The cheapest and fastest trains from Florence Santa Maria Novella to Domodossola station
Cheapest price
$37
Average price
$45
Fastest journey
6 h 54 m
Average duration
8 h
Trains per day
6
Distance
349 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Domodossola station is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Domodossola station will cost around $45 if you buy it on the day, but the cheapest tickets can be found for only $37.
Of the 6 trains that leave Florence Santa Maria Novella for Domodossola station on Wed, Jun 10, 6 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Jun 10 the direct trains cover the 349 km distance in an average of 8 h but if you time it right, some trains will get you there in just 6 h 54 m .
On Wed, Jun 10 the slowest trains will take 11 h 23 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
2:09 PM6h57Florence Santa Maria Novella9:06 PMDomodossola station$371One-way0 transfers
1:10 PM6h54Florence Santa Maria Novella8:04 PMDomodossola station$371One-way0 transfers
1:09 PM7h01Florence Santa Maria Novella8:10 PMDomodossola station$451One-way0 transfers
3:30 AM11h23Florence Santa Maria Novella2:53 PMDomodossola station$471One-way0 transfers
10:40 PM15h13Florence Santa Maria Novella1:53 PMDomodossola station$471One-way0 transfers
1:10 PM6h54Florence Santa Maria Novella8:04 PMDomodossola station$371One-way0 transfers
2:09 PM6h57Florence Santa Maria Novella9:06 PMDomodossola station$371One-way0 transfers
1:09 PM7h01Florence Santa Maria Novella8:10 PMDomodossola station$451One-way0 transfers
6:21 AM7h47Florence Santa Maria Novella2:08 PMDomodossola station$581One-way0 transfers
3:30 AM11h23Florence Santa Maria Novella2:53 PMDomodossola station$471One-way0 transfers
Travel Information
Compare train and bus for Florence Santa Maria Novella to Domodossola station
Omio recommends booking the train as it is the most popular option from Florence Santa Maria Novella to Domodossola station among Omio's users. If you are prioritising price take the train with prices starting from $36. For those with little time consider booking a bus which can get you there in 4h 19m. The ticket price range depends on the travel mode: a train costs an average of $36, and a bus costs an average of $93.
Distance: 216 miles (349 km)
Compare train with
Most popular Train | Bus | Driving |
|---|---|---|
$54 Average price Cheapest | $96 Average price | $128 Average price (fuel + tolls) |
4h 57m Average total duration 4h 27m Onboard + 30m Additional time* | 4h 49m Average total duration Fastest 4h 19m Onboard + 30m Additional time* | 4h 26m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options |
This is compared to other travel options from Florence Santa Maria Novella to Domodossola station:
A train is $42 (€35) less than a bus for this route with tickets for a bus from Florence Santa Maria Novella to Domodossola station costing on average $96 (€78).
Other travel options to Domodossola station take longer:
Train takes on average 4h 27m.
Tickets start at around $54 (€44) compared to roughly $128 (€104) in fuel and tolls — a saving of about $74 (€60). The journey takes 4h 27m versus 4h 26m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Florence Santa Maria Novella to Domodossola station train times
The table below shows live departures for Florence Santa Maria Novella to Domodossola station trains for today, Tuesday, June 9. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
Intercity 580+ Autobus EC064 | 8:21 AM Florence Santa Maria Novella | 7h59 | 4:20 PM Domodossola station | 1 transfer | |
Intercity 580+ Regionale TRENORD 2946 · Regionale 10228 | 8:21 AM Florence Santa Maria Novella | 7h27 | 3:48 PM Domodossola station | 2 transfers | |
Regionale 18361+ Intercity 670+ Autobus EC066 | 9:53 AM Florence Santa Maria Novella | 9h27 | 7:20 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9308+ Regionale TRENORD 2948 · Regionale TRENORD 2428 | 11:10 AM Florence Santa Maria Novella | 4h43 | 3:53 PM Domodossola station | 2 transfers | |
Regionale 94455+ Intercity 608+ Autobus EC046 | 11:40 AM Florence Santa Maria Novella | 8h40 | 8:20 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9310+ Regionale TRENORD 2952 · Regionale TRENORD 2430 | 12:10 PM Florence Santa Maria Novella | 4h43 | 4:53 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9514+ Regionale TRENORD 2956 · Regionale TRENORD 2432 | 12:55 PM Florence Santa Maria Novella | 4h58 | 5:53 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9532+ Regionale TRENORD 2960 · Regionale TRENORD 2434 | 1:55 PM Florence Santa Maria Novella | 4h58 | 6:53 PM Domodossola station | 2 transfers | |
FRECCIAROSSA 9320+ Regionale TRENORD 2972 · Regionale TRENORD 2440 | 5:10 PM Florence Santa Maria Novella | 4h43 | 9:53 PM Domodossola station | 2 transfers | |
| Wednesday, June 10 | |||||
![]() | 3:30 AM Florence Santa Maria Novella | 11h23 | 2:53 PM Domodossola station | 0 transfersDirect | |
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Domodossola station by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Jun 10
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Jun 16
Why should you book Florence Santa Maria Novella to Domodossola station trains with Omio?
Why book with Omio vs Frecciarossa?
- Compare with other providers: On Omio, you can not only buy tickets for Frecciarossa, but also compare tickets for the likes of Italo, Regionale, Trenitalia or Intercity to find the best option for your trip from Florence Santa Maria Novella to Domodossola station.
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are train and bus to ensure you get the best deal for traveling from Florence Santa Maria Novella to Domodossola station.
Why book with Omio over Raileurope or Wanderu?
- Compare with other providers: On Omio, you can also compare tickets for the likes of Italo, Regionale, Trenitalia or Intercity to find the best option for your trip from Florence Santa Maria Novella to Domodossola station.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Florence Santa Maria Novella to Domodossola station.
Journey information
Overview: Train from Florence Santa Maria Novella to Domodossola station
Trains from Florence Santa Maria Novella to Domodossola station run on average 11 times per day, taking around 4h 27m. Cheap train tickets for this journey start at $36 (€29) if you book in advance.
The earliest train runs at 03:20, the last at 23:40. The fastest train covers the 216 miles (349 km) distance in 4h 43m.
Distance 216 miles (349 km) |
Average train duration 4h 27m |
Cheapest ticket price $36 (€29) |
Trains per day 11 |
Fastest train 4h 43m |
First train 3:20 AM |
Last train 11:40 PM |
Cheapest Month Aug |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jul - Sep |
Busiest Day Mon |
Least Busy Day Thu |
Train companies: Frecciarossa, Italo, Regionale, Trenitalia, Intercity from Florence Santa Maria Novella to Domodossola station trainsFrecciarossa, Italo, Regionale, Trenitalia, Intercity trains will get you between Florence Santa Maria Novella and Domodossola station from $36 (€29). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
Italo
Regionale
Trenitalia
Intercity
FAQs: Trains from Florence Santa Maria Novella to Domodossola station
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Domodossola station by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Domodossola station, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Domodossola station
- Mon - Sun: 06:00 - 21:00
- Free WiFi (30 minutes limit).
- Provided by KiPoint and located on the ground floor, on the side of Piazza Adua. Open daily from 06:00 to 23:00.
- 12oz Coffee Joint
- Casa Maioli
- Don Nino
- Fratelli Cuore
- McDonald´s
- Panella
- Segafredo Zanetti
- Spizzico
- Venchi
- & many more
- Elevators, escalators, step-free access. Mobility assistance is available with the Sala Blu, located next to Platform 1.
- Hotel Luxor Florence
- Joy Hotel Florence
- Diplomat Hotel Florence
- Mon - Sun: 06:00 - 21:00
- Located inside and outside the station.
- Tram lines: T1, T2
- Bus lines: 6, 11, 12, 13, 17, 23, 36, 37, C4
- Train lines: FR, FA, Italo
- 6:00 AM - 8:00 PM Monday - Sunday
- Free
- The car park is open 7 days a week, accessible from the main entrance.
- Ristorante La Meridiana
- Osteria Vecchio Borgo
- Outside the main entrance.
- Elevators, ramps.
- €1
- Hotel Corona
- Hotel Ristorante Eurossola
- Hotel Domodossola
- Located in the main hall
- Avis
- Europcar
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-5 for trains to Switzerland and regional destinations
- Train: Regional and Eurocity trains
- Bus: Several local lines available
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Domodossola station
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