The cheapest and fastest trains from Florence Santa Maria Novella to Domodossola station
Cheapest price
$43
Average price
$62
Fastest journey
3 h 54 m
Average duration
6 h 2 m
Trains per day
3
Distance
349 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Domodossola station is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Domodossola station will cost around $62 if you buy it on the day, but the cheapest tickets can be found for only $43.
Of the 3 trains that leave Florence Santa Maria Novella for Domodossola station on Sat, Feb 14, 3 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sat, Feb 14 the direct trains cover the 349 km distance in an average of 6 h 2 m but if you time it right, some trains will get you there in just 3 h 54 m .
On Sat, Feb 14 the slowest trains will take 9 h 23 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.






Travel Information
Compare train and bus for Florence Santa Maria Novella to Domodossola station
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Domodossola station among Omio's users. If you are prioritising price take the train with prices starting from €27. For those with little time consider booking a bus which can get you there in 4h 19m. The ticket price range depends on the travel mode: a train costs an average of €27, and a bus costs an average of €81.
Distance: 216 miles (349 km)
Compare train with
Most popular Train | Bus |
|---|---|
€40 Average price Cheapest | €81 Average price |
4h 59m Average total duration 4h 29m Onboard + 30m Additional time* | 4h 49m Average total duration Fastest 4h 19m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Domodossola station train times
The table below shows live departures for Florence Santa Maria Novella to Domodossola station trains for tomorrow, Saturday, February 14. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 3:30 AM Florence Santa Maria Novella | 9h23 | 12:53 PM Domodossola station | 0 transfersDirect | |
![]() | 10:10 AM Florence Santa Maria Novella | 4h48 | 2:58 PM Domodossola station | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Domodossola station by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 14
Feb 15
Feb 16
Feb 17
Feb 18
Feb 19
Feb 20
Why should you book Florence Santa Maria Novella to Domodossola station trains with Omio?
Why book with Omio vs Italo?
- Compare with other providers: On Omio, you can not only buy tickets for Italo, but also compare tickets for the likes of Frecciarossa, Regionale, Trenitalia or Intercity to find the best option for your trip from Florence Santa Maria Novella to Domodossola station.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Italo with all available travel options, which are train and bus to ensure you get the best deal for traveling from Florence Santa Maria Novella to Domodossola station.
Why book with Omio over Raileurope or Wanderu?
- Official reseller: Italo tickets can only be bought on Omio or Italo's website as Omio is the only official third party seller for Italo tickets. Raileurope or Wanderu do not sell Italo tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Florence Santa Maria Novella to Domodossola station.
Journey information
Overview: Train from Florence Santa Maria Novella to Domodossola station
Trains from Florence Santa Maria Novella to Domodossola station run on average 11 times per day, taking around 4h 29m. Cheap train tickets for this journey start at $34 (€27) if you book in advance.
The earliest train runs at 03:20, the last at 16:10. The fastest train covers the 216 miles (349 km) distance in 3h 54m.
Distance 216 miles (349 km) |
Average train duration 4h 29m |
Cheapest ticket price $34 (€27) |
Trains per day 11 |
Fastest train 3h 54m |
First train 03:20 |
Last train 16:10 |
Train companies: Italo, Frecciarossa, Regionale, Trenitalia, Intercity from Florence Santa Maria Novella to Domodossola station trainsItalo, Frecciarossa, Regionale, Trenitalia, Intercity trains will get you between Florence Santa Maria Novella and Domodossola station from $34 (€27). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Italo
Frecciarossa
Regionale
Trenitalia
Intercity
FAQs: Trains from Florence Santa Maria Novella to Domodossola station
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Domodossola station by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Domodossola station, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Domodossola station
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, accessible from the main entrance.
- Ristorante La Meridiana
- Osteria Vecchio Borgo
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Corona
- Hotel Ristorante Eurossola
- Hotel Domodossola
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-5 for trains to Switzerland and regional destinations
- Train: Regional and Eurocity trains
- Bus: Several local lines available
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Domodossola station
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