Day Tue |
High Season Apr - Jun |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Thu |
Best time to book 49 days |
Train companies: Frecciarossa, Italo, Regionale from Mestre to Siena trainsFrecciarossa, Italo, Regionale trains will get you between Mestre and Siena from $13 (€10). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
Italo
Regionale
FAQs: Trains from Mestre to Siena
Find answers to the most common questions about traveling from Mestre to Siena by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mestre to Siena
- 6:00 AM - 10:00 PM Monday - Sunday
- Parking is available near the station, open 24/7.
- Outside the main entrance.
- €1
- Hotel Villa Sara
- Hotel Altieri
- Hotel Ducale
- Located near the main entrance
- The station has a simple layout with two platforms and a small waiting area.
- Bus: Several ACTV lines available
- Tram: Line T1
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available near the station, open 24/7.
- Ristorante Il Vinaio
- Osteria Le Logge
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Italia
- NH Siena
- Hotel Minerva
- Located near the main entrance
- Located near the main entrance
- Free
- The station has a single-level layout with platforms accessible from the main hall.
- Bus: Several local and regional lines available
- Taxi: Available outside the station
Most popular train connections from Mestre
More options for your journey from Mestre to Siena
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