Mestre to Siena train with Frecciarossa

Sat, Mar 21
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Frecciarossa
Italo
Regionale
Deutsche Bahn
iryo
2,000+ travel companies
Frecciarossa
Italo
Regionale
Deutsche Bahn
iryo
2,000+ travel companies
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The cheapest and fastest trains from Mestre to Siena

Showing times and prices for Mar 23

Cheapest price

$52

Average price

$77

Fastest journey

4 h 18 m

Average duration

4 h 20 m

Trains per day

48

Distance

252 km

Cheap tickets

The best way to find a cheap train ticket from Mestre to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.

The average ticket from Mestre to Siena will cost around $77 if you buy it on the day, but the cheapest tickets can be found for only $52.

Fast trains

It's difficult to get from Mestre to Siena without transferring at least once.

RegionaleRegionale 16791+IntercityIntercity 594+RegionaleRegionale 18227
02:58PM5h42
Venezia Mestre Ospedale
08:40PMSiena station
$521One-way
2 transfers
RegionaleRegionale 16775+IntercityIntercity 584+RegionaleRegionale 18223
12:26PM6h14
Venezia Mestre Ospedale
06:40PMSiena station
$521One-way
2 transfers
Italo8911+RegionaleRegionale 18217
11:17AM4h20
Venice Mestre
03:37PMSiena station
$661One-way
1 transfer
Italo8925+RegionaleTUSCANY LINE 18323 · Regionale 19057
05:17PM4h59
Venice Mestre
10:16PMSiena station
$661One-way
2 transfers
Italo8927+RegionaleRegionale 18233
06:17PM4h59
Venice Mestre
11:16PMSiena station
$661One-way
1 transfer

Travel Information

Compare bus and train for Mestre to Siena

Omio recommends booking the bus as it is the most popular option from Mestre to Siena among Omio's users. If you are prioritising price take the bus with prices starting from $12. For those with little time consider booking a train which can get you there in 4h 4m. The ticket price range depends on the travel mode: a bus costs an average of $12, and a train costs an average of $37.

Distance: 156 miles (252 km)

Compare train with

Train
Most popular
Bus

$50

Average price

$22

Average price

Cheapest

4h 34m

Average total duration

Fastest

4h 4m

Onboard

+

30m

Additional time*

4h 49m

Average total duration

4h 19m

Onboard

+

30m

Additional time*

Frecciarossa

Most popular train company

Itabus

Most popular bus company

Direct Options

Direct Options

Live departures

Mestre to Siena train times

The table below shows live departures for Mestre to Siena trains for tomorrow, Sunday, March 22. You can also manually refresh the results below to see updated train journeys.

Last updated at 9:57 PM
ProviderDepartsDurationArrivesTransfers
Tickets
trenitaliaregRegionale 16037+frecciarossaFRECCIAROSSA 9401+trenitaliaregRegionale 182034:20 AM Venezia Mestre Ospedale
4h18
8:38 AM Siena station2 transfers
trenitaliaregRegionale 16845+frecciarossaFRECCIAROSSA 9403+trenitaliaregRegionale 182054:58 AM Venezia Mestre Ospedale
4h42
9:40 AM Siena station2 transfers
trenitaliaregRegionale 16757+frecciarossaFRECCIAROSSA 9405+trenitaliaregRegionale 182075:58 AM Venezia Mestre Ospedale
4h42
10:40 AM Siena station2 transfers
italo8903+trenitaliaregRegionale 18211
On time
6:17 AM Venice Mestre
6h23
12:40 PM Siena station
1 transfer
italo8903+trenitaliaregRegionale 18209
On time
6:17 AM Venice Mestre
5h21
11:38 AM Siena station
1 transfer
italo8903+trenitaliaregRegionale 18207
On time
6:17 AM Venice Mestre
4h23
10:40 AM Siena station
1 transfer
italo8905+trenitaliaregRegionale 18211
On time
7:17 AM Venice Mestre
5h23
12:40 PM Siena station
1 transfer
italo8905+trenitaliaregRegionale 18215
On time
7:17 AM Venice Mestre
6h23
1:40 PM Siena station
1 transfer
italo8905+trenitaliaregRegionale 18209
On time
7:17 AM Venice Mestre
4h21
11:38 AM Siena station
1 transfer
trenitaliaregRegionale 16874+frecciarossaFRECCIAROSSA 1000 9411+trenitaliaregRegionale 182117:58 AM Venezia Mestre Ospedale
4h42
12:40 PM Siena station2 transfers
italo8907+trenitaliaregRegionale 182178:20 AM Venice Mestre
6h17
2:37 PM Siena station1 transfer
italo8907+trenitaliaregRegionale 182158:20 AM Venice Mestre
5h20
1:40 PM Siena station1 transfer
italo8907+trenitaliaregRegionale 182118:20 AM Venice Mestre
4h20
12:40 PM Siena station1 transfer
trenitaliaregRegionale 16680+frecciarossaFRECCIAROSSA 1000 9413+trenitaliaregRegionale 182178:58 AM Venezia Mestre Ospedale
5h39
2:37 PM Siena station2 transfers
italo8902+trenitaliaregRegionale 182159:17 AM Venice Mestre
4h23
1:40 PM Siena station1 transfer
italo8902+trenitaliaregRegionale 182179:17 AM Venice Mestre
5h20
2:37 PM Siena station1 transfer
italo8902+trenitaliaregRegionale 182199:17 AM Venice Mestre
6h23
3:40 PM Siena station1 transfer
italo8911+trenitaliaregRegionale 18217
On time
10:17 AM Venice Mestre
4h20
2:37 PM Siena station
1 transfer
italo8911+trenitaliaregRegionale 18219
On time
10:17 AM Venice Mestre
5h23
3:40 PM Siena station
1 transfer
italo8911+trenitaliaregRegionale 18221
On time
10:17 AM Venice Mestre
6h21
4:38 PM Siena station
1 transfer
trenitaliaregRegionale 16232+frecciarossaFRECCIAROSSA 1000 8419+trenitaliaregRegionale 1821910:58 AM Venezia Mestre Ospedale
4h42
3:40 PM Siena station2 transfers
italo8929+trenitaliaregRegionale 18221
On time
11:17 AM Venice Mestre
5h21
4:38 PM Siena station
1 transfer
italo8929+trenitaliaregRegionale 18219
On time
11:17 AM Venice Mestre
4h23
3:40 PM Siena station
1 transfer
italo8929+trenitaliaregRegionale 18223
On time
11:17 AM Venice Mestre
6h23
5:40 PM Siena station
1 transfer
trenitaliaregRegionale 16775+trenitaliaintIntercity 584+trenitaliaregRegionale 1822311:26 AM Venezia Mestre Ospedale
6h14
5:40 PM Siena station2 transfers
trenitaliaregRegionale 16779+frecciarossaFRECCIAROSSA 9421+trenitaliaregRegionale 1822111:58 AM Venezia Mestre Ospedale
4h40
4:38 PM Siena station2 transfers
italo8913+trenitaliaregRegionale 1822312:17 PM Venice Mestre
5h23
5:40 PM Siena station1 transfer
italo8913+trenitaliaregRegionale 1822512:17 PM Venice Mestre
6h21
6:38 PM Siena station1 transfer
italo8913+trenitaliaregRegionale 1822112:17 PM Venice Mestre
4h21
4:38 PM Siena station1 transfer
trenitaliaregRegionale 16783+frecciarossaFRECCIAROSSA 1000 9425+trenitaliaregRegionale 1822312:58 PM Venezia Mestre Ospedale
4h42
5:40 PM Siena station2 transfers
italo8915+trenitaliaregRegionale 18225
On time
1:17 PM Venice Mestre
5h21
6:38 PM Siena station
1 transfer
italo8915+trenitaliaregRegionale 18227
On time
1:17 PM Venice Mestre
6h23
7:40 PM Siena station
1 transfer
italo8915+trenitaliaregRegionale 18223
On time
1:17 PM Venice Mestre
4h23
5:40 PM Siena station
1 transfer
trenitaliaregRegionale 16791+trenitaliaintIntercity 594+trenitaliaregRegionale 182271:58 PM Venezia Mestre Ospedale
5h42
7:40 PM Siena station2 transfers
trenitaliaregRegionale 16791+frecciarossaFRECCIAROSSA 1000 9427+trenitaliaregRegionale 182251:58 PM Venezia Mestre Ospedale
4h40
6:38 PM Siena station2 transfers
italo8919+trenitaliaregRegionale 18229
On time
2:17 PM Venice Mestre
6h22
8:39 PM Siena station
1 transfer
italo8919+trenitaliaregRegionale 18225
On time
2:17 PM Venice Mestre
4h21
6:38 PM Siena station
1 transfer
italo8919+trenitaliaregRegionale 18227
On time
2:17 PM Venice Mestre
5h23
7:40 PM Siena station
1 transfer
trenitaliaregRegionale 16768+frecciarossaFRECCIAROSSA 1000 9431+trenitaliaregRegionale 182272:58 PM Venezia Mestre Ospedale
4h42
7:40 PM Siena station2 transfers
italo8923+trenitaliaregRegionale 182273:17 PM Venice Mestre
4h23
7:40 PM Siena station1 transfer
italo8923+trenitaliaregRegionale 182333:17 PM Venice Mestre
6h59
10:16 PM Siena station1 transfer
italo8923+trenitaliaregRegionale 182293:17 PM Venice Mestre
5h22
8:39 PM Siena station1 transfer
trenitaliaregRegionale 16805+frecciarossaFRECCIAROSSA 1000 9433+trenitaliaregRegionale 182293:58 PM Venezia Mestre Ospedale
4h41
8:39 PM Siena station2 transfers
italo8925+trenitaliaregTUSCANY LINE 18323 · Regionale 19057
On time
4:17 PM Venice Mestre
4h59
9:16 PM Siena station
2 transfers
italo8925+trenitaliaregRegionale 18229
On time
4:17 PM Venice Mestre
4h22
8:39 PM Siena station
1 transfer
italo8925+trenitaliaregRegionale 18233
On time
4:17 PM Venice Mestre
5h59
10:16 PM Siena station
1 transfer
trenitaliaregRegionale 16852+frecciarossaFRECCIAROSSA 9435+trenitaliaregRegionale 182334:58 PM Venezia Mestre Ospedale
5h18
10:16 PM Siena station2 transfers
italo8927+trenitaliaregRegionale 182335:17 PM Venice Mestre
4h59
10:16 PM Siena station1 transfer

This is the last train of the day.

Find all the dates and times for this journey

Compare prices and tickets Mestre to Siena by bus or train

Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Mon
Mar 23
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Mar 27
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Mar 29

Why should you book Mestre to Siena trains with Omio?

Frecciarossa as well as Italo or Regionale offer trains services from Mestre to Siena.
Omio is an official ticket reseller for all your travel options from Mestre to Siena.

Why book with Omio vs Frecciarossa?

  • Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo or Regionale to find the best option for your trip from Mestre to Siena.
  • Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
  • Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are bus and train to ensure you get the best deal for traveling from Mestre to Siena.

Why book with Omio over Raileurope?

  • Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Mestre to Siena.

Journey information

Overview: Train from Mestre to Siena

ItalyItaly
ItalyItaly
Icon of train

Trains from Mestre to Siena run on average 11 times per day, taking around 4h 4m. Cheap train tickets for this journey start at $37 (€30) but you can travel from only $12 (€10) by bus.

There are 1 trains per day. The earliest train runs at 05:00, the last at 21:26. The fastest train covers the 156 miles (252 km) distance in 4h 18m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $12 (€10)
Distance
156 miles (252 km)
Average train duration
4h 4m
Cheapest ticket price
$37 (€30)
Trains per day
11
Direct trains
1
Fastest train
4h 18m
First train
05:00
Last train
21:26
Cheapest month
Sep
Cheapest day
Tue
High season
Jan - Mar
Low season
Oct - Dec
Busiest day
Sat
Least busy day
Wed
Best day to book ahead
49 days
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Bus from $12 (€10)

Train companies: Frecciarossa, Italo, Regionale from Mestre to Siena trainsFrecciarossa, Italo, Regionale trains will get you between Mestre and Siena from $12 (€10). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Frecciarossa

About
Step on board a Frecciarossa train and relax as you travel across Italy. Trenitalia’s Frecciarossa high-speed trains make around 200 connections across the country each day and are renowned for their comfort, speed, and reduced environmental impact. Reaching speeds of up to 186 mph (300 km/h), they connect major destinations such as Rome, Florence, Milan, Venice, and Naples quickly and efficiently. When booking your Frecciarossa journey, you can choose between four classes: Standard, Premium, Business, and Executive. While each class offers different levels of comfort, all provide free Wi-Fi access, power outlets, air conditioning, bathrooms, luggage storage, onboard entertainment, and restaurant and bar services. Ticket options include Super Economy, Economy, and Base, making it easy to find the right balance of comfort and price for your trip.
Luggage & cancellation policy
Average Duration
4h 18m
Cheapest Price
$58 (€47)
Luggage included
1 carry-on bag and 1 suitcase per passenger
Luggage storage
Overhead racks, dedicated luggage areas at carriage ends, under seats
Cancellation Policy
Refund policy depends on ticket type
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Restaurant car with full meals, bar service with snacks and beverages, at-seat service in Executive class
Seat reservation
Included in Executive class, optional fee for other classes
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible toilets, assistance service available
Pets
Small pets in carriers travel free, larger dogs require paid ticket and muzzle, service animals free
Quiet zone

Italo

About
Italo is Italy’s private high-speed train service operated by Nuovo Trasporto Viaggiatori (NTV), connecting major cities such as Rome, Milan, Naples, Florence, Turin, Bologna, and Salerno. Its fleet includes the Italo AGV 575, capable of speeds up to 186 mph (300 km/h), and the eco-friendly Italo EVO, which reaches up to 150 mph (250 km/h). Passengers can choose from four classes — Smart, Comfort, Prima, and Club Executive — all offering modern amenities such as free Wi-Fi, power outlets, reclining leather seats, footrests, bathrooms, snack machines, and Italo Live entertainment with movies, music, and games. Italo offers three fare types — Low Cost, Economy, and Flex — providing different levels of price and flexibility. Popular routes include Rome–Milan, Rome–Florence, and Milan–Turin, making Italo a fast, comfortable, and convenient way to travel around Italy.
Luggage & cancellation policy
Luggage included
2 pieces of hand luggage (max 55x35x25cm) and 1 piece of luggage (max 75x53x30cm)
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
Cancellation possible according to ticket conditions
Refund
Full refund provided for canceled trains
Amenities on board the train
Wifi
Food sold onboard
Snack bar service available in most trains with drinks and light refreshments. Welcome service in Prima and Club Executive classes
Seat reservation
Included in Prima and Club Executive. Optional extra cost in Smart and Comfort
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle. Guide dogs travel free
Quiet zone

Regionale

About
Regionale is the regional train service of national carrier Trenitalia connecting all of Italy. It is the most convinient way to travel to both big cities and the smallest villages all over the Italian country. The regional trains have different names depending on the region they serve, such as Treno Regionale Veloce (TRV) and Treno Regionale Lento (TRL). Treno Rock and Treno pop are the two new trains part of Trenitalia regionale fleet. Trenitalia Regionale offers a variety of ticket types, including single tickets (economy and standard), return tickets, and season tickets. Onboard facilities include free Wi-Fi, air conditioning, and power sockets. The most popular routes for Regionale are between Rome and Milan, Naples and Florence, and Turin and Venice.
Luggage & cancellation policy
Luggage included
Free hand luggage allowance included in ticket price
Luggage storage
Overhead racks and designated luggage areas between seats
Cancellation Policy
According to ticket conditions
Refund
Full refund provided
Amenities on board the train
Wifi
Food sold onboard
Bar service available on some trains with snacks and beverages
Seat reservation
Seat reservation included in ticket price for most services
Toilets
USB plugs
Accessibility
Wheelchair spaces and assistance available for passengers with reduced mobility
Pets
Small pets in carriers travel free. Larger dogs require paid ticket and muzzle
Quiet zone

FAQs: Trains from Mestre to Siena

Find answers to the most common questions about traveling from Mestre to Siena by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

FAQs
Train ticket prices from Mestre to Siena can vary. The cheapest ticket starts at $37 (€30), while the average price is around $50 (€41).
The train from Mestre to Siena takes 4h 18m and runs 11 per day.
The first train from Mestre to Siena leaves at 5:00 AM.
The distance by train from Mestre to Siena is 156 miles (252 km).
The last train from Mestre to Siena leaves at 9:26 PM.
Yes, there is a high-speed train from Mestre to Siena.
There is no direct train service currently available from Mestre to Siena.
Unfortunately, there is no night train available from Mestre to Siena.
The train station in Mestre that goes to Siena is Venezia Mestre Ospedale, which connects to Siena station.
The cheapest way to get from Mestre to Siena is by bus, with a cost of around $12 (€10).
The train journey from Mestre to Siena offers diverse scenery, including views of the Venetian plains, rolling Tuscan hills, and charming medieval towns, making it a picturesque experience.
A day trip from Mestre to Siena is not feasible as the journey takes 4h 18m and the distance is 156 miles (252 km). Trains run 12 times per day.
In Siena, you can visit Torre del Mangia for panoramic views, explore religious art at Museo dell'Opera del Duomo, and relax at Fortezza Medicea. Enjoy Italian wines at Enoteca Italiana, or take a cooking class to learn traditional Tuscan dishes. Don't miss the Piazza del Campo with its historic ambiance or the magnificent Siena Cathedral. Also, check out the Palazzo Pubblico, Basilica of San Domenico, and Santa Maria della Scala for a rich cultural experience.
To fully experience Siena, including its historic sites, museums, and local cuisine, plan to spend 2 to 3 days.
Yes, you can take the train from Mestre to Siena.

popular train stations

Popular train stations from Mestre to Siena

Mestre
Siena
The major train station for departures in Mestre is Venezia Mestre Ospedale. Find all the information you need to know about services, amenities and connections at Venezia Mestre Ospedale for your trip from Mestre to Siena.
Amenities at train station
ParkingParking
DiningDining
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
Ticket OfficeTicket Office
Bike ParkingBike Parking
Information DeskInformation Desk
information
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • 6:00 AM - 10:00 PM Monday - Sunday
ticketOfficeHours
Distance to city center
2 km
platformCount
Number of platforms
2
Parking
Parking
  • Parking is available near the station, open 24/7.
Taxis
Taxis
  • Outside the main entrance.
WC
WC
  • €1
Hotel
Hotel
  • Hotel Villa Sara
  • Hotel Altieri
  • Hotel Ducale
Information Desk
Information Desk
  • Located near the main entrance
Station Plan
  • The station has a simple layout with two platforms and a small waiting area.
Public transit options for Venezia Mestre Ospedale
  • Bus: Several ACTV lines available
  • Tram: Line T1

More options for your journey from Mestre to Siena

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