- Must visit
Museo Civico
Siena’s main civic museum displays Lorenzetti’s frescoes and superb medieval art inside the historic town hall. It is essential for understanding the city.
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The cheapest and fastest trains from Mestre to Siena
Showing times, prices and bookable tickets for Sep 21
Cheapest price on Sep 21
$33
Average ticket price on Sep 21
$51
Fastest journey on Sep 21
4 h 20 m
Average journey duration on Sep 21
4 h 20 m
Trains on Sep 21
49
Distance
252 km
Cheap tickets
The best way to find a cheap train ticket from Mestre to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Siena will cost around $51 if you buy it on the day, but the cheapest tickets can be found for only $33.
Fast trains
It's difficult to get from Mestre to Siena without transferring at least once.
Regionale 16680+
Intercity 584+Regionale 182199:58 AM6h42Venezia Mestre Ospedale4:40 PMSiena station$331One-way2 transfers- Regionale 16791+Intercity 594+Regionale 182272:58 PM5h42Venezia Mestre Ospedale8:40 PMSiena station$331One-way2 transfers
8927+Regionale 182336:17 PM4h59Venice Mestre11:16 PMSiena station$381One-way1 transfer- 8915+Regionale 182232:17 PM4h23Venice Mestre6:40 PMSiena station$421One-way1 transfer
- 8925+Regionale 182335:17 PM5h59Venice Mestre11:16 PMSiena station$421One-way1 transfer
- 8911+Regionale 1821711:17 AM4h20Venice Mestre3:37 PMSiena station$571One-way1 transfer
- 8907+Regionale 182119:20 AM4h20Venice Mestre1:40 PMSiena station$571One-way1 transfer
- Regionale 16037+
FRECCIAROSSA 9401+Regionale 182035:18 AM4h20Venezia Mestre Ospedale9:38 AMSiena station$431One-way2 transfers - 8913+Regionale 182211:17 PM4h21Venice Mestre5:38 PMSiena station$461One-way1 transfer
- 8905+Regionale 182098:17 AM4h21Venice Mestre12:38 PMSiena station$501One-way1 transfer
Travel Information
Compare train and bus for Mestre to Siena
Omio recommends booking the bus as it is the most popular option from Mestre to Siena among Omio's users. If you are prioritising price, take the train, with an average ticket price of $31 For those with little time, consider booking a train, which has an average total journey time of 4h 7m. Average ticket prices depend on the travel mode: a train costs an average of $31, while a bus costs an average of $37.
Distance: 156 miles (252 km)
Compare train with
| Train | Most popular Bus | Driving |
|---|---|---|
$31 Average price Cheapest | $37 Average price | $91 Average price (fuel + tolls) |
4h 7m Average total duration Fastest 3h 37m Onboard + 30m Additional time* | 5h 25m Average total duration 4h 55m Onboard + 30m Additional time* | 3h 8m Average total duration (door-to-door) |
Most popular train company |  Most popular bus company | Your own car or car rental |
Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Mestre to Siena is a train with an average price of $31.
This is compared to other travel options from Mestre to Siena:
A train is $6 less than a bus for this route with tickets for a bus from Mestre to Siena costing on average $37.
The fastest way to travel from Mestre to Siena is by train with an average journey time of 3h 37m.
Other travel options to Siena take longer:
Bus takes on average 4h 55m.
It's helpful to compare your options as there are 2 ways to travel between Mestre and Siena including taking a train and bus.
We recommend using the bus as it is the most popular way to get from Mestre to Siena among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.
Tickets start at around $31 compared to roughly $91 in fuel and tolls — a saving of about $60. The journey takes 3h 37m versus 3h 8m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Direct services run with Italo.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Mestre to Siena train times
The table below shows live departures for Mestre to Siena trains for today, Sunday, September 20. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 8:20 AM Mestre | 2h00 | 10:20 AM Siena | 0 transfersDirect | |
| Monday, September 21 | |||||
| Regionale 16037+FRECCIAROSSA 9401+Regionale 18203 | 5:18 AM Venezia Mestre Ospedale | 4h20 | 9:38 AM Siena station | 2 transfers | |
| Regionale 16845+FRECCIAROSSA 9403+Regionale 18205 | 5:56 AM Venezia Mestre Ospedale | 4h44 | 10:40 AM Siena station | 2 transfers | |
| Regionale 16757+FRECCIAROSSA 9405+Regionale 18207 | 6:56 AM Venezia Mestre Ospedale | 4h44 | 11:40 AM Siena station | 2 transfers | |
| 8903+Regionale 18209 | 7:17 AM Venice Mestre | 5h21 | 12:38 PM Siena station | 1 transfer | |
| 8903+Regionale 18211 | 7:17 AM Venice Mestre | 6h23 | 1:40 PM Siena station | 1 transfer | |
| 8903+Regionale 18207 | 7:17 AM Venice Mestre | 4h23 | 11:40 AM Siena station | 1 transfer | |
| Regionale 16870+FRECCIAROSSA 9409+Regionale 18209 | 7:58 AM Venezia Mestre Ospedale | 4h40 | 12:38 PM Siena station | 2 transfers | |
| 8905+Regionale 18215 | 8:17 AM Venice Mestre | 6h23 | 2:40 PM Siena station | 1 transfer | |
| 8905+Regionale 18209 | 8:17 AM Venice Mestre | 4h21 | 12:38 PM Siena station | 1 transfer | |
| 8905+Regionale 18211 | 8:17 AM Venice Mestre | 5h23 | 1:40 PM Siena station | 1 transfer | |
| Regionale 16874+FRECCIAROSSA 9411+Regionale 18211 | 8:58 AM Venezia Mestre Ospedale | 4h42 | 1:40 PM Siena station | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mestre to Siena by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mon
Sep 21
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Sep 27
Why should you book Mestre to Siena trains with Omio?
Italo as well as Frecciarossa or Regionale offer trains services from Mestre to Siena.
Omio is the only official third party seller for Italo tickets.
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa or Regionale to find the best option for your trip from Mestre to Siena.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train and bus to ensure you get the best deal for traveling from Mestre to Siena.
Journey information
Overview: Train from Mestre to Siena
ItalyItaly
Trains from Mestre to Siena run on average 43 times per day, taking around 3h 37m. Cheap train tickets for this journey start at $12 but you can travel from only $11 by bus.
The earliest train runs at 05:00, the last at 21:26. The fastest train covers the 156 miles (252 km) distance in 3h 27m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $11
Distance 156 miles (252 km) |
Average train duration 3h 37m |
Cheapest ticket price $12 |
Trains per day 43 |
Fastest train 3h 27m |
First train 5:00 AM |
Last train 9:26 PM |
Cheapest Month Sep |
Cheapest Day Thu |
High Season Jan - Mar |
Low Season Oct - Dec |
Busiest Day Sat |
Least Busy Day Wed |
Best time to book 49 days |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $11
Train companies: Italo, Frecciarossa, Intercity from Mestre to Siena trainsItalo, Frecciarossa, Intercity trains will get you between Mestre and Siena from $11. With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Average Italo Duration
3h 27m
Cheapest Italo Price
$12
Italo frequency
32 a day
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone
Frecciarossa
About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Frecciarossa Duration
3h 33m
Cheapest Frecciarossa Price
$68
Frecciarossa frequency
12 a day
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone
Intercity
About
Trenitalia Intercity is a high-speed train service operated by the Italian national railway company, Trenitalia. It operates throughout the country, with services running from early morning to late evening. The Intercity trains come in two types: the Intercity Plus, which is the fastest and most comfortable, and the Intercity, which is slightly slower but still offers a comfortable journey. Onboard facilities include air conditioning, power sockets, Wi-Fi, and a bar service. There are several ticket types available, including Standard, Super Economy, and Business. The most popular routes for Trenitalia Intercity are from Rome to Milan, Naples to Florence, and Turin to Venice.
Luggage & cancellation policy
Average Intercity Duration
4h 20m
Cheapest Intercity Price
$50
Intercity frequency
2 a day
Luggage included
2 pieces of luggage up to 30kg total
Luggage storage
Overhead racks and designated luggage areas at end of carriages
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with hot meals and snacks, trolley service in some trains. But do not count on the presence of a buffet car. So if having access to food and drink on the train is important to you, it’s best to bring your own refreshments onboard.
Seat reservation
Seat reservation included in ticket price for most routes
Toilets
USB plugs
Accessibility
Wheelchair spaces and accessible toilets available
Pets
Small pets in carriers allowed free, larger dogs require paid ticket
Quiet zone
Complete guide to Siena
Things to do in Siena
Discover the best of Siena — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Siena trip today.
- Must visit
Santa Maria della Scala
This major museum complex occupies a former hospital and combines archaeology, frescoes, chapels, and underground spaces in a memorable setting.
- Must visit
Museo dell'Opera del Duomo
The cathedral museum preserves sculptures, stained glass, and treasures from the Duomo complex, including close views of masterpieces and architecture.
- Must visit
Piazza del Campo
Siena’s iconic shell-shaped square is the social and visual heart of the city, perfect for architecture, people-watching, and understanding the Palio.
- Must visit
Piazza del Duomo
This broad square in front of the cathedral frames some of Siena’s finest Gothic monuments and is a natural stop on any walking route.
- Recommended
Via di Città
The city’s main pedestrian street links major sights with shops and noble facades. It is ideal for a first walk through Siena’s historic core.
- Vegetarian
- Vegan
Ribollita
Thick rustic soup of bread, beans, cavolo nero and vegetables. A Tuscan staple in Siena, prized for peasant roots and deep, comforting flavor.
- Vegetarian
Acquacotta
Dense vegetable and bread soup made with beans, tomato, onion, celery and stale bread. Traditional cucina povera, often linked to Sienese home cooking.
Pici
Hand-rolled thick spaghetti, usually served with rich garlic-forward tomato sauce or duck ragù. A classic Tuscan pasta common in Siena trattorie.
La Taverna Di San Giuseppe
Popular central trattoria focused on pici, ribollita and other regional staples, offering a casual atmosphere near major sights.
Osteria Le Logge
Well-known osteria for classic Tuscan and Sienese dishes, with a cozy brick interior and strong local wine selection.
Ristorante Tar-Tufo
Elegant Michelin-starred restaurant near Piazza del Campo, known for refined Tuscan tasting menus and polished historic atmosphere.
Euro (€)
Moderate for Italy: lodging and dining cost more than small towns, but transit is limited and many sights are walkable.
Average meal costs
- Budget
- €8-15 for pizza slices, panini, or casual lunch.
- Mid-range
- €20-35 per person for a restaurant meal.
- Fine dining
- €60+ per person for upscale dining.
- Coffee
- €1.30-3 for espresso or cappuccino.
Tipping culture
Service is often included or covered by coperto. Round up or leave 5-10% for great restaurant service; taxis are usually rounded up; cafés need no tip.
at bus
Get the appOfficial public transport app
Prices
- Single ticket
- €1.50
- Day pass
- €5.50
To the city center
Siena Railway Station -> Piazza del Campo
- Distance
- 2 km
- Travel time
- 15 min
- Urban buses are run by at bus. Buy tickets in the app, at authorized retailers, or on board where available.
- Contactless bank card payment is available on many buses, but not guaranteed on every vehicle. Validate paper tickets when boarding.
FAQs: Trains from Mestre to Siena
Find answers to the most common questions about traveling from Mestre to Siena by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.
Train ticket prices from Mestre to Siena can vary. The cheapest ticket starts at $12, while the average price is around $31.
The train from Mestre to Siena takes 3h 27m and runs 43 per day.
The distance by train from Mestre to Siena is 156 miles (252 km).
The first train from Mestre to Siena leaves at 5:00 AM.
The last train from Mestre to Siena leaves at 9:26 PM.
Yes, there is a high-speed train from Mestre to Siena.
Yes, there is a direct train from Mestre to Siena. This service operates 0 times per day, provided by Italo.
Unfortunately, there is no night train available from Mestre to Siena.
The train station in Mestre that goes to Siena is Venezia Mestre Ospedale, which connects to Siena station.
The cheapest way to get from Mestre to Siena is by bus, with a cost of around $11.
The train journey from Mestre to Siena offers diverse scenery, including views of the Venetian plains, rolling Tuscan hills, and charming medieval towns, making it a picturesque experience.
A day trip from Mestre to Siena is not feasible as the journey takes 3h 27m and the distance is 156 miles (252 km). Trains run 12 times per day.
In Siena, you can visit Torre del Mangia for panoramic views, explore religious art at Museo dell'Opera del Duomo, and relax at Fortezza Medicea. Enjoy Italian wines at Enoteca Italiana, or take a cooking class to learn traditional Tuscan dishes. Don't miss the Piazza del Campo with its historic ambiance or the magnificent Siena Cathedral. Also, check out the Palazzo Pubblico, Basilica of San Domenico, and Santa Maria della Scala for a rich cultural experience.
To fully experience Siena, including its historic sites, museums, and local cuisine, plan to spend 2 to 3 days.
Yes, you can take the train from Mestre to Siena.
Since both Mestre and Siena are in the Schengen Area, a passport is not required for European Union (EU) or Schengen-associated country citizens. A national ID card is sufficient.
Popular day trips by train from Siena include Florence, San Gimignano, Montepulciano, Poggibonsi, Livorno.
We recommend using the bus as it is the most popular way to get from Mestre to Siena among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
Yes, rail passes such as the Eurail Italy Pass and Interrail Italy Pass are valid on most trains operated by Trenitalia and Italo within Italy, including regional, intercity, and high-speed trains, though some restrictions and seat reservation fees may apply.
Italy uses the euro (EUR) as its currency. Travelers generally find it convenient to use cards for most payments, especially in cities and larger establishments, but carrying some cash is advisable for small shops, markets, and rural areas where card acceptance may be limited.
In Siena, travelers should be cautious of pickpocketing, especially in crowded areas like Piazza del Campo and on public transportation. Common scams include overpriced taxi rides and unofficial ticket sellers near popular attractions. Staying aware of surroundings and using authorized services helps ensure a safe visit.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Mestre to Siena
Most Mestre to Siena trains use the Venezia Mestre to Siena station pair. Use this guide to compare Mestre and Siena train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Departure train stations in Mestre
Arrival train stations in Siena
Which Mestre station do trains to Siena leave from?
Trains from Mestre to Siena leave from Venezia Mestre. The station is 5 miles (9 km) from Mestre city centre at Viale Stazione, 30171 Venice, Italy.
Venezia Mestre OspedaleVia Don Federico Tosatto, 30174 Mestre, Venice, Italy+39 041 272 2111
City-centre transport
Getting to Venezia Mestre Ospedale from Mestre city centre
Venezia Mestre Ospedale is 2 km from Mestre city centre. Public transport options include:
TrainRe · 7m · $1 · every ~2 min
Bus32H, 48H, 33H, 34H, 31H · 46m · $2 · every ~5 min
Venezia Mestre Ospedale train station facilities and services
Venezia Mestre Ospedale has practical services for this route, including Parking, Dining, Taxis, Accessibility, WC, Hotel, Ticket Office, Bike Parking, and Information Desk.
Food and drink
Food and drink options are available at Venezia Mestre Ospedale.
Tickets and information
Ticket office support is available at Venezia Mestre Ospedale. Information desks are located near the main entrance.
Parking, taxis and toilets
Available at Venezia Mestre Ospedale: Parking, Taxis, WC.
Bike and car services
Available at Venezia Mestre Ospedale: Bike Parking.
Accessibility
Accessibility facilities are available at Venezia Mestre Ospedale.
Shops, hotels and contact
Nearby hotels include Hotel Villa Sara, Hotel Altieri, Hotel Ducale.
Which Siena station do trains from Mestre arrive at?
Trains from Mestre to Siena most often arrive at Siena. Some services arrive at Firenze Santa Maria Novella, so check your ticket before travel to confirm your Siena arrival station.
SienaPiazzale Carlo Rosselli, 53100 Siena SI, Italy+39 0577 207413
City-centre transport
Getting to Siena from Siena city centre
Siena is 1 km from Siena city centre. Public transport options include:
BusS10, 0S3, 544 · 6m · $1 · every ~6 min
Siena train station facilities and services
Siena has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Information Desk, and Luggage Carts.
Food and drink
Food options include: Ristorante Il Vinaio, Osteria Le Logge
Wi-Fi and ATMs
Free. ATMs are available in the train station.
Tickets and information
Ticket office support is available at Siena. Information desks are located near the main entrance.
Luggage and lost property
Luggage storage is available at Siena. Lost and found is available at the station.
Parking, taxis and toilets
Available at Siena: Parking, Taxis, WC.
Bike and car services
Available at Siena: Bike Parking, Bike Rental.
Accessibility
Accessibility facilities are available at Siena: Elevators, ramps.
Shops, hotels and contact
Nearby hotels include Hotel Italia, NH Siena, Hotel Minerva.
Most popular train connections from Mestre
More options for your journey from Mestre to Siena
Here are some other resources that might have the information you need
Most popular trains to and from Siena and Mestre
Most popular train connections to Siena
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