- Must visit
Art Institute of Chicago
World-class art museum with masterpieces from Monet to Hopper and the famous Modern Wing.
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The cheapest and fastest buses from Clayton, MO to Chicago, IL
Showing times and prices for Aug 05
Cheapest price
€45
Average price
€45
Fastest journey
7 h
Average duration
7 h
Buses per day
1
Distance
423 km
Cheap tickets
The best way to find a cheap bus ticket from Clayton, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Clayton, MO to Chicago, IL will cost around €45 if you buy it on the day, but the cheapest tickets can be found for only €45.
Fast buses
Of the 1 buses that leave Clayton, MO for Chicago, IL on Wed, Aug 05, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Wed, Aug 05 the direct buses cover the 423 km distance in an average of 7 h but if you time it right, some buses will get you there in just 7 h .
On Wed, Aug 05 the slowest buses will take 7 h and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.
3:30 PM7h00Clayton, MO10:30 PMChicago, IL€451One-way0 transfers
- 3:30 PM7h00Clayton, MO10:30 PMChicago, IL€451One-way0 transfers
Journey information
Overview: Bus from Clayton, MO to Chicago, IL
USAUSA
Buses from Clayton, MO to Chicago, IL run on average 5 times per day, taking around 6h 27m. Cheap bus tickets for this journey start at €45 but you can travel from only €26 by train.
There are 3 buses per day. The earliest bus runs at 04:30, the last at 21:00. The fastest bus covers the 262 miles (423 km) distance in 6h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from €26
Distance 262 miles (423 km) |
Average bus duration 6h 27m |
Cheapest ticket price €45 |
Buses per day 5 |
Direct buses 3 |
Fastest bus 6h 5m |
First bus 4:30 AM |
Last bus 9:00 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from €26
Clayton, MO to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:30AM | Arrival Time 10:45AM | Duration 6h15 | Departure days Tue | Cheapest price €48 |
Operator Metro St. Louis | Departure Time 08:27AM | Arrival Time 04:30PM | Duration 8h03 | Departure days Sun | Cheapest price €46 |
Operator Metro St. Louis | Departure Time 02:27PM | Arrival Time 10:05PM | Duration 7h38 | Departure days Sun | Cheapest price €46 |
Operator Metro St. Louis | Departure Time 02:33PM | Arrival Time 10:05PM | Duration 7h32 | Departure days Sun | Cheapest price €47 |
Operator FlixBus | Departure Time 03:30PM | Arrival Time 10:30PM | Duration 7h00 | Departure days Wed | Cheapest price €45 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 03:05AM | Duration 6h05 | Departure days Mon | Cheapest price €46 |
Operator Metro St. Louis | Departure Time 10:32PM | Arrival Time 05:45AM | Duration 7h13 | Departure days Sun | Cheapest price €46 |
Operator Metro St. Louis | Departure Time 11:32PM | Arrival Time 04:30PM | Duration 16h58 | Departure days Sun | Cheapest price €46 |
Live departures
Clayton, MO to Chicago, IL bus times
The table below shows live departures for Clayton, MO to Chicago, IL buses for tomorrow, Wednesday, August 5. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
| 3:30 PM Clayton, MO | 7h00 | 10:30 PM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Complete guide to Chicago, IL
Things to do in Chicago, IL
Discover the best of Chicago, IL — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago, IL trip today.
- Must visit
Field Museum
Major natural history museum with Sue the T. rex, ancient cultures, and strong family appeal.
- Must visit
Museum of Science and Industry
Hands-on science museum in a grand former fair building, popular for exhibits and a U-505 submarine.
- Must visit
Millennium Park
Lively lakefront park with Cloud Gate, Crown Fountain, gardens, and major public art in central Chicago.
- Must visit
Magnificent Mile
Famous shopping boulevard lined with architecture, hotels, riverfront views, and major city energy.
- Must visit
Chicago Riverwalk
Scenic pedestrian-friendly riverwalk with boat docks, public art, bridges, and standout skyline perspectives.
Deep-Dish Pizza
Deep-dish pizza is Chicago’s iconic pie with a tall buttery crust, layers of cheese and toppings, and chunky tomato sauce baked on top.
Chicago-Style Hot Dog
The Chicago-style hot dog is an all-beef frank on a poppy seed bun with mustard, relish, onion, tomato, pickle, peppers, and celery salt.
Italian Beef Sandwich
Italian beef is thin-sliced roast beef piled onto a roll, often dipped in savory juices and topped with sweet peppers or spicy giardiniera.
Johnnie's Beef
Classic spot for juicy Italian beef sandwiches, especially dipped and topped with spicy giardiniera, with a casual local feel.
Superdawg Drive-In
Legendary stand for Chicago-style hot dogs and char-grilled sausages, served fast in a no-frills local landmark.
Alinea
World-famous fine dining destination offering a highly creative tasting menu and refined service in an elegant setting.
US dollar ($)
Moderate for a major US city: hotels can be pricey, but transit is affordable and dining ranges from cheap eats to upscale options.
Average meal costs
- Budget
- $10-18 for fast food or casual takeout.
- Mid-range
- $20-40 per person for a restaurant meal.
- Fine dining
- $75+ per person for upscale restaurants.
- Coffee
- $3-6 for coffee or cappuccino.
Tipping culture
Tip 18-20% at restaurants, $1-2 per drink at bars, 10-15% for taxis, and optional small change at cafes.
FAQs: Bus from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Clayton, MO to Chicago, IL can start from as little as €45 when you book in advance. The average bus ticket price for Clayton, MO to Chicago, IL is €46 ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Clayton, MO to Chicago, IL is 6h 5m to travel the 262 miles (423 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Clayton, MO to Chicago, IL leaves at 4:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Clayton, MO to Chicago, IL leaves at 9:00 PM.
When departing from Clayton, MO , you have various bus station options to start your journey from including St. Louis, S 15th St (Civic center), St. Louis, MO . When arriving in Chicago, IL , you can end your journey in bus stations like Chicago, Greyhound Bus Station, Chicago, Union Station (Amtrak), IL, Chicago, IL .Passengers board the bus most frequently from St. Louis, S 15th St (Civic center), which is located around away from the city centre, and they get off the bus at Chicago, Greyhound Bus Station, located 2 away from the city centre.
It's helpful to compare your options as there are 3 ways to travel between Clayton, MO and Chicago, IL including taking a train, bus, and flight.
No, the bus from Clayton, MO to Chicago, IL has no accessibility options.
No, there are no bathrooms on board the bus from Clayton, MO to Chicago, IL.
No, bikes are not allowed on board the bus from Clayton, MO to Chicago, IL.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Clayton, MO to Chicago, IL.
No, luggage for the bus from Clayton, MO to Chicago, IL needs to be booked in addition.
No, there are no additional luggage options for the bus from Clayton, MO to Chicago, IL.
Unfortunately, pets are not allowed on the bus from Clayton, MO to Chicago, IL.
No, there are no USB plugs on board the bus from Clayton, MO to Chicago, IL.
No, there is no WiFi on board the bus from Clayton, MO to Chicago, IL.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Clayton, MO to Chicago, IL
Most Clayton, MO to Chicago, IL buses use the St. Louis, S 15th St (Civic center) to Chicago, Greyhound Bus Station station pair, with some services arriving at Chicago, Union Station (Amtrak). Use this guide to compare Clayton, MO and Chicago, IL bus stations on this route, check city-centre transport, alongside checking practicalities like bus station facilities and services.
Departure bus stations in Clayton
Arrival bus stations in Chicago
Which Chicago, IL station do buses from Clayton, MO arrive at?
Buses from Clayton, MO to Chicago, IL most often arrive at Chicago, Greyhound Bus Station. Some services arrive at Chicago, Union Station (Amtrak), so check your ticket before travel to confirm your Chicago, IL arrival station.
Chicago, Greyhound Bus Station630 W Harrison St, Chicago, IL 60607, USA
City-centre transport
Getting to Chicago, Greyhound Bus Station from Chicago city centre
Chicago, Greyhound Bus Station is 2 km from Chicago city centre. Public transport options include:
Bus7 · 8m · €3 · every ~6 min
Chicago, Greyhound Bus Station bus station facilities and services
Chicago, Greyhound Bus Station has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Snack shop and vending machines available
Wi-Fi and ATMs
Free Wi-Fi in waiting area. ATMs are located near entrance.
Tickets and information
Ticket office support is available at Chicago, Greyhound Bus Station.
Parking, taxis and toilets
Available at Chicago, Greyhound Bus Station: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Greyhound Bus Station: Wheelchair accessible entrances and seating.
Chicago, Union Station (Amtrak)Chicago Union Station, 225 S Canal St, Chicago, IL 60606, USA
City-centre transport
Getting to Chicago, Union Station (Amtrak) from Chicago city centre
Chicago, Union Station (Amtrak) is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · €3 · every ~13 min
Chicago, Union Station (Amtrak) bus station facilities and services
Chicago, Union Station (Amtrak) has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Multiple dining options are available inside the station.
Wi-Fi and ATMs
Free Wi-Fi is available in waiting areas. ATMs are aTMs are located near the main entrance.
Tickets and information
Ticket office support is available at Chicago, Union Station (Amtrak).
Parking, taxis and toilets
Available at Chicago, Union Station (Amtrak): Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago, Union Station (Amtrak): Station is accessible with elevators and ramps.
ChicagoChicago (Bus Station), Chicago, IL 60607, USA
City-centre transport
Getting to Chicago from Chicago city centre
Chicago is 3 km from Chicago city centre. Public transport options include:
Bus28, 151 · 7m · €3 · every ~13 min
Chicago bus station facilities and services
Chicago has practical services for this route, including Wifi, Parking, Dining, ATM, Taxis, Accessibility, WC, Shower, and Ticket Office.
Food and drink
Food options include: Fast food outlets are available.
Wi-Fi and ATMs
Free Wi-Fi available in the waiting area. ATMs are aTM located near the main entrance.
Tickets and information
Ticket office support is available at Chicago.
Parking, taxis and toilets
Available at Chicago: Parking, Taxis, WC.
Accessibility
Accessibility facilities are available at Chicago: Wheelchair accessible with ramps and elevators.
More options for your journey from Clayton, MO to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Clayton, MO
Most popular bus connections to Chicago, IL
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