- Must visit
The Art Institute Of Chicago
One of the premier art museums in the United States, known for its Impressionist masterpieces, modern works, and iconic collections in a landmark downtown building.
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Travel Information
Compare train, bus, and flight for Clayton, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $33. For those with little time consider booking a flight which can get you there in 1h 29m. The ticket price range depends on the travel mode: a train costs an average of $33, and a flight costs an average of $379.
Distance: 262 miles (423 km)
Compare train with
Most popular Train | Flight | Bus | Driving |
|---|---|---|---|
$38 Average price Cheapest | $420 Average price | $58 Average price | $62 Average price (fuel + tolls) |
5h 28m Average total duration 4h 58m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 6h 57m Average total duration 6h 27m Onboard + 30m Additional time* | 4h 38m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Clayton, MO to Chicago, IL is a train with an average price of $38 (€31).
This is compared to other travel options from Clayton, MO to Chicago, IL:
A train is $19 (€16) less than a bus for this route with tickets for a bus from Clayton, MO to Chicago, IL costing on average $58 (€46).
A train is $382 (€308) less than a flight for this route with tickets for a flight from Clayton, MO to Chicago, IL costing on average $420 (€339).
The fastest way to travel from Clayton, MO to Chicago, IL is by flight with an average journey time of 1h 29m.
Other travel options to Chicago, IL take longer:
Train takes on average 4h 58m.
Bus takes on average 6h 27m.
It's helpful to compare your options as there are 3 ways to travel between Clayton, MO and Chicago, IL including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Clayton, MO to Chicago, IL among Omio's users.
Take the train. It's the cheaper option, and the extra time on board is usually more relaxing than driving it.
Tickets start at around $38 (€31) compared to roughly $62 (€50) in fuel and tolls — a saving of about $24 (€19). The journey takes 4h 58m versus 4h 38m by car, so you'll arrive a bit later, but you can work, read, or sleep along the way rather than spending the time behind the wheel. You'll also save the hassle of parking at the other end.
Driving is worth it if you're on a tight schedule, travelling as a group, or want to stop somewhere en route.
Live departures
Clayton, MO to Chicago, IL train times
The table below shows live departures for Clayton, MO to Chicago, IL trains for today, Monday, May 25. You can also manually refresh the results below to see updated train journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 10:14 AM Clayton, MO | 4h11 | 2:25 PM Chicago, IL | 0 transfersDirect | |
| 8:39 PM Clayton, MO | 4h21 | 1:00 AM Chicago, IL | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Clayton, MO to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Clayton, MO to Chicago, IL
USAUSA
Trains from Clayton, MO to Chicago, IL run on average 14 times per day, taking around 4h 58m. Cheap train tickets for this journey start at $33 (€26) if you book in advance.
There are 11 trains per day. The earliest train runs at 10:14, the last at 20:39. The fastest train covers the 262 miles (423 km) distance in 4h 11m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance 262 miles (423 km) |
Average train duration 4h 58m |
Cheapest ticket price $33 (€26) |
Trains per day 14 |
Direct trains 11 |
Fastest train 4h 11m |
First train 10:14 AM |
Last train 8:39 PM |
Cheapest Month Mar |
Cheapest Day Mon |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Train companies: Amtrak, Metro St. Louis from Clayton, MO to Chicago, IL trainsAmtrak, Metro St. Louis trains will get you between Clayton, MO and Chicago, IL from $33 (€26). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
4h 11m
Cheapest Price
$33 (€26)
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone
Metro St. Louis
Luggage & cancellation policy
Average Duration
5h 41m
Cheapest Price
$57 (€46)
Metro St. Louis frequency
5 a day
Complete guide to Chicago
Things to do in Chicago
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
- Must visit
Field Museum
A world-class natural history museum famous for its dinosaur fossils, ancient cultures, and major scientific collections, including the celebrated T. rex specimen SUE.
- Must visit
Museum Of Science And Industry
A large interactive science museum in Hyde Park with hands-on exhibits, transportation displays, and family-friendly experiences in a grand historic building.
- Must visit
Millennium Park
Chicago’s signature downtown park combines major public art, gardens, and event spaces, making it one of the city’s essential first stops for visitors.
- Must visit
The Magnificent Mile
The city’s best-known stretch of Michigan Avenue is lined with landmark buildings, shops, and hotels, and serves as a central walking route for first-time visitors.
- Must visit
Chicago Riverwalk
A highly popular waterfront promenade with excellent architecture views, bridges, and easy access to boat tours. It is one of the city’s most scenic urban walks.
Deep-Dish Pizza
Chicago’s iconic thick, buttery-crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce.
Chicago-Style Hot Dog
An all-beef hot dog on a poppy seed bun topped with mustard, onions, relish, tomato, pickle spear, sport peppers, and celery salt.
Italian Beef Sandwich
Thin-sliced seasoned roast beef served on a long roll, often dipped in jus and topped with sweet peppers or giardiniera.
Girl & the Goat
A celebrated West Loop restaurant with bold small plates, creative flavors, and a vibrant, modern atmosphere.
Alinea
Chicago’s internationally renowned fine-dining destination known for highly creative tasting menus and theatrical presentation.
Lou Malnati's Pizzeria
A classic Chicago pizzeria famous for buttery-crust deep-dish pizza and a relaxed, family-friendly atmosphere.
United States Dollar
Moderate for a major U.S. city: casual food is reasonable, but hotels, parking, and fine dining add up fast.
Average meal costs
- Budget
- USD 10-18 for fast food or casual takeout.
- Mid-range
- USD 25-45 per person at a mid-range restaurant.
- Fine dining
- USD 80+ per person before drinks and tip.
- Coffee
- USD 4-7 for a coffee drink.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Bars: USD 1-2 per drink. Taxis/rideshares: 10-15%. Hotels: USD 2-5 for housekeeping; USD 1-2 per bag.
FAQs: Trains from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Train ticket prices from Clayton, MO to Chicago, IL can vary. The cheapest ticket starts at $33 (€26), while the average price is around $38 (€31).
The train from Clayton, MO to Chicago, IL takes 4h 11m and runs 14 per day.
The distance by train from Clayton, MO to Chicago, IL is 262 miles (423 km).
The first train from Clayton, MO to Chicago, IL leaves at 10:14 AM.
The last train from Clayton, MO to Chicago, IL leaves at 8:39 PM.
There is no high speed train available from Clayton, MO to Chicago, IL.
There is no direct train service currently available from Clayton, MO to Chicago, IL.
Unfortunately, there is no night train available from Clayton, MO to Chicago, IL.
The train station in Clayton, MO that goes to Chicago, IL is St. Louis Station, St. Louis, MO, which connects to Chicago Union Station, Chicago, IL.
The cheapest way to get from Clayton, MO to Chicago, IL is by train, with a cost of around $33 (€26).
The train journey from Clayton, MO to Chicago, IL offers scenic views of the Midwest's rolling landscapes, farmland, and small towns, providing a picturesque and relaxing ride.
A day trip from Clayton, MO to Chicago, IL is not feasible as the journey takes 4h 11m. Trains run 11 times per day, and the distance is 262 miles (423 km).
In Chicago, IL, you can explore the Museum of Science and Industry and its interactive exhibits, enjoy the vibrant neighborhoods like Wicker Park and Lincoln Park, take a river cruise to view iconic architecture, and attend a live performance at the historic Chicago Theatre. Visit Lincoln Park Zoo for a free and enjoyable day. For sights, don't miss Millennium Park with its modern art, the renowned Art Institute of Chicago, the entertainment hub of Navy Pier, panoramic views from Willis Tower Skydeck, and the fascinating exhibits at the Field Museum.
To fully experience Chicago, IL, plan for at least 3-4 days to visit key attractions such as Millennium Park, The Art Institute of Chicago, Navy Pier, and explore diverse neighborhoods.
Yes, you can take the train from Clayton, MO to Chicago, IL.
Since neither Clayton, MO nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
Popular day trips by train from Chicago, IL include Milwaukee, WI, South Bend, IN, New Buffalo, MI, Racine, WI, Elkhart, IN.
We recommend using the train as it is the most popular way to get from Clayton, MO to Chicago, IL among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular train stations
Popular train stations from Clayton, MO to Chicago, IL
Clayton
Chicago
Amenities at train station
Wifi
Lockers
Parking
Dining
ATM
Taxis
Accessibility
WC
Hotel
Lounge
Lost and Found Office
Ticket Office
Bike Parking
Car Rental
Information Desk
Luggage Cartsinformation
Ticket Office Hours
- 5:00 AM - 12:00 AM Monday - Sunday
Distance to city center
3 km
Number of platforms
24Wifi
- Free
Parking
- The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
Dining
- The Chicago Firehouse Restaurant
- Lou Mitchell's
Taxis
- Outside the main entrance.
Accessibility
- Elevators, ramps, restrooms.
WC
- $1
Hotel
- The Kimpton Gray Hotel
- JW Marriott Chicago
- W Chicago - City Center
Lounge
- Located in the main hall
Lost and Found Office
- Located in the main hall
Car Rental
- Avis
- Budget
- Enterprise
Information Desk
- Located in the main hall
Luggage Carts
- Free
Station Plan
- Hall 1: main entrance, Amtrak services
- Hall 2: Metra services
- Hall 3: food court and retail shops
Public transit options for Union Station
- Bus: Several lines available
- CTA: Blue Line, Pink Line
More options for your journey from Clayton, MO to Chicago, IL
Here are some other resources that might have the information you need
Most popular trains to and from Chicago, IL and Clayton, MO
Most popular train connections to Chicago, IL
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