Clayton, MO to Chicago, IL train with Amtrak

Fri, Apr 10
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Amtrak
Regionale
Deutsche Bahn
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Frecciarossa
2,000+ travel companies
Amtrak
Regionale
Deutsche Bahn
iryo
Frecciarossa
2,000+ travel companies
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Travel Information

Compare train and bus for Clayton, MO to Chicago, IL

Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $137. For those with little time consider booking a train which can get you there in 4h 58m. The ticket price range depends on the travel mode: a train costs an average of $137, and a bus costs an average of $158.

Distance: 262 miles (423 km)

Compare train with

Most popular
Train
Bus

$137

Average price

Cheapest

$159

Average price

5h 28m

Average total duration

Fastest

4h 58m

Onboard

+

30m

Additional time*

9h 6m

Average total duration

8h 36m

Onboard

+

30m

Additional time*

Direct Options

Direct Options

Compare prices and tickets Clayton, MO to Chicago, IL by train or bus

Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.

Sat
Apr 11
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Journey information

Overview: Train from Clayton, MO to Chicago, IL

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Trains from Clayton, MO to Chicago, IL run on average 12 times per day, taking around 4h 58m. Cheap train tickets for this journey start at $137 (€110) if you book in advance.

There are 10 trains per day. The earliest train runs at 00:49, the last at 16:59. The fastest train covers the 262 miles (423 km) distance in 5h 41m.

Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Distance
262 miles (423 km)
Average train duration
4h 58m
Cheapest ticket price
$137 (€110)
Trains per day
12
Direct trains
10
Fastest train
5h 41m
First train
12:49 AM
Last train
4:59 PM
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information

Train companies: Amtrak from Clayton, MO to Chicago, IL trainsAmtrak trains will get you between Clayton, MO and Chicago, IL from $137 (€110). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.

Amtrak

About
Amtrak is the main passenger train operator in the United States, providing medium- and long-distance intercity services across 46 states and three Canadian provinces. Operating over 300 trains daily and serving more than 500 destinations, Amtrak connects cities and regions nationwide through routes such as the high-speed Acela in the Northeast Corridor, the scenic Coast Starlight along the West Coast, and the Empire Builder linking Chicago to the Midwest and the Pacific Northwest. Other notable services include the Northeast Regional, Keystone Service, and the unique Auto Train, which allows passengers to bring their cars onboard. Amtrak offers a variety of classes to suit different budgets and travel needs, including Coach, Business, First Class, and Sleeper Class with options like Roomettes, Bedrooms, and Bedroom Suites for overnight journeys. Ticket types include Saver, Value, Flexible, Business, and Premium. Onboard amenities vary by service but may include comfortable seating, Wi-Fi, power outlets, dining options, and lounge access on select trains. Popular routes include Washington, D.C.–Boston, San Diego–San Luis Obispo, San Jose–Sacramento, and Chicago–Seattle.
Luggage & cancellation policy
Average Duration
4h 19m
Cheapest Price
$42 (€34)
Amtrak frequency
12 a day
Luggage included
2 personal items and 2 carry-on bags included free
Luggage storage
Overhead racks, under seats, and designated luggage areas at end of cars
Cancellation Policy
Cancellation policies depend on ticket type and timing
Refund
Full refund if train is canceled by Amtrak
Amenities on board the train
Wifi
Food sold onboard
Café car with snacks, beverages, and light meals. Long-distance trains have full-service dining cars
Seat reservation
Included in ticket price for Business and First Class. Optional fee for Coach Class
Toilets
USB plugs
Accessibility
Wheelchair spaces, accessible restrooms, Red Cap assistance service, accessible platforms and stations
Pets
Small pets under 20 pounds allowed for $26 fee. Must be in carrier. Service animals travel free
Quiet zone

FAQs: Trains from Clayton, MO to Chicago, IL

Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

FAQs
Train ticket prices from Clayton, MO to Chicago, IL can vary. The cheapest ticket starts at $137 (€110), while the average price is around $137 (€110).
The train from Clayton, MO to Chicago, IL takes 5h 41m and runs 12 per day.
The first train from Clayton, MO to Chicago, IL leaves at 12:49 AM.
The distance by train from Clayton, MO to Chicago, IL is 262 miles (423 km).
The last train from Clayton, MO to Chicago, IL leaves at 4:59 PM.
There is no high speed train available from Clayton, MO to Chicago, IL.
Yes, there is a direct train from Clayton, MO to Chicago, IL. This service operates 10 times per day, provided by Amtrak.
Unfortunately, there is no night train available from Clayton, MO to Chicago, IL.
The train station in Clayton, MO that goes to Chicago, IL is St. Louis Station, St. Louis, MO, which connects to Chicago Union Station, Chicago, IL.
The cheapest way to get from Clayton, MO to Chicago, IL is by train, with a cost of around $137 (€110).
The train journey from Clayton, MO to Chicago, IL offers scenic views of the Midwest's rolling landscapes, farmland, and small towns, providing a picturesque and relaxing ride.
A day trip from Clayton, MO to Chicago, IL is not feasible as the journey takes 5h 41m. Trains run 11 times per day, and the distance is 262 miles (423 km).
In Chicago, IL, you can explore the Museum of Science and Industry and its interactive exhibits, enjoy the vibrant neighborhoods like Wicker Park and Lincoln Park, take a river cruise to view iconic architecture, and attend a live performance at the historic Chicago Theatre. Visit Lincoln Park Zoo for a free and enjoyable day. For sights, don't miss Millennium Park with its modern art, the renowned Art Institute of Chicago, the entertainment hub of Navy Pier, panoramic views from Willis Tower Skydeck, and the fascinating exhibits at the Field Museum.
To fully experience Chicago, IL, plan for at least 3-4 days to visit key attractions such as Millennium Park, The Art Institute of Chicago, Navy Pier, and explore diverse neighborhoods.
Yes, you can take the train from Clayton, MO to Chicago, IL.
Since neither Clayton, MO nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
Popular day trips by train from Chicago, IL include Milwaukee, WI, South Bend, IN, New Buffalo, MI, Racine, WI, Elkhart, IN.
We recommend using the train as it is the most popular way to get from Clayton, MO to Chicago, IL among Omio's users.
Items not allowed on trains typically include hazardous materials such as explosives, flammable liquids, corrosive substances, and illegal drugs. Additionally, large or bulky items that may obstruct aisles or emergency exits, as well as pets without proper carriers, may be restricted. Specific prohibited items can vary by train operator and region, so please check the rules for your particular journey.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.

popular train stations

Popular train stations from Clayton, MO to Chicago, IL

Clayton
Chicago
Amenities at train station
WifiWifi
LockersLockers
ParkingParking
DiningDining
ATMATM
TaxisTaxis
AccessibilityAccessibility
WCWC
HotelHotel
LoungeLounge
Lost and Found OfficeLost and Found Office
Ticket OfficeTicket Office
Bike ParkingBike Parking
Car RentalCar Rental
Information DeskInformation Desk
Luggage CartsLuggage Carts
information
phone
Phone Number
ticketOfficeHours
Ticket Office Hours
  • 5:00 AM - 12:00 AM Monday - Sunday
ticketOfficeHours
Distance to city center
3 km
platformCount
Number of platforms
24
Wifi
Wifi
  • Free
Parking
Parking
  • The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
Dining
Dining
  • The Chicago Firehouse Restaurant
  • Lou Mitchell's
Taxis
Taxis
  • Outside the main entrance.
Accessibility
Accessibility
  • Elevators, ramps, restrooms.
WC
WC
  • $1
Hotel
Hotel
  • The Kimpton Gray Hotel
  • JW Marriott Chicago
  • W Chicago - City Center
Lounge
Lounge
  • Located in the main hall
Lost and Found Office
Lost and Found Office
  • Located in the main hall
Car Rental
Car Rental
  • Avis
  • Budget
  • Enterprise
Information Desk
Information Desk
  • Located in the main hall
Luggage Carts
Luggage Carts
  • Free
Station Plan
  • Hall 1: main entrance, Amtrak services
  • Hall 2: Metra services
  • Hall 3: food court and retail shops
Public transit options for Union Station
  • Bus: Several lines available
  • CTA: Blue Line, Pink Line

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