The cheapest and fastest trains from Mendrisio to Karlsruhe
Cheapest price
$163
Average price
$163
Fastest journey
5 h 25 m
Average duration
5 h 25 m
Trains per day
1
Distance
352 km
The best way to find a cheap train ticket from Mendrisio to Karlsruhe is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mendrisio to Karlsruhe will cost around $163 if you buy it on the day, but the cheapest tickets can be found for only $163.
It's difficult to get from Mendrisio to Karlsruhe without transferring at least once.
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Travel Information
Compare train, bus, and flight for Mendrisio to Karlsruhe
Omio recommends booking the flight as it is the most popular option from Mendrisio to Karlsruhe among Omio's users. If you are prioritising price take the bus with prices starting from €23. For those with little time consider booking a flight which can get you there in 1h 10m. The ticket price range depends on the travel mode: a bus costs an average of €23, and a train costs an average of €132.
Distance: 218 miles (352 km)
Compare train with
| Train | Most popular Flight | Bus |
|---|---|---|
€132 Average price | €71 Average price | €32 Average price Cheapest |
5h 55m Average total duration 5h 25m Onboard + 30m Additional time* | 4h 10m Average total duration Fastest 1h 10m Onboard + 3h 0m Additional time* | 11h 14m Average total duration 10h 44m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Mendrisio to Karlsruhe train times
The table below shows live departures for Mendrisio to Karlsruhe trains for today, Saturday, December 20. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:04 PM Mendrisio | 5h25 | 5:29 PM Karlsruhe | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Mendrisio to Karlsruhe by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 21
Dec 22
Dec 23
Dec 24
Dec 25
Dec 26
Dec 27
Why should you book Mendrisio to Karlsruhe trains with Omio?
Swiss Railways (SBB/CFF/FFS) operates all train services from Mendrisio to Karlsruhe. Omio is the only official third party seller for Swiss Railways (SBB/CFF/FFS) tickets.
Why book with Omio vs Swiss Railways (SBB/CFF/FFS)?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Swiss Railways (SBB/CFF/FFS) with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Mendrisio to Karlsruhe.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Swiss Railways (SBB/CFF/FFS) tickets can only be bought on Omio or Swiss Railways (SBB/CFF/FFS)'s website as Omio is the only official third party seller for Swiss Railways (SBB/CFF/FFS) tickets. Trainline, RailEurope, and Rail.Ninja do not sell Swiss Railways (SBB/CFF/FFS) tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Mendrisio to Karlsruhe.
Journey information
Overview: Train from Mendrisio to Karlsruhe
Trains from Mendrisio to Karlsruhe run on average 1 times per day, taking around 5h 25m. Cheap train tickets for this journey start at $165 (€132) but you can travel from only $29 (€23) by bus.
The earliest train runs at 12:04, the last at 12:04. The fastest train covers the 218 miles (352 km) distance in 5h 25m.
Distance 218 miles (352 km) |
Average train duration 5h 25m |
Cheapest ticket price $165 (€132) |
Trains per day 1 |
Fastest train 5h 25m |
First train 12:04 |
Last train 12:04 |
Train companies: Swiss Railways (SBB/CFF/FFS) from Mendrisio to Karlsruhe trainsSwiss Railways (SBB/CFF/FFS) trains will get you between Mendrisio and Karlsruhe from $29 (€23). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Swiss Railways (SBB/CFF/FFS)
FAQs: Trains from Mendrisio to Karlsruhe
Find answers to the most common questions about traveling from Mendrisio to Karlsruhe by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Karlsruhe, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Mendrisio to Karlsruhe
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- Parking is available 24/7 in the nearby parking lot.
- Ristorante Pizzeria Corona
- Osteria Lanterna
- Outside the main entrance.
- Ramps, restrooms.
- CHF 1
- Hotel Coronado
- Albergo Stazione Mendrisio
- Hotel Milano
- Located in the main hall
- 200 places, covered
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-3 for trains to Italy and regional destinations
- Train: S10, S40
- Bus: Several lines available
- Monday: 06:30 - 21:00
- Tuesday: 06:30 - 21:00
- Wednesday: 06:30 - 21:00
- Thursday: 06:30 - 21:00
- Friday: 06:30 - 21:00
- Saturday: 08:00 - 19:00
- Sunday: 09:00 - 20:00
- Vinarte
- Am Tiergarten
- Panorama
- Alter Brauhof
- Hotel Barbarossa
- Hotel Avisa
- Am Tiergarten
- Aparthotel Aijana
Most popular train connections from Mendrisio
More options for your journey from Mendrisio to Karlsruhe
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