The cheapest and fastest trains from Cape Girardeau, MO to Chicago, IL
Cheapest price
$52
Average price
$52
Fastest journey
18 h 29 m
Average duration
18 h 29 m
Trains per day
1
Distance
530 km
The best way to find a cheap train ticket from Cape Girardeau, MO to Chicago, IL is to book your journey as far in advance as possible and to avoid traveling at rush hour.
The average ticket from Cape Girardeau, MO to Chicago, IL will cost around $52 if you buy it on the day, but the cheapest tickets can be found for only $52.
Of the 1 trains that leave Cape Girardeau, MO for Chicago, IL on Sun, Dec 21, 1 travel direct so it’s quite easy to avoid journeys where you’ll have to change along the way.
On Sun, Dec 21 the direct trains cover the 530 km distance in an average of 18 h 29 m but if you time it right, some trains will get you there in just 18 h 29 m .
On Sun, Dec 21 the slowest trains will take 18 h 29 m and usually involve a change or two along the way, but you might be able to save a few pennies if you’re on a budget.


Travel Information
Compare train and bus for Cape Girardeau, MO to Chicago, IL
Omio recommends booking the train as it is the most popular option from Cape Girardeau, MO to Chicago, IL among Omio's users. If you are prioritising price take the train with prices starting from €32. For those with little time consider booking a train which can get you there in 5h 37m. The ticket price range depends on the travel mode: a train costs an average of €32, and a bus costs an average of €53.
Distance: 329 miles (530 km)
Compare train with
Most popular Train | Bus |
|---|---|
€40 Average price Cheapest | €53 Average price |
6h 7m Average total duration Fastest 5h 37m Onboard + 30m Additional time* | 9h 5m Average total duration 8h 35m Onboard + 30m Additional time* |
Direct Options | Direct Options |
Live departures
Cape Girardeau, MO to Chicago, IL train times
The table below shows live departures for Cape Girardeau, MO to Chicago, IL trains for today, Saturday, December 20. You can also manually refresh the results below to see updated train journeys.
| Provider | Departs | Duration | Arrives | Transfers | Tickets |
|---|---|---|---|---|---|
![]() | 9:15 PM Cape Girardeau, MO | 5h30 | 2:45 AM Chicago, IL | 0 transfersDirect | |
| Sunday, December 21 | |||||
![]() | 8:16 AM Cape Girardeau, MO | 18h29 | 2:45 AM Chicago, IL | 0 transfersDirect | |
This is the last train of the day. | |||||
Find all the dates and times for this journey
Compare prices and tickets Cape Girardeau, MO to Chicago, IL by train or bus
Compare train and bus prices over the next three weeks. See the best deals at a glance, find the lowest fares, and choose the option that fits your budget.
Dec 21
Dec 22
Dec 23
Dec 24
Dec 25
Dec 26
Dec 27
Why should you book Cape Girardeau to Chicago trains with Omio?
Amtrak operates all train services from Cape Girardeau to Chicago. Omio is the only official third party seller for Amtrak tickets.
Why book with Omio vs Amtrak?
- Designed for International Travelers: Omio is in your language including 24/7 customer service and offers multiple payment options, including PayPal, credit cards, and bank transfer, in your preferred currency.
- Compare all your options: Omio allows you to compare Amtrak with all available travel options, which are train and bus to ensure you get the best deal for traveling from Cape Girardeau to Chicago.
Why book with Omio over Trainline and Rail Europe?
- Official reseller: Amtrak tickets can only be bought on Omio or Amtrak's website as Omio is the only official third party seller for Amtrak tickets. Trainline, RailEurope, and Rail.Ninja do not sell Amtrak tickets as they are not official sellers.
- Multiple modes of transport: Omio allows you to compare travel options including train and bus to find the ideal travel option from Cape Girardeau to Chicago.
Journey information
Overview: Train from Cape Girardeau, MO to Chicago, IL
Trains from Cape Girardeau, MO to Chicago, IL run on average 4 times per day, taking around 5h 37m. Cheap train tickets for this journey start at $40 (€32) if you book in advance.
There are 3 trains per day. The earliest train runs at 03:16, the last at 20:05. The fastest train covers the 329 miles (530 km) distance in 5h 30m.
Distance 329 miles (530 km) |
Average train duration 5h 37m |
Cheapest ticket price $40 (€32) |
Trains per day 4 |
Direct trains 3 |
Fastest train 5h 30m |
First train 03:16 |
Last train 20:05 |
Train companies: Amtrak from Cape Girardeau, MO to Chicago, IL trainsAmtrak trains will get you between Cape Girardeau, MO and Chicago, IL from $40 (€32). With over 1000 travel companies on Omio, you can find the best train times and tickets for your trip.
Amtrak
FAQs: Trains from Cape Girardeau, MO to Chicago, IL
Find answers to the most common questions about traveling from Cape Girardeau, MO to Chicago, IL by train. From journey times and ticket prices to direct connections, first and last departures, and even whether the route is scenic, our FAQs cover everything you need to plan your trip. Whether you’re looking for the fastest train, the cheapest option, or tips for making the most of your visit at Chicago, IL, this guide helps you travel smarter and with confidence.

popular train stations
Popular train stations from Cape Girardeau, MO to Chicago, IL
- 5:00 AM - 12:00 AM Monday - Sunday
- Free
- The car park is open 7 days a week from 5:00 a.m. to 12:00 a.m. Departures can be made outside of opening hours. Access via Canal Street.
- The Chicago Firehouse Restaurant
- Lou Mitchell's
- Outside the main entrance.
- Elevators, ramps, restrooms.
- $1
- The Kimpton Gray Hotel
- JW Marriott Chicago
- W Chicago - City Center
- Located in the main hall
- Located in the main hall
- Avis
- Budget
- Enterprise
- Located in the main hall
- Free
- Hall 1: main entrance, Amtrak services
- Hall 2: Metra services
- Hall 3: food court and retail shops
- Bus: Several lines available
- CTA: Blue Line, Pink Line
More options for your journey from Cape Girardeau, MO to Chicago, IL
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