4.9
4.6The cheapest and fastest buses from Clayton, MO to Chicago, IL
Cheapest price
$161
Average price
$161
Fastest journey
7 h 28 m
Average duration
8 h 10 m
Buses per day
3
Distance
423 km
The best way to find a cheap bus ticket from Clayton, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Clayton, MO to Chicago, IL will cost around $161 if you buy it on the day, but the cheapest tickets can be found for only $161.
It's difficult to get from Clayton, MO to Chicago, IL without transferring at least once.
Travel Information
Compare train and bus for Clayton, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $138. For those with little time consider booking a train which can get you there in 4h 58m. The ticket price range depends on the travel mode: a train costs an average of $138, and a bus costs an average of $160.
Distance: 262 miles (423 km)
Compare bus with
| Bus | Most popular Train |
|---|---|
$160 Average price | $138 Average price Cheapest |
9h 6m Average total duration 8h 36m Onboard + 30m Additional time* | 5h 28m Average total duration Fastest 4h 58m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Clayton, MO to Chicago, IL bus times
The table below shows live departures for Clayton, MO to Chicago, IL buses for tomorrow, Tuesday, February 24. You can also manually refresh the results below to see updated bus journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets | |
|---|---|---|---|---|---|---|
| 7:27 AM Clayton, MO | 7h28 | 2:55 PM Chicago, IL | 1 transfer | ||
| 12:27 PM Clayton, MO | 8h33 | 9:00 PM Chicago, IL | 1 transfer | ||
| 12:32 PM Clayton, MO | 8h28 | 9:00 PM Chicago, IL | 2 transfers | ||
This is the last bus of the day. | ||||||
Find all the dates and times for this journey
Compare prices and tickets Clayton, MO to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Feb 24
Feb 25
Feb 26
Feb 27
Feb 28
Mar 01
Mar 02
Journey information
Overview: Bus from Clayton, MO to Chicago, IL
USAUSA
Buses from Clayton, MO to Chicago, IL run on average 4 times per day, taking around 8h 36m. Cheap bus tickets for this journey start at $160 (€127) but you can travel from only $138 (€110) by train.
There are 1 buses per day. The earliest bus runs at 07:27, the last at 23:32. The fastest bus covers the 262 miles (423 km) distance in 7h 25m.
Distance 262 miles (423 km) |
Average bus duration 8h 36m |
Cheapest ticket price $160 (€127) |
Buses per day 4 |
Direct buses 1 |
Fastest bus 7h 25m |
First bus 07:27 |
Last bus 23:32 |
Bus providers: Metro St. Louis from Clayton, MO to Chicago, ILYou can travel by bus between Clayton, MO to Chicago, IL with Metro St. Louis for as low as $138 (€110). When you search for schedules and tickets, Omio will show you the best journey
Metro St. Louis
FAQs: Bus from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
popular bus stations
Popular bus stations from Clayton, MO to Chicago, IL
More options for your journey from Clayton, MO to Chicago, IL
Here are some other resources that might have the information you need
Most popular buses to and from Chicago, IL and Clayton, MO
Most popular bus connections to Chicago, IL
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