- Must visit
ZKM | Center for Art and Media Karlsruhe
Major contemporary art and media museum known for interactive digital exhibitions in a former industrial hall. One of Karlsruhe’s signature cultural venues.
Cheapest price
$150
Average price
$150
Fastest journey
5 h 25 m
Average duration
5 h 25 m
Trains per day
1
Distance
352 km
The best way to find a cheap train ticket from Mendrisio to Karlsruhe is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mendrisio to Karlsruhe will cost around $150 if you buy it on the day, but the cheapest tickets can be found for only $150.
It's difficult to get from Mendrisio to Karlsruhe without transferring at least once.


Omio recommends booking the bus as it is the most popular option from Mendrisio to Karlsruhe among Omio's users. If you are prioritising price take the bus with prices starting from $38. For those with little time consider booking a train which can get you there in 5h 25m. The ticket price range depends on the travel mode: a bus costs an average of $38, and a train costs an average of $150.
Distance: 218 miles (352 km)
| Train | Most popular Bus | Driving |
|---|---|---|
$150 Average price | $38 Average price Cheapest | $105 Average price (fuel + tolls) |
5h 55m Average total duration Fastest 5h 25m Onboard + 30m Additional time* | 11h 0m Average total duration 10h 30m Onboard + 30m Additional time* | 4h 59m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Mendrisio to Karlsruhe:
A bus is $112 (€92) less than a train for this route with tickets for a train from Mendrisio to Karlsruhe costing on average $150 (€123).
Other travel options to Karlsruhe take longer:
Bus takes on average 10h 30m.
Tickets start at around $150 (€123) compared to roughly $105 (€86) in fuel and tolls — a saving of about $-45.19 (€-37.02). The journey takes 5h 25m versus 4h 59m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Mendrisio to Karlsruhe trains for today, Friday, June 19. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:04 PM Mendrisio | 5h25 | 5:29 PM Karlsruhe | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mendrisio to Karlsruhe run on average 1 times per day, taking around 5h 25m. Cheap train tickets for this journey start at $150 (€123) but you can travel from only $38 (€31) by bus.
The earliest train runs at 12:04, the last at 12:04. The fastest train covers the 218 miles (352 km) distance in 5h 25m.
Distance 218 miles (352 km) |
Average train duration 5h 25m |
Cheapest ticket price $150 (€123) |
Trains per day 1 |
Fastest train 5h 25m |
First train 12:04 PM |
Last train 12:04 PM |
High Season Jan - Mar |
Low Season Oct - Dec |
Discover the best of Karlsruhe — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Karlsruhe trip today.
Major contemporary art and media museum known for interactive digital exhibitions in a former industrial hall. One of Karlsruhe’s signature cultural venues.
State museum in Karlsruhe Palace with archaeology, decorative arts, and regional history collections. A key stop for understanding Baden’s past.
Important fine arts museum with European paintings from several centuries. A core destination for classical art lovers in the city.
Large palace park ideal for walking, relaxing, and classic views back toward Karlsruhe Palace. A favorite green space for locals and visitors.
Historic central square with the Karlsruhe Pyramid, shops, and civic buildings. One of the city’s main meeting points.
Hill area above Durlach known for panoramic views, sunset photos, and one of the most popular scenic spots around Karlsruhe.
Large Swabian pasta pockets filled with minced meat, spinach, onions, and herbs, often served in broth or pan-fried. A beloved regional staple commonly found in Baden-Württemberg.
Soft egg noodles layered with melted cheese and topped with fried onions. This comforting southern German dish is popular across the region and widely eaten in Karlsruhe.
A thin, crisp tart from the Upper Rhine area, traditionally topped with crème fraîche, onions, and bacon. It is closely associated with nearby Alsace and Baden food culture.
Well-regarded modern fine dining restaurant offering creative tasting menus and polished service in an elegant setting.
Traditional Baden restaurant known for regional dishes, local wines, and a classic rustic atmosphere in central Karlsruhe.
Established venue in a historic industrial-style setting, popular for upscale regional and seasonal cuisine with a stylish atmosphere.
Moderate for Germany. Public transport and casual dining are reasonable, while hotels and fine dining cost more during fairs and peak periods.
Service is usually included. In restaurants, round up or leave about 5-10% for good service. Round up taxis. Small tips are appreciated at cafés; not expected for counter service.
Official public transport app
Karlsruhe Hbf, Karlsruhe -> Marktplatz, Karlsruhe
Find answers to the most common questions about traveling from Mendrisio to Karlsruhe by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Karlsruhe, this guide helps you travel smarter and with confidence.

Most Mendrisio to Karlsruhe trains use the Mendrisio to Karlsruhe Hbf station pair. Use this guide to compare Mendrisio and Karlsruhe train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Mendrisio has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ristorante Pizzeria Corona, Osteria Lanterna
Free.
Ticket office support is available at Mendrisio. Information desks are located in the main hall.
Luggage storage is available at Mendrisio. Lost and found is available at the station.
Available at Mendrisio: Parking, Taxis, WC.
Available at Mendrisio: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Mendrisio: Ramps, restrooms.
Nearby hotels include Hotel Coronado, Albergo Stazione Mendrisio, Hotel Milano.
Karlsruhe Hbf is 1 km from Karlsruhe city centre. Public transport options include:
Karlsruhe Hbf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: Vinarte, Am Tiergarten, Panorama, Alter Brauhof
Wi-Fi is available at Karlsruhe Hbf. ATMs are available at Karlsruhe Hbf.
Ticket office support is available at Karlsruhe Hbf. Information desks are available at Karlsruhe Hbf.
Luggage storage is available at Karlsruhe Hbf. Lost and found is available at the station.
Available at Karlsruhe Hbf: Parking, Taxis, WC.
Available at Karlsruhe Hbf: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Karlsruhe Hbf.
Nearby hotels include Hotel Barbarossa, Hotel Avisa, Am Tiergarten, Aparthotel Aijana.
Here are some other resources that might have the information you need