- Must visit
The Art Institute Of Chicago
One of the premier art museums in the United States, known for its Impressionist masterpieces, modern works, and iconic collections in a landmark downtown building.
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Travel Information
Compare train, bus, and flight for Clayton, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Clayton, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from $33. For those with little time consider booking a flight which can get you there in 1h 29m. The ticket price range depends on the travel mode: a train costs an average of $33, and a flight costs an average of $379.
Distance: 262 miles (423 km)
Compare bus with
| Bus | Most popular Train | Flight | Driving |
|---|---|---|---|
$58 Average price | $38 Average price Cheapest | $420 Average price | $62 Average price (fuel + tolls) |
6h 57m Average total duration 6h 27m Onboard + 30m Additional time* | 5h 28m Average total duration 4h 58m Onboard + 30m Additional time* | 4h 29m Average total duration Fastest 1h 29m Onboard + 3h 0m Additional time* | 4h 38m Average total duration (door-to-door) |
Direct Options | Direct Options | Direct Options | Direct Options |
The cheapest way to travel from Clayton, MO to Chicago, IL is a train with an average price of $38 (€31).
This is compared to other travel options from Clayton, MO to Chicago, IL:
A train is $19 (€16) less than a bus for this route with tickets for a bus from Clayton, MO to Chicago, IL costing on average $58 (€46).
A train is $382 (€308) less than a flight for this route with tickets for a flight from Clayton, MO to Chicago, IL costing on average $420 (€339).
The fastest way to travel from Clayton, MO to Chicago, IL is by flight with an average journey time of 1h 29m.
Other travel options to Chicago, IL take longer:
Train takes on average 4h 58m.
Bus takes on average 6h 27m.
It's helpful to compare your options as there are 3 ways to travel between Clayton, MO and Chicago, IL including taking a train, bus, and flight.
We recommend using the train as it is the most popular way to get from Clayton, MO to Chicago, IL among Omio's users.
Take the bus. On this route, it's both cheaper and quicker than driving.
You'll arrive about {timeSavings} sooner ({durationInMinutes} by bus vs {drivingDurationInMinutes} by car) and save roughly {savingsAmount} compared to fuel and tolls ({cheapestPrice} vs {drivingPriceInCents}). You also skip the drive itself — no traffic stress, no parking, and you can use the time to work, nap, or catch up on a series with the onboard Wi-Fi.
Direct coaches are operated by {directProviders}.
Driving is still worth considering if you're travelling with bulky luggage, need flexibility on departure times, or plan to stop along the way.
Clayton, MO to Chicago, IL Bus Timetables
| Operator | Departure Time | Arrival Time | Duration | Departure days | Cheapest price |
|---|---|---|---|---|---|
Operator FlixBus | Departure Time 04:30AM | Arrival Time 10:45AM | Duration 6h15 | Departure days Tue | Cheapest price $60 |
Operator Metro St. Louis | Departure Time 08:27AM | Arrival Time 04:30PM | Duration 8h03 | Departure days Sun | Cheapest price $57 |
Operator Metro St. Louis | Departure Time 02:27PM | Arrival Time 10:05PM | Duration 7h38 | Departure days Sun | Cheapest price $57 |
Operator Metro St. Louis | Departure Time 02:33PM | Arrival Time 10:05PM | Duration 7h32 | Departure days Sun | Cheapest price $58 |
Operator FlixBus | Departure Time 03:30PM | Arrival Time 10:30PM | Duration 7h00 | Departure days Wed | Cheapest price $56 |
Operator FlixBus | Departure Time 09:00PM | Arrival Time 03:05AM | Duration 6h05 | Departure days Mon | Cheapest price $57 |
Operator Metro St. Louis | Departure Time 10:32PM | Arrival Time 05:45AM | Duration 7h13 | Departure days Sun | Cheapest price $57 |
Operator Metro St. Louis | Departure Time 11:32PM | Arrival Time 04:30PM | Duration 16h58 | Departure days Sun | Cheapest price $57 |
Live departures
Clayton, MO to Chicago, IL bus times
The table below shows live departures for Clayton, MO to Chicago, IL buses for today, Monday, May 25. You can also manually refresh the results below to see updated bus journeys.
Last updated at
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
 | 9:00 PM Clayton, MO | 6h05 | 3:05 AM Chicago, IL | 0 transfersDirect | |
This is the last bus of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Clayton, MO to Chicago, IL by train, bus, or flight
Compare train, bus, and flight prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
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Journey information
Overview: Bus from Clayton, MO to Chicago, IL
USAUSA
Buses from Clayton, MO to Chicago, IL run on average 5 times per day, taking around 6h 27m. Cheap bus tickets for this journey start at $56 (€45) but you can travel from only $33 (€26) by train.
There are 3 buses per day. The earliest bus runs at 04:30, the last at 21:00. The fastest bus covers the 262 miles (423 km) distance in 6h 5m.
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $33 (€26)
Distance 262 miles (423 km) |
Average bus duration 6h 27m |
Cheapest ticket price $56 (€45) |
Buses per day 5 |
Direct buses 3 |
Fastest bus 6h 5m |
First bus 4:30 AM |
Last bus 9:00 PM |
Cheapest Month May |
Cheapest Day Wed |
High Season Apr - Jun |
Low Season Jan - Mar |
Fares are the lowest economy prices found on Omio. Early booking often means lower prices. Prices change daily and are subject to availability. Discount cards, coach trips, and booking fees are not included.
Price information
Cheapest alternative travel mode
Train from $33 (€26)
Complete guide to Chicago
Things to do in Chicago
Discover the best of Chicago — top attractions, local food, transport tips, budget advice, and currency essentials. Plan your perfect Chicago trip today.
- Must visit
Field Museum
A world-class natural history museum famous for its dinosaur fossils, ancient cultures, and major scientific collections, including the celebrated T. rex specimen SUE.
- Must visit
Museum Of Science And Industry
A large interactive science museum in Hyde Park with hands-on exhibits, transportation displays, and family-friendly experiences in a grand historic building.
- Must visit
Millennium Park
Chicago’s signature downtown park combines major public art, gardens, and event spaces, making it one of the city’s essential first stops for visitors.
- Must visit
The Magnificent Mile
The city’s best-known stretch of Michigan Avenue is lined with landmark buildings, shops, and hotels, and serves as a central walking route for first-time visitors.
- Must visit
Chicago Riverwalk
A highly popular waterfront promenade with excellent architecture views, bridges, and easy access to boat tours. It is one of the city’s most scenic urban walks.
Deep-Dish Pizza
Chicago’s iconic thick, buttery-crust pizza baked in a deep pan with layers of cheese, toppings, and chunky tomato sauce.
Chicago-Style Hot Dog
An all-beef hot dog on a poppy seed bun topped with mustard, onions, relish, tomato, pickle spear, sport peppers, and celery salt.
Italian Beef Sandwich
Thin-sliced seasoned roast beef served on a long roll, often dipped in jus and topped with sweet peppers or giardiniera.
Girl & the Goat
A celebrated West Loop restaurant with bold small plates, creative flavors, and a vibrant, modern atmosphere.
Alinea
Chicago’s internationally renowned fine-dining destination known for highly creative tasting menus and theatrical presentation.
Lou Malnati's Pizzeria
A classic Chicago pizzeria famous for buttery-crust deep-dish pizza and a relaxed, family-friendly atmosphere.
United States Dollar
Moderate for a major U.S. city: casual food is reasonable, but hotels, parking, and fine dining add up fast.
Average meal costs
- Budget
- USD 10-18 for fast food or casual takeout.
- Mid-range
- USD 25-45 per person at a mid-range restaurant.
- Fine dining
- USD 80+ per person before drinks and tip.
- Coffee
- USD 4-7 for a coffee drink.
Tipping culture
Tip 18-20% at restaurants; 20%+ for great service. Bars: USD 1-2 per drink. Taxis/rideshares: 10-15%. Hotels: USD 2-5 for housekeeping; USD 1-2 per bag.
FAQs: Bus from Clayton, MO to Chicago, IL
Find answers to the most common questions about traveling from Clayton, MO to Chicago, IL by bus. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest bus, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.
Cheap bus tickets from Clayton, MO to Chicago, IL can start from as little as $56 (€45) when you book in advance. The average bus ticket price for Clayton, MO to Chicago, IL is $58 (€46) ; however, prices vary depending on the time of day and class and they tend to be more expensive on the day.
The average journey time by bus from Clayton, MO to Chicago, IL is 6h 5m to travel the 262 miles (423 km) long journey. Journey times can vary on weekends and holidays, so use our Journey Planner to search for a specific date.
The earliest bus from Clayton, MO to Chicago, IL leaves at 4:30 AM. Plan your trip with the Journey Planner from Omio.
The latest bus from Clayton, MO to Chicago, IL leaves at 9:00 PM.
A trip to Chicago, IL from Clayton, MO is worth doing but not as a day trip with a journey time of 6h 5m each way. Check with Omio app the best way to travel.
The cheapest month for a bus from Clayton, MO to Chicago, IL is May.
It's helpful to compare your options as there are 3 ways to travel between Clayton, MO and Chicago, IL including taking a train, bus, and flight.
No, the bus from Clayton, MO to Chicago, IL has no accessibility options.
No, there are no bathrooms on board the bus from Clayton, MO to Chicago, IL.
Some of the most interesting sights to explore in Chicago, IL are:
- Millennium Park, a public park known for its modern art installations and the iconic Cloud Gate sculpture
- Art Institute of Chicago, a renowned museum housing an extensive collection of art from around the world
- Navy Pier, a popular entertainment destination featuring rides, restaurants, and lakefront views
- Willis Tower Skydeck, an observation deck offering panoramic views of the city from one of the tallest buildings in the Western Hemisphere
- Field Museum, a natural history museum with vast exhibits including the famous T. rex skeleton, Sue.
The best things to do in Chicago, IL include:
- Museum of Science and Industry, an interactive museum featuring exhibits on science, technology, and industry
- Explore the vibrant neighborhoods of Chicago, such as Wicker Park and Lincoln Park, known for their unique shops and eateries
- Take a river cruise to see the city's iconic architecture from a different perspective
- Attend a live performance at the historic Chicago Theatre
- Enjoy a day at Lincoln Park Zoo, one of the oldest zoos in the U.S., offering free admission.
No, bikes are not allowed on board the bus from Clayton, MO to Chicago, IL.
Tickets are often cheaper when booked early. Traveling during off-peak hours or on weekdays can help you save money. Sort results by price to quickly identify the most affordable options. Check for promotions or discounts available on our website and app.
No, there is no food available to purchase on board the bus from Clayton, MO to Chicago, IL.
No, luggage for the bus from Clayton, MO to Chicago, IL needs to be booked in addition.
No, there are no additional luggage options for the bus from Clayton, MO to Chicago, IL.
Unfortunately, pets are not allowed on the bus from Clayton, MO to Chicago, IL.
No, there are no USB plugs on board the bus from Clayton, MO to Chicago, IL.
No, there is no WiFi on board the bus from Clayton, MO to Chicago, IL.
Since neither Clayton, MO nor Chicago, IL are in the Schengen Area, passport requirements depend on the specific immigration rules of United States and United States. Entry and visa requirements can be subject to change. For the latest information, check with your destination's embassy or consulate.
We recommend using the train as it is the most popular way to get from Clayton, MO to Chicago, IL among Omio's users.
The currency used in the United States is the US Dollar (USD). For travelers, using cards is generally more convenient and widely accepted, especially credit and debit cards, while cash is useful for small purchases or places that do not accept cards.
In Chicago, IL, travelers should be cautious of pickpocketing and purse snatching, especially in crowded areas like public transit and popular tourist spots. Common scams include fake charity solicitations and distraction thefts. It is advisable to stay alert in neighborhoods outside downtown after dark and use authorized transportation services to avoid unlicensed taxi scams. Keeping valuables secure and being aware of surroundings helps mitigate these risks.
Pack lightweight, versatile clothing suitable for the destination's climate, and use secure, lockable luggage to protect belongings. Keep essential items like travel documents, medication, and valuables in a carry-on bag for easy access. Use packing organizers or cubes to maximize space and maintain order. Lastly, include a small first aid kit and personal hygiene items for added comfort during travel.
popular bus stations
Popular bus stations from Clayton, MO to Chicago, IL
Clayton
Chicago
Chicago, Greyhound Bus Station
information
Chicago, Union Station (Amtrak)
information
More options for your journey from Clayton, MO to Chicago, IL
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Most popular buses to and from Chicago, IL and Clayton, MO
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