The cheapest and fastest trains from Mestre to Siena
Cheapest price
$52
Average price
$77
Fastest journey
4 h 18 m
Average duration
4 h 20 m
Trains per day
48
Distance
252 km
The best way to find a cheap train ticket from Mestre to Siena is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mestre to Siena will cost around $77 if you buy it on the day, but the cheapest tickets can be found for only $52.
It's difficult to get from Mestre to Siena without transferring at least once.
Regionale 16791+
Intercity 594+
Regionale 18227
Regionale 16775+
Intercity 584+
Regionale 18223
8911+
Regionale 18217
8925+
TUSCANY LINE 18323 · Regionale 19057
8927+
Regionale 18233
Regionale 16037+
FRECCIAROSSA 9401+
Regionale 18203
8911+
Regionale 18217
8907+
Regionale 18211
8919+
Regionale 18225
8913+
Regionale 18221Travel Information
Compare bus and train for Mestre to Siena
Omio recommends booking the bus as it is the most popular option from Mestre to Siena among Omio's users. If you are prioritising price take the bus with prices starting from $12. For those with little time consider booking a train which can get you there in 4h 4m. The ticket price range depends on the travel mode: a bus costs an average of $12, and a train costs an average of $37.
Distance: 156 miles (252 km)
Compare train with
| Train | Most popular Bus |
|---|---|
$50 Average price | $22 Average price Cheapest |
4h 34m Average total duration Fastest 4h 4m Onboard + 30m Additional time* | 4h 49m Average total duration 4h 19m Onboard + 30m Additional time* |
![]() Most popular train company | ![]() Most popular bus company |
Direct Options | Direct Options |
Live departures
Mestre to Siena train times
The table below shows live departures for Mestre to Siena trains for tomorrow, Sunday, March 22. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Regionale 16037+ FRECCIAROSSA 9401+ Regionale 18203 | 4:20 AM Venezia Mestre Ospedale | 4h18 | 8:38 AM Siena station | 2 transfers | |
Regionale 16845+ FRECCIAROSSA 9403+ Regionale 18205 | 4:58 AM Venezia Mestre Ospedale | 4h42 | 9:40 AM Siena station | 2 transfers | |
Regionale 16757+ FRECCIAROSSA 9405+ Regionale 18207 | 5:58 AM Venezia Mestre Ospedale | 4h42 | 10:40 AM Siena station | 2 transfers | |
8903+ Regionale 18211 | On time 6:17 AM Venice Mestre | 6h23 | 12:40 PM Siena station | 1 transfer | |
8903+ Regionale 18209 | On time 6:17 AM Venice Mestre | 5h21 | 11:38 AM Siena station | 1 transfer | |
8903+ Regionale 18207 | On time 6:17 AM Venice Mestre | 4h23 | 10:40 AM Siena station | 1 transfer | |
8905+ Regionale 18211 | On time 7:17 AM Venice Mestre | 5h23 | 12:40 PM Siena station | 1 transfer | |
8905+ Regionale 18215 | On time 7:17 AM Venice Mestre | 6h23 | 1:40 PM Siena station | 1 transfer | |
8905+ Regionale 18209 | On time 7:17 AM Venice Mestre | 4h21 | 11:38 AM Siena station | 1 transfer | |
Regionale 16874+ FRECCIAROSSA 1000 9411+ Regionale 18211 | 7:58 AM Venezia Mestre Ospedale | 4h42 | 12:40 PM Siena station | 2 transfers | |
8907+ Regionale 18217 | 8:20 AM Venice Mestre | 6h17 | 2:37 PM Siena station | 1 transfer | |
8907+ Regionale 18215 | 8:20 AM Venice Mestre | 5h20 | 1:40 PM Siena station | 1 transfer | |
8907+ Regionale 18211 | 8:20 AM Venice Mestre | 4h20 | 12:40 PM Siena station | 1 transfer | |
Regionale 16680+ FRECCIAROSSA 1000 9413+ Regionale 18217 | 8:58 AM Venezia Mestre Ospedale | 5h39 | 2:37 PM Siena station | 2 transfers | |
8902+ Regionale 18215 | 9:17 AM Venice Mestre | 4h23 | 1:40 PM Siena station | 1 transfer | |
8902+ Regionale 18217 | 9:17 AM Venice Mestre | 5h20 | 2:37 PM Siena station | 1 transfer | |
8902+ Regionale 18219 | 9:17 AM Venice Mestre | 6h23 | 3:40 PM Siena station | 1 transfer | |
8911+ Regionale 18217 | On time 10:17 AM Venice Mestre | 4h20 | 2:37 PM Siena station | 1 transfer | |
8911+ Regionale 18219 | On time 10:17 AM Venice Mestre | 5h23 | 3:40 PM Siena station | 1 transfer | |
8911+ Regionale 18221 | On time 10:17 AM Venice Mestre | 6h21 | 4:38 PM Siena station | 1 transfer | |
Regionale 16232+ FRECCIAROSSA 1000 8419+ Regionale 18219 | 10:58 AM Venezia Mestre Ospedale | 4h42 | 3:40 PM Siena station | 2 transfers | |
8929+ Regionale 18221 | On time 11:17 AM Venice Mestre | 5h21 | 4:38 PM Siena station | 1 transfer | |
8929+ Regionale 18219 | On time 11:17 AM Venice Mestre | 4h23 | 3:40 PM Siena station | 1 transfer | |
8929+ Regionale 18223 | On time 11:17 AM Venice Mestre | 6h23 | 5:40 PM Siena station | 1 transfer | |
Regionale 16775+ Intercity 584+ Regionale 18223 | 11:26 AM Venezia Mestre Ospedale | 6h14 | 5:40 PM Siena station | 2 transfers | |
Regionale 16779+ FRECCIAROSSA 9421+ Regionale 18221 | 11:58 AM Venezia Mestre Ospedale | 4h40 | 4:38 PM Siena station | 2 transfers | |
8913+ Regionale 18223 | 12:17 PM Venice Mestre | 5h23 | 5:40 PM Siena station | 1 transfer | |
8913+ Regionale 18225 | 12:17 PM Venice Mestre | 6h21 | 6:38 PM Siena station | 1 transfer | |
8913+ Regionale 18221 | 12:17 PM Venice Mestre | 4h21 | 4:38 PM Siena station | 1 transfer | |
Regionale 16783+ FRECCIAROSSA 1000 9425+ Regionale 18223 | 12:58 PM Venezia Mestre Ospedale | 4h42 | 5:40 PM Siena station | 2 transfers | |
8915+ Regionale 18225 | On time 1:17 PM Venice Mestre | 5h21 | 6:38 PM Siena station | 1 transfer | |
8915+ Regionale 18227 | On time 1:17 PM Venice Mestre | 6h23 | 7:40 PM Siena station | 1 transfer | |
8915+ Regionale 18223 | On time 1:17 PM Venice Mestre | 4h23 | 5:40 PM Siena station | 1 transfer | |
Regionale 16791+ Intercity 594+ Regionale 18227 | 1:58 PM Venezia Mestre Ospedale | 5h42 | 7:40 PM Siena station | 2 transfers | |
Regionale 16791+ FRECCIAROSSA 1000 9427+ Regionale 18225 | 1:58 PM Venezia Mestre Ospedale | 4h40 | 6:38 PM Siena station | 2 transfers | |
8919+ Regionale 18229 | On time 2:17 PM Venice Mestre | 6h22 | 8:39 PM Siena station | 1 transfer | |
8919+ Regionale 18225 | On time 2:17 PM Venice Mestre | 4h21 | 6:38 PM Siena station | 1 transfer | |
8919+ Regionale 18227 | On time 2:17 PM Venice Mestre | 5h23 | 7:40 PM Siena station | 1 transfer | |
Regionale 16768+ FRECCIAROSSA 1000 9431+ Regionale 18227 | 2:58 PM Venezia Mestre Ospedale | 4h42 | 7:40 PM Siena station | 2 transfers | |
8923+ Regionale 18227 | 3:17 PM Venice Mestre | 4h23 | 7:40 PM Siena station | 1 transfer | |
8923+ Regionale 18233 | 3:17 PM Venice Mestre | 6h59 | 10:16 PM Siena station | 1 transfer | |
8923+ Regionale 18229 | 3:17 PM Venice Mestre | 5h22 | 8:39 PM Siena station | 1 transfer | |
Regionale 16805+ FRECCIAROSSA 1000 9433+ Regionale 18229 | 3:58 PM Venezia Mestre Ospedale | 4h41 | 8:39 PM Siena station | 2 transfers | |
8925+ TUSCANY LINE 18323 · Regionale 19057 | On time 4:17 PM Venice Mestre | 4h59 | 9:16 PM Siena station | 2 transfers | |
8925+ Regionale 18229 | On time 4:17 PM Venice Mestre | 4h22 | 8:39 PM Siena station | 1 transfer | |
8925+ Regionale 18233 | On time 4:17 PM Venice Mestre | 5h59 | 10:16 PM Siena station | 1 transfer | |
Regionale 16852+ FRECCIAROSSA 9435+ Regionale 18233 | 4:58 PM Venezia Mestre Ospedale | 5h18 | 10:16 PM Siena station | 2 transfers | |
8927+ Regionale 18233 | 5:17 PM Venice Mestre | 4h59 | 10:16 PM Siena station | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mestre to Siena by bus or train
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Mar 23
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Why should you book Mestre to Siena trains with Omio?
Why book with Omio vs Frecciarossa?
- Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo or Regionale to find the best option for your trip from Mestre to Siena.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are bus and train to ensure you get the best deal for traveling from Mestre to Siena.
Why book with Omio over Raileurope?
- Multiple modes of transport: Omio allows you to compare travel options including bus and train to find the ideal travel option from Mestre to Siena.
Journey information
Overview: Train from Mestre to Siena
Trains from Mestre to Siena run on average 11 times per day, taking around 4h 4m. Cheap train tickets for this journey start at $37 (€30) but you can travel from only $12 (€10) by bus.
There are 1 trains per day. The earliest train runs at 05:00, the last at 21:26. The fastest train covers the 156 miles (252 km) distance in 4h 18m.
Distance 156 miles (252 km) |
Average train duration 4h 4m |
Cheapest ticket price $37 (€30) |
Trains per day 11 |
Direct trains 1 |
Fastest train 4h 18m |
First train 05:00 |
Last train 21:26 |
Cheapest month Sep |
Cheapest day Tue |
High season Jan - Mar |
Low season Oct - Dec |
Busiest day Sat |
Least busy day Wed |
Best day to book ahead 49 days |
Train companies: Frecciarossa, Italo, Regionale from Mestre to Siena trainsFrecciarossa, Italo, Regionale trains will get you between Mestre and Siena from $12 (€10). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
Italo
Regionale
FAQs: Trains from Mestre to Siena
Find answers to the most common questions about traveling from Mestre to Siena by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Siena, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mestre to Siena
- 6:00 AM - 10:00 PM Monday - Sunday
- Parking is available near the station, open 24/7.
- Outside the main entrance.
- €1
- Hotel Villa Sara
- Hotel Altieri
- Hotel Ducale
- Located near the main entrance
- The station has a simple layout with two platforms and a small waiting area.
- Bus: Several ACTV lines available
- Tram: Line T1
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available near the station, open 24/7.
- Ristorante Il Vinaio
- Osteria Le Logge
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Italia
- NH Siena
- Hotel Minerva
- Located near the main entrance
- Located near the main entrance
- Free
- The station has a single-level layout with platforms accessible from the main hall.
- Bus: Several local and regional lines available
- Taxi: Available outside the station
Most popular train connections from Mestre
More options for your journey from Mestre to Siena
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