- Must visit
Städel Museum
One of Germany’s leading art museums, with major European works from the Middle Ages to contemporary art on the Museumsufer.
Cheapest price
$187
Average price
$187
Fastest journey
6 h 40 m
Average duration
6 h 40 m
Trains per day
1
Distance
473 km
The best way to find a cheap train ticket from Mendrisio to Frankfurt am Main is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Mendrisio to Frankfurt am Main will cost around $187 if you buy it on the day, but the cheapest tickets can be found for only $187.
It's difficult to get from Mendrisio to Frankfurt am Main without transferring at least once.


Omio recommends booking the flight as it is the most popular option from Mendrisio to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from $76. For those with little time consider booking a flight which can get you there in 1h 20m. In case you are seeking to minimise your carbon footprint the bus is your best bet as it emits only 0.5 - 1.2kg. The ticket price range depends on the travel mode: a bus costs an average of $76, and a train costs an average of $187.
Distance: 293 miles (473 km)
| Train | Most popular Flight | Bus | Driving |
|---|---|---|---|
$187 Average price | $88 Average price | $87 Average price Cheapest | $135 Average price (fuel + tolls) |
7h 10m Average total duration 6h 40m Onboard + 30m Additional time* | 4h 20m Average total duration Fastest 1h 20m Onboard + 3h 0m Additional time* | 15h 55m Average total duration 15h 25m Onboard + 30m Additional time* | 6h 21m Average total duration (door-to-door) |
- CO2 emissions | 1.4 - 2.8kg CO2 emissions | 0.5 - 1.2kg CO2 emissions Lowest | - CO2 emissions |
Direct Options | Direct Options | Direct Options | Direct Options |
Additional time: Average total travel duration to departure point, security checks and transfers.
This is compared to other travel options from Mendrisio to Frankfurt am Main:
A bus is $0.59 (€0.48) less than a flight for this route with tickets for a flight from Mendrisio to Frankfurt am Main costing on average $88 (€72).
A bus is $100 (€82) less than a train for this route with tickets for a train from Mendrisio to Frankfurt am Main costing on average $187 (€153).
Other travel options to Frankfurt am Main take longer:
Train takes on average 6h 40m.
Bus takes on average 15h 25m.
Tickets start at around $187 (€153) compared to roughly $135 (€110) in fuel and tolls — a saving of about $-51.97 (€-42.58). The journey takes 6h 40m versus 6h 21m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Mendrisio to Frankfurt am Main trains for tomorrow, Friday, June 19. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:04 PM Mendrisio | 6h40 | 6:44 PM Frankfurt am Main | 1 transfer | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare train, flight, and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Mendrisio to Frankfurt am Main run on average 1 times per day, taking around 6h 40m. Cheap train tickets for this journey start at $187 (€153) but you can travel from only $24 (€20) by flight.
The earliest train runs at 02:25, the last at 20:51. The fastest train covers the 293 miles (473 km) distance in 6h 40m.
Distance 293 miles (473 km) |
Average train duration 6h 40m |
Cheapest ticket price $187 (€153) |
Trains per day 1 |
Fastest train 6h 40m |
First train 2:25 AM |
Last train 8:51 PM |
High Season Jan - Mar |
Low Season Oct - Dec |
Discover the best of Frankfurt am Main — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Frankfurt am Main trip today.
One of Germany’s leading art museums, with major European works from the Middle Ages to contemporary art on the Museumsufer.
Major exhibition hall for temporary art shows, especially popular for high-profile international exhibitions in the old town area.
A favorite for families and science lovers, famous for dinosaur skeletons and extensive natural history collections.
Frankfurt’s historic central square, rebuilt with traditional character and surrounded by major sights, making it the city’s classic starting point.
The rebuilt old town quarter blends reconstructed timber houses, museums, shops, and lanes that have become highly popular with visitors.
A top skyline viewpoint that has become especially popular for sunset photos and sweeping views over the financial district.
A cold herb sauce made with seven fresh herbs, traditionally served with boiled eggs and potatoes. It is one of Frankfurt’s best-known regional specialties.
Frankfurt’s traditional tart apple wine, usually served in a ribbed glass. It is the city’s signature drink and central to local tavern culture.
A thin smoked pork sausage with protected regional status, typically served with mustard, bread, and potato salad. It is a classic Frankfurt snack.
One of Frankfurt’s best-known fine dining restaurants, offering refined modern cuisine in an elegant setting near the Palmengarten.
A long-established local tavern serving Hessian comfort food and apple wine. It is popular for an authentic neighborhood atmosphere and reliable regional dishes.
Frankfurt’s iconic indoor market hall with many established stalls for local sausages, cheeses, pastries, and casual regional bites in a lively setting.
Prices are high by German standards, especially hotels and dining in the centre, but transit and bakeries help keep daily costs manageable.
Service is usually included. Round up small bills, or tip about 5-10% in restaurants for good service. Round up taxis. Little or no tip is fine for counter service.
Official public transport app
Frankfurt am Main Flughafen -> Frankfurt (Main) Hauptbahnhof
Find answers to the most common questions about traveling from Mendrisio to Frankfurt am Main by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.

Most Mendrisio to Frankfurt am Main trains use the Mendrisio to Frankfurt (Main) Hbf station pair, with some services arriving at Frankfurt Flughafen Fernbf. Use this guide to compare Mendrisio and Frankfurt am Main train stations on this route, check city-centre transport, alongside checking practicalities like train station facilities and services.
Mendrisio has practical services for this route, including Wifi, Lockers, Parking, Dining, Taxis, Accessibility, WC, Hotel, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, Information Desk, and Luggage Carts.
Food options include: Ristorante Pizzeria Corona, Osteria Lanterna
Free.
Ticket office support is available at Mendrisio. Information desks are located in the main hall.
Luggage storage is available at Mendrisio. Lost and found is available at the station.
Available at Mendrisio: Parking, Taxis, WC.
Available at Mendrisio: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Mendrisio: Ramps, restrooms.
Nearby hotels include Hotel Coronado, Albergo Stazione Mendrisio, Hotel Milano.
Frankfurt (Main) Hbf is 1 km from Frankfurt am Main city centre. Public transport options include:
Frankfurt (Main) Hbf has practical services for this route, including Wifi, Lockers, Shopping, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Bike Rental, Car Rental, and Information Desk.
Food options include: asiagourmet, Burger King, Ciao Bella, Coffee Fellows, Crepes de France Express, dean&david, Starbucks, Uddin's Sky Sportsbar, McDonald's, Dunkin Donuts, & many more
Free Wi-Fi in the station. ATMs are available at Frankfurt (Main) Hbf.
Ticket office support is available at Frankfurt (Main) Hbf. Information desks are located opposite Platforms 12 and 13.
Luggage storage is luggage lockers are located in the main hall. Lost and found is available at the station.
Available at Frankfurt (Main) Hbf: Parking, Taxis, WC.
Available at Frankfurt (Main) Hbf: Bike Parking, Bike Rental, Car Rental.
Accessibility facilities are available at Frankfurt (Main) Hbf: Step-free access and step markings. Contact the Mobility Service Centre at +49 3065212888 or [email protected].
Nearby hotels include Hotel Cristall, Grand Hotel Empire, Hotel Carlton.
Frankfurt Flughafen Fernbf is 10 km from Frankfurt am Main city centre. Public transport options include:
Frankfurt Flughafen Fernbf has practical services for this route, including Wifi, Lockers, Parking, Dining, ATM, Taxis, Accessibility, WC, Hotel, Shower, Lounge, Lost and Found Office, Ticket Office, Bike Parking, Car Rental, Information Desk, and Luggage Carts.
Food options include: Restaurant Käfer's, McDonald's, Asia Snack Box
Free. ATMs are available in the train station.
Ticket office support is available at Frankfurt Flughafen Fernbf. Information desks are located in the main hall.
Luggage storage is available at Frankfurt Flughafen Fernbf. Lost and found is available at the station.
Available at Frankfurt Flughafen Fernbf: Parking, Taxis, WC.
Available at Frankfurt Flughafen Fernbf: Bike Parking, Car Rental.
Accessibility facilities are available at Frankfurt Flughafen Fernbf: Elevators, ramps.
Nearby hotels include Sheraton Frankfurt Airport Hotel, Hilton Frankfurt Airport, Hilton Garden Inn Frankfurt Airport.
Here are some other resources that might have the information you need