Travel Information
Compare train and bus for Clayton, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $137. For those with little time consider booking a train which can get you there in 4h 58m. The ticket price range depends on the travel mode: a train costs an average of $137, and a bus costs an average of $158.
Distance: 262 miles (423 km)
Compare train with
Most popular Train | Bus |
|---|---|
$137 Average price Cheapest | $159 Average price |
5h 28m Average total duration Fastest 4h 58m Onboard + 30m Additional time* | 9h 6m Average total duration 8h 36m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Compare prices and tickets Clayton, MO to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Train from Clayton, MO to Chicago, IL
Trains from Clayton, MO to Chicago, IL run on average 12 times per day, taking around 4h 58m. Cheap train tickets for this journey start at $137 (€110) if you book in advance.
There are 10 trains per day. The earliest train runs at 00:49, the last at 16:59. The fastest train covers the 262 miles (423 km) distance in 5h 41m.
Distance 262 miles (423 km) |
Average train duration 4h 58m |
Cheapest ticket price $137 (€110) |
Trains per day 12 |
Direct trains 10 |
Fastest train 5h 41m |
First train 12:49 AM |
Last train 4:59 PM |
Train companies: Amtrak from Clayton, MO to Chicago, IL trainsAmtrak trains will get you between Clayton, MO and Chicago, IL from $137 (€110). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Clayton, MO to Chicago, IL
- 5:00 AM - 12:00 AM Monday - Sunday
- Free
- The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
- The Chicago Firehouse Restaurant
- Lou Mitchell's
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $1
- The Kimpton Gray Hotel
- JW Marriott Chicago
- W Chicago - City Center
- Located in the main hall
- Located in the main hall
- Avis
- Budget
- Enterprise
- Located in the main hall
- Free
- Hall 1: main entrance, Amtrak services
- Hall 2: Metra services
- Hall 3: food court and retail shops
- Bus: Several lines available
- CTA: Blue Line, Pink Line
More options for your journey from Clayton, MO to Chicago, IL
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