- Recommended
Palazzo San Francesco - Musei Civici Gian Giacomo Galletti
The city museum inside a former Franciscan complex, presenting local archaeology, art, and historical collections linked to Ossola and Domodossola.
Cheapest price
$43
Average price
$48
Fastest journey
7 h 29 m
Average duration
7 h 38 m
Trains per day
2
Distance
349 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Domodossola is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Domodossola will cost around $48 if you buy it on the day, but the cheapest tickets can be found for only $43.
Of the 2 trains that leave Florence Santa Maria Novella for Domodossola on Mon, Jun 22, 2 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Mon, Jun 22 the direct trains cover the 349 km distance in an average of 7 h 38 m but if you time it right, some trains will get you there in just 7 h 29 m .
On Mon, Jun 22 the slowest trains will take 7 h 47 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.




Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Domodossola among Omio's users. If you are prioritising price take the train with prices starting from $35. For those with little time consider booking a bus which can get you there in 4h 15m. The ticket price range depends on the travel mode: a train costs an average of $35, and a bus costs an average of $88.
Distance: 216 miles (349 km)
Most popular Train | Bus | Driving |
|---|---|---|
$45 Average price Cheapest | $88 Average price | $127 Average price (fuel + tolls) |
4h 59m Average total duration 4h 29m Onboard + 30m Additional time* | 4h 45m Average total duration Fastest 4h 15m Onboard + 30m Additional time* | 4h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Florence Santa Maria Novella to Domodossola:
A train is $43 (€35) less than a bus for this route with tickets for a bus from Florence Santa Maria Novella to Domodossola costing on average $88 (€72).
Other travel options to Domodossola take longer:
Train takes on average 4h 29m.
Tickets start at around $45 (€37) compared to roughly $127 (€104) in fuel and tolls — a saving of about $82 (€67). The journey takes 4h 29m versus 4h 26m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
The table below shows live departures for Florence Santa Maria Novella to Domodossola trains for today, Sunday, June 21. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Intercity 580+ Autobus EC064 | 8:21 AM Florence Santa Maria Novella | 7h59 | 4:20 PM Domodossola station | 1 transfer | |
Intercity 580+ Regionale TRENORD 2406 · Autobus TRENORD 4406A | 8:21 AM Florence Santa Maria Novella | 7h31 | 3:52 PM Domodossola station | 2 transfers | |
Regionale Veloce 4021+ Intercity 670+ Autobus EC066 | 10:28 AM Florence Santa Maria Novella | 8h52 | 7:20 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9520+ Regionale TRENORD 2406 · Autobus TRENORD 4406A | 10:55 AM Florence Santa Maria Novella | 4h57 | 3:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9310+ Regionale TRENORD 2428 · Autobus TRENORD 4428A | 12:10 PM Florence Santa Maria Novella | 4h42 | 4:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9514+ Regionale TRENORD 2430 · Autobus TRENORD 4430A | 12:55 PM Florence Santa Maria Novella | 4h57 | 5:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9532+ Regionale TRENORD 2432 · Autobus TRENORD 4432A | 1:55 PM Florence Santa Maria Novella | 4h57 | 6:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9320+ Regionale TRENORD 2438 · Autobus TRENORD 4438A | 5:10 PM Florence Santa Maria Novella | 4h42 | 9:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9588+ Regionale TRENORD 2440 · Autobus TRENORD 4440A | 5:55 PM Florence Santa Maria Novella | 4h57 | 10:52 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9552+ Regionale TRENORD 2442 · Autobus TRENORD 4442A | 6:55 PM Florence Santa Maria Novella | 4h57 | 11:52 PM Domodossola station | 2 transfers | |
Find all the dates and times for this journey
Compare bus and train prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Trains from Florence Santa Maria Novella to Domodossola run on average 12 times per day, taking around 4h 29m. Cheap train tickets for this journey start at $35 (€29) if you book in advance.
The earliest train runs at 03:30, the last at 22:40. The fastest train covers the 216 miles (349 km) distance in 3h 54m.
Distance 216 miles (349 km) |
Average train duration 4h 29m |
Cheapest ticket price $35 (€29) |
Trains per day 12 |
Fastest train 3h 54m |
First train 3:30 AM |
Last train 10:40 PM |
Cheapest Month Jan |
Cheapest Day Thu |
High Season Apr - Jun |
Low Season Jan - Mar |
Busiest Day Wed |
Least Busy Day Sun |
Discover the best of Domodossola — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Domodossola trip today.
The city museum inside a former Franciscan complex, presenting local archaeology, art, and historical collections linked to Ossola and Domodossola.
A local history museum focused on the Simplon area, useful for understanding the Alpine routes, trade, and military history that shaped Domodossola.
A small natural science museum with zoological, mineral, and botanical displays, appreciated by visitors interested in regional nature and education.
Domodossola's signature square, lined with arcades and historic buildings, famous for markets, events, and its highly photogenic old-town atmosphere.
The old town is the best area for strolling, with cobbled lanes, arcades, stone houses, and a lively but compact historic core.
One of the most characteristic streets in the center, appreciated for its traditional architecture, arcaded sections, and local boutiques.
Rich mountain polenta enriched with local butter and melted alpine cheese, a classic Ossola comfort dish tied to the valleys around Domodossola.
A slow-cooked minced meat stew, traditionally flavored with wine and herbs, commonly served with polenta in the Ossola area.
Rustic potato gnocchi prepared in local style, often with butter, cheese, and sometimes cured meat, reflecting hearty alpine cooking.
Modern dining venue in Domodossola appreciated for creative Italian cooking, careful presentation, and a more contemporary ambiance.
Established restaurant in Domodossola known for refined Piedmontese and Ossola dishes in an elegant, traditional setting.
Well-regarded casual spot serving regional mountain cuisine, local wines, and classic comfort dishes in a warm historic atmosphere.
Generally moderate by Italian standards: coffee and casual meals are reasonable, while hotel and tourist-area prices can be higher.
Service is often included or covered by a coperto. Tipping is not obligatory; round up or leave EUR 1-2 at cafes, 5-10% for excellent restaurant service, and round up taxis.
Official public transport app
Domodossola Railway Station, Domodossola -> Piazza del Mercato, Domodossola
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Domodossola by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Domodossola, this guide helps you travel smarter and with confidence.

Here are some other resources that might have the information you need