The cheapest and fastest trains from Florence Santa Maria Novella to Frankfurt am Main
Cheapest price
$272
Average price
$293
Fastest journey
9 h 34 m
Average duration
9 h 42 m
Trains per day
2
Distance
731 km
The best way to find a cheap train ticket from Florence Santa Maria Novella to Frankfurt am Main is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Florence Santa Maria Novella to Frankfurt am Main will cost around $293 if you buy it on the day, but the cheapest tickets can be found for only $272.
It's difficult to get from Florence Santa Maria Novella to Frankfurt am Main without transferring at least once.




Travel Information
Compare train, bus, and flight for Florence Santa Maria Novella to Frankfurt am Main
Omio recommends booking the flight as it is the most popular option from Florence Santa Maria Novella to Frankfurt am Main among Omio's users. If you are prioritising price take the bus with prices starting from €60. For those with little time consider booking a flight which can get you there in 2h 16m. The ticket price range depends on the travel mode: a bus costs an average of €60, and a flight costs an average of €152.
Distance: 454 miles (731 km)
Compare train with
| Train | Most popular Flight | Bus |
|---|---|---|
€239 Average price | €288 Average price | €91 Average price Cheapest |
10h 12m Average total duration 9h 42m Onboard + 30m Additional time* | 5h 16m Average total duration Fastest 2h 16m Onboard + 3h 0m Additional time* | 19h 31m Average total duration 19h 1m Onboard + 30m Additional time* |
Direct Options | Direct Options | Direct Options |
Live departures
Florence Santa Maria Novella to Frankfurt am Main train times
The table below shows live departures for Florence Santa Maria Novella to Frankfurt am Main trains for today, Monday, December 1. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 8:55 AM Florence Santa Maria Novella | 9h49 | 6:44 PM Frankfurt am Main | 1 transfer | |
![]() | 9:10 AM Florence Santa Maria Novella | 9h34 | 6:44 PM Frankfurt am Main | 2 transfers | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Florence Santa Maria Novella to Frankfurt am Main by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 02
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Dec 08
Why should you book Florence Santa Maria Novella to Frankfurt am Main trains with Omio?
Frecciarossa operates all train services from Florence Santa Maria Novella to Frankfurt am Main. Omio is the only official third party seller for Frecciarossa tickets.
Why book with Omio vs Frecciarossa?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Frecciarossa with all available travel options, which are train, bus and flight to ensure you get the best deal for traveling from Florence Santa Maria Novella to Frankfurt am Main.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Frecciarossa tickets can only be bought on Omio or Frecciarossa's website as Omio is the only official third party seller for Frecciarossa tickets. Trainline, RailEurope, and Rail.Ninja do not sell Frecciarossa tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train, bus and flight to find the ideal travel option from Florence Santa Maria Novella to Frankfurt am Main.
Journey information
Overview: Train from Florence Santa Maria Novella to Frankfurt am Main
Trains from Florence Santa Maria Novella to Frankfurt am Main run on average 1 times per day, taking around 9h 42m. Cheap train tickets for this journey start at $274 (€222) but you can travel from only $74 (€60) by bus.
The earliest train runs at 08:55, the last at 09:10. The fastest train covers the 454 miles (731 km) distance in 9h 34m.
Distance 454 miles (731 km) |
Average train duration 9h 42m |
Cheapest ticket price $274 (€222) |
Trains per day 1 |
Fastest train 9h 34m |
First train 08:55 |
Last train 09:10 |
Train companies: Frecciarossa from Florence Santa Maria Novella to Frankfurt am Main trainsFrecciarossa trains will get you between Florence Santa Maria Novella and Frankfurt am Main from $74 (€60). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Frecciarossa
FAQs: Trains from Florence Santa Maria Novella to Frankfurt am Main
Find answers to the most common questions about traveling from Florence Santa Maria Novella to Frankfurt am Main by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Frankfurt am Main, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Florence Santa Maria Novella to Frankfurt am Main
- Merals Imbiss
- Bootshaus am Eisernen Steg
- Freigut
- Holbein's
- Hotel am Berg
- Leonardo Royal Hotel Frankfurt
- Hotel Ritter
- Lindner Main Plaza
- Immer Satt
- Café Crumble
- Café Albatros
- Cafe Extrablatt
- Frankfurt Marriott Hotel
- Imperial
- Sophien Hotel
- Hotel Isha
- Chipotle
- McDonald's
- Estragon
- The Westin Grand Frankfurt
- Steigenberger Frankfurter Hof
- Hilton Frankfurt City Centre
- Hotel Villa Orange
- 6:00 AM - 10:00 PM Monday - Sunday
- Free
- The car park is open 24/7, accessible via Terminal 1 and Terminal 2 parking areas.
- Restaurant Käfer's
- McDonald's
- Asia Snack Box
- Outside the main entrance.
- Elevators, ramps.
- €1
- Sheraton Frankfurt Airport Hotel
- Hilton Frankfurt Airport
- Hilton Garden Inn Frankfurt Airport
- Cost €6
- Located in the main hall
- Located in the main hall
- Avis
- Europcar
- Hertz
- Located in the main hall
- Free
- Hall 1: main entrance, platform 1-4 for long-distance and regional trains
- Hall 2: connection to Terminal 1 of the airport
- Hall 3: connection to Terminal 2 of the airport
- S-Bahn: Lines S8, S9
- Bus: Several lines available
- Long-distance buses: Available at the airport
Most popular train connections from Florence Santa Maria Novella
More options for your journey from Florence Santa Maria Novella to Frankfurt am Main
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