The cheapest and fastest trains from Clayton, MO to Chicago, IL
Cheapest price
$137
Average price
$137
Fastest journey
5 h 41 m
Average duration
6 h 21 m
Trains per day
5
Distance
423 km
The best way to find a cheap train ticket from Clayton, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Clayton, MO to Chicago, IL will cost around $137 if you buy it on the day, but the cheapest tickets can be found for only $137.
It's difficult to get from Clayton, MO to Chicago, IL without transferring at least once.










Travel Information
Compare train and bus for Clayton, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from €112. For those with little time consider booking a train which can get you there in 4h 58m. The ticket price range depends on the travel mode: a train costs an average of €112, and a bus costs an average of €129.
Distance: 262 miles (423 km)
Compare train with
Most popular Train | Bus |
|---|---|
€112 Average price Cheapest | €129 Average price |
5h 28m Average total duration Fastest 4h 58m Onboard + 30m Additional time* | 9h 6m Average total duration 8h 36m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Clayton, MO to Chicago, IL train times
The table below shows live departures for Clayton, MO to Chicago, IL trains for tomorrow, Saturday, November 8. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 12:49 AM Clayton, MO | 8h36 | 9:25 AM Chicago, IL | 1 transfer | |
![]() | 5:59 AM Clayton, MO | 5h41 | 11:40 AM Chicago, IL | 1 transfer | |
![]() | 7:39 AM Clayton, MO | 6h05 | 1:44 PM Chicago, IL | 1 transfer | |
![]() | 2:19 PM Clayton, MO | 5h41 | 8:00 PM Chicago, IL | 1 transfer | |
![]() | 4:59 PM Clayton, MO | 5h44 | 10:43 PM Chicago, IL | 1 transfer |
Find all the dates and times for this journey
Compare prices and tickets Clayton, MO to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Nov 08
Nov 09
Nov 10
Nov 11
Nov 12
Nov 13
Nov 14
Journey information
Overview: Train from Clayton, MO to Chicago, IL
Distance 262 miles (423 km) |
Average train duration 4h 58m |
Cheapest ticket price $138 (€112) |
Trains per day 11 |
Direct trains 9 |
Fastest train 5h 41m |
First train 00:49 |
Last train 16:59 |
Key Takeaways
Train Ticket Prices
- Budget Options: Train tickets from Clayton, MO to Chicago, IL start from as low as $138 (€112) if booked well in advance.
- Standard Fares: Typically, trains cost $138 (€112) depending on the train type and class.
Train companies: Amtrak from Clayton, MO to Chicago, IL trainsAmtrak trains will get you between Clayton, MO and Chicago, IL from $138 (€112). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Clayton, MO to Chicago, IL
- 5:00 AM - 12:00 AM Monday - Sunday
- Free
- The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
- The Chicago Firehouse Restaurant
- Lou Mitchell's
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $1
- The Kimpton Gray Hotel
- JW Marriott Chicago
- W Chicago - City Center
- Located in the main hall
- Located in the main hall
- Avis
- Budget
- Enterprise
- Located in the main hall
- Free
- Hall 1: main entrance, Amtrak services
- Hall 2: Metra services
- Hall 3: food court and retail shops
- Bus: Several lines available
- CTA: Blue Line, Pink Line
More options for your journey from Clayton, MO to Chicago, IL
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